hydroxychloroquine / Generic mfg. - LARVOL DELTA

A multicenter, randomized, controlled, open-label, phase II trial of autologous tumor-infiltrating lymphocytes (GC101 TIL) in patients with advanced melanoma. (ASCO 2026) - P2 | "Clinical Trial Registration Number: NCT06703398 Background: Tumor-infiltrating lymphocyte (TIL) therapy is effective in advanced melanoma but hampered by toxicity from high-dose IL-2 and lymphodepletion (cyclophosphamide/fludarabine)...GC101 therapy consists of tumor resection, low-intensity preconditioning (cyclophosphamide 20 mg/kg/d, pre-infusion d -5 to- 3; hydroxychloroquine 600 mg, pre-infusion d -5), followed by infusion of IL-2-free TIL and sintilimab (100 mg at infusion, then 100 mg Q6W × 4)... GC101 TIL significantly improved PFS and ORR versus investigator-choice chemotherapy in anti-PD-1-resistant melanoma, with manageable safety, supporting its potential as a new later-line therapy."

Clinical • Late-breaking abstract • Metastases • P2 data • Tumor-infiltrating lymphocyte • Eye Cancer • Melanoma • Mucosal Melanoma • Oncology • Solid Tumor • Uveal Melanoma

Synovial Histology in CPPD Disease and the Impact of Therapy on Synovial Inflammation: Interim Results of a Phase II Randomized Trial (ACR Convergence 2026) - "Eligible patients fulfilling the 2023 ACR/EULAR CPPD criteria are randomized to baricitinib 4 mg/day or investigator-selected SOC (one or a combination of colchicine, methotrexate, hydroxychloroquine, corticosteroids or NSAIDs). This interim analysis provides the first description of CPPD synovium, identifying three patterns: highly inflammatory, intermediate, and fibrotic. In such a clinically multifaceted disease, histologic characterization could offer crucial pathogenic insights to guide new therapies. Treatment efficacy depends on baseline inflammation, with histological improvements occurring exclusively in high-grade synovitis."

Clinical • P2 data • Cardiovascular • Fibrosis • Hematological Disorders • Inflammation • Inflammatory Arthritis • Retinal Vein Occlusion • Rheumatoid Arthritis • Thrombosis • CD20 • CD68 • CD8

Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty (clinicaltrials.gov) - P2 | N=80 | Recruiting | Sponsor: NYU Langone Health | Not yet recruiting ➔ Recruiting | Trial completion date: Sep 2027 ➔ Jan 2028 | Initiation date: Sep 2025 ➔ Dec 2025 | Trial primary completion date: Sep 2027 ➔ Jan 2028

Enrollment open • Trial completion date • Trial initiation date • Trial primary completion date • Orthopedics • Psoriatic Arthritis • Rheumatology

Anti-MDA5 Dermatomyositis Presenting With Lupus-Like Mucocutaneous Features and Inflammatory Arthritis: A Case Report. (PubMed, Case Reports Immunol) - "Initial treatment involved the administration of high-dose methylprednisolone followed by a gradual dose reduction, hydroxychloroquine, and mycophenolate sodium after the secondary skin infection resolved. Accurate diagnosis requires a comprehensive clinical and serological evaluation, as well as a deep understanding of the classification criteria for each disease to avoid overclassification. Early diagnosis and aggressive treatment targeting the primary driving pathology can improve the prognosis and quality of life of patients."

Journal • Dermatology • Dermatomyositis • Immunology • Infectious Disease • Inflammatory Arthritis • Interstitial Lung Disease • Lupus • Melanoma • Musculoskeletal Diseases • Musculoskeletal Pain • Myositis • Oncology • Pulmonary Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Solid Tumor • IFIH1

PRIMARY COLON SQUAMOUS CELL CARCINOMA OCCULT IN A SMALL COLONIC POLYP (UEGW 2026) - "Clinical Case Summary: A 61-year-old male underwent colonoscopy due to positive fecal occult blood.He had a 3-year history of colonic polypectomy and 6-month systemic lupus erythematosus, with long-term oral hydroxychloroquine sulfate, prednisone acetate, etc. No family malignancy history. 2) No prior literature reports the link between long-term systemic lupus erythematosus (immune dysfunction) and colon SCC. 3) Occult SCC was detected via complete EMR or ESD, highlighting the importance of standardized polyp resection to avoid missed diagnosis."

Colonic Polyps • Gastroenterology • Immunology • Inflammatory Arthritis • Leukopenia • Lupus • Oncology • Squamous Cell Carcinoma • Systemic Lupus Erythematosus

PANNICULITIS, ANEMIA, WEIGHT LOSS AND ARTHRALGIA: A LONG JOURNEY TO WHIPPLE DISEASE (UEGW 2026) - "pylori eradication, iron replacement, rifaximin, and therapy of possible functional symptoms had a partial effect. During the next couple of years, she periodically had diarrhea that was relieved with short courses of trimethoprim/sulfamethoxazole...Initial treatment with ceftriaxone IV for 14 days with subsequent starting of doxycycline and hydroxychloroquine has been effective for symptom relief. This clinical case emphasizes the complexity of the WD diagnosis, the clinical presentation of which may mimic other diagnoses, including functional GI disorders, and where appropriate, initial diagnostic workup may not give a right diagnosis. Therefore, repeating of a comprehensive diagnostic work-up should be considered in any doubtful cases even though rare diseases are «rare»."

Anemia • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Musculoskeletal Pain • Rare Diseases

LUPUS ENTERITIS AND PERITONITIS PRESENTING AS INITIAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS: DIAGNOSTIC CHALLENGE IN TUBERCULOSIS-ENDEMIC REGIONS (UEGW 2026) - "EULAR/ACR 2019 score was 19, confirming SLE with lupus enteritis and serositis. He improved rapidly on corticosteroids and was discharged on hydroxychloroquine and tapering steroids, with sustained improvement on follow-up."

Cardiovascular • Cough • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Musculoskeletal Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Systemic Lupus Erythematosus • Tuberculosis

Phloretin Modulates STING Ubiquitination Degradation to Restrain Dendritic Cell Overactivation and Alleviate Sjögren's Syndrome. (PubMed, Pharmaceuticals (Basel)) - "In vivo experiments were conducted on NOD/Ltj SS mice with phloretin treatment, using hydroxychloroquine as a positive control... DCs and STING-driven innate immunity critically contribute to SS progression. Phloretin effectively ameliorates SS-related immune disorders by restraining DC overactivation and STING signaling, supporting it as a promising candidate agent for SS treatment."

Journal • Immunology • Inflammation • Sjogren's Syndrome • Targeted Protein Degradation • ITGAX • STING

Need for Medication Review and Deprescribing in People Living with HIV: A Longitudinal Observational Study. (PubMed, Pharmaceuticals (Basel)) - "Four were DDIs: cobicistat/alprazolam associated with sedation and dyspnoea, rilpivirine/hydroxychloroquine with QT prolongation, bictegravir/ursodeoxycholic acid with rising viremia, and atorvastatin/fenofibrate with myalgia...After medication review, alprazolam was replaced with zolpidem, rilpivirine-based HAART with bictegravir/emtricitabine/tenofovir alafenamide, and atorvastatin/fenofibrate with simvastatin/ezetimibe, and ursodeoxycholic acid and supplements were discontinued... This study highlights the importance of predicting DDIs/DSIs in PLWH undergoing polypharmacy. Medication review supports clinical decision-making, preventing avoidable adverse outcomes."

Journal • Observational data • Anesthesia • Human Immunodeficiency Virus • Infectious Disease • Musculoskeletal Pain • Pain • Pulmonary Disease

Therapeutic strategies in childhood diffuse alveolar haemorrhage and idiopathic pulmonary hemosiderosis, a CRC chILD-EU study (ERS 2026) - "Treatments were classified into four categories: first-line (corticosteroids), second-line (hydroxychloroquine), third-line (mycophenolate mofetil, Janus kinase inhibitors, azathioprine), and last-resort therapies (cyclophosphamide, rituximab, obinutuzumab, plasma exchange, embolization). This study identifies new risk factors for IPH recurrence and shows that standard first- and second-line therapies do not reduce relapse risk. Third-line treatments appear effective and their role in long-term IPH management warrants reconsideration."

Clinical • Developmental Disorders • Genetic Disorders • Immunology • Pulmonary Disease • Respiratory Diseases

Updates on the Evaluation of Lupus Arthritis. (PubMed, Rheumatol Ther) - "Therapeutically, hydroxychloroquine (HCQ) remains the foundation of treatment. Belimumab and anifrolumab are US Food and Drug Administration (FDA)-approved biologics now recommended as standard of care for persistent disease, alongside conventional immunosuppressants such as methotrexate, mycophenolate, or azathioprine when indicated. Additional targeted therapies including obinutuzumab and Janus kinase (JAK) inhibitors are closely following behind. Chimeric antigen receptor T cell (CAR-T) represents a promising approach that may transform the future management of SLE."

IO biomarker • Journal • Review • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Musculoskeletal Diseases • Musculoskeletal Pain • Rheumatology • Systemic Lupus Erythematosus • IL17A • IL6

A case of suspected hydroxychloroquine-induced cardiomyopathy: From therapy to toxicity. (PubMed, JHLT Open) - "Hydroxychloroquine (HCQ)-induced cardiomyopathy is often under-recognized, especially in patients with moderate treatment durations, as its presentation can mimic other causes of heart failure. Early recognition is essential, as prompt discontinuation of HCQ may allow for meaningful recovery of cardiac function."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Renal Disease • Rheumatology • Systemic Lupus Erythematosus

A Diagnosis Delayed: IBD Mimicking Connective Tissue Disease (ACG 2026) - "She was prescribed hydroxychloroquine with PRN colchicine for mouth sores...Patient was started on 60 mg IV methylprednisolone daily...ANA positivity often occurs in patients with IBD and should not be used in isolation as an indicator of rheumatologic disease vs IBD. Figure: Figure 1: Representative colonoscopy image of sigmoid colon"

Dental Disorders • Hematological Disorders • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Rheumatology

Uncontrolled Systemic Lupus Erythematosus Causing Recurrent Pancreatitis (ACG 2026) - "The patient had previously been unable to tolerate multiple immunosuppressive therapies, including azathioprine, methotrexate, mycophenolate sodium, and mycophenolate mofetil, and was not consistently following with rheumatology or receiving treatment for SLE. Rheumatology was consulted during admission, and treatment was initiated with dexamethasone, cyclophosphamide, and hydroxychloroquine...Clinicians should maintain a high index of suspicion for pancreatitis in SLE patients presenting with abdominal pain, particularly those with poorly controlled disease. This case also emphasizes the importance of consistent rheumatologic follow-up and immunosuppressive therapy, as adequate control of underlying SLE reduces the risk of recurrent pancreatic inflammation and complications."

Cardiovascular • Chronic Kidney Disease • Gastroenterology • Glomerulonephritis • Hypertension • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Pancreatitis • Renal Disease • Systemic Lupus Erythematosus

Whipple's Disease With CNS Involvement (ACG 2026) - "Based on these findings and social considerations, the patient was discharged on oral doxycycline and hydroxychloroquine...He was later transitioned to complete intravenous ceftriaxone for a total of 14 days, followed by trimethoprim sulfamethoxazole with planned 12-month therapy...Histiocytes showing granular positivity with this OAS-D stain, consistent with Whipple's disease. D: Endoscopic View of second portion of duodenum 6-months into treatment with improving inflammation."

CNS Disorders • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Musculoskeletal Pain

A Septuagenarian Surprise: Wilson Disease Presenting as Fulminant Acute Liver Failure in a 70-Year-Old Woman (ACG 2026) - "Case Description/ A 70-year-old woman with rheumatoid arthritis and systemic lupus erythematosus on low-dose methotrexate and hydroxychloroquine presented with confusion, progressive jaundice, nausea, poor oral intake, and fatigue...Viral hepatitis, autoimmune markers, and acetaminophen testing were negative, and she was treated with N-acetylcysteine for possible drug-induced liver injury...Despite D-penicillamine and zinc, she progressed to multiorgan failure...Recognition of this biochemical pattern is crucial, because medical therapy alone is rarely sufficient and survival depends on early liver transplantation evaluation. Figure: Table 1: Laboratory parameters and trends since admission Figure: Figure 1: CT image showing cirrhotic-appearing liver with ascites"

Clinical • Autoimmune Hepatitis • CNS Disorders • Genetic Disorders • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Liver Failure • Lupus • Metabolic Disorders • Movement Disorders • Rheumatoid Arthritis • Systemic Lupus Erythematosus

Disseminated Histoplasmosis Mimicking Decompensated Cryptogenic Cirrhosis With Portal Hypertension (ACG 2026) - "Case Description/ A 68-year-old woman with rheumatoid arthritis previously treated with abatacept, methotrexate, and hydroxychloroquine and presumed cryptogenic cirrhosis was admitted with markedly elevated liver enzymes and a right frontoparietal subdural hematoma after a ground-level fall...Liposomal amphotericin B was initiated, complicated by SIRS requiring ICU care, then transitioned to oral itraconazole...Figure: Figure 1. Axial CT abdomen demonstrating scattered, small to moderate volume ascites."

Cardiovascular • CNS Disorders • Fibrosis • Gastrointestinal Disorder • Hepatology • Immunology • Infectious Disease • Inflammatory Arthritis • Neuroendocrine Tumor • Portal Hypertension • Rheumatoid Arthritis • Solid Tumor • CHGA

IgG4-Related Colitis Masquerading as Crohn's Disease: A Diagnostic Challenge (ACG 2026) - "Case Description/ A 42-year-old woman with a history of lupus, Sjögren's syndrome, and mixed connective tissue disease â managed on anifrolumab, prednisone and hydroxychloroquine â presented to the IBD clinic regarding newly diagnosed Crohnâs colitis...She was started on corticosteroids and infliximab but had a lack of response with significant obstipation, abdominal pain and bloody diarrhea...The patient clinically improved post-LAR and was referred to rheumatology for continued therapy and consideration of rituximab...Figure: Figure 1. Rectosigmoid stricture."

Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Lupus • Nephrology • Renal Calculi • Sjogren's Syndrome

Subhepatic Lymphocele in a Patient With Systemic Lupus Erythematosus: A Rare Complication of Cholecystectomy (ACG 2026) - "The patient previously had abnormal liver enzymes on routine labs two months prior to her hospital presentation with subsequent discontinuation of hydroxychloroquine...MRCP plays a key role in excluding biliary communication and establishing the diagnosis. Figure: Image A and B: CT scan of the abdomen, showing a 10.6 cm lobulated fluid attenuation structure (red arrows) abutting the inferior margin of the liver, the pancreas, common bile duct, inferior vena cava, and the right kidney, inferiorly."

Clinical • Asthma • Immunology • Inflammatory Arthritis • Lupus • Respiratory Diseases • Solid Tumor • Systemic Lupus Erythematosus • Uterine Leiomyoma

From Gastric Pneumatosis to Fungal Necrosis: Invasive Candida Gastritis Mimicking Gastric Malignancy (ACG 2026) - "Case Description/ A 51-year-old man with type 1 diabetes on an insulin pump, sarcoidosis on hydroxychloroquine, chronic opioid use, and CAD s/p CABG was admitted weeks earlier for a 1% TBSA hand burn requiring hospitalization and wound care...Anidulafungin was initiated; repeat EGD showed ulcer improvement, tissue biopsies confirmed Candida, and therapy was transitioned to fluconazole for 21 days with clinical recovery...Figure: Figure 2 (A) H&E stain demonstrating a fibrinopurulent ulcer bed with extensive acute inflammation and necrotic debris overlying the gastric mucosa; no viable epithelium is identified. (B) GMS stain highlighting abundant fungal yeast forms and hyphal elements within the necrotic ulcer bed, consistent with invasive Candida gastritis."

Cardiovascular • Diabetes • Gastric Adenocarcinoma • Gastrointestinal Disorder • Immunology • Infectious Disease • Metabolic Disorders • Oncology • Sarcoidosis • Solid Tumor • Type 1 Diabetes Mellitus

Herpes Simplex Virus Hepatitis Presenting as Acute Liver Failure: A Diagnostic Challenge (ACG 2026) - "Case Description/ We present a case of a 60 year-old female with a history of alcohol use disorder, Hashimotoâs thyroiditis, and unspecified autoimmune disease on hydroxychloroquine who presented to an outside hospital with right upper quadrant pain and predominantly hepatocellular liver injury...She was intubated and started on empiric IV Valganciclovir and N-acetylcysteine prior to transferring to a liver transplant center...HSV hepatitis is often fatal if left untreated, and treatment with empiric IV acyclovir should be initiated promptly because of its favorable safety profile and potential survival benefit...HE 60x stain depicts viral inclusions with associated necrosis. HSV 1 and 2 IHC 60x of the liver confirms the diagnosis of HSV hepatitis."

Addiction (Opioid and Alcohol) • Autoimmune Hepatitis • Cardiovascular • CNS Disorders • Endocrine Disorders • Hepatitis C • Hepatology • Herpes Simplex • Immunology • Infectious Disease • Inflammation • Liver Failure

Renal and Colonic Malakoplakia Mimicking Metastatic Cancer in a Patient on Long-Term Immunosuppression for Rheumatoid Arthritis (ACG 2026) - "Case Description/ A 68-year-old woman with RA on prednisone, methotrexate, and hydroxychloroquine, and pulmonary embolism (PE) on apixaban, presented with two weeks of flu-like symptoms and urinary frequency. Management begins with reducing immunosuppression and macrophage-penetrating antibiotics such as trimethoprim-sulfamethoxazole or fluoroquinolones, with surgery reserved for mass effect or failure of medical therapy. Figure: A. Renal parenchyma (on right side) B. Higher power view of A showing histiocytic inflammation C. + CD68 immunostain marker of histiocytes and macrophages D. Negative AE1/AE3 immunostain arguing against carcinoma E. CT scan illustrating renal mass with colonic involvement F. Diverticulum with ulcerated mucosa G. Panned out view of descending colon diverticulum H. Inside the ulcerated diverticular defect"

Clinical • Metastases • Acute Kidney Injury • Gastrointestinal Disorder • Immunology • Inflammatory Arthritis • Nephrology • Oncology • Pulmonary Embolism • Renal Cell Carcinoma • Renal Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Urology • CD68 • KIT

Beyond Nausea: Methotrexate-Induced Contained Gastric Perforation With Partial Gastric Outlet Obstruction - A Novel Structural Complication and the Critical Role of EUS in Excluding Lymphoproliferative Disease (ACG 2026) - "Case Description/ A 61-year-old woman with RA (prior MTX, transitioned to hydroxychloroquine), PUD with prior GI bleeding, and morbid obesity presented with symptomatic anemia (Hgb 7.1 g/dL), nausea, diarrhea, and abdominal cramping. Non-operative management succeeded, consistent with reported success rates up to 82% in stable patients. Clinicians must recognize that MTX gastropathy can cause structural GI complications even after DMARD transition."

Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Mucositis • Obesity • Peptic Ulcer

A Rare Gut Feeling: An Elusive Acute Abdomen Unmasking Isolated Lupus Enteritis (ACG 2026) - "She was subsequently started on cyclophosphamide, which she tolerated well, and symptoms improved steadily. She was discharged in stable condition on prednisolone 40 mg and hydroxychloroquine 300 mg, with regular follow-up...Figure: Figure 2. MRI abdomen coronal view showing (1) mesenteric haziness, (2) thickened distal ileum, and (3) target cells."

Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Respiratory Diseases • Systemic Lupus Erythematosus • Tuberculosis

PCR-Confirmed Whipple's Disease Presenting With Small Bowel Lymphangiectasia and Nondiagnostic Histopathology (ACG 2026) - "The patient was started on doxycycline 100 mg twice daily and hydroxychloroquine for a planned 12-month course. This case highlights the potential discordance between histopathology and PCR testing and underscores the importance of integrating molecular diagnostics with clinical findings. It also emphasizes that PAS-positive, diastase-resistant staining without the presence of identifiable organisms is not alone sufficient for diagnosis, and PCR may be required for confirmation."

Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Pain • Rheumatoid Arthritis