tobramycin/dexamethasone / Generic mfg. - LARVOL DELTA

Tobramycin-dexamethasone Ointment in the Pediatric Airway: A Novel Adjuvant Therapy (AAO-HNSF 2026) - "Tobramycin-dexamethasone appears safe for use in pediatric patients with glottic and subglottic granulation and was associated with improved clinical outcomes. Further studies are necessary to better delineate its benefits compared with other adjunctive therapies."

Clinical • Infectious Disease • Inflammation • Ophthalmology • Pediatrics

Insulin Eye Drops and Epithelial Healing After Corneal Cross-linking (clinicaltrials.gov) - P2/3 | N=24 | Completed | Sponsor: Cairo University

New P2/3 trial • Conjunctivitis • Ophthalmology • Pain

Subconjunctival Injection of Mesenchymal Stem Cells for Corneal Wound Healing After Chemical Injury: Impact on Epithelial Coverage, Limbal Ischemia, and Ocular Surface Inflammatory. (PubMed, Front Med (Lausanne)) - "Concurrently, all patients underwent amniotic membrane transplantation (AMT) and received a standard 4-week topical regimen (Tobradex, recombinant human epidermal growth factor, and Solcoseryl)...Subconjunctival UC-MSC delivery is a safe and feasible adjunctive therapy for managing severe corneal chemical injuries. This cell-based intervention synergizes with conventional therapies to suppress acute inflammation, rescue limbal perfusion while potentially mitigating subsequent corneal neovascularization, and accelerate the structural reconstruction of the ocular surface microenvironment."

Journal • Cardiovascular • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology • Transplantation • Uveitis • HER-2

Hidradenitis Suppurativa Presenting with Ocular Manifestations in a 44-Year-Old Male: A Case Report. (PubMed, Case Rep Ophthalmol) - "Treatment at this stage included topical dexamethasone, tobramycin, and systemic corticosteroids...Interdisciplinary management is essential for preserving vision. To our knowledge, this is the first report of posterior scleritis, PUK and conjunctival granuloma in the context of HS."

Journal • Acne Vulgaris • Dermatology • Hidradenitis Suppurativa • Immunology • Keratitis • Ocular Inflammation • Oncology • Ophthalmology • Pain • Rheumatology • Sarcoidosis • Scleritis • Uveitis

Intraocular Pressure Elevation among Pediatric Patients Given Corticosteroids after Strabismus Surgery. (PubMed, Acta Med Philipp) - "All patients were administered Tobramycin + Dexamethasone eyedrops, ointment or both...IOP elevation following strabismus surgery was frequently associated with topical steroid usage, and most patients experienced considerable IOP elevation. It is highly advised to closely monitor IOP following strabismus surgery, particularly in children receiving topical steroid treatment."

Journal • Glaucoma • Inflammation • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Pediatrics • Strabismus

Detection and analysis of antibiotic ointment in the anterior chamber following cataract surgery: A case report and literature review. (PubMed, J Int Med Res) - "The primary causes of endothelial cell loss included contact with white petrolatum, mineral oil present in tobramycin-dexamethasone ointment, and mechanical compression within the anterior chamber...To reduce intraocular lens contamination, ointment removal surgery should be performed without preoperative pupil dilation. Vigilance and timely intervention are essential, given the potential severity of these rare complications."

Journal • Review • Cataract • Ophthalmology

Dual-Drug Loaded PLGA Thin Film for Ocular Drug Delivery (ARVO 2026) - "We aimed to develop a biodegradable PLGA film co-loaded with dexamethasone and tobramycin, mimicking the gold standard Tobradex eyedrop formulation...If future testing confirms these early results, this simple film could improve healing, reduce the burden of eye drops for patients and caregivers, and help prevent infections after cataract surgery. It represents a promising step toward easier and more reliable post-surgery care."

Cataract • Ocular Inflammation • Ophthalmology • CXCL8 • IL6

Comparing Three Steroid-Antibiotic Treatments Following Blepharoplasty (ARVO 2026) - "This study evaluates how choice of steroid-antibiotic treatments, including Maxitrol Drops, Maxitrol Ointment, and Tobradex Ointment, impact signs of infection, such as wound warmth, leakage of purulent fluid, post-procedure fever, and subsequent need for antibiotics. There are three standard of care treatments that have been shown to be effective and this project looks to evaluate if there are differences between them. Because there is no significant difference in a range of wound healing variables found between treatments, the treatment decision can be deferred to factors such as patient preference and cost."

Ophthalmology

Concurrent Extranodal Marginal Zone Lymphoma of the Ocular Adnexa and Stomach in a Pediatric Patient (ASPHO 2026) - "The lesion briefly improved with Tobradex but recurred after cessation...Empiric doxycycline treatment for C. psittaci did not produce improvement...The patient is currently receiving quadruple therapy (amoxicillin, metronidazole, lansoprazole, bismuth subsalicylate), with repeat imaging planned to assess response. This case highlights an unusual dual-site presentation of pediatric EMZL involving both conjunctival and gastric mucosa. Awareness of atypical ocular findings may facilitate timely diagnosis, early comprehensive staging, and targeted management."

Clinical • Endocrine Disorders • Extranodal Marginal Zone Lymphoma • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Marginal Zone Lymphoma • Non-Hodgkin’s Lymphoma • Ocular Inflammation • Pediatrics • Sjogren's Syndrome

Topical Tobradex Airway Application (T2A2): Pilot Study of a Protocol Driven Approach to Pediatric Intubation Injury (COSM 2026) - "Seven included patients were treated between 2023 and 2025; 71.4% female. Patients underwent a mean (SD) of 6(3.65) TD applications with 69% occurring at the bedside. Three patients (42.9%) had a tracheostomy placed and 1 (14.3%) patient underwent airway reconstruction."

Clinical • Intubation • Inflammation • Otorhinolaryngology • Pediatrics • Respiratory Diseases

Effect of calcium hydroxide vs. tobradex intracanal medicament on postoperative endodontic pain: a pragmatic prospective study. (PubMed, BMC Oral Health) - No abstract available

Journal • Pain

The Role of Corneal Densitometry and Tear Cytokine Profiling in Personalizing Post-FS-LASIK Pharmacotherapy (ChiCTR) - P=N/A | N=200 | Recruiting | Sponsor: Zigong First People's Hospital; Zigong First People's Hospital

New trial

In vitro, ex vivo, and in vivo evaluation of ophthalmic ointments containing dexamethasone and tobramycin. (PubMed, Int J Pharm ) - "However, formulations indistinguishable in vitro were typically similar in their in vivo ocular pharmacokinetics. By integrating tiered models, the framework enhances understanding of critical quality attributes, supports regulatory decision-making, and may help reduce reliance on animal studies, thereby expediting the development of therapeutically equivalent generic ophthalmic ointments."

Journal • Preclinical • Ophthalmology

Tobradex as Intracanal Medicament (clinicaltrials.gov) - P=N/A | N=43 | Completed | Sponsor: Umm Al-Qura University

New trial • Dental Disorders • Pain

Optimal pulse technology combined with tobramycin and dexamethasone eye ointment in the treatment of blepharokeratoconjunctivitis: an impact on ocular surface disease index. (PubMed, Pharmacology) - "The addition of OPT to standard therapy for BKC is safe and provides superior short-term efficacy. It can alleviate lid margin inflammation, improve ocular surface symptoms, and enhance visual-related quality of life."

Journal • Conjunctivitis • Dry Eye Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Difficulties in management of ocular surface in the late phase of toxic epidermal necrolysis - a rare case report. (PubMed, Ann Agric Environ Med) - "This case highlights the significant challenges of managing late-phase ocular complications in SJS/TEN, emphasizing the need for a multidisciplinary approach and aggressive intervention to preserve ocular structure and function."

Journal • Ophthalmology • Pain • Steven-Johnson Syndrome • Transplantation

Effect of Periplaneta americana Extract on Corneal Fibrosis and Epithelial Healing After Rabbit Lamellar Keratectomy. (PubMed, Transl Vis Sci Technol) - "SLK was performed on the right eyes of 48 New Zealand White rabbits, randomized into three treatment groups (n = 16/group): normal saline (NS), Tobradex eye drops (TE), and PAE group...This biphasic regulatory effect may be attributed to promoting TGF-β1 expression in the early stage, followed by its inhibition in the later stages. PAE modulates TGF-β1 to balance corneal healing and fibrosis as a novel topical corticosteroid alternative, warranting human trials for its dual-phase healing/scarring action."

Journal • Preclinical • Corneal Abrasion • Fibrosis • Immunology • Inflammation • TGFB1

Erratum: Clinical Efficacy of Tobramycin Dexamethasone+Pranoprofen Eye Drops on Endophthalmitis in Cataract Patients Complicated with Diabetes Mellitus after Intraocular Lens Implantation. (PubMed, Niger J Clin Pract) - No abstract available

Journal • Cataract • Diabetes • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

Effect of Topical Application of Dexamethasone on CC Chemokine Receptor 3 Expression in Human Pterygium. (PubMed, J Ocul Pharmacol Ther) - " Forty cases of patients with pterygium were divided into a dexamethasone group and a control group, which were treated topically with 3 g/L tobramycin + dexamethasone or 3 g/L tobramycin eye drops in the surgical eyes 2 weeks before surgery... CCR3 signaling may play an important role in the pathogenesis of pterygium. The proangiogenic and profibrotic functions of CCR3 signaling may be by promoting tube formation and proliferation of vascular endothelial cells and promoting proliferation and migration of fibroblasts."

Journal • Fibrosis • Ophthalmology • CCR3 • FGF

Acute Central Toxic Keratopathy Induced by Exposure to Chinese Herbal Medicine Fluid for Verruca Plana: A Case Report. (PubMed, Case Rep Ophthalmol Med) - "Thus, tobramycin dexamethasone eye drops and artificial tears were prescribed for her, which proved effective. Her clinical symptoms and signs were both resolved after steroid treatment and remained stable at the 1-month follow-up. Acute central toxic keratopathy could occur after exposure to Chinese herbal medicine fluid, and enhanced topical steroid treatment worked well for alleviating inflammation and reducing corneal opacity."

Journal • Inflammation • Ophthalmology • Pain

Tacrolimus eye drops treatment for recurrent exposure of the Ahmed glaucoma valve tube. (PubMed, Eur J Med Res) - "Treatment with 0.1% tacrolimus eye drops demonstrated satisfactory results in managing recurrent exposure following allogeneic scleral patch graft coverage and autologous scleral tunnel repair, suggesting its potential as an effective alternative to conventional treatments."

Journal • Glaucoma • Ophthalmology • Transplantation

Effect of pranoprofen, tobramycin and dexamethasone combination on recurrence prevention and tear inflammatory factors after pterygium surgery. (PubMed, Pak J Pharm Sci) - "At 6-month follow-up, recurrence rates were comparable (1.85% vs. 9.43%, P>0.05), though the observation group trended lower. In conclusion, Pranoprofen + tobramycin/dexamethasone offers enhanced pain control, tear function and anti-inflammatory effects, with a potential recurrence-lowering benefit, supporting its clinical utility in pterygium management."

Clinical • Journal • Ophthalmology • Pain • CXCL8 • IL6 • TNFA

Comparison of Tobramycin-Dexamethasone Combination Eyedrop Versus Artificial Tear Eyedrop for the Management of Presumed Viral Epidemic Conjunctivitis: A Randomized Treatment Trial. (PubMed, Curr Eye Res) - "To compare the efficacy and safety of one-time povidone-iodine (PovI) administration followed by a course of tobramycin-dexamethasone eye drops versus artificial tears in acute viral conjunctivitis (AVC). A course of tobramycin-dexamethasone combination eyedrops after PovI may lead to early symptomatic relief, but recovery was similar to artificial tears by day 7. No significant/sight-threatening complications were observed in any groups."

Journal • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain

The Potential Role of Topical Losartan in Reducing Subepithelial Haze in Traumatic Laser-Assisted In Situ Keratomileusis (LASIK) Flap Avulsion. (PubMed, Cureus) - "A bandage contact lens was placed combined with moxifloxacin eye drops...The patient was continued on moxifloxacin four times a day (QID) and transitioned to Tobradex drops QID at day nine with improvement in UDVA to 20/30-2...Topical losartan 0.8 mg/mL was added six times per day along with fluorometholone two times a day (BID)...Uncorrected visual acuity after LASIK flap amputation is generally favorable, especially if corneal haze can be prevented. Topical losartan has anti-fibrotic activity through inhibition of the transforming growth factor-beta (TGF-β) signaling pathway, and in conjunction with topical steroids, may be effective in improving corneal haze in patients with a traumatic LASIK flap amputation."

Journal • Pain • TGFB1

Staphylococcus cohnii Causing a Latent Endophthalmitis: A Case Report. (PubMed, Case Rep Ophthalmol Med) - "A vitreous tap, with intraocular injection of ceftazidime, was performed, and topical dexamethasone and tobramycin were initiated. Staphylococcus cohnii is a gram-positive coagulase-negative bacterium that produces biofilm. Biofilm can promote adherence to implants leading to failure of therapy."

Journal • Infectious Disease • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology • Uveitis