INCB098377 / Incyte - LARVOL DELTA

Discovery of INCB098377: a potent inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) (AACR 2023) - "In addition, INCB098377 inhibited neutrophil migration in the Carrageenan-induced paw inflammation model. INCB098377, a potent and selective inhibitor of PI3Kγ, shows effective anti-tumor activity in a variety of mouse and humanized cancer models through the inhibition of immunosuppressive cells trafficking into the tumor, modulation of myeloid cell function, and enhancement of T cell proliferation.Acknowledgments: Diana Alvarez Arias and Stephen Douglass contributed equally to this study."

Oncology • CD163 • CD80 • MRC1 • PIK3CG