Octreosphere (octreotide extended release) / Xbrane - LARVOL DELTA

The Silent Thrombosis: A Non-Cirrhotic Pathway to Variceal Formation (ACG 2025) - "He received tranexamic acid, Protonix, octreotide, ceftriaxone, vitamin K. EGD showed gastric varices, underwent gastric and splenic artery embolization and TIPS as well...Diagnosis begins with Doppler ultrasonography, CT angiography and MRI that assist in identifying thrombus extension, and preferred in cases of suspected chronic PVT. It is important to consider PVT as a potential cause in patients with GI bleed.Figure: CT abdomen pelvis with IV contrast"

Anemia • Cardiovascular • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Liver Cirrhosis • Myeloproliferative Neoplasm • Portal Hypertension • Thrombocytosis • Thrombosis • JAK2

A Rare Case of a Portal Vein Pseudoaneurysm (ACG 2025) - "A. Bleeding in jejunal limb near pancreatojejunal anastomsis B. Bleeding in jejunal limb near pancreatojejunal anastomosis C. Bleeding in jejunal limb near pancreatojejunal anastomosis with clip placed both proximal and distal D. Friable mucosa at gastrojejunal anastomosis site"

Clinical • Biliary Cancer • Cardiovascular • Cholangiocarcinoma • Hematological Disorders • Infectious Disease • Solid Tumor

Black Esophagus: A Unique Cause of Hematemesis (ACG 2025) - "She was started on pantoprazole drip and taken to the ICU where emergent bedside EGD demonstrated diffuse necrosis throughout the esophagus, consistent with AEN...Common complications include esophageal perforation, mediastinitis, and death, with a reported mortality ranging from 12.5% to 32% of all patients, although this is typically related to the underlying condition causing AEN rather than AEN itself. Following resolution of the acute critical illness, most patients experience resolution of necrosis with conservative management, with up to 25% developing esophageal strictures which may require repeated endoscopic dilations.Figure: EGD demonstrating circumferential esophageal necrosis Figure: EGD demonstrating necrotic mucosa consistent with AEN"

Addiction (Opioid and Alcohol) • Cardiovascular • Chronic Kidney Disease • Diabetes • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Hepatology • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Pancreatitis • Renal Disease • Septic Shock

CAM2029 Octreotide Subcutaneous Depot Maintains Control of IGF-I and Symptoms of Acromegaly Across the 4-Week Dosing Interval and During Intervals Greater Than 28 Days: Data from the ACROINNOVA 1 Trial (ENDO 2025) - P3 | "Similarly, over intervals of >28 days, CAM2029 maintained stable mean AIS overall scores across W20 (4.3), W22 (4.3) and W24/EOT (4.7) assessments.ConclusionsCAM2029 effectively maintained stable biochemical and symptom control both throughout the intended 4-week dosing interval and with extended dosing intervals. These data inform on the efficacy profile of CAM2029 when administration occurs both within and beyond a 28-day dosing window."

Acromegaly • Endocrine Disorders • IGF1 • SSTR

CAM2029 Octreotide Subcutaneous Depot Maintains Control of IGF-I and Symptoms of Acromegaly Across the 4-Week Dosing Interval and During Intervals Greater Than 28 Days: Data from the ACROINNOVA 1 Trial (ENDO 2025) - P3 | "Similarly, over intervals of >28 days, CAM2029 maintained stable mean AIS overall scores across W20 (4.3), W22 (4.3) and W24/EOT (4.7) assessments.ConclusionsCAM2029 effectively maintained stable biochemical and symptom control both throughout the intended 4-week dosing interval and with extended dosing intervals. These data inform on the efficacy profile of CAM2029 when administration occurs both within and beyond a 28-day dosing window."

Acromegaly • Endocrine Disorders • IGF1 • SSTR

Detection of Somatostatin Receptors by Ligand Derivative Staining in Breast Tumors. (PubMed, Anticancer Res) - "Our findings revealed that immunohistochemistry allows specific detection of SSTR isoforms, whereas LDS could comprehensively evaluate SSTR expression. To the best of our knowledge, this is the first study to detect SSTR expression in breast cancer tissues using LDS, and the results suggest LDS as a new mode of evaluating SSTR status in clinical specimens."

Biomarker • Journal • Breast Cancer • Hormone Receptor Breast Cancer • Neuroendocrine Tumor • Oncology • Solid Tumor • ER • SSTR • SSTR2

Methadone Induced Hypoglycemia (ENDO 2025) - "It can cause hypoglycemia by direct action on pancreas (mu opioid receptors) which increases insulin levels along with suppressing counter regulatory hormones like glucagon and epinephrine... Methadone is a rare cause of hypoglycemia. It has a dose dependent effect and due to long half-life, can cause recurrent episodes of hypoglycemia. Therefore, clinicians should be vigilant of this potential complication."

Addiction (Opioid and Alcohol) • Anorexia • Back Pain • Endocrine Disorders • Hypoglycemia • Metabolic Disorders • Musculoskeletal Pain • Oncology • Pain • Pancreatic Cancer • Solid Tumor

Complexities of managing refractory hypoglycemia in a rare case of metastatic grade 2 pancreatic neuroendocrine tumor. (ASCO 2025) - "treatment options which include but not limited to lanreotide/octreotide LAR shots or everolimus. Ultimately, the case emphasizes the importance of a multidisciplinary approach to optimize outcomes for patients with stage 4 pNETs. Further research is needed to expand the therapeutic arsenal for these rare and aggressive tumors, aiming to improve survival and quality of life for affected individuals."

Clinical • Metastases • Endocrine Cancer • Hepatocellular Cancer • Hypoglycemia • Neuroendocrine Tumor • Oncology • Pancreatic Cancer • Solid Tumor • CA 19-9 • NCAM1 • SYP

Case Report: Lymphangiogram and embolization for malignant chylothorax in cancer patients. (PubMed, Front Oncol) - "Lymphangiogram with embolization is a safe and effective intervention for malignant chylothorax, regardless of surgical history. Early intervention can alleviate chyle leaks, facilitate ongoing cancer therapy, and improve patient outcomes, making it an important option in multidisciplinary oncology care."

Journal • Breast Cancer • Hematological Malignancies • HER2 Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Negative Breast Cancer • Lung Cancer • Lymphoma • Non Small Cell Lung Cancer • Non-Hodgkin’s Lymphoma • Oncology • Solid Tumor • T Cell Non-Hodgkin Lymphoma • Transplantation • ALK • HER-2

Carcinoid Heart Disease With Left Sided Hepatic Hydrothorax and Trapped Lung (ATS 2025) - "Here we discuss a unique case of carcinoid heart disease presenting with unilateral left-sided hepatic hydrothorax with trapped lung physiology.A 21-year-old male diagnosed with metastatic neuroendocrine tumor, carcinoid syndrome and extensive DVTs on octreotide LAR therapy presented to the ER with dyspnea on exertion and abdominal pain...Surgery involving Tricuspid valve replacement is a common management option for cases refractory to octreotide maintenance therapy and is indicated for severe valvular dysfunction with symptomatic right ventricular failure. While this case provides a unique presentation of CHD with refractory left sided hepatic hydrothorax with a trapped lung, it reiterates the significant of recognizing CHD and promptly referring for replacement of the affected valve."

Carcinoid Syndrome • Carcinoid Tumor • Cardiovascular • Congestive Heart Failure • Endocrine Cancer • Fatigue • Heart Failure • Hepatology • Infectious Disease • Neuroendocrine Tumor • Oncology • Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Use of portable elastomeric pump for home-based continuous enteral carbohydrate administration through gastrostomy in children with congenital hyperinsulinism or ketotic hypoglycemia (ESPE-ESE 2025) - "Prior or concomitant treatment included continuous i.v. glucose (n=7), continuous i.v. glucagon (n=3), diazoxide (n=8), octreotide (n=8) long-acting somatostatin analogue (n=5), sirolimus (n=3), dietary cornstarch (n=9), extended-release cornstarch (n=9), protein supplementation (n=8), and/or overnight gastrostomy tube feeding with liquid full-dietary products (n= 9), glucose (n=8), or maltose (n=8)... ePEP therapy with carbohydrates is a promising supplement to selected patients with CHI or pKH, although not continued by all due to insufficient effect, hyperglycemia or difficulties. This should encourage to formal trials with long-term follow-up on dose, effect, quality of life and adverse effects, e.g. on the intestinal microbiome."

Clinical • Hypoglycemia • Pain • Pediatrics

TO EAT OR NOT TO EAT: A CASE OF POSTPRANDIAL HYPOTENSION DUE TO PORTAL HYPERTENSIVE GASTROPATHY AND ESOPHAGEAL VARICES AFTER TREATMENT OF A MALLORY-WEISS TEAR (CHEST 2024) - "Gastroenterology was consulted, and the patient was provided with fluid resuscitation, a proton pump inhibitor, antibiotic prophylaxis with Ceftriaxone, Octreotide and Erythromycin as a prokinetic agent... While it is unclear what role repairing the MW tear plays, Octreotide's ability to reduce gastric perfusion and its vasoconstrictive effects further suggests that PHG, hypertension and EV all play a role in the acute development of PPH in patients with portal hypertension."

Clinical • Anemia • CNS Disorders • Diabetic Neuropathy • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Hypotension • Immunology • Liver Cirrhosis • Movement Disorders • Pain • Parkinson's Disease • Portal Hypertension

Novel Heterozygous Mutations of PIEZO1 Leading To Fetal Hydrops and Generalized Lymphatic Dysplasia Successfully Treated With Propranolol (ATS 2024) - "Management included reintroduction of MCT formula, and initiation of furosemide and propranolol... Generalized lymphatic dysplasia should be suspected in a neonate with NIHF and prolonged chylothorax. LMPHM6 caused by PIEZO1 can be controlled by diuretics and propranolol."

Cardiovascular • Critical care • Inflammation • Pulmonary Disease • Respiratory Diseases

AN ALTERNATE ENDOSCOPIC TREATMENT OPTION IN MANAGING BLEEDING RECTAL VARICES. (DDW 2024) - "Rectal variceal bleeding is life-threatening without established treatment guidelines. This case highlights the efficacy of endoclips in managing lower GI variceal bleeding emphasizing their consideration when conventional options are constrained or fail."

Cardiovascular • CNS Disorders • Fibrosis • Gastroenterology • Hematological Disorders • Hepatic Encephalopathy • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Thrombosis • Varicose Veins • Venous Thromboembolism

Metastatic Extra-gastrointestinal Stromal Tumor Presenting As Hypoglycemia (ENDO 2024) - "Tumor-directed therapy with TKIs, primarily imatinib, appears promising in achieving remission. Our case is a clinical reminder that hypoglycemia secondary to NICTH can be the predominant presenting feature in patients with underlying E-GIST."

Late-breaking abstract • Metastases • Stroma • Gastrointestinal Cancer • Gastrointestinal Disorder • Gastrointestinal Stromal Tumor • Hepatology • Hypoglycemia • Metabolic Disorders • Oncology • Pancreatic Cancer • Sarcoma • Severe Hypoglycemia • Solid Tumor • IGF1 • IGF2

Profiling of unfolded protein response markers and effect of IRE1α-specific inhibitor in pituitary neuroendocrine tumor. (PubMed, Endocrinology) - "UPR markers in FPitNETs are implicated as dominant A-UPR but blunted T-UPR. KIRA8, enhanced with octreotide, unbalances UPR, leading to anti-tumor effects. Targeting IRE1α may provide a novel strategy to treat PitNETs."

Journal • Acromegaly • Endocrine Cancer • Endocrine Disorders • Neuroendocrine Tumor • Oncology • Solid Tumor • IGF1 • TXNIP • XBP1

Successful Management of Insulinoma by Computed Tomography Guided Ethanol Ablation (ACG 2023) - "Ablation is less invasive than surgery and may be considered in poor surgical candidates or those with poorly localized tumors. Figure: A: EUS showing cystic mass in pancreatic head B: CT-guided ethanol ablation of pancreatic lesion (yellow arrow)"

Cardiovascular • Endocrine Cancer • Gastrointestinal Cancer • Hypoglycemia • Neuroendocrine Tumor • Pancreatic Cancer • Solid Tumor • SSTR

Randomized, Placebo-Controlled Phase 3 Trial Protocol Assessing the Efficacy and Safety of Octreotide Subcutaneous Depot (CAM2029) in Patients with Acromegaly (ENDO 2023) - P3 | "Key inclusion criteria included a biochemical and clinical diagnosis of acromegaly due to a pituitary adenoma with persistent or recurrent disease, treatment with a stable dose of octreotide long-acting release or lanreotide Autogel for at least 3 months as monotherapy, and controlled disease with IGF-1 =1 x upper limit of normal (ULN). Key exclusion criteria included GH =2.5 µg/L at screening, pituitary surgery within 6 months of screening, prior pituitary irradiation, and recent treatment with pasireotide, pegvisomant, or dopamine agonists...Abstracts presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*"

Clinical • P3 data • Acromegaly • Endocrine Disorders • Oncology • Pituitary Gland Carcinoma • IGF1

An Unusual Case of Bilateral Transudative Chylothorax (ATS 2023) - "Management revolves around medically treating the underlying cirrhosis with diuretics and propranolol...Management revolves around medically treating the underlying cirrhosis with diuretics and propranolol...Tsauo et al. review of literature showed a successful role for transjugular intrahepatic portosystemic shunting (TIPS) in cases refractory to conservative management."

Clinical • Cardiovascular • Congestive Heart Failure • Fibrosis • Glomerulonephritis • Heart Failure • Hematological Malignancies • Hepatology • Hypertriglyceridemia • Immunology • Infectious Disease • Lymphoma • Mood Disorders • Nephrology • Non-alcoholic Fatty Liver Disease • Oncology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Tuberculosis

EARLY CLIP DISLODGEMENT AFTER USING GASTRODUODENAL FULL-THICKNESS ENDOSCOPIC RESECTION DEVICE IN REMOVAL OF SCARRED GASTRIC SUB-EPITHELIAL LESION LEADING TO DELAYED PERFORATION: A CASE SERIES (DDW 2023) - "In scarred lesions, alternative resection strategies including free-hand EFTR with robust closure techniques may be considered. Improvements in OTSC design to prevent early dislodgement need to be considered in the future iterations of GD-FTRD."

Clinical • Brain Cancer • Breast Cancer • Cardiovascular • Endocrine Cancer • Gastroenterology • Neuroendocrine Tumor • Oncology • Pain • Solid Tumor • GAST

EARLY CLIP DISLODGEMENT AFTER USING GASTRODUODENAL FULL-THICKNESS ENDOSCOPIC RESECTION DEVICE IN REMOVAL OF SCARRED GASTRIC SUB-EPITHELIAL LESION LEADING TO DELAYED PERFORATION: A CASE SERIES (DDW 2023) - "In scarred lesions, alternative resection strategies including free-hand EFTR with robust closure techniques may be considered. Improvements in OTSC design to prevent early dislodgement need to be considered in the future iterations of GD-FTRD."

Clinical • Brain Cancer • Breast Cancer • Cardiovascular • Endocrine Cancer • Gastroenterology • Neuroendocrine Tumor • Oncology • Pain • Solid Tumor • GAST

Severe Hypoglycemic encephalopathy (EUSEM 2022) - "27-years-old male with a history of depression, previous suicide attempt and a recent diagnosis of insulin-dependent diabetes mellitus found unconsciousness surrounded by a diazepam blister and lots of rapid-acting (1800 UI) and slow-acting (600 UI) insulin-pens...Tracheal intubation was performed using midazolam, etomidate and rocuronium and fluid management with three units of 50%glucose, 500ml of 10%glucose and 500 ml of 5%glucose was started with a capillary glycemic of 130mg/dL prior the transfer to the emergency room (ER)...The electroencephalography showed periodic 1 Hz activity that during the ICU stay progressed to a pattern of cortical damage and epileptics crisis that were controlled with the use of antiepileptic drugs (levetiracetam, lacosamide and clonazepam)...Besides it, we can use iv or im glucagon, iv octreotide, iv hydrocortisone and support with complex carbohydrates...Half of the patients will have good outcomes while the other half will end-up in..."

CNS Disorders • Depression • Dermatology • Diabetes • Epilepsy • Hypoglycemia • Hypotension • Immunology • Metabolic Disorders • Psychiatry • Type 1 Diabetes Mellitus

Severe Hypoglycemic encephalopathy (EUSEM 2022) - "27-years-old male with a history of depression, previous suicide attempt and a recent diagnosis of insulin-dependent diabetes mellitus found unconsciousness surrounded by a diazepam blister and lots of rapid-acting (1800 UI) and slow-acting (600 UI) insulin-pens...Tracheal intubation was performed using midazolam, etomidate and rocuronium and fluid management with three units of 50%glucose, 500ml of 10%glucose and 500 ml of 5%glucose was started with a capillary glycemic of 130mg/dL prior the transfer to the emergency room (ER)...The electroencephalography showed periodic 1 Hz activity that during the ICU stay progressed to a pattern of cortical damage and epileptics crisis that were controlled with the use of antiepileptic drugs (levetiracetam, lacosamide and clonazepam)...Besides it, we can use iv or im glucagon, iv octreotide, iv hydrocortisone and support with complex carbohydrates...Half of the patients will have good outcomes while the other half will end-up in..."

CNS Disorders • Depression • Dermatology • Diabetes • Epilepsy • Hypoglycemia • Hypotension • Immunology • Metabolic Disorders • Psychiatry • Type 1 Diabetes Mellitus

Severe Hypoglycemic encephalopathy (EUSEM 2022) - "27-years-old male with a history of depression, previous suicide attempt and a recent diagnosis of insulin-dependent diabetes mellitus found unconsciousness surrounded by a diazepam blister and lots of rapid-acting (1800 UI) and slow-acting (600 UI) insulin-pens...Tracheal intubation was performed using midazolam, etomidate and rocuronium and fluid management with three units of 50%glucose, 500ml of 10%glucose and 500 ml of 5%glucose was started with a capillary glycemic of 130mg/dL prior the transfer to the emergency room (ER)...The electroencephalography showed periodic 1 Hz activity that during the ICU stay progressed to a pattern of cortical damage and epileptics crisis that were controlled with the use of antiepileptic drugs (levetiracetam, lacosamide and clonazepam)...Besides it, we can use iv or im glucagon, iv octreotide, iv hydrocortisone and support with complex carbohydrates...Half of the patients will have good outcomes while the other half will end-up in..."

CNS Disorders • Depression • Dermatology • Diabetes • Epilepsy • Hypoglycemia • Hypotension • Immunology • Metabolic Disorders • Psychiatry • Type 1 Diabetes Mellitus

Severe Hypoglycemic encephalopathy (EUSEM 2022) - "27-years-old male with a history of depression, previous suicide attempt and a recent diagnosis of insulin-dependent diabetes mellitus found unconsciousness surrounded by a diazepam blister and lots of rapid-acting (1800 UI) and slow-acting (600 UI) insulin-pens...Tracheal intubation was performed using midazolam, etomidate and rocuronium and fluid management with three units of 50%glucose, 500ml of 10%glucose and 500 ml of 5%glucose was started with a capillary glycemic of 130mg/dL prior the transfer to the emergency room (ER)...The electroencephalography showed periodic 1 Hz activity that during the ICU stay progressed to a pattern of cortical damage and epileptics crisis that were controlled with the use of antiepileptic drugs (levetiracetam, lacosamide and clonazepam)...Besides it, we can use iv or im glucagon, iv octreotide, iv hydrocortisone and support with complex carbohydrates...Half of the patients will have good outcomes while the other half will end-up in..."

CNS Disorders • Depression • Dermatology • Diabetes • Epilepsy • Hypoglycemia • Hypotension • Immunology • Metabolic Disorders • Psychiatry • Type 1 Diabetes Mellitus