levodropropizine / Generic mfg. - LARVOL DELTA

CHAO Tos: Codeina, HederA Helix, LevOdropropizina Para La TOS (clinicaltrials.gov) - P4 | N=184 | Not yet recruiting | Sponsor: Pontificia Universidad Catolica de Chile

New P4 trial • Cough • Infectious Disease • Respiratory Diseases

PREVALENCE AND ASSOCIATED RISK FACTORS OF HEPATITIS B VIRUS INFECTION IN LAFIA METROPOLIS, NASARAWA STATE, NIGERIA. (PubMed, Afr J Infect Dis) - "A cross-sectional study was conducted from September to November 2023, utilizing a validated questionnaire to assess 461 randomly selected participants from four communities (Azuba, Bukan Sidi, Danka Sarki, and Doka), representing diverse sociodemographic profiles and varying degrees of exposure to risk factors associated with HBV infection...These findings highlight the need for targeted public health interventions and policies aimed at reducing HBV transmission among high-risk sociodemographic groups in Lafia Metropolis. This approach could potentially reduce the burden of HBV and improve health outcomes in affected communities."

Journal • Fibrosis • Gastroenterology • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Cancer • Liver Cirrhosis • Oncology • Solid Tumor

Peripheral antitussives affect temporal features of tracheobronchial coughing in cats. (PubMed, J Appl Physiol (1985)) - "Peripherally acting antitussives 3-Aminopropylphosphinic Acid (3APPi, 5mg/kg) and levodropropizine (Levo, 3mg/kg) were injected i.v. in anesthetized spontaneously breathing cats (13 males, 2 females; 4.38 ± 0.19 kg)...Peripherally induced cough suppression is accompanied with changes in cough temporal characteristics that are not observed after administration of centrally acting antitussives. The motor output produced by the cough central pattern generator differs significantly when coughing is perturbed by peripherally and centrally acting antitussives."

Journal • Anesthesia • Cough • Hypotension • Respiratory Diseases

Management of children with acute post-viral cough: a primary care experience with levodropropizine. (PubMed, Minerva Pediatr (Torino)) - "This experience showed that levodropropizine was an effective and safe remedy for children with acute post-viral cough."

Journal • Cough • Respiratory Diseases

Levodropropizine for children and adolescents with acute post-viral cough: an evidence-based choice. (PubMed, Minerva Pediatr (Torino)) - "Non-pharmacological remedies tend to be safe, but few substances have a documented degree of efficacy. Therefore, when managing children and adolescents with a post-viral cough, the practical approach may be based on levodropropizine use, which is preferable when the cough is particularly persistent and disturbs sleep."

Journal • Cough • Respiratory Diseases • Sleep Disorder

INFURO: The Impact of Inhaled Furosemide and Perorally Administered Levodropropizine on Dyspnea in Patients With Respiratory Diseases (clinicaltrials.gov) - P2/3 | N=102 | Recruiting | Sponsor: University Hospital Hradec Kralove | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: Jun 2024 ➔ Dec 2024

Enrollment open • Trial completion date • Trial primary completion date • Pulmonary Disease • Respiratory Diseases

Green and inventive fluorescence approach for levodropropizine determination in human plasma. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "Thorough validation confirmed its reliability, successfully determining LVP in tablets with an average recovery of 98.64 ± 1.07 %. Furthermore, the method's applicability extended to estimate the studied drug in spiked human plasma with excellent obtained percentage recoveries (98.68 ± 1.28-100.14 ± 1.23)."

Journal

Pharmacokinetic Analysis of Levodropropizine and Its Potential Therapeutic Advantages Considering Eosinophil Levels and Clinical Indications. (PubMed, Pharmaceuticals (Basel)) - "Interestingly, changes in an individual's plasma exposure to levodropropizine depending on eosinophil levels could be interpreted as a therapeutic advantage based on pharmacokinetic benefits linked to the clinical indications for levodropropizine. This study presents effective candidate covariates that can explain the inter-individual pharmacokinetic variability of levodropropizine and provides a useful perspective on the first-line choice of levodropropizine in the treatment of inflammatory respiratory diseases."

Journal • PK/PD data • Cough • Hepatology • Respiratory Diseases

INFURO: The Impact of Inhaled Furosemide and Perorally Administered Levodropropizine on Dyspnea in Patients With Respiratory Diseases (clinicaltrials.gov) - P2/3 | N=102 | Not yet recruiting | Sponsor: University Hospital Hradec Kralove

New P2/3 trial • Pulmonary Disease • Respiratory Diseases

Eco-friendly novel deconvoluted synchronous spectrofluorimetric approach for the determination of favipiravir, levodropropizine and moxifloxacin hydrochloride as an effective therapeutic combination for COVID-19; application in laboratory prepared mixtures and spiked human plasma. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The method's validation was carried out effectively in accordance with guidelines recommended by the ICH. Finally, the Eco-scale and Green Analytical Procedure Index (GAPI) techniques have been used to evaluate the greenness of the proposed method."

Journal • Infectious Disease • Novel Coronavirus Disease

Population pharmacokinetic modeling of levodropropizine: extended application to comparative analysis between commercial formulations and exploration of pharmacokinetic effects of diet. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "For levodropropizine CR tablets, a high-fat diet significantly delayed gastrointestinal absorption but maintained overall plasma exposure equivalent. This study provides useful quantitative judgment data for precision medicine of levodropropizine and can be helpful in predicting the pharmacokinetics of levodropropizine based on commercialized formulation switching."

Journal • PK/PD data • Chronic Obstructive Pulmonary Disease • Gastrointestinal Disorder • Pulmonary Disease • Respiratory Diseases

Effectiveness and Safety of Codeine and Levodropropizine in Patients With Chronic Cough. (PubMed, J Korean Med Sci) - "Codeine is an effective and generally well-tolerated antitussive for chronic cough. However, it may induce side effects in some patients. Individual responses and adverse events should be carefully monitored when codeine is used to treat chronic cough."

Journal • Chronic Cough • Constipation • Cough • Gastroenterology • Gastrointestinal Disorder • Immunology • Pain • Pulmonary Disease • Respiratory Diseases

"@toshiba @danka @KonicaMinoltaUS @konicaminolta a story of Speed Racing and Print business ⚡️⚡️🔵🏁 !!!" (@jmneg)

Chiral probe for mass spectrometric identification and quantitation of levodropropizine and its enantiomer, dextrodropropizine. (PubMed, Chirality) - "The degree of isomer recognition was investigated at different collision energies and determined as R  ≈ 1.5. Thus, this study gives the way to the mass spectrometric identification and quantitation of levodropropizine and its enantiomer, and the developed method represents a new and practical technique for rapid and sensitive determination and quality control of enantiomers of chiral drugs."

Journal

[VIRTUAL] Efficacy perception and prescription of treatments for refractory/unexplained chronic cough by Spanish physicians (ERS 2021) - "Neuromodulators, mucolytics (except for PCP, score 5), levodropropizine and terpenic derivates showed median scores of efficacy and prescription of 3 or below...Funded by MSD Spain. We thank SEAIC, SEPAR, SEMFYC, SEMG, SEMERGEN for helping with survey execution"

Clinical • Pulmonary Disease • Renal Cell Carcinoma • Respiratory Diseases

Levodropropizine in children: over thirty years of clinical experience. (PubMed, J Biol Regul Homeost Agents) - No abstract available

Clinical • Journal • Infectious Disease • Respiratory Diseases

Acute cough in children and adolescents: A systematic review and a practical algorithm by the Italian Society of Pediatric Allergy and Immunology. (PubMed, Allergol Immunopathol (Madr)) - "An acute cough may significantly affect the quality of life of patients and their family.Several algorithms for the management of acute cough have been adopted and validated in clinical practice; however, unlike the latter, we developed an algorithm focused on pediatric age, and, also, in accordance to the Italian National Health System, which regularly follows the child from birth to all lifelong. Based on our findings, infants from 6 months, children, and adolescents with acute cough without cough pointers can be safely managed using well-known medications, preferably non-sedative agents, such as levodropropizine and/or natural compounds, including honey, glycerol, and herb-derived components."

Clinical • Journal • Review • Allergy • Immunology • Infectious Disease • Pediatrics • Respiratory Diseases

"toxin? I'm afraid you've triggered @DanKaszeta" (@alcebaid)

"@ekrem_imamoglu @mansuryavas06 @ZeydanKaralar01 @SelcukRSirin bizim şehirlerimiz neden altın madalya almasınlar?" (@eyupagaogullari)

Asymmetric Total Synthesis of Dankasterones A and B and Periconiastone A Through Radical Cyclization. (PubMed, Angew Chem Int Ed Engl) - "Interconversion of dankasterone B and periconiastone A was realized through biomimetic intramolecular aldol and retro-aldol reactions. The MHAT-based approach, serves as a new dissection means, is complementary to the conventional ways to establish cis -decalin framework."

Journal

"Welcome to Jordan Karp, MD @JordanKarp1, @UAZMedTucson Psychiatry's New Department Chair! https://t.co/22NNpo2uSx" (@michaelgrandner)

Psychiatry

"Congrats to my @PittPsychiatry colleagues on this work! @AlexDombrovski1 @marta_pecina @KarimH349 @JordanKarp1!" (@ahmari_lab)

Psychiatry

Induced terreins production from marine red algal-derived endophytic fungus Aspergillus terreus EN-539 co-cultured with symbiotic fungus Paecilomyces lilacinus EN-531. (PubMed, J Antibiot (Tokyo)) - "The production of the known secondary metabolites terrein (3), butyrolactone I (4), and dankasterone (6), derived from A. terreus EN-539, were depressed significantly in the coculture. Compounds 1-3 exhibited inhibitory activity against Alternaria brassicae, Escherichia coli, Physalospora piricola, and Staphylococcus aureus with MIC values ranging from 4 to 64 μg ml."

Journal • Preclinical

Progress toward the total synthesis of Gymnastatin G (ACS-Sp 2017) - "Gymnastatin F-H are natural alkaloids isolated from the sponge-derived fungus Gymnascella dankaliensis. As an alternative to the oxidation, we employed an oxidative decarboxylation reaction with Pb(OAc)4 in a model system to generate the tertiary alcohol. We have revised our synthetic strategy and will present our current progress towards gymnastatin G."

Biosimilar • Oncology

Nsaid and Antitussives in Patients With Upper Respiratory Tract Infection-Related Cough: A Good Combination? (CHEST 2017) - "Either central and peripheral antitussives with different NSAIDs is efficacious in the reduction of coughing days. Moreover the combination levodropropizine and KLS shows better result compared with other combinations.nCLINICAL IMPLICATIONS: The association of antitussive and NSAIDs could be an effective therapy for URTI related cough, and the better result are achieved by the combination ketoprofen lysine salt and levodropropizine."

Clinical • Biosimilar • Immunology