WM-D2 / WMBIO - LARVOL DELTA

Multivariate white matter microstructure alterations in older adults with coronary artery disease. (PubMed, J Neurosci) - "Relationships between WM D2 and cognition (executive function and processing speed) were also assessed...These changes were also related to slower processing speed, a key marker of cognitive aging. These findings provide new insight into how CAD may affect brain health and cognition, and could inform future efforts to detect and prevent cognitive decline in this population."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Coronary Artery Disease • Dementia

Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer's disease. (PubMed, Neurobiol Aging) - "Lastly, the links between WM D2 and cognition were explored...Our findings reveal that combined exposure to multiple cardiometabolic risk factors negatively impacts microstructural health, which may subsequently affect cognition. Notably, APOE4 carriers exhibited a different risk pattern, especially in the role of LDL, suggesting distinct underlying mechanisms in this group."

Journal • Alzheimer's Disease • CNS Disorders • APOE

Biomarkers. (PubMed, Alzheimers Dement) - "The different patterns of associations observed suggest there are sex-specific risk profiles associated with WM microstructure differences in this population of older adults at risk of AD. The WM tracts affected in each sex were also associated with specific cognitive profiles."

Biomarker • Journal • Alzheimer's Disease • CNS Disorders

Alzheimer's Imaging Consortium. (PubMed, Alzheimers Dement) - "The different patterns of associations observed suggest there are sex-specific risk profiles associated with WM microstructure differences in this population of older adults at risk of AD. The WM tracts affected in each sex were also associated with specific cognitive profiles."

Journal • Alzheimer's Disease • CNS Disorders

Links between cognition and multivariate brain white matter differences in individuals with family history of Alzheimer's disease (AAIC 2024) - "Partial Least Squares (PLS) analyses were then performed to relate WM D2 with cognition (RBANS) and AD risk factors, separately in each sex...Conclusion : The different patterns of associations observed suggest there are sex-specific risk profiles associated with WM microstructure differences in this population of older adults at risk of AD. The WM tracts affected in each sex were also associated with specific cognitive profiles."

Clinical • Alzheimer's Disease • CNS Disorders

Links between cognition and multivariate brain white matter differences in individuals with family history of Alzheimer's disease (AAIC 2024) - "Partial Least Squares (PLS) analyses were then performed to relate WM D2 with cognition (RBANS) and AD risk factors, separately in each sex... The different patterns of associations observed suggest there are sex-specific risk profiles associated with WM microstructure differences in this population of older adults at risk of AD. The WM tracts affected in each sex were also associated with specific cognitive profiles."

Clinical • Alzheimer's Disease • CNS Disorders

Multivariate white matter differences links to cognition in individuals with family history of Alzheimer's disease and APOE4 genetic risk (AAIC 2023) - "Associations between WM D2 and cognitive performance were then investigated (Fig3)...Conclusion : Our findings suggest that microstructural alterations in the posterior part of the CC may play a role in memory deficit in older adults who are at greater risk of developing AD. This is in line with other studies that showed a link between CC degeneration and memory impairments in early AD stages."

Clinical • Alzheimer's Disease • CNS Disorders

Multivariate white matter differences links to cognition in individuals with family history of Alzheimer's disease and APOE4 genetic risk (AAIC 2023) - "Associations between WM D2 and cognitive performance were then investigated (Fig3)... Our findings suggest that microstructural alterations in the posterior part of the CC may play a role in memory deficit in older adults who are at greater risk of developing AD. This is in line with other studies that showed a link between CC degeneration and memory impairments in early AD stages.1 1. Qiu et al."

Clinical • Alzheimer's Disease • CNS Disorders