diacerein / Generic mfg. - LARVOL DELTA

Intra-articular dual-targeted hydrogel co-delivering diacerein nanoparticles and ketorolac for modulating neuroimmune interplay and cartilage degeneration in osteoarthritis. (PubMed, Drug Deliv Transl Res) - "In conclusion, embedding SLN within an injectable hydrogel enabled targeted, site-specific, and sustained intra-articular drug delivery, reducing systemic exposure while enhancing efficacy. These results demonstrate the DC-SLN gel as a promising translational platform that unites targeted pain management with disease-modifying potential for advanced OA therapy."

Journal • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • CCL2 • CD68 • IL1B • MIR140 • MMP13

Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers. (PubMed, Molecules) - "The present review integrates pharmacological, toxicological, and formulation-focused evidence to provide a unified assessment of emodin and the anthraquinone scaffold. Particular emphasis is placed on bidirectional, dose- and context-dependent effects on the liver and kidney; the modulation of cytochrome P450 enzymes, UGTs, and transporters; and emerging preclinical formulation strategies that aim to decouple intrinsic bioactivity from pharmacokinetic limitations."

Journal • Review • Cardiovascular • Gastrointestinal Disorder • Immunology • Oncology • AMPK • NLRP3

Diacerein improves liver fibrosis, steatosis, and atherosclerosis in ApoE knockout mice. (PubMed, J Mol Med (Berl)) - "The expression of pro-inflammatory cytokines was reduced. Treatment of apoE knockout mice fed an HFD with diacerein effectively ameliorated liver steatosis/fibrosis and atherosclerosis."

Journal • Preclinical • Addiction (Opioid and Alcohol) • Atherosclerosis • Cardiovascular • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • APOE • IL1B • TNFA

Understanding the efficacy and tolerability of topical therapies for epidermolysis bullosa. (PubMed, Expert Rev Clin Pharmacol) - "This review examines the clinical efficacy and tolerability of topical therapies for EB, with a particular focus on approved treatments such as beremagene geperpavec (B-VEC) and Oleogel-S10, as well as emerging agents like allantoin, diacerein, sirolimus, gentamicin, gentian violet and calcipotriol...The continued use of standardized outcome measures will affect the future progress of studies, as well as using real-world data. Whilst a definitive cure is unlikely for EB, evolving topical strategies have strong potential in providing control of the disease's symptoms and ultimately can improve long-term outcomes."

Journal • Review • Dermatology • Pain

Inflammatory Knee Osteoarthritis Does Not Improve With Oral Diacerein. (PubMed, JAMA Intern Med) - No abstract available

Journal • Immunology • Osteoarthritis • Pain • Rheumatology

Diacerein for Knee Osteoarthritis: A Randomized Clinical Trial. (PubMed, JAMA Intern Med) - P2 | "These findings do not support diacerein for treating knee pain in this population. Australian New Zealand Clinical Trials Registry: ACTRN12618001656224."

Clinical • Journal • Immunology • Inflammation • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology • IL1B

Design and optimization of diacerein loaded lipid nanocarriers: Characterization, in vitro and in vivo evaluation for anti-arthritic activity. (PubMed, Nanomedicine) - "DC-SLNPs resulted in optimal protection against LPS-induced stress (1 μg/ml) when compared with DC. These were observed in optimized DC loaded SLNPs in comparison to DC·In vivo anti-arthritic activity and satisfactory percentage bias (1.32-3.15) suggested the potentiality of DC-SLNPs."

Journal • Preclinical • Inflammation

Diacerein Downregulates Nfkb, Induces ALP Activity and Inhibits Osteoblast Apoptosis in Alveolar Bone of Rats with Periodontitis. (PubMed, Biomedicines) - " Therefore, the diacerein-induced TNF-α and IL-1β inhibitory effect caused Nfkb1 downregulation and, hence, prevented apoptosis in osteoblasts. The increased ALP activity and IL-10 in PDG indicate that diacerein mitigates periodontitis impact on alveolar bone in rat molars."

Journal • Preclinical • Dental Disorders • Oncology • Periodontitis • BMP2 • CASP3 • IL10 • IL1B • TNFA

Treatment Landscape for Epidermolysis Bullosa Simplex: A Review of Established and Emerging Therapies. (PubMed, Pediatr Dermatol) - "A number of emerging treatments targeting EBS inflammatory pathways under investigation include apremilast, dapsone, diacerein ointment, deucravacitinib, and topical broccoli sprout extract. Tetracycline antibiotics are commonly used off-label for blister prevention. Ongoing bench research and gene-editing techniques like siRNA, TALEN, and CRISPR-Cas9 offer hope for translational advancements."

Journal • Review • Dermatology • Infectious Disease • Pain

Diacerein protects against Ovariectomy-Induced bone loss via reversal of NRF2 epigenetic suppression. (PubMed, Biochem Pharmacol) - "The upregulation of NRF2 appears to be primarily mediated through rhein's inhibition of DNA methyltransferases (DNMTs) 1 and 3a. In summary, our study suggests that diacerein, a drug with a well-established safety profile and suitability for long-term use, represents a promising therapeutic candidate for the treatment of osteoporosis."

Journal • Immunology • Musculoskeletal Diseases • Orthopedics • Osteoarthritis • Osteoporosis • Pain • Rheumatology

Topical Diacerein in Psoriasis Vulgaris (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: Cairo University

New P4 trial • Dermatology • Immunology • Psoriasis

Advances in Drug Delivery Science for Diacerein: Strategies to Enhance Solubility, Bioavailability, and Pharmacokinetic Performance. (PubMed, Pharmaceutics) - "Together, these strategies provide a comprehensive platform for the rational design of diacerein formulations, offering promising avenues to overcome its clinical limitations and improve patient outcomes. The insights presented here may also guide the development of more effective delivery systems for other poorly soluble anti-inflammatory agents."

Journal • PK/PD data • Review • Immunology • Osteoarthritis • Pain • Rheumatology

Response to Comments on "Diacerein-Loaded Oleoliposome Dry-Powder Inhalation Nano-Formulation for COPD". (PubMed, J Pharm Sci) - No abstract available

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Clinical Translation Considerations for Diacerein-Loaded Oleoliposome Dry-Powder Inhalation in COPD. (PubMed, J Pharm Sci) - No abstract available

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Coral-YOLO: An Intelligent Optical Vision Sensing Framework for High-Fidelity Marine Habitat Monitoring and Forecasting. (PubMed, Sensors (Basel)) - "Evaluated on our newly curated, multi-year CR-Mix dataset, Coral-YOLO achieves a state-of-the-art 50.3% AP (average precision at IoU threshold 0.5:0.95, following COCO metrics), representing a +1.8 percentage point improvement over the YOLOv12-m baseline, with particularly pronounced gains on small objects (+2.6 percentage points in APS)...Coral-YOLO sets a new performance benchmark and enables proactive reef conservation. It provides a powerful tool to identify at-risk corals long before severe bleaching becomes visually apparent."

Journal

Diacerein ameliorates acute urarthritis in rats through the Nrf-2/HO-1 and NF-κB pathways. (PubMed, Inflammopharmacology) - "The anti-inflammatory, analgesic, and renal protective effects of high-dose diacerein are comparable to those of indomethacin, and its oral administration is convenient, which provides experimental references for the subsequent clinical transformation research of diacerein in acute urarthritis and the development of multi-target anti-gout drugs."

Journal • Preclinical • Gout • Immunology • Inflammation • Inflammatory Arthritis • Pain • Rheumatology • GAPDH • IL1B • IL6 • NFKBIA • RELA • TNFA

Targeting the Galectin Axis in Osteoarthritis: Chondroprotective Effects of Dietary and Pharmacological Phytochemicals. (PubMed, Molecules) - "Our study identifies Brazilin, Diacerein, and Resveratrol as promising modulators of galectin-driven cartilage degeneration and demonstrates the translational potential of patient-derived chondrogenic pellets as a human-relevant platform for preclinical drug evaluation in OA. The 3D culture effectively recapitulates key aspects of OA pathophysiology and offers a robust system to advance therapeutic discovery targeting ECM remodeling."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology • COL1A1 • COL2A1 • MMP1 • MMP13 • MMP3

Risk factors for severe knee osteoarthritis and efficacy of diacerein in obese vietnamese patients: A randomized, single-blind, noncontrolled clinical trial. (PubMed, Medicine (Baltimore)) - "Increased waist circumference, plasma TG, and TG/high density of lipoprotein cholesterol ratio raise the risk of severe knee OA. Diacerein treatment improves symptoms and joint function in patients with knee OA accompanied by obesity, with the 100-mg/day dose showing earlier and more effective improvement than the 50-mg/day dose."

Clinical • Journal • Genetic Disorders • Immunology • Obesity • Osteoarthritis • Pain • Rheumatology

Diacerein attenuates sepsis shock mortality through combined suppression of vascular inflammation, stiffness, and permeability. (PubMed, Phytomedicine) - "Diacerein attenuates sepsis shock mortality by concurrently suppressing vascular inflammation via NF-κB and chemokines, improving macrovascular reactivity/ECM remodeling, and reducing microvascular leakage by selectively inhibiting endothelial STAT2 activation. This is the first study to comprehensively demonstrate the efficacy of Diacerein in septic shock through a multi-mechanism vascular strategy and to identify its novel inhibitory effect on the STAT2 pathway in the endothelium."

Journal • Hypotension • Infectious Disease • Inflammation • Septic Shock • CDH5 • COL1A1 • COL3A1 • STAT2 • TJP1

Design and Evaluation of Diacerein-Loaded Oleoliposome Dry-Powder Inhalation Nano-Formulation for Targeted Anti-Inflammatory Therapy in COPD. (PubMed, J Pharm Sci) - "The developed DIA-OL nano-dry powder inhaler (DIA-OL) combines small aerodynamic diameter, high lung deposition, sustained release, and potent anti-inflammatory action, positioning it as a promising non-steroidal, biologic-free inhalation therapy for COPD and related inflammatory lung disorders."

Journal • Chronic Obstructive Pulmonary Disease • Fibrosis • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • IL1B • IL6 • NFKBIA

Inflammation and Immune Pathways in Myopia: An Overview on Pathomechanisms and Treatment Prospects. (PubMed, Clin Rev Allergy Immunol) - "Anti-inflammatory agents, including diacerein, resveratrol, and lactoferrin, have demonstrated therapeutic potential in experimental models by modulating inflammatory pathways, reducing pro-inflammatory cytokines, and preserving ECM integrity. However, their clinical efficacy and long-term safety require further validation. Elucidating the complex interplay between inflammation and myopia is pivotal for the development of targeted interventions, moving the focus of myopia management beyond optical correction towards disease-modifying strategies."

Journal • Review • Age-related Macular Degeneration • Inflammation • Macular Degeneration • Ocular Inflammation • Ophthalmology • Retinal Disorders • MMP2

Diacerein in the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease (clinicaltrials.gov) - P=N/A | N=74 | Not yet recruiting | Sponsor: Hongyan Wu

New trial • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease

Toward Reliable Individual-Level Optical Coherence Tomography Biomarkers in Multiple Sclerosis: A Protocol Comparison Study (ECTRIMS 2025) - "At each visit, five macular scan protocols were performed in randomized order: standard (49 lines, high-speed [HS], automated real-time tracking [ART] 9), high-ART (49 lines, HS, ART 50), high-lines (97 lines, HS, ART 9), high-resolution (49 lines, high-resolution [HR], ART 9), and maximum (97 lines, HR, ART 50)... All evaluated OCT protocols demonstrated excellent test-retest and inter-protocol reliability in measuring GCIPL thickness. Balancing reliability with time efficiency, high-lines and high-resolution protocols offer an optimal compromise between data quality and practical feasibility. Standardized acquisition parameters are strongly recommended to ensure reproducibility and comparability of findings across studies."

Biomarker • Clinical • CNS Disorders • Multiple Sclerosis

Amelioration of intestinal ischemia reperfusion injury by diacerein via regulation of inflammasome/caspase-1/IL-1β and Wnt/β-catenin pathways in juvenile rats. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "This effect of DIA is greatly attributed to its pharmacological properties including IL-1β antagonist effect, anti-oxidant, anti-apoptotic, and anti-inflammatory properties. Thus, DIA could be considered as an adjuvant future medical therapy for those cases of II/R."

Journal • Preclinical • Cardiovascular • Reperfusion Injury • CASP3 • IL1B

Dissolvable microneedle-assisted transdermal administration of diacerein nanoparticles achieved satisfactory therapeutic effects in tendon-bone insertion repair by reducing oxidative stress and inflammation. (PubMed, Mater Today Bio) - "These findings suggest that DMN/PLGA@Dia is capable of promoting tendon-bone insertion repair by alleviating oxidative stress and regulating the immune microenvironment strategies. Simple DMN/PLGA@Dia may be an effective and safe nanomedicine delivery system for tendon-bone insertion repair."

Journal • Inflammation