tobramycin/dexamethasone / Generic mfg. - LARVOL DELTA

Optimal pulse technology combined with tobramycin and dexamethasone eye ointment in the treatment of blepharokeratoconjunctivitis: an impact on ocular surface disease index. (PubMed, Pharmacology) - "The addition of OPT to standard therapy for BKC is safe and provides superior short-term efficacy. It can alleviate lid margin inflammation, improve ocular surface symptoms, and enhance visual-related quality of life."

Journal • Conjunctivitis • Dry Eye Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Difficulties in management of ocular surface in the late phase of toxic epidermal necrolysis - a rare case report. (PubMed, Ann Agric Environ Med) - "This case highlights the significant challenges of managing late-phase ocular complications in SJS/TEN, emphasizing the need for a multidisciplinary approach and aggressive intervention to preserve ocular structure and function."

Journal • Ophthalmology • Pain • Steven-Johnson Syndrome • Transplantation

Effect of Periplaneta americana Extract on Corneal Fibrosis and Epithelial Healing After Rabbit Lamellar Keratectomy. (PubMed, Transl Vis Sci Technol) - "SLK was performed on the right eyes of 48 New Zealand White rabbits, randomized into three treatment groups (n = 16/group): normal saline (NS), Tobradex eye drops (TE), and PAE group...This biphasic regulatory effect may be attributed to promoting TGF-β1 expression in the early stage, followed by its inhibition in the later stages. PAE modulates TGF-β1 to balance corneal healing and fibrosis as a novel topical corticosteroid alternative, warranting human trials for its dual-phase healing/scarring action."

Journal • Preclinical • Corneal Abrasion • Fibrosis • Immunology • Inflammation • TGFB1

Erratum: Clinical Efficacy of Tobramycin Dexamethasone+Pranoprofen Eye Drops on Endophthalmitis in Cataract Patients Complicated with Diabetes Mellitus after Intraocular Lens Implantation. (PubMed, Niger J Clin Pract) - No abstract available

Journal • Cataract • Diabetes • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

Effect of Topical Application of Dexamethasone on CC Chemokine Receptor 3 Expression in Human Pterygium. (PubMed, J Ocul Pharmacol Ther) - " Forty cases of patients with pterygium were divided into a dexamethasone group and a control group, which were treated topically with 3 g/L tobramycin + dexamethasone or 3 g/L tobramycin eye drops in the surgical eyes 2 weeks before surgery... CCR3 signaling may play an important role in the pathogenesis of pterygium. The proangiogenic and profibrotic functions of CCR3 signaling may be by promoting tube formation and proliferation of vascular endothelial cells and promoting proliferation and migration of fibroblasts."

Journal • Fibrosis • Ophthalmology • CCR3 • FGF

Acute Central Toxic Keratopathy Induced by Exposure to Chinese Herbal Medicine Fluid for Verruca Plana: A Case Report. (PubMed, Case Rep Ophthalmol Med) - "Thus, tobramycin dexamethasone eye drops and artificial tears were prescribed for her, which proved effective. Her clinical symptoms and signs were both resolved after steroid treatment and remained stable at the 1-month follow-up. Acute central toxic keratopathy could occur after exposure to Chinese herbal medicine fluid, and enhanced topical steroid treatment worked well for alleviating inflammation and reducing corneal opacity."

Journal • Inflammation • Ophthalmology • Pain

Tacrolimus eye drops treatment for recurrent exposure of the Ahmed glaucoma valve tube. (PubMed, Eur J Med Res) - "Treatment with 0.1% tacrolimus eye drops demonstrated satisfactory results in managing recurrent exposure following allogeneic scleral patch graft coverage and autologous scleral tunnel repair, suggesting its potential as an effective alternative to conventional treatments."

Journal • Glaucoma • Ophthalmology • Transplantation

Effect of pranoprofen, tobramycin and dexamethasone combination on recurrence prevention and tear inflammatory factors after pterygium surgery. (PubMed, Pak J Pharm Sci) - "At 6-month follow-up, recurrence rates were comparable (1.85% vs. 9.43%, P>0.05), though the observation group trended lower. In conclusion, Pranoprofen + tobramycin/dexamethasone offers enhanced pain control, tear function and anti-inflammatory effects, with a potential recurrence-lowering benefit, supporting its clinical utility in pterygium management."

Clinical • Journal • Ophthalmology • Pain • CXCL8 • IL6 • TNFA

Comparison of Tobramycin-Dexamethasone Combination Eyedrop Versus Artificial Tear Eyedrop for the Management of Presumed Viral Epidemic Conjunctivitis: A Randomized Treatment Trial. (PubMed, Curr Eye Res) - "To compare the efficacy and safety of one-time povidone-iodine (PovI) administration followed by a course of tobramycin-dexamethasone eye drops versus artificial tears in acute viral conjunctivitis (AVC). A course of tobramycin-dexamethasone combination eyedrops after PovI may lead to early symptomatic relief, but recovery was similar to artificial tears by day 7. No significant/sight-threatening complications were observed in any groups."

Journal • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain

The Potential Role of Topical Losartan in Reducing Subepithelial Haze in Traumatic Laser-Assisted In Situ Keratomileusis (LASIK) Flap Avulsion. (PubMed, Cureus) - "A bandage contact lens was placed combined with moxifloxacin eye drops...The patient was continued on moxifloxacin four times a day (QID) and transitioned to Tobradex drops QID at day nine with improvement in UDVA to 20/30-2...Topical losartan 0.8 mg/mL was added six times per day along with fluorometholone two times a day (BID)...Uncorrected visual acuity after LASIK flap amputation is generally favorable, especially if corneal haze can be prevented. Topical losartan has anti-fibrotic activity through inhibition of the transforming growth factor-beta (TGF-β) signaling pathway, and in conjunction with topical steroids, may be effective in improving corneal haze in patients with a traumatic LASIK flap amputation."

Journal • Pain • TGFB1

Staphylococcus cohnii Causing a Latent Endophthalmitis: A Case Report. (PubMed, Case Rep Ophthalmol Med) - "A vitreous tap, with intraocular injection of ceftazidime, was performed, and topical dexamethasone and tobramycin were initiated. Staphylococcus cohnii is a gram-positive coagulase-negative bacterium that produces biofilm. Biofilm can promote adherence to implants leading to failure of therapy."

Journal • Infectious Disease • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology • Uveitis

Unilateral Iris Transillumination Resembling BAIT Phenotype Following Contralateral Vitrectomy. (PubMed, Case Rep Ophthalmol Med) - "Postoperative topical treatment of tobramycin/dexamethasone was administered. To the best of our knowledge, this case is the first to show a unilateral phenotype of BAIT after contralateral vitrectomy. This suggests that previous vitrectomy, injection of vancomycin, or topical corticosteroids or chloramphenicol could be protective against the development of acute iris transillumination."

Journal • Achromatopsia • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders • Scleritis • Uveitis

OCULAR MANIFESTATIONS IN A PATIENT WITH HIDRADENITIS SUPPURATIVA: A CASE STUDY. (PubMed, Georgian Med News) - "As this case shows, a multidisciplinary approach is absolutely essential when tackling HS including the eyes. Early diagnosis and tailored treatment plans allow one to improve patient outcomes, maintain visual function, and minimize repercussions. More study is needed to better grasp the pathophysiology of HS-related ocular problems and create more sensible treatment plans."

Journal • Corneal Abrasion • Dermatology • Dry Eye Disease • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology

Dropless vitrectomy surgery for epiretinal membranes; Efficacy and safety compared to standard of care (ARVO 2025) - "Methods A retrospective review was conducted on patients who underwent PPV for ERM removal.Group 1 received an intravitreal injection of Tri-Moxi (0.3mL, delivering 4.5mg triamcinolone acetonide & 0.3mg moxifloxacin) at the conclusion of surgery.Group 2 received a standard postoperative regimen of Tobradex eye drops every 4 hours for 1 week, tapered over 5 additional weeks(6 weeks total)...This method facilitates the direct delivery of concentrated anti-inflammatory and antibacterial agents to the retina and vitreous cavity, where these effects are most beneficial after PPV. In our study, we demonstrated that administering a low dose of intravitreal triamcinolone acetonide directly into the vitreous effectively achieves therapeutic levels for managing postoperative inflammation following PPV for ERM removal."

Clinical • Surgery • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

Screening of dry eye scheme based on cyclosporine, dexamethasone, perfluoroethyloctane eye drops for the treatment of diabetes patients with cataract and interpretation of its internal mechanism (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: The First People's Hospital of Zigong City; The First People's Hospital of Zigong City

New trial • Cataract • Diabetes • Dry Eye Disease • Metabolic Disorders • Ophthalmology

Use of Pranoprofen After Strabismus Surgery in Children. (PubMed, J Clin Med) - "Patients were divided into three groups of 30 patients according to the method of topical postoperative treatment (group I: tobramycin, pranoprofen, dexpanthenol; group II: tobramycin, dexamethasone, dexpanthenol; group III: tobramycin, pranoprofen, dexamethasone, dexpanthenol)... Pranoprofen used postoperatively is as effective as a glucocorticosteroid, and from our observations, carries fewer complications in cases requiring prolonged use of the anti-inflammatory treatment. Systematic postoperative follow-up is essential for the diagnosis and possible management of postsurgical complications."

Journal • Allergy • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology • Pediatrics • Strabismus

Rescue of Corneal Schwann Cell and Axon Networks by Tobradex in Chemical Injury (ARVO 2025) - "Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Ocular Inflammation • Ophthalmology • PLP1

Clinical efficacy of tobramycin dexamethasone eye ointment combined with a catheter in endoscopic dacryocystorhinostomy. (PubMed, J Laryngol Otol) - "Using tobramycin dexamethasone eye ointment combined with a catheter slightly prolongs the operation time and increases bleeding, but promotes anastomotic healing, accelerates tear drainage, improves the operation success rate and is economically efficient."

Clinical • Journal

Clinical Efficacy of Tobramycin Dexamethasone+Pranoprofen Eye Drops on Endophthalmitis in Cataract Patients Complicated with Diabetes Mellitus after Intraocular Lens Implantation. (PubMed, Niger J Clin Pract) - "Tobramycin dexamethasone+pranoprofen eye drops can inhibit inflammation better, recover vision faster, and make the incidence of adverse reactions lower in treating cataract patients complicated with DM developing endophthalmitis induced."

Clinical • Journal • Cataract • Diabetes • Inflammation • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

N-acetylcysteine and chitosan conjugate modified dexamethasone nanostructured lipid carriers: Enhanced permeability, precorneal retention and lower inflammation for the treatment of dry eye syndrome. (PubMed, Int J Biol Macromol) - "Dexamethasone (Dex) is a primary medication for treating dry eye syndrome, and tobramycin-dexamethasone eye drops are commercially available. ELISA results showed a reduction in inflammation caused by dry eye. These findings suggest that CS-NAC@Dex-NLC is a promising vector for dry eye treatment, offering significant clinical relevance."

Journal • Corneal Abrasion • Dry Eye Disease • Inflammation • Ocular Inflammation • Ophthalmology

Delayed Stevens-Johnson syndrome induced by combined administration of carbamazepine and botulinum toxin: A case report. (PubMed, Medicine (Baltimore)) - "In order to prevent severe adverse reactions, patients using carbamazepine in conjunction with other medications should be vigilant for the early symptoms of serious drug rashes."

Journal • Cerebral Hemorrhage • Hematological Disorders • Steven-Johnson Syndrome

Efficacy of 0.05% Cyclosporine-A eye drops (II) and 3% Diquafosol ophthalmic solution in the treatment of dry eye after cataract surgery. (PubMed, Pak J Med Sci) - "Patients were divided into three groups based on the treatment: Conventional group (tobramycin & dexamethasone eye drops combined with pranoprofen eye drops, n=41), DQS group (3% DQS based on the conventional treatment, n=42), and CsA group (0.05% CsA eye drops(II) based on the conventional treatment, n=40). However, these indexes were comparable in the DQS and the CsA group (P>0.05). Compared to the conventional treatment alone, the addition of 3% DQS or 0.05% CsA eye drops (II) to the conventional treatment both are effective and might more effectively alleviate DE in patients undergoing CS."

Journal • Surgery • Cataract • Dry Eye Disease • Ocular Inflammation • Ophthalmology

Conjunctival Phlyctenule and Nodular Scleritis in a Patient with Previous Herpes Simplex Virus-2 Exposure: Causative Agent or Innocent Bystander? (PubMed, Case Rep Ophthalmol) - "Initial treatment for epidemic keratoconjunctivitis with tobramycin-dexamethasone improved her symptoms...The patient failed topical corticosteroid monotherapy; however, she responded to oral valacyclovir...Thorough infectious workups and alternative treatment approaches are crucial in managing unconventional cases. Experimental treatments based on laboratory findings can be valuable for patients preferring conservative management, emphasizing the need for close follow-up and personalized care in ocular inflammatory diseases."

Journal • Conjunctivitis • Dry Eye Disease • Herpes Simplex • Immunology • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Scleritis

The efficacy of tobramycin dexamethasone combined with pranoprofen in middle-aged and elderly post-cataract patients and the value of improving inflammatory factor levels. (PubMed, Am J Transl Res) - "The combination of pranoprofen and tobramycin dexamethasone can improve the inflammatory reaction, ocular symptoms, anterior chamber flare value, macular center thickness, corneal oedema, and clarity of the posterior lens capsule in middle-aged and elderly cataract patients. This regimen also helps restore intraocular pressure and visual acuity of the patients, with relatively low adverse reactions, indicating an ideal clinical outcome."

Journal • Cataract • Ophthalmology

Epi Off Pack-Cxl As Treatment For Acanthamoeba Epitheliopathy (ESCRS 2024) - "These symptoms occurred 10 days before and partially remised with tobramycin-dexamethasone ophthalmic suspension...It could be debated whether Acanthamoeba epitheliopathy might be effectively resolved only through epithelial removal enhanced by CXL, without requiring prolonged use of biguanide. To conclude, the early stage of Acanthamoeba keratitis marks a critical window in clinical management: corneal debridement, CXL and antiseptics provide a valid therapeutic option to eradicate infection confined to epithelium."

Keratitis • Ocular Inflammation • Ophthalmology