dapsone / Generic mfg. - LARVOL DELTA

Comparison of Topical 20% Azelaic Acid and 7.5% Dapsone in the Treatment of Mild-To-Moderate Papulopustular Rosacea. (PubMed, J Cosmet Dermatol) - "Topical dapsone is as effective as azelaic acid in treating mild-to-moderate papulopustular rosacea and is associated with fewer side effects, making it a safer option."

Clinical • Journal • Retrospective data • Dermatology • Inflammation • Rosacea

Recalcitrant isotretinoin-induced acne fulminans successfully treated with oral dapsone. (PubMed, Ital J Dermatol Venerol) - No abstract available

Journal • Acne Vulgaris

Chlorproguanil-Dapsone in Pregnant Women (clinicaltrials.gov) - P1 | N=132 | Terminated | Sponsor: Centers for Disease Control and Prevention | Suspended ➔ Terminated

Trial termination • Infectious Disease • Malaria

Aortic dissection type A, common carotid artery occlusion, and stroke after dapsone for 20 years. (PubMed, J Family Med Prim Care) - "He underwent aortic valve and aortic replacement and achieved a modified Ranking score of 2 after administration of phenprocumon, bisoprolol, atorvastatin, and sertraline and intensive rehabilitation. This case demonstrates that long-term use of dapsone may contribute to vascular pathology that ultimately leads to aortic dissection. Unless necessary, dapsone should not be given for years."

Journal • Atopic Dermatitis • Cardiovascular • Dermatology • Immunology • Ischemic stroke

Dapsone-Induced Heinz Body Hemolytic Anemia: A Case Report. (PubMed, Clin Case Rep) - "In our patient's case, workup was significant for Heinz body hemolytic anemia due to home dapsone. Patient's anemia ultimately resolved with drug cessation."

Journal • Anemia • Hematological Disorders • Metabolic Disorders

Management of folliculitis decalvans: The EADV task force on hair diseases position statement. (PubMed, J Eur Acad Dermatol Venereol) - "Oral isotretinoin should be considered as the first-line therapy in patients with mild active disease (perifollicular erythema and hyperkeratosis, no pustules or crusts)...Photodynamic therapy, biologics (preferably adalimumab), JAK inhibitors, oral dapsone, hydroxychloroquine or cyclosporine may also be effective...Topical tacrolimus 0.1% or dapsone 5% may be considered as second-line topical therapeutic options. In patients with folliculitis decalvans, surgical excision or laser therapy can be useful. Hair transplantation can be considered in patients with inactive disease."

Journal • Aesthetic Medicine • Alopecia • Dermatology • Immunology • Inflammation • Transplantation

Preparation, Characterization, and Leishmanicidal Assessment of Silver- and Dapsone-Loaded Niosomes Co-administration: In Silico and In Vitro Study. (PubMed, Adv Pharm Bull) - "Moreover, the outcomes of the molecular docking showed a high binding affinity between dapsone and iNOS, stimulating the immune response in Th1 direction. In general, the multifunctional leishmanicidal activity of dapsone and silver-niosomes co-administration should be considered for further in vivo and clinical studies."

Journal • Preclinical • Dermatology • Infectious Disease

BLUE SHOCK: UNVEILING CARDIOGENIC CRISIS INDUCED BY DAPSONE-LINKED METHEMOGLOBINEMIA - Chukwunonyelum Uche (ACC 2025) - "Suspected cardiogenic shock prompted the initiation of dobutamine and diuresis with bumetanide, resulting in improved blood pressure and resolution of lactic acidosis, although there was no significant change in oxygenation or congestion.Decision-making: Despite improving arterial blood gas (ABG) parameters (PaO₂ from 78 to 162 mmHg), the patient had persistently low oxygen saturation (88-94%) on 2-4 L supplemental oxygen...Dapsone was replaced with atovaquone for PJP prophylaxis. This case highlights the importance of considering MetHgb in persistent hypoxia and cardiogenic shock, especially with oxidizing agents exposure. This case highlights the importance of considering MetHgb in persistent hypoxia and cardiogenic shock, especially with oxidizing agents exposure. Reduced oxygen delivery can cause myocardial ischemia, contributing to shock. Hypoxia-induced lactate elevation worsens acidosis and cardiac function."

Acute Myelogenous Leukemia • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Hematological Disorders • Hematological Malignancies • Hypotension • Infectious Disease • Leukemia • Metabolic Disorders • Myocardial Ischemia • Nephrology • Oncology • Pneumonia • Renal Disease • Respiratory Diseases

Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, and Somatic (VEXAS) Syndrome: A Diagnostic and Therapeutic Conundrum. (PubMed, Cureus) - "A diagnosis of Lyme disease was assumed, and a trial of doxycycline for two weeks was introduced, as well as hydroxychloroquine at a maximum dosage of 5 mg/kg, without noticeable improvement...Although an increase in prednisolone to 0.5 mg/kg/day and an association with methotrexate and dapsone were tried, no improvement was noted...A genetic analysis revealed a Met41Leu mutation at the ubiquitin-activating enzyme 1 (UBA1) gene, confirming the diagnosis of VEXAS syndrome. The patient was started on tocilizumab 6 mg/kg, but a profound neutropenia required a therapeutical switch to ruxolitinib."

Journal • Cardiovascular • Dermatomyositis • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Lyme Disease • Myelodysplastic Syndrome • Myositis • Neutropenia • Oncology • Targeted Protein Degradation • Thrombosis • CRP

Efficacy and safety of treatment with dapsone in patients with pediatric IgA vasculitis refractory to conventional treatment (EULAR 2025) - No abstract available

Clinical • Pediatrics • Vasculitis

UBC4: A Repurposed Drug Regimen for Adjunctive Use During Bladder Cancer Treatment. (PubMed, Biomedicines) - "This paper now outlines extensive preclinical data showing that four drugs from general medical practice meet these criteria-the melatonergic drug ramelteon, the antidepressant fluoxetine, the antibiotic dapsone, and the analgesic drug celecoxib. This is the UBC4 regimen, meant as a possible adjunct added to standard treatments of metastatic bladder cancer. Three factors justify a clinical pilot trial of UBC4: (1) the UBC4 drugs are usually well tolerated and carry a low risk of harm, (2) the commonly fatal outcome of bladder cancer once it has widely metastasized, plus (3) the strong preclinical database showing UBC growth inhibition by each of the individual UBC4 drugs as outlined in this paper."

Journal • Review • Bladder Cancer • Genito-urinary Cancer • Oncology • Pain • Solid Tumor

Spectrum of drug-induced liver injury:Experience from Nepal. (APASL 2025) - " Retrospective study of patients who came to our center for liver disease from June 2021 to June 2024 and diagnosed with DILI based on International DILI expert group criteria and Rausel Uclaf Causality assessment was done.Multivariate logistic regression was performed to determine predictors of mortality Among 76 patients ,40 (52.63%) were male and 36 (47.37%) were female with a mean age of 42+/- 13.2 years.Presenting symptoms were jaundice (72.4%),itching (15.6%),anorexia (32.4%),ascites (8%),and hepatic encephalopathy (3.2%).A prodormal history was noted in 12% of patients.Causative drugs included complimentary and alternative medicine(CAM,52.63%),anti-tubercular therapy(ATT,35.52%).Anti retroviral therapy,dapsone,and methotrexate each contributed to 3 cases.Acute hepatocellular hepatitis (70.2%) was the predominant form,with acute cholestatic hepatitis (20.6%),chronic hepatitis (5.1%),and chronic cholestasis (4.1%) less frequent. CAM and ATT are the most common..."

Anorexia • Cholestasis • CNS Disorders • Hepatic Encephalopathy • Hepatology • Inflammation • Liver Failure • Pruritus

Lacrimal sac rhinosporidiosis presented as nasal obstruction symptoms without any ocular manifestations: a case report. (PubMed, Ann Med Surg (Lond)) - "Postoperatively, the patient was given Dapsone for 6 months...Although rhinosporidiosis predominantly affects the nasal mucosa, lacrimal sac involvement should be considered in the differential diagnosis. Surgical excision along with postoperative medication and regular follow-up forms the mainstay in the management of the disease to avoid recurrence."

Journal • Infectious Disease • Ophthalmology

Eosinophilic fasciitis induced by immune checkpoint inhibitors successfully controlled with dapsone. (PubMed, Eur J Dermatol) - No abstract available

Checkpoint inhibition • Journal • Oncology

Getting the Blues: A Case of Dapsone-Induced Methemoglobinemia (IARS-SOCCA 2025) - "His medications included acyclovir, amlodipine, clotrimazole, dapsone, mycophenolate mofetil, prednisone, and tacrolimus. Methemoglobinemia, a potentially fatal condition, should be suspected in cases of unexplained cyanosis and hypoxemia. Traditional pulse oximetry may falsely indicate low SpO2 due to methemoglobin's high absorption at specific wavelengths, making the SpO2-PaO2 gap on ABG a useful diagnostic indicator. Management depends on the severity of hypoxia and patient characteristics."

Clinical • Anesthesia • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Endocrine Disorders • Epilepsy • Fatigue • Gastroenterology • Gastroesophageal Reflux Disease • Genetic Disorders • Hematological Disorders • Hypertension • Metabolic Disorders • Nephrology • Pain • Polycystic Kidney Disease • Pulmonary Disease • Renal Disease

Unveiling Silent Culprit: Methemoglobinemia Causing Acute Hypoxic Respiratory Failure From Long-term Dapsone Use (ATS 2025) - No abstract available

Hematological Disorders • Respiratory Diseases

Challenges associated with dapsone for leprosy treatment in Indonesia - urgent need for access to alternative antimicrobial drugs. (PubMed, Lancet Reg Health Southeast Asia) - "Additionally, alternative dapsone-sparing treatment regimens are usually unavailable or unaffordable, restraining individuals onto suboptimal dual-therapy with rifampicin and clofazimine, which has uncertain efficacy. We raise concerns regarding the safety of dapsone-containing MDT without routine pharmacogenetic screening and the unavailability of alternative regimens. We call for action to address persisting global health inequities in care delivery, ensuring all individuals receive the safest and most effective leprosy treatment options."

Journal • Review • Hematological Disorders • Immunology • Metabolic Disorders • HLA-B

Is dapsone safe for Pneumocystis jirovecii pneumonia prophylaxis in kidney and pancreas transplant recipients? (NKF-SCM 2025) - "Introduction Dapsone is a second-line agent for PJP prophylaxis (ppx) in kidney and kidney-pancreas transplant recipients (KTRs/SPKRs) allergic or intolerant to sulfamethoxazole/trimethoprim, but has up to a 30% discontinuation rate due to adverse effects (ADEs). Consider avoiding dapsone use until graft stabilization in KTRs/SPKRs. These findings confirm an increased risk of ADEs in this population, emphasizing the need for close monitoring with dapsone use."

Clinical • Anemia • Hematological Disorders • Hepatology • Infectious Disease • Pneumonia • Respiratory Diseases • Transplantation

Blue in the Face: Dapsone Induced Methemoglobinemia in a Female with Minimal Change Disease (NKF-SCM 2025) - "While glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is a risk factor for developing methemoglobinemia, this complication can develop in its absence.Methods A 23-year-old female with minimal change disease flare and a previous allergic reaction to trimethoprim-sulfamethoxazole was placed on prednisone 30 mg daily with concurrent dapsone for PJP prophylaxis. Methylene blue remains the first-line therapy for symptomatic methemoglobinemia.Conclusion This case underscores the need to vigilantly monitor patients taking dapsone, regardless of age or traditional risk factors. A high index of suspicion for methemoglobinemia in the setting of unexplained cyanosis or hypoxia can potentially prevent more serious complications."

Glomerulonephritis • Hematological Disorders • Infectious Disease • Pneumonia • Respiratory Diseases

Alpha-Lipoic Acid Reduces Neuroinflammation and Oxidative Stress Induced by Dapsone in an Animal Model. (PubMed, Nutrients) - " ALA was able to reduce the effects of DDS, such as reducing microglial and astrocytic activation, as well as to decrease the levels of pro-inflammatory cytokines and increase BDNF, in addition to increasing antioxidant capacity and reducing oxidative damage caused by iron accumulation. Therefore, ALA is considered a useful and promising therapeutic alternative for the treatment of diseases related to oxidative stress and neuroinflammation."

Journal • Preclinical • CNS Disorders • Hematological Disorders • Immunology • Inflammation • BDNF • IL1B

Effectiveness and tolerability of methylthioninium chloride (methylene blue) for the treatment of methemoglobinemia: twenty-four years of experience at a single poison center. (PubMed, Clin Toxicol (Phila)) - "A relatively large proportion of cases receiving multiple doses were associated with dapsone exposure. In this series, methylthioninium chloride was both efficacious and well tolerated in patients with methemoglobinemia, with a single dose of 1-2 mg/kg being sufficient to treat most patients."

Journal • Anesthesia • Hematological Disorders

Eosinophilic Annular Erythema Treated with Narrowband UVB Phototherapy (AAD 2025) - "Dapsone, hydroxychloroquine or systemic corticosteroids are 2nd line options...During her last pregnancy she was treated with levothyroxine, and methyldopa due to preeclampsia, both of which have been suspended. She is currently breastfeeding and is being treated with sertraline due to postpartum depression...Lesions kept spreading despite topical clobetasol 0.05% bid for 2 weeks...The patient refused systemic treatment due to concerns regarding her daughter, for that reason narrow band UVB phototherapy was used (280 mJ/cm2 with weekly increases of 20 mJ/cm2) achieving remission in two months. Patient has remained asymptomatic for 6 months."

CNS Disorders • Depression • Dermatology • Gynecology • Hepatology • Postpartum Depression • Psychiatry • Rare Diseases • Vasculitis

Persistence and Adherence Among Patients with Chronic Spontaneous Urticaria Initiating Advanced Therapies: A Real-World, Claims Database Study (AAD 2025) - " Using IQVIA PharMetrics claims data, patients (12–64 years) who newly initiated AT (systemic immunosuppressant [SI] [cyclosporine, tacrolimus, mycophenolate mofetil, methotrexate, azathioprine], systemic anti-inflammatories [SAI] [colchicine, dapsone, hydroxychloroquine, olsalazine, sulfasalazine] or omalizumab; first dispensation=index date) within 14 days of a diagnosis code for CSU between January 2021 and December 2022 were identified. Persistence and adherence to AT in CSU were suboptimal, highlighting the need for additional treatment options."

Adherence • Claims database • Clinical • Metastases • Real-world • Real-world evidence • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

Dermatology and Incarceration: Where We're Coming from and Where We're Going (AAD 2025) - "Trials of treatments, such as tretinoin and dapsone, were performed on these patients as well as experiments that elucidated pathophysiology of venereology and wound healing...The field of dermatology has inadequately addressed our troubled legacy with incarceration while failing to meet this population's needs in the modern day. It is an ethical duty of dermatologists to advocate for increased access to care for this population."

Dermatology

Infectious skin diseases among global refugee and migrant population: A Systematic Review (AAD 2025) - "Effective treatments included rifampin, dapsone, and clofazimine for leprosy; miltefosine and sodium stibogluconate for cutaneous leishmaniasis; and itraconazole for mycetoma. Targeted dermatological interventions are crucial for refugee and migrant populations. Emphasizing timely diagnosis, access to care, and preventative measures can improve outcomes and guide evidence-based care for these patients."

Clinical • Review • Dermatology • Infectious Disease • Novel Coronavirus Disease