RGX-019
/ Inspirna, Rockefeller University
- LARVOL DELTA
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December 03, 2023
Targeting Myeloid Epithelial Tyrosine Kinase (MERTK) Receptor in Acute Myeloid Leukemia Using a Novel Antibody Drug Conjugate, Rgx-019-MMAE
(ASH 2023)
- "Finally, we investigated the synergistic effect of RGX-019-MMAE with Venetoclax (BCL2 inhibitor) or 5-Azacytidine in vitro. RGX-019-MMAE significantly induced cell death in AML cell lines and primary AML patient samples. RGX-019-MMAE, combined with chemotherapeutic agents and targeted therapy, produces a synergistic anti-leukemic effect. Our data indicates that MERTK is a potential therapeutic target in AML patients with monocytic subtypes of leukemia."
IO biomarker • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • Solid Tumor • AXL • MERTK • PTPN11
March 06, 2024
Targeting myeloid epithelial tyrosine kinase (MERTK) receptor in acute myeloid leukemia using a novel antibody-drug conjugate, RGX-019-MMAE
(AACR 2024)
- "High MERTK expression in monocytic AML suggested that MERTK is a promising therapeutic target in this subtype. RGX-019-MMAE significantly induced AML cell death and produced a synergistic anti-leukemic effect in combination with chemotherapeutic agents and targeted therapy in vitro, suggesting its potential for targeting patients with high-risk AML."
IO biomarker • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • AXL • MERTK • PTPN11
April 27, 2023
RGX-019-MMAE, a novel MERTK-targeting antibody-drug conjugate (ADC) with robust anti-tumor efficacy in both solid and liquid tumors.
(ASCO 2023)
- "Collectively, RGX-019-MMAE’s robust anti-tumor efficacy in multiple aggressive tumors, and MERTK’s expression profile on cancer cells and normal tissue support further advancement of RGX-019-MMAE as a drug candidate for development in solid and liquid cancers."
Clinical • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Oncology • Ophthalmology • Solid Tumor • Triple Negative Breast Cancer • MERTK • PTPN11
May 16, 2020
[VIRTUAL] In vivo efficacy and safety of RGX-019, a MerTK targeting monoclonal antibody
(AACR-II 2020)
- "Additionally, no clinical hematologic toxicities were observed. Pro-inflammatory macrophage-related cytokines were detected in the plasma after RGX-019 dosing, confirming target engagement in vivo.The MOA and safety profile of RGX-019, along with its high selectivity, affinity, in vivo efficacy, and immunologic activity, support further advancement of RGX-019 as a clinical candidate for development in solid and liquid cancers."
Late-breaking abstract • Breast Cancer • Leukemia • Lung Cancer • Melanoma • Multiple Myeloma • Non Small Cell Lung Cancer • Oncology • Thoracic Cancer • AXL • GAS6 • MERTK • PROS1
June 22, 2020
RGENIX Presents Results from Preclinical Safety and Efficacy Studies of RGX-019 at the 2020 AACR Annual Meeting
(Businesswire)
- "...RGX-019 demonstrated a favorable safety profile in a 28-day dose-range finding toxicology study in monkeys. Of note, retinal toxicity - a finding associated with other MerTK targeting approaches - was not observed at any dose of RGX-019. The results overall demonstrate that RGX-019 can potently target MerTK signaling on both cancer cells and immune-suppressive M2 macrophages with a novel mechanism, resulting in anti-tumor activity with a wide therapeutic window."
Preclinical • Oncology • Solid Tumor
April 05, 2019
Characterization of the anti-cancer and immunologic activity of RGX-019, a novel pre-clinical stage humanized monoclonal antibody targeting the MERTK receptor
(AACR 2019)
- "This activity results in robust repression of cancer cell growth both in vitro and in vivo. Overall, these data support further development of RGX-019 as a cancer therapeutic."
Late-breaking abstract
April 04, 2019
"#Rgenix To Present Abstract on #RGX-019 at #AACR19 https://t.co/gWFKrvMFoT"
(@1stOncology)
April 03, 2019
Rgenix presents pre-clinical data on RGX-019 at the 2019 AACR Annual Meeting
(Businesswire)
- “Rgenix, Inc….announced today it is presenting pre-clinical data from ongoing research of RGX-019...for the treatment of advanced cancer. In a presentation of a late-breaking abstract, 'Characterization of the anti-cancer and immunologic activity of RGX-019, a novel pre-clinical stage humanized monoclonal antibody targeting the MERTK receptor,' which was accepted for the 2019 American Association of Cancer Research Annual Meeting, Isabel Kurth Ph.D., Rgenix VP of Research, discussed data showing RGX-019 to be a potent and selective inhibitor of MERTK signaling, resulting in suppression of cancer growth and activation of the innate immune response.”
Late-breaking abstract • Preclinical
April 01, 2019
Newly added product
(Businesswire)
- Preclinical, Triple Negative Breast Cancer
Pipeline update
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