2-iminobiotin (2-IB) / Neurophyxia - LARVOL DELTA

Neuronal and inducible nitric oxide synthase inhibitor for cerebral protection during deep hypothermic circulatory arrest in porcine hippocampus. (PubMed, J Appl Physiol (1985)) - "Based on previously published data, we used 2-iminobiotin, a selective inhibitor of both neuronal NOS (nNOS) and inducible NOS (iNOS)...NOS inhibition reduces neuronal degeneration and microglial activation in the hippocampus following DHCA. These findings suggest that the NOS inhibitor reduces neuronal degeneration by ameliorating inflammation."

Journal • Preclinical • Cardiovascular • CNS Disorders • Inflammation • Vascular Neurology • NOS1

The Influence of Plastic Processing on the Corrosion Resistance of the Alloy Based on the FeAl Intermetallic Phase After Long-Term Oxidation in Air Atmosphere. (PubMed, Materials (Basel)) - "This work presents a study of oxide-scale development on a B2 FeAl-based alloy (Fe40Al5Cr0.2TiB) during long-term isothermal oxidation at 700 °C in air, with particular emphasis on the effect of plastic processing...The results demonstrate that plastic processing influences oxidation behavior primarily through microstructural modification, while the protective character of the alumina scale remains preserved. These findings provide data relevant to FeAl-based materials considered for high-temperature energy applications."

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Comparison of Oxide Scale Morphology on FeAl-Based Alloy After Long-Term Oxidation in Air and Water Vapor at 700 °C. (PubMed, Materials (Basel)) - "The present study investigates the morphology, chemical composition, and phase constitution of oxide scales formed on the Fe40Al5Cr0.2TiB intermetallic alloy after long-term oxidation at 700 °C for 2000 h in air and water vapor environments...The study demonstrates that reliable characterization of ultrathin oxide scales requires careful optimization of SEM parameters and the combined use of complementary techniques, including EDS/WDS, XRD, and EBSD. The findings highlight the importance of methodological considerations in the analysis of thin oxide layers and provide guidance for the correct interpretation of experimental data in similar systems."

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Change in the Morphology of Alloy Corrosion Products Based on the FeAl Intermetallic Phase After Oxidation in Water Vapor at a Temperature of 700 °C for up to 2000 h. (PubMed, Materials (Basel)) - "The surface of the Fe40Al5Cr0.2TiB alloy, after oxidation in steam at 700 °C, showed a varied morphology dependent on oxidation time...Optical profilometry revealed a significant increase in roughness parameters (Ra and Rz) after long-term exposure (2000 h), which correlates with the thickening and sinterization of the oxide layer. The obtained results indicate that in a water vapor environment, a stable α-Al2O3 phase can already be formed at a temperature of 700 °C, and its development leads to increased roughness."

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Variations of heterometallic cores and magnetic properties in Co(iii)-Y/Ln isobutyrate clusters with N-butyldiethanolamine: from tetranuclear to octanuclear clusters. (PubMed, RSC Adv) - "The series includes tetranuclear [Co2M2(OH)2(ib)4(bdea)2(NO3)2]·2MeCN (M(III) = Y (1), Ho (2), Er (3)), pentanuclear [Co3M2(OH)(ib)5(bdea)3(NO3)3]·nMeCN (M(iii) = Pr (n = 1.5, 4), Nd (n = 1.5, 5), Sm (n = 2, 6)), hexanuclear [Co2Eu4(OH)2(ib)8(bdea)2(NO3)4(H2O)2]·(7) and [Co3Yb3(OH)4(ib)6(bdea)3(H2O)3](NO3)2·3MeCN·1.5H2O (8), and octanuclear [Co4M4(OH)4(ib)8(bdea)4(NO3)4] (M(iii) = Gd (9), Tb (10)) clusters...AC magnetic data show relevant out-of-phase signals only for 3 below 4 K and by application of static magnetic bias fields. First principles calculations have been performed to estimate the magnetic anisotropy energies of the prepared compounds and to calculate the exchange coupling between the lanthanides in them."

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PHENOTYPE AND GENOTYPE CORRELATION OF HEPATIC GLYCOGEN STORAGE DISEASE: A SINGLE CENTRE OBSERVATIONAL STUDY (ESPGHAN 2025) - "GSD Types Gene affected No of cases (n=25) Ia G6PC/SLC37A4 2 Ib G6PC/SLC37A4 2 IIIa AGL 7 IIIb AGL 4 IV GBE1 1 VI PYGL 4 IXa PHKA2 1 IXb PHKB 2 XI GLUT2/SLC2A2 2 Conclusions Early diagnosis and dietary management are the mainstay of treatment till gene therapy is readily available. Good metabolic control alleviates metabolic complications and a liver transplant is seldom needed."

Clinical • Observational data • Cardiovascular • CNS Disorders • Diabetes • Epilepsy • Fibrosis • Gene Therapies • Genetic Disorders • Hepatology • Hypoglycemia • Immunology • Metabolic Disorders • Pancreatitis • Portal Hypertension • Renal Calculi • SLC2A2

Oxidation of the Alloy Based on the Intermetallic Phase FeAl in the Temperature Range of 700-1000 °C in Air and Possibilities of Practical Application. (PubMed, Materials (Basel)) - "In this way, conditions were created that fundamentally changed the surface condition (structure and physicochemical properties) of the system: steel as a substrate-intermetallic phase Fe40Al5Cr0.2TiB as a surfacing layer, in order to increase resistance to high-temperature corrosion and erosion (in the environment of gases and solid impurities in gases) often occurring in corrosive environments, especially in the power industry (boilers, pipes, installation elbows) and the chemical industry (fittings). At the same time, the surfacing method used is one of the cheapest methods of changing the surface properties of the material and regenerating or repairing the native material with a material with better properties, especially for applications in high-temperature corrosion conditions."

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Safety, Tolerability, and Pharmacokinetics of the Neuroprotectant 2-Iminobiotin in Patients With Large-Vessel Occlusion Ischemic Stroke Treated With Endovascular Thrombectomy. (PubMed, Stroke) - "The efficacy of 2-IB needs to be investigated further in a phase 2b/3 clinical trial. URL: www.onderzoekmetmensen.nl; Unique identifier: NL-OMON51194."

Journal • PK/PD data • Cardiovascular • Ischemic stroke

Structure and Corrosion Resistance of Fe40Al5Cr0.2TiB Alloy After Casting and After Homogenization Annealing. (PubMed, Materials (Basel)) - "This alloy showed a more non-homogeneous and coarse-grained microstructure compared to the alloy after homogenization annealing. The investigation of the surface condition of FeAl alloys after corrosion tests showed the presence of pits, particularly in the case of the alloy after casting."

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The Impact of Interceptor G2 & PermaNet 3.0 Insecticidal Treated Nets on Entomological transmission indicators in Gaya & Guidimouni, Niger, West Africa (ASTMH 2024) - "In Guidimouni, EIR was 4.8 ib/p/m in 2021 with >70% reduction following the ITN campaign in 2022 (1,2 ib/p/m) but then rose to 1.9 ib/p/m in 2023...Pre-exposure to PBO synergist increased mortality of mosquitoes but only fully restored susceptibility to alpha-cypermethrin and deltamethrin in 2023. The overall data suggest that ITN types have an impact on entomological transmission indicators, though monitoring for an additional year is necessary to determine whether efficacy of nets reduces two years after deployment."

Construction of Cell Membrane Chromatography Screening Materials Based on Avi-Tag Fused G Protein-Coupled Receptors. (PubMed, Anal Chem) - "Our study showed that 2-iminobiotin (IB) can be a BirA substrate, enabling the development of a new cell membrane stationary phase (CMSP) based on the chemical properties (modifying carboxyl silica gel and specifically labeling the Avi tag) of IB...Our IB-Avi tag-based CMC approach effectively decreased nonspecific adsorption of the screening materials. The Avi-tag-based 2D/CMC platform is suitable for screening potential drug candidates."

Journal • Allergy

Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector. (PubMed, Parasit Vectors) - "Whereas An. funestus s.s. is the dominant malaria vector in the Funestus group in Tanzania, this survey confirms the occurrence of Plasmodium-infected An. parensis, an observation previously made in at least two other occasions in the country. The findings indicate the need to better understand the ecology and vectorial capacity of this and other secondary malaria vectors in the region to improve malaria control."

Journal • Infectious Disease • Malaria

Safety and Preliminary Efficacy of the Neuroprotectant 2-Iminobiotin in Patients With Stroke Treated With Mechanical Thrombectomy (ISC 2024) - "No significant differences on vital signs or adverse events were found in all treatment groups. Efficacy of 2-IB needs to be investigated in a larger trial."

Clinical • Late-breaking abstract • Neuroprotectant • Cardiovascular • Ischemic stroke • Reperfusion Injury

The role of the major viral pathogens in a respiratory disease outbreak of broiler flocks in Eastern Iran. (PubMed, Iran J Vet Res) - "Variant 2 IB viruses were widely distributed in the province and half of them were mostly similar to the ones that had been detected in northern neighboring province, Khorasan Razavi...The high coverage and multiple doses of vaccination against Newcastle disease possibly had reduced the prevalence of NDV. Considering the regional origin of IBV strains, strong biosecurity measures should be implemented and vaccination programs using appropriate vaccine strains should be used."

Journal • Infectious Disease • Influenza • Pulmonary Disease • Respiratory Diseases

2-iminobiotin, a selective inhibitor of nitric oxide synthase, improves memory and learning in a rat model after four vessel occlusion, mimicking cardiac arrest. (PubMed, PLoS One) - "Adult rats treated s.c. with 3 gifts of 2-IB every 12 h in a dose range of 1.1-30 mg/kg/dose directly upon reperfusion showed significant improved memory and learning after four vessel occlusion compared to vehicle-treated rats. Since 2-IB has already shown to be safe in a phase 1 clinical trial in adult human volunteers, it is a suitable candidate for translation to a human phase 2 study after OHCA."

Journal • Preclinical • Cardiovascular • Cognitive Disorders

Urban malaria vector bionomics and human sleeping behavior in three cities in Senegal. (PubMed, Parasit Vectors) - "Anopheles arabiensis was the primary malaria vector in the three surveyed cities. The species showed an outdoor biting tendency, which represents a risk for the large proportion of the population sleeping outdoors. As all current vector control measures implemented in the country target endophilic vectors, these data highlight potential gaps in population protection and call for complementary tools and approaches targeting outdoor biting malaria vectors."

Journal • Infectious Disease • Malaria

Late Breaking Abstract - Did changes in referral pathways during the Covid 19 pandemic influence lung cancer diagnosis and staging (ERS 2023) - "Staging at diagnosis and 12-month mortality are summarised below: Stage Pre - Pandemic staging (%) During Pandemic - staging (%) Pre Pandemic - 12 month mortality (%) During Pandemic - 12 month mortality (%) I 2.6 5.0 2.2 1.9 Ia 1.6 4.0 1.6 1.2 Ib 0.9 1.0 0.6 0.7 II 2.2 3.3 0.9 1.0 IIa 0 0.3 0 0 IIb 2.2 2.9 0.9 0.5 III 17.5 16.5 8.1 7.5 IIIa 5.5 5.2 2.2 2.4 IIIb 7.1 7.5 3.9 3.1 IIIc 4.8 3.6 1.9 1.9 IV 63.8 63.8 32.2 42.5 IVa 33.8 28.1 15.9 17.5 IVb 28.9 34.2 15.9 23.9 Conclusion Data shows an increase in the percentage of early stage lung cancers diagnosed during the pandemic compared to prior, although mortality rates at these stages were similar. This pattern was seen in primary care and hospital referrals.; Epidemiology; General respiratory patient care; Imaging; Pulmonary function testing; Endoscopy and interventional pulmonology; Public health; Surgery"

Late-breaking abstract • Infectious Disease • Lung Cancer • Novel Coronavirus Disease • Oncology • Solid Tumor