cefepime hydrochloride / Generic mfg. - LARVOL DELTA

Impact of broad-spectrum antibiotic exposure on outcomes following autologous stem cell transplantation for patients with relapsed diffuse large B-cell lymphoma or Hodgkin lymphoma (ASH 2025) - "Antibiotic exposure in the peri-transplant period was recorded, defined as receipt of greater than one day of: broad-spectrum intravenous antibiotics (cefepime, piperacillin-tazobactam, cephalosporins, or monobactams) or vancomycin. The BSA group was separately analyzed according to specific anaerobic coverage (metronidazole, carbapenems, piperacillin-tazobactam, or clindamycin) or not... In this retrospective cohort study of ASCT recipients, early exposure to BSA and AA were associated with decreased OS in univariate analysis, however in multivariate analysis only age remained significant. These findings suggest that while antibiotic exposure may correlate with outcomes, its effect is likely mediated by other clinical factors such as age, or may reflect underlying illness severity, rather than a direct causal relationship. Prospective studies are needed to clarify whether modification of antibiotic exposure can meaningfully improve long-term transplant outcomes without..."

Clinical • B Cell Lymphoma • Bone Marrow Transplantation • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Non-Hodgkin’s Lymphoma • Transplantation

HSV-1 infection as a rare trigger of methotrexate toxicity: A diagnostic and therapeutic challenge (ASH 2025) - "Four days earlier, she was seen in an outpatient clinic for a cold sore near the corner of her right lip and was prescribed valacyclovir 500 mg twice daily for three days for HSV infection. Her home medications included prednisone 2.5 mg, leucovorin 5 mg and methotrexate 12.5 mg weekly along with adalimumab 40 mg every 14 days...Intravenous hydrocortisone 50 mg twice daily was initiated...After a five-day course of IV steroids and a seven-day course of IV cefepime, she was discharged home on oral acyclovir to complete a 14-day total antiviral course... This case suggests that corticosteroids may be a valuable adjunct in patients with suspected methotrexate toxicity who do not respond to leucovorin. Further studies are needed to evaluate the role of corticosteroids in such cases."

Cardiovascular • Congestive Heart Failure • Diabetes • Endocrine Disorders • Febrile Neutropenia • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Herpes Simplex • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Metabolic Disorders • Nephrology • Neutropenia • Renal Disease • Rheumatoid Arthritis • Rheumatology • Scleroderma • Systemic Sclerosis • Thrombocytopenia • Type 2 Diabetes Mellitus

A rare case of gelatinous transformation of the bone marrow secondary to untreated hypothyroidism and congestive heart failure (ASH 2025) - "He was empirically treated with cefepime and azithromycin for presumed sepsis...He was started on levothyroxine 25 mcg, Jardiance 10 mg, and spironolactone 25 mg for HFpEF...Diagnosing GTBM requires a high index of suspicion and exclusion of other pancytopenia causes. Early recognition and treatment of the underlying disorder can reverse both GTBM and associated cytopenias."

Clinical • Aplastic Anemia • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Hematological Malignancies • Human Immunodeficiency Virus • Immunology • Infectious Disease • Pituitary Gland Carcinoma • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • IL2

Impact of antibiotic timing on survival outcomes in CD19 and BCMA CAR-T cell therapy (ASH 2025) - "In particular, the PIM(piperacillin-tazobactam, imipenem, and meropenem) have been implicated with poor outcomes.This ispossibly related to dysregulation of the gut microbiome and/or impairment of hematopoietic recovery.Here, we aimed to investigate the effect of pre and post CAR-T antibiotics in patients receiving both CD19and BCMA CAR-T cell therapy. This is a single-center retrospective study of adult patients with multiple myeloma, B-celllymphoma, and acute lymphoblastic leukemia treated with autologous CD19 and BCMA targeting CAR-Tcell therapy at our center between April 2017 and August 2024. CD19 CAR-T cell products includedlisocabtagene maraleucel, tisagenlecleucel, brexucabtagene autoleucel, and axicabtagene ciloleucel.BCMA CAR-T cell products included idecabtagene vicleucel and ciltacabtagene autoleucel...Post CAR-T antibiotics were largely fourthgeneration cephalosporins such as cefepime in combination with vancomycin... Exposure to antibiotics in the 30 days..."

CAR T-Cell Therapy • Acute Lymphocytic Leukemia • B Cell Lymphoma • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma

Efficacy Enhancement of Cefepime with Lemon Leaf-Reduced Silver Nanoparticles against Drug-Resistant Bacteria. (PubMed, Curr Microbiol) - "Regarding DPPH radical scavenging, it was observed with 81 ± 0.03% at 125 µg/mL, and 85 ± 0.04% reduction in inflammation at 125 µg/mL. These findings suggested that CEF-Ag NPs have not only enhanced antimicrobial efficacy but it is also biocompatible, making a promising candidate for combating multidrug-resistant bacterial infections."

Journal • Hematological Disorders • Infectious Disease • Inflammation

Genomic insights and molecular epidemiology through whole genome sequencing in clinical Serratia marcescens ST-367 isolated from the Kingdom of Bahrain. (PubMed, J Infect Public Health) - "To our knowledge, this is the first report of S. marcescens ST-367 in the Gulf Cooperation Council. The genetic diversity and mechanisms of virulence and antibiotic resistance in this isolate shed light on the evolution of high-risk isolates. Additionally, this will serve as a foundation for future extensively drug-resistant isolates."

Journal • Gene Therapies • Infectious Disease

Application of Epithelial Lining Fluid Drug Concentrations to MICi-Based PK/PD Modeling of Cefepime/Nacubactam in a Murine Model of CPE Pneumonia. (PubMed, J Infect Chemother) - "These findings support the utility of MICi-based PK/PD analysis for optimizing combination antibiotic therapy in pneumonia."

Journal • PK/PD data • Preclinical • Infectious Disease • Pneumonia • Respiratory Diseases

First case of bloodstream infection caused by Cupriavidus metallidurans in Japan. (PubMed, IDCases) - "His condition improved with the administration of cefmetazole, cefepime, and levofloxacin, and antibiotic therapy was discontinued on the 17th day after the onset of fever. To date, only five cases of bloodstream infection caused by this species have been reported, in Canada and Italy, and this is the first reported case in Japan. As this bacterium is present in the Japanese environment, reports of its detection may increase in the future, particularly among elderly or immunocompromised patients."

Journal • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Infectious Disease • Metabolic Disorders • CRP

Antibiotic-Associated Encephalopathy Induced by Cefmetazole in a Hemodialysis Patient: Case Report. (PubMed, J Infect Chemother) - "While cefepime, ceftazidime, and ceftriaxone are well-documented causes, cefmetazole (CMZ) has not been widely recognized for neurotoxicity. A Naranjo score of 5 supported a diagnosis of CMZ-induced AAE. This case underscores the potential neurotoxicity of CMZ and emphasizes the importance of early recognition of AAE in patients with renal dysfunction."

Journal • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Epilepsy • Infectious Disease • Movement Disorders • Nephrology • Renal Disease

Pathogen distribution, antimicrobial resistance and attributable cost analysis of neonatal sepsis in neonatal intensive care units: a propensity score matching study. (PubMed, Front Pediatr) - "Antimicrobial resistance analysis revealed high resistance rates of Gram-positive bacteria to penicillin G (94.6%) and oxacillin (89.3%). Gram-negative pathogens exhibited high resistance to levofloxacin (75.0%), ceftriaxone (66.7%), cefepime (66.7%), and meropenem (58.3%)...NS significantly increases the hospitalization resource consumption in NICUs. This study provides key evidence for optimizing antibiotic use strategies and advancing precision healthcare payment reform, and calls for integrating resistance surveillance with cost-control measures to reduce the health economic impact of NS."

HEOR • Journal • Critical care • Infectious Disease • Septic Shock

Antimicrobial Resistance Patterns and Prevalence of Salmonella Species in Blood Samples: Insights From a Tertiary Care Center in Nepal. (PubMed, Interdiscip Perspect Infect Dis) - "No multidrug resistance was observed, and all isolates were susceptible to third- and fourth-generation cephalosporins (e.g., cefixime, ceftriaxone, and cefepime) and β-lactamase inhibitors (e.g., piperacillin-tazobactam).Salmonella Paratyphi showed 100% sensitivity to ampicillin, amoxicillin, and cotrimoxazole, while susceptibility to chloramphenicol was high for both S. Typhi (88.9%) and S. Paratyphi (92.9%)...High resistance to ciprofloxacin and gentamicin was observed, while susceptibility to ampicillin, chloramphenicol, and cotrimoxazole re-emerged, suggesting their potential for reintroduction in treatment. No multidrug resistance or resistance to third- and fourth-generation cephalosporins (e.g., cefixime, ceftriaxone, cefepime) and β-lactamase inhibitors (e.g., piperacillin-tazobactam) was noted, supporting their reliability for empirical therapy. These findings underscore the need for ongoing antimicrobial surveillance to guide effective treatment strategies."

Journal • Infectious Disease

Pharmacokinetics, safety, and tolerability of nacubactam (OP0595) after intravenous infusion: a randomized, double-blind, placebo-controlled phase I clinical trial in healthy Chinese male subjects. (PubMed, Clin Exp Med) - P1 | "Nacubactam, a novel β-lactamase inhibitor, combined with cefepime or aztreonam, effectively supports CRE infection treatment...Its combination with ceftazidime or aztreonam is promising for treating multidrug-resistant Gram-negative bacterial infections...In this work, we conducted a phase I randomized, double-blind, placebo-controlled trial to clinically evaluate nacubactam for the first time in healthy Chinese male subjects, demonstrating its good safety profile, dose-proportional pharmacokinetics, and mainly renal excretion. These data provide insights into the clinical application of nacubactam.Trial registration This trial was registered on the Chinese Clinical Trial Registration website, registration number ChiCTR2500103582."

Clinical • Journal • P1 data • PK/PD data • Infectious Disease

A Risk Worth Taking: Fibrinolytics in Post-Splenectomy Thalassaemic with Empyema (APSR 2025) - "A chest drainage was inserted, and the pleural fluid analysis confirmed an exudative effusion, culture grew Enterobacter roggenkampii which sensitive to Cefepime and Ciprofloxacin...Intrapleural alteplase 5 mg and 5 mg dornase alfa were administered into both locules for 3 cycles over a 3-day period...Discussion : Fibrinolytic therapy in high-risk patients particularly those with a history of surgical intervention, thalassemia, low haemoglobin levels, and an elevated risk of bleeding—can be considered a safe and justifiable approach. It significantly reduces the likelihood of requiring surgical decortication and helps prevent the progression to severe sepsis."

Beta-Thalassemia • Cough • Genetic Disorders • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Septic Shock • CRP

Morganella morganii Urinary Tract Infection in Jordanian Children: Case series from a Tertiary Hospital. (PubMed, Infect Chemother) - "M. morganii should be considered in pediatric UTIs, especially among children with urinary tract anomalies or catheter use. Awareness of its distinct resistance profile is critical for selecting appropriate empiric therapy."

Journal • Infectious Disease • Nephrology • Pediatrics

Cefepime-Induced Neurotoxicity in an Elderly Patient: A Case Report. (PubMed, Cureus) - "Cefepime-induced neurotoxicity (CIN) was suspected; the drug was discontinued and replaced with piperacillin-tazobactam. Neurological status recovered fully within 48 hours. This case underscores the need to recognize cefepime neurotoxicity in elderly patients with renal dysfunction, ensuring timely intervention through dose adjustment or discontinuation."

Journal • Chronic Kidney Disease • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

Building a Beta-Lactam Model-Informed Precision Dosing Service in a Quaternary Care Children's Hospital. (PubMed, Clin Transl Sci) - "At our institution, a quaternary children's hospital, we launched a new PK consult service utilizing a model-informed precision dosing (MIPD) approach to provide personalized dosing recommendations for cefepime...We then present the workflow and infrastructure of our beta-lactam PK consult service to provide guidance for other institutions who may be interested in launching a similar service. Lessons learned throughout the process of building the service, including the importance of engaging multiple, diverse stakeholders early on and starting with one drug at a time, are provided."

Journal • Review • Pediatrics

Incidence and antimicrobial resistance of non-typhoidal Salmonella enterica in stool samples from children under five in peri-urban Ouagadougou, Burkina Faso. (PubMed, BMC Microbiol) - "This study demonstrates a substantial burden of NTS infections in children under five in peri-urban Burkina Faso. Although MDR prevalence was low, high tetracycline resistance indicates widespread circulation of resistant strains. Continuous AMR surveillance is essential to guide treatment and preserve antibiotic efficacy."

Journal • Infectious Disease

Regulatory relationships among aldB, ampH, and acoR and their impact on β-lactam susceptibility in Phytobacter diazotrophicus. (PubMed, Front Microbiol) - "Compared with the wild-type strain, the ampH-knockout strain exhibited significantly increased MICs for carbenicillin, piperacillin, cefalotin, cefoxitin, cefuroxime, cefotaxime, ceftazidime, cefepime, aztreonam, and ertapenem by at least 2-, 4-, 8-, 4-, 4-, 4-, 4-, 4-, 4-, and 2-fold, respectively. Under ceftazidime stress, P. diazotrophicus reduced aldB expression to increase its tolerance to the antibiotic. The discovery of the mechanism by which AcoR regulates aldB expression provides preliminary evidence for subsequent research on drug resistance mechanisms."

IO biomarker • Journal • Infectious Disease • ACACA • PD-1

Rational design of 1H-pyrrole-2-carboxylic acid inhibitors of NDM-1 metallo-β-lactamase restoring β-lactam efficacy against resistant Enterobacterales. (PubMed, Eur J Med Chem) - "Lead compounds restored the activity of cefepime and meropenem against NDM-positive E. coli and K. pneumoniae strains, while triple combinations with serine β-lactamase inhibitors further enhanced antimicrobial efficacy. These results highlight 1H-pyrrole-2-carboxylic acids as a versatile scaffold for MBL inhibition and provide a rational framework for the development of therapeutics against multidrug-resistant pathogens."

Journal • Infectious Disease • Pneumonia

Phenyllactic Acid as a Marker of Antibiotic-Induced Metabolic Activity of Nosocomial Strains of Klebsiella pneumoniae In Vitro Experiment. (PubMed, Microorganisms) - "Doxycycline, nitrofurantoin, rifampicin, and tigecycline significantly suppressed metabolic activity, confirmed by decreased PhLA levels. Conversely, meropenem, cephalosporins (ceftriaxone, cefepime, cefotaxime, and ceftazidime), ciprofloxacin, and amikacin stimulated PhLA production, suggesting that bacterial metabolic activity was maintained despite the presence of antibiotics. PhLA is a promising biomarker for quantifying K. pneumoniae's metabolic response to antibiotics. This potentially introduces a novel approach for future investigations into resistance mechanisms and has the potential to increase the effectiveness of therapies for multidrug-resistant K. pneumoniae infections by providing an additional analytical tool to traditional susceptibility testing methodologies."

Journal • Preclinical • Infectious Disease • Pneumonia • Septic Shock

A One Health Comparative Study of MDR Escherichia coli Isolated from Clinical Patients and Farm Animals in Satu Mare, Romania. (PubMed, Antibiotics (Basel)) - "Antimicrobial susceptibility testing was performed against eight antimicrobials (amikacin, ampicillin, cefotaxime, ceftazidime, cefepime, ciprofloxacin, gentamicin, sulfamethoxazole/trimethoprim) using standardized methods. Even in clinically healthy animals, resistance levels exceeded those observed in human isolates. These findings emphasize the need for coordinated One Health monitoring and stricter antimicrobial use policies in livestock to reduce transmission risks across human and animal populations."

Journal

Aerobic Pathogens and Antimicrobial Susceptibility in Odontogenic Infections: A One-Year Observational Study from Southwestern Romania. (PubMed, Medicina (Kaunas)) - "remained susceptible to penicillin G (82.3%), amoxicillin-clavulanate (76.4%), and clindamycin (70.5%), but only 55.0% to erythromycin. Most S. aureus isolates were methicillin-susceptible (92.9%), while coagulase-negative staphylococci showed high methicillin resistance (59.3%) yet full susceptibility to linezolid, vancomycin, and teicoplanin. Enterobacterales were resistant to ampicillin (90%) and amoxicillin-clavulanate (65%) but remained susceptible to ceftriaxone (80%) and ciprofloxacin (85%)...aeruginosa isolates were fully susceptible to piperacillin-tazobactam, ceftazidime, cefepime, and meropenem...Surgical drainage remains central to management, and antibiotic therapy should be guided by local susceptibility patterns. These data provide baseline information to inform empirical therapy and stewardship efforts and highlight the need for multicenter studies including anaerobic and molecular analyses."

Journal • Observational data • Infectious Disease

Evaluation of high dose post-dialytic versus daily beta-lactam dosing in hemodialysis patients using Monte Carlo simulation. (PubMed, Int J Clin Pharm) - "High-dose post-HD dosing appears feasible for ceftazidime/avibactam but may be inadequate for cefepime and meropenem over a 3-day interdialytic period. Elevated neurotoxicity risk predicted with higher cefepime doses highlights the importance of cautious dosing and consideration of therapeutic drug monitoring."

Journal • Infectious Disease • Renal Disease

Calculating the Risk of Triphasic Waves on EEG using Demographic, Laboratory, Medication, and Radiological Data (AES 2025) - "From these data we generated multiple predictors: age and biological sex of patients; CBC and BMP values (if obtained with 2 days of EEG); cefepime exposure, which was considered present if patients were exposed to at least 3 days of cefepime prior to EEG; and one binary variable indicating the presence of microvascular ischemic disease (MID) on brain imaging reports, and another scalar variable reflecting the severity of MID where 1 is mild, 2 is moderate and 3 is severe... In line with previously described associations, markers of renal dysfunction i.e. increased creatinine, decreased eGFR and increased sodium, were predictive of TWs; though unexpectedly decreased phosphorus increases risk of TWs, perhaps reflecting higher risk in the setting of acute versus chronic kidney injury. Increased WBCs predicting TWs likely reflects increased TWs burden in infected states. We also found that moderate or severe microvascular disease more strongly predicts TWs than mild..."

CNS Disorders • Nephrology • Renal Disease

Providencia rettgeri as an unusual pathogen in diabetic foot osteomyelitis: A case report and literature review. (PubMed, SAGE Open Med Case Rep) - "The patient declined further surgery and was treated with 6 weeks of cefepime and metronidazole, with outpatient wound care, achieving wound closure in 3 months...This case expands the limited literature and highlights the importance of culture-driven antibiotic therapy in complex infections. Recognition of Providencia rettgeri as a rare but clinically significant pathogen in diabetic foot osteomyelitis has implications for empiric antibiotic selection and clinical outcomes."

Journal • Cardiovascular • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Peripheral Arterial Disease