AK1830 / Asahi Kasei Therapeutics, Pfizer - LARVOL DELTA

Changes in nerve growth factor signaling in female mice with cyclophosphamide-induced cystitis. (PubMed, Front Urol) - "Here, we show effects of CYP treatment and pharmacological inhibition of p75 (via LM11A-31) and TrkA (ARRY-954) on NGF signaling-related proteins: NGF, TrkA, phosphorylated (p)-TrkA, p75, p-ERK1/2, and p-JNK. Both TrkA and p75 inhibition affected the activation of signaling pathways downstream of TrkA, supporting the hypothesis that NGF actions during cystitis are primarily TrkA-mediated. Our findings, in tandem with our recent companion paper demonstrating the effects of TrkA, TrkB, and p75 inhibition on bladder function in a mouse model of cystitis, highlight a variety of potent therapeutic targets and provide further insight into the involvement of NGF signaling in sustained conditions of bladder inflammation."

Journal • Preclinical • Gynecology • Inflammation • Interstitial Cystitis • Musculoskeletal Pain • Pain • NGF • NTRK2