cefepime hydrochloride / Generic mfg. - LARVOL DELTA

Trans-Fascial Extension of a Pyogenic Liver Abscess Into the Anterior Abdominal Wall (ACG 2026) - "Cultures grew Citrobacter freundii and cefepime was initiated...Figure: Abdominal exam demonstrating a large, fluctuant anterior abdominal wall mass consistent with abscess formation. Figure: CT abdomen demonstrating a complex left hepatic lobe collection contiguous with a thick-walled, septated anterior abdominal wall abscess."

Gastrointestinal Disorder • Hepatology • Infectious Disease • Melanoma • Solid Tumor

Upper Gastrointestinal Hemorrhage From Duodenal Varices Presenting as out of Hospital Cardiac Arrest (ACG 2026) - "The patient was started on IV pantoprazole, octreotide, and cefepime. CT angiography findings of paraduodenal varices with active extravasation into the duodenum Figure: Image 2. Coil and liquid embolization of the duodenal varices using balloon-occluded antegrade transvenous obliteration (BATO)"

Clinical • Addiction (Opioid and Alcohol) • Cardiovascular • Fibrosis • Hematological Disorders • Hepatology • Hypertension • Immunology • Portal Hypertension

Biopsy-Proven CAPEOX-Induced Pancolitis Complicated by Ogilvie Syndrome and Multiorgan Failure (ACG 2026) - "Case Description/ A 68-year-old male with stage III rectal adenocarcinoma (pT3N1b) status post low anterior resection was initiated on dose-reduced CAPEOX therapy consisting of one oxaliplatin infusion followed by oral capecitabine at approximately 50% of the standard recommended dose...Despite empiric cefepime and metronidazole, symptoms worsened with repeat imaging demonstrating progressive colonic dilation consistent with Ogilvie syndrome, with transverse colon dilation measuring 9.6 cm...Intravenous methylprednisolone improved diarrhea, hemodynamics, liver enzymes, and colonic distention...Early corticosteroid therapy was associated with clinical improvement. Early recognition and multidisciplinary management are critical to improve outcomes."

Biopsy • Acute Kidney Injury • Colorectal Adenocarcinoma • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Immunology • Metabolic Disorders • Nephrology • Rectal Adenocarcinoma • Renal Disease • Solid Tumor

Malignant Gastric Perforation Presenting as Pneumonia (ACG 2026) - "She was started on broad spectrum antibiotics with vancomycin, cefepime and metronidazole and surgical oncology was consulted. However when closure was attempted endoscopically, visualization and fluoroscopy as well as application of methylene blue confirmed that the leak had closed. Figure: Figure 11 Figure: Figure 2."

Cough • Gastric Cancer • Gastrointestinal Disorder • Hepatocellular Cancer • Infectious Disease • Pneumonia • Respiratory Diseases • Solid Tumor

Large Thoracic Epidural Abscess Masquerading as an Esophageal Malignancy Presenting With Dysphagia (ACG 2026) - "The patient was started on cefepime and underwent an emergency T3âT6 laminectomy for decompression...Figure: MRI Thoracic Spine with and without contrast was performed after endoscopy. Enhancement of the T4 and T5 with surrounding inflammatory changes and epidural enhancement with posterior soft tissue fluid collection noted."

Back Pain • CNS Disorders • Esophageal Cancer • Gastric Cancer • Gastrointestinal Disorder • Infectious Disease • Metabolic Disorders • Musculoskeletal Pain • Oncology

An Unusual Habitat for a Familiar Pathogen: A Case of Fulminant C. difficile Enteritis (ACG 2026) - "He was treated with oral vancomycin, intravenous (IV) metronidazole, and IV cefepime. Gut Pathog. 2009;1(1):7."

Clinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Septic Shock • Ulcerative Colitis

Ischemic Colitis With Coexisting Taenia Species on Biopsy (ACG 2026) - "She was treated with albendazole for Taenia spp., along with cefepime and metronidazole for ischemic colitis. Figure: Figure 2: Taenia Spp. eggs in the terminal ileum with increasing magnification from left to right"

Biopsy • Cardiovascular • Chronic Kidney Disease • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Hypotension • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Pancreatitis • Renal Disease • Septic Shock • Thrombosis

An Unusual Mimic of Neutropenic Enterocolitis: Hemophagocytic Lymphohistiocytosis as a Diagnostic Pitfall (ACG 2026) - "She was treated empirically for NE with cefepime, metronidazole, and vancomycin throughout her hospital course, as well as G-CSF without clinical improvement or neutrophilic recovery. In this patient, persistent agranulocytosis, negative infectious studies, hepatosplenomegaly, and markedly elevated ferritin were key clues to an alternative diagnosis. Gastroenterologists should avoid anchoring on infection in neutropenic colitis, as delayed recognition of HLH may postpone life-saving immunosuppressive therapy."

Addiction (Opioid and Alcohol) • Agranulocytosis • Dyslipidemia • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Granulocytopenia • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hepatology • Hypertriglyceridemia • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Neutropenia • Rare Diseases • Thrombocytopenia

Isolated Lung Involvement in Pancreatic Cancer: A Rare Initial Site of Metastasis (ACG 2026) - "The patient was subsequently placed on Vancomycin, Cefepime, and Heparin with minimal improvement in overall picture. A shift in thinking about the initial site of pancreatic cancer metastasis from liver only to liver and lung could expedite diagnosis, which could decrease hospitalizations and preventable complications such as hemoptysis and pleural effusions. Figure: Figure 1: CT scan of chest displaying enlarged Station 11L lymph nodes"

Gastric Cancer • Gastroenterology • Gastroesophageal Reflux Disease • Infectious Disease • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pancreatic Adenocarcinoma • Pancreatic Cancer • Pneumonia • Pulmonary Embolism • Respiratory Diseases • Solid Tumor • CDX2 • CK19 • KRT19 • NKX2-1

Clostridioides septicum Prosthetic Joint Infection Revealing Cecal Adenocarcinoma (ACG 2026) - "Empiric cefepime and vancomycin were initiated for presumed septic arthritis. Blood cultures grew C. septicum after 16 hours, prompting change to ertapenem...Figure: Image 2. Biopsy of ulcerated mass confirming invasive moderately differentiated adenocarcinoma."

Colon Cancer • Colorectal Cancer • Immunology • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Oncology

From Bile Duct to Heart Valve: A Case Report of Polymicrobial Infective Endocarditis Complicating Recurrent Ascending Cholangitis After Roux-en-Y Hepaticojejunostomy (ACG 2026) - "Antimicrobial stewardship involved multiple agents over several life threatening hospitilazations, including daptomycin, ciprofloxacin, ceftriaxone, metronidazole, meropenem, and cefepime. Systematic reviews have confirmed that the rate of recurrent non-stenotic cholangitis across studies is approximately 4% of all hepaticojejunostomies, with optimal treatment remaining poorly defined. The case report of this gentleman highlights core learning objectives: recognizing recurrent RYHJ-associated cholangitis as a source of IE in patients; and understanding that non-surgical management emphasizes percutaneous biliary source control, tailored antimicrobial therapy, and longitudinal cardiac surveillance."

Case report • Clinical • Cardiovascular • Gastrointestinal Disorder • Hepatology • Infectious Disease • Pneumonia • Septic Shock

Localized Multidrug-Resistant Morganella morganii Urinary Tract Infection in a Dapagliflozin-Treated Man with Bladder Outlet Obstruction and Incomplete Ureteral Duplication: A Case Report. (PubMed, Reports (MDPI)) - "Antimicrobial susceptibility (VITEK® 2 Compact, EUCAST v14.0, 2024) demonstrated resistance to ampicillin, amoxicillin-clavulanate, ampicillin-sulbactam, ceftriaxone, ceftazidime, gentamicin and trimethoprim-sulfamethoxazole, with susceptibility (S) retained only to piperacillin-tazobactam, levofloxacin/norfloxacin, cefepime and carbapenems (ertapenem, meropenem)...Transurethral resection of the prostate (TUR-P) was performed 18 days after completing antibiotics (28 days after presentation) for bladder outlet obstruction refractory to tamsulosin 0.4 mg daily, with complete resolution of symptoms, normalization of inflammatory markers and PVR 0 mL...The narrative is hypothesis-generating; urinary stasis was the dominant modifiable factor. Culture-guided therapy, individualized decisions on SGLT2 continuation, and definitive correction of outlet obstruction are the practical takeaways."

Journal • Benign Prostatic Hyperplasia • Cardiovascular • Infectious Disease • Nephrology • Pain • Urology

Ignatzschineria indica bacteremia in a fatal case of accidental wound myiasis. (PubMed, Folia Microbiol (Praha)) - "Antimicrobial susceptibility tests using gradient diffusion demonstrated susceptibility to all tested antibiotics (cefotaxime, cefepime, meropenem, piperacillin/tazobactam, ciprofloxacin, trimethoprim-sulfamethoxazole and gentamicin). This is unique in Central Europe, where no report on lethal infection with I. indica has been reported so far. Hence, this paper can serve as a valuable piece of knowledge on the treatment of maggot-infested wounds, particularly where I. indica infections are concerned."

Journal • Cardiovascular • Critical care • Fibrosis • Gastroenterology • Hepatology • Hypertension • Immunology • Infectious Disease • Liver Cirrhosis • Musculoskeletal Diseases • Orthopedics • Pulmonary Arterial Hypertension • Septic Shock

PMT for MDRO Decolonization (clinicaltrials.gov) - P2 | N=32 | Completed | Sponsor: University of Pennsylvania | Active, not recruiting ➔ Completed

Trial completion • Infectious Disease • Transplantation

Phenotypic screening for metallo-β-lactamases and extended-spectrum β-lactamases in Pseudomonas aeruginosa using the VITEK-2 AST-N443 and Phoenix NMIC-486 cards. (PubMed, Microbiol Spectr) - "However, these groups exhibit distinct susceptibility patterns to novel β-lactam/β-lactamase inhibitor (BL/BLI) combinations, including ceftolozane/tazobactam (C/T), ceftazidime/avibactam (C/A), imipenem/relebactam (I/R), and meropenem/vaborbactam (M/V)...Antimicrobial susceptibility testing was performed using the VITEK-2 AST-N443 and Phoenix NMIC-486 cards on 135 whole-genome-sequenced international CRPA isolates resistant by disc diffusion to ceftazidime, cefepime, imipenem, and/or meropenem...Our study identifies reliable screening cut-offs for MBL- and ESBL-production in CRPA using standard VITEK 2 and Phoenix automated AST panels. This readily available approach may accelerate detection, support routine laboratory workflows, reduce unnecessary confirmatory testing, and facilitate earlier targeted therapy and infection-control interventions in laboratories using these systems worldwide without requiring additional specialized testing or infrastructure."

Journal • Infectious Disease

Volumetric Microsampling for Patient-Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review. (PubMed, J Clin Pharmacol) - "Fixed conversion factors performed well for lacosamide and levetiracetam but were less reliable for lamotrigine at high concentrations. Several analyte-matrix combinations, including cefepime, vancomycin, meropenem, paclitaxel, abiraterone, and mitotane, did not consistently meet agreement criteria. Volumetric microsampling can support patient-centered drug monitoring when validated for the specific analyte, matrix, device, and clinical application. Future research should prioritize drug-specific optimization, multicenter validation, standardized conversion reporting, and integration with MIPD platforms."

Journal • Review

Performance of a rapid direct-from-blood antibiotic susceptibility test based on MIC test strips on Enterobacterales blood cultures. (PubMed, J Antimicrob Chemother) - "MTS-AST provided rapid results (in 5 h) that correlated well with the comparator method on blood culture broth containing Enterobacterales. Given the shorter time to results, the reduced time cost, the limited handwork and the reduced cost per test, the MTS-AST constitutes a fast and reliable method."

Journal

Community dissemination of blaCTX-M-dominant extended-spectrum β-lactamase-producing Escherichia coli with widespread multidrug resistance in domestic cats from Ecuador: A One Health molecular epidemiological study. (PubMed, Vet World) - "All isolates remained susceptible to imipenem and meropenem, whereas the highest resistance rates were recorded for trimethoprim-sulfamethoxazole, tetracycline, cefepime, levofloxacin, and doxycycline. Domestic cats in Machala showed a high prevalence of -dominant, multidrug-resistant ESBL-producing E. coli. These findings indicate widespread community dissemination and support the inclusion of companion animals in Ecuadorian antimicrobial resistance surveillance and stewardship programs under a coordinated One Health framework."

Journal

Analysis of Antimicrobial Resistance and Infection Characteristics of Myroides odoratimimus Harboring the bla MOC-1 Metallo-β-Lactamase Gene. (PubMed, Infect Drug Resist) - "Antimicrobial susceptibility testing showed that the isolate exhibited broad-spectrum resistance and was only susceptible to minocycline, doxycycline, levofloxacin, and cefepime. The patient presented with severe septic shock, showed no response to empirical therapy, developed multiple organ injury, and exhibited abnormally elevated biomarkers of inflammation, metabolism, and cardiovascular function. The findings of this study suggest that the blaMOC-1 gene is carried by this strain and is associated with its broad-spectrum antimicrobial resistance characteristics."

Journal • Cardiovascular • Critical care • Infectious Disease • Inflammation • Septic Shock

Implementing a Model-Informed Precision Dosing Service for Cefepime in a Quaternary Children's Hospital: A First-Year Experience. (PubMed, Ther Drug Monit) - "These findings support the feasibility and clinical utility of an MIPD consultation service for cefepime. The service enabled timely identification of high or low exposures, including in patients on extracorporeal support, and guided individualized dosing decisions to optimize target attainment."

Journal • Infectious Disease • Pediatrics

SEVERE CEFEPIME-INDUCED NEUTROPENIA: A RARE ADVERSE EFFECT OF LONG-TERM CEFEPIME USE (CHEST 2026) - No abstract available

Adverse events • Hematological Disorders • Neutropenia

CEFEPIME-INDUCED ISOLATED APHASIA MIMICKING ACUTE ISCHEMIC STROKE (CHEST 2026) - No abstract available

Cardiovascular • Ischemic stroke

MORE THAN NEUROTOXICITY: CEFEPIME-INDUCED MEDULLARY ANGIITIS CAUSING SEVERE ACUTE KIDNEY INJURY (CHEST 2026) - No abstract available

Acute Kidney Injury • Nephrology • Renal Disease • Vasculitis

NEUROLOGIC OUTCOMES WITH EMPIRIC CEFEPIME VS MEROPENEM IN ACUTELY ILL ADULTS (CHEST 2026) - No abstract available

Clinical

Survey of Antibiotic Resistance of Acinetobacter Baumannii and Pseudomonas Aeruginosa at Ninh Thuan Province General Hospital in Vietnam in 2023. (PubMed, Endocr Metab Immune Disord Drug Targets) - "The high prevalence of antimicrobial resistance in hospitals and the general population highlights the urgent need for effective control programs. Future regional epidemiological data on ABR and AMR patterns will be essential for implementing rigorous national antibiotic policies aimed not only at limiting the spread of resistant bacteria but also at identifying more effective solutions, both in Vietnam and in Italy."

Journal • Infectious Disease