ciprofloxacin oral / Generic mfg. - LARVOL DELTA

Machine-Learning and Gene-Synergy Networks Reveal Interpretable Drivers of Antibiotic Resistance in Staphylococcus aureus. (PubMed, Int J Antimicrob Agents) - "Our findings indicate that antibiotic resistance in S. aureus involves distinct genetic network architectures depending on the antibiotic, highlighting the diverse regulatory pathways bacteria employ to acquire resistance. This discovery-oriented framework prioritizes interpretable determinants and generates testable mechanistic hypotheses, with prospective standardized evaluations aimed at assessing its translatability to clinical settings."

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Enhanced detection of bacterial etiologies, antibiotic resistance profile, and treatment outcomes of meningitis patients in Ethiopia: a prospective cross-sectional study. (PubMed, BMC Microbiol) - "PCR significantly outperformed culture in detecting bacterial pathogens. E. coli was the most common causative agent of bacterial meningitis, and we observed high rates of antibiotic resistance among Gram-negative bacteria. While most patients had favorable outcomes, low Glasgow Coma Scale scores, comorbidities, and delayed presentation to healthcare facilities were independently associated with unfavorable outcomes."

Journal • Observational data • CNS Disorders • Infectious Disease • Influenza • Pneumonia • Respiratory Diseases

A cyclometalated iridium(III) complex with 2-acetylpyridine-N(4)-ortho-chlorophenyl thiosemicarbazone: Potent antiproliferative and antibacterial activities. (PubMed, J Inorg Biochem) - "The antibacterial activity of Ir(III) complex against Gram-positive Bacillus subtillis bacteria was comparable to that of ciprofloxacin used as a control. The results of the present work represent a significant contribution to the investigations on the pharmacological profile of iridium(III) complexes."

Journal • Genito-urinary Cancer • Infectious Disease • Oncology • Prostate Cancer • Solid Tumor

In silico assessment of neuromuscular blocking agents and fluoroquinolones as ligands of the Mas-related G protein-coupled receptor X2. (PubMed, Pharmacol Rep) - "In contrast to fluoroquinolones, NMBAs displayed different affinity for MRGPRX2. Cellular responses in bench experiments closely reflected the MD predictions. Alanine scanning revealed that the MRGPRX2 binding pocket exhibits low susceptibility to single-site mutations that enhance receptor responsiveness."

Journal • Immunology

Tailoring Nanoparticle Surfaces Empowered by Multivariate Techniques for Detection of Multiple Antibiotic Fingerprints in Real Samples Using Hand-Held Colorimetric Signal Readout. (PubMed, ACS Appl Mater Interfaces) - "With 100% accuracy, the sensor array successfully discriminates between eight antibiotics (amoxicillin, azithromycin, neomycin, streptomycin, chloramphenicol, ofloxacin, fluconazole, and ciprofloxacin), with detection limits ranging from 1.7 to 8.3 μM. Further, for the real-time applications, we have developed prototypes for colorimetric analysis and also modified the previously developed 96-well plate reader, which functions similarly to the UV-visible absorption spectrophotometer. These on-site sensing methods, with straightforward preparation, quick response, exceptional sensitivity, and consistently stable high-throughput signal output, show significant potential for practical use in food forensics and for environmental remediation."

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P097 Atypical pemphigoid and an acneiform eruption in a patient with inflammatory bowel disease. (PubMed, Br J Dermatol) - "The differential diagnosis included fungal and bacterial infections, and his scalp responded to terbinafine and ciprofloxacin, with partial improvement of his face and trunk...He responded rapidly to high-dose oral prednisolone, which was tapered over 3 months...His working diagnosis is two concurrent conditions: an atypical pemphigoid and a separate acneiform/pustular eruption possibly on the pyoderma gangrenosum-hidradenitis suppurativa spectrum in the context of irritable bowel disease. He is now well controlled on dapsone and doxycycline, with isotretinoin added recently, given an overarching clinical feature of an acneiform eruption at present."

Journal • Acne Vulgaris • Dermatology • Gastroenterology • Gastrointestinal Disorder • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pyoderma Gangrenosum • Ulcerative Colitis

GD04 (P064) A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

Prevalence, Antibiotic Resistance Pattern, and Molecular Characteristics of Staphylococcus epidermidis Isolated From Milk of Pure Breeds of Dairy Cattle With Subclinical Mastitis. (PubMed, J Trop Med) - "Our antibiogram results underscored a high resistance of S. epidermidis isolates, particularly against cefoxitin (56.25%) and penicillin (43.75%), while demonstrating remarkable susceptibility to amikacin (2.08%), clindamycin (0%), ciprofloxacin (0%), and chloramphenicol (0%). Further research is needed to examine geographic and farm-specific factors affecting S. epidermidis prevalence, and genetic techniques like multilocus sequence typing should be employed to study clonal spread and horizontal gene transfer. Routine antimicrobial sensitivity assessments and continuous monitoring of medication use are essential to develop sustainable strategies against antibiotic resistance in the dairy industry."

Journal • Gene Therapies • Inflammation

GD09 Spotted fever after safari: a case of African tick bite fever highlighting the value of eschar swabs for the molecular detection of rickettsial disease. (PubMed, Br J Dermatol) - "He was commenced on empirical doxycycline and ciprofloxacin to cover for eschar-associated diseases, and a dermatology opinion was sought with a view to performing a diagnostic biopsy. Our case highlights the value of using noninvasive eschar samples to support the diagnosis of ATBF. It is a simple, quick method that can be performed in a variety of clinical settings compared with traditional eschar biopsy."

Journal • Cardiovascular • Dermatology • Infectious Disease • Inflammation • Influenza • Musculoskeletal Pain • Pain • Respiratory Diseases • CRP

P064 A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

Prevalence and Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Effects of Antimicrobial Use in Multiple Pig Industry Sectors in Korea. (PubMed, Ann Lab Med) - "Pig-derived E. coli isolates had antimicrobial resistance (AMR) rates of 80.4%, 47.2%, 32.6%, 36.7%, 43.4%, 62.4%, and 72.1% to ampicillin, piperacillin, cefazoline, ciprofloxacin, cotrimoxazole, chloramphenicol, and tetracycline, respectively. The findings highlight the significance of elucidating AMR networks among humans, animals, and the environment. Prudent antimicrobial usage and continuous AMR monitoring in the pig industry are crucial to safeguard food safety."

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Repurposing Povidone-Iodine for the Treatment of Chronic Suppurative Otitis Media in Nigerian Children. (PubMed, Otol Neurotol) - "This study shows that 0.5% povidone-iodine aural irrigation is at least as effective as 0.3% ciprofloxacin otic suspension in treating uncomplicated CSOM. In addition, any benefit from the use of oral antibiotics in treating uncomplicated CSOM appears to be negligible."

Clinical • Journal • Inflammation • Otorhinolaryngology • Pediatrics

The sero-prevalence and virulence determinants of Klebsiella pneumoniae isolated from urine in outpatient units: a 20-year collection from Taiwan as a herald for serotype vaccine selection. (PubMed, Microbiol Spectr) - "Resistance to cephalosporins, carbapenems, and ciprofloxacin increased significantly after 2014...This 20-year analysis provides detailed data on the distribution of bacterial types and their resistance patterns in Taiwan. The findings offer valuable insight for selecting vaccine targets that cover the most prevalent and drug-resistant strains, supporting the development of effective preventive tools against multidrug-resistant infections."

Journal • Infectious Disease • Nephrology • Pneumonia

Assessment of the Antimicrobial Activity of Cistus salviifolius L. and Helichrysum stoechas (L.) DC Extracts and Their Synergistic Potential with Conventional Antibiotics Against Staphylococcus aureus. (PubMed, Int J Mol Sci) - "When combined with antibiotics such as ampicillin, ciprofloxacin, or vancomycin, the extracts of C. salviifolius and H. stoechas predominantly exhibited synergistic (FICI value ≤ 0.5) or additive effects (0.5 < FICI ≤ 1), with some combinations resensitizing resistant strains...The presence of compounds such as myricetin 3 O-galactoside, catechin derivatives, gallic acid, kaempferol, and chlorogenic acid in the extracts may contribute to their anti-Staphylococcus activity. These results demonstrated the dual antimicrobial and antivirulence potential of C. salviifolius and H. stoechas extracts, highlighting their promise as therapeutic agents or adjuvants against S. aureus. These extracts can be promising candidates for further studies on the development of novel strategies targeting multiple pathogenic pathways."

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Prevalence and Antimicrobial Resistance Patterns of Salmonella in Asymptomatic Horses in Eastern Spain: A One Health Perspective. (PubMed, Animals (Basel)) - "The highest resistance rates were against sulfamethoxazole and gentamicin, followed by ciprofloxacin and tigecycline. (4) Healthy horses can act as silent carriers of multidrug-resistant Salmonella, highlighting the need for surveillance, strengthened biosecurity, and prudent antimicrobial use within a One Health framework."

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Molecular Epidemiology and Antibiotic Resistance of Sheep-Derived Mannheimia haemolytica in Northwestern China. (PubMed, Animals (Basel)) - "Antibiotic susceptibility testing showed sensitivity to ciprofloxacin, azithromycin, gentamicin, and levofloxacin, while resistance was observed for tiamulin and enrofloxacin. These findings indicate a high prevalence and strong pathogenicity of ovine M. haemolytica in Shaanxi, underscore the presence of key resistance traits, and provide a genomic and pathogenic reference to guide region-specific surveillance, therapeutic decisions, and vaccine-oriented control in small ruminant herds. Importantly, these results highlight the need for region-specific monitoring and judicious antibiotic use, which are essential to forestall the spread of resistant strains and to ensure sustainable disease management strategies."

Journal • Respiratory Diseases

Challenges and Management Outcomes of Osteoarticular Infections in Adult Sickle Cell Disease Patients. (PubMed, J Clin Med) - "Most patients were managed conservatively (93.5%), primarily with clindamycin and ciprofloxacin, for approximately six weeks, resulting in an excellent cure rate of 96.8%. The current study highlights the specific clinical features of osteoarticular infections in adult patients with SCD, identifies radiological findings on Magnetic Resonance Imaging, and suggests a conservative, non-invasive approach for management with excellent outcomes."

Journal • Genetic Disorders • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Rheumatology • Sickle Cell Disease

Genomic insights and molecular epidemiology through whole genome sequencing in clinical Serratia marcescens ST-367 isolated from the Kingdom of Bahrain. (PubMed, J Infect Public Health) - "To our knowledge, this is the first report of S. marcescens ST-367 in the Gulf Cooperation Council. The genetic diversity and mechanisms of virulence and antibiotic resistance in this isolate shed light on the evolution of high-risk isolates. Additionally, this will serve as a foundation for future extensively drug-resistant isolates."

Journal • Gene Therapies • Infectious Disease

The impact of middle ear packing materials on tympanoplasty outcomes: a systematic review and meta-analysis. (PubMed, Acta Otolaryngol) - "To systematically compare the efficacy and safety of different middle ear packing materials-including platelet-rich fibrin (PRF), hyaluronic acid (HA), Gelfoam, fat, and ciprofloxacin-soaked packing-on tympanoplasty outcomes...PRF and HA are superior to traditional packing materials in tympanoplasty, optimising graft survival and functional outcomes. Evidence-based selection of biologically active materials is recommended to improve patient care, with further research needed to standardise protocols and confirm long-term benefits."

Journal • Retrospective data • Review • Novel Coronavirus Disease • Otorhinolaryngology

Bacterıal pathogens ın ventılator-assocıated pneumonıa; molecular assessment of resıstance profıles. (PubMed, Folia Microbiol (Praha)) - "baumannii strains exhibited 100% resistance to ciprofloxacin and carbapenems, and 70.83% to colistin...pneumoniae strains demonstrated 94.73% resistance to carbapenems and 100% to piperacillin-tazobactam and colistin...This study provides a comprehensive molecular characterisation of VAP pathogens based on an extensive dataset. The results underscore the need for stricter infection control, restrained use of broad-spectrum antibiotics, and ongoing surveillance of resistance mechanisms."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

99mTc-labeled antibiotics for infection imaging along with diagnostic potential: a comparative study of cephalosporin and fluoroquinolone. (PubMed, Nucl Med Commun) - "This study examines 99mTc labeling of cefixime, ceftriaxone, and ciprofloxacin, achieving high binding efficiency. It compares their potential in infection imaging, distinguishing infections from inflammation, and exploring therapeutic applications."

Clinical • Journal • Infectious Disease • Inflammation

Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock. (PubMed, Sci Rep) - "Extended-spectrum beta-lactamase (ESBL) and ampicillin resistance gene type C (ampC) in foodborne Citrobacter freundii (C...Also, the investigation of the antibacterial activity of chitosan (CS) 1%, 2%, and chitosan nanoparticles (CSNPs), including the estimation of minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) and their combinations with ciprofloxacin (CIP), were evaluated...The concerning prevalence of PDR like-C. freundii in food animals is brought to light by our results, which also provide credence to the use of 2% CS-CIP and CSNPs-CIP combinations as potential substitute treatments for resistant infections."

Journal • Infectious Disease

Biosynthesis and characterization of zinc oxide nanoparticles using Dennettia tripetala for the antioxidant and drug release potentials. (PubMed, Sci Rep) - "In-vitro drug release studies using ciprofloxacin-loaded ZnONPs demonstrated controlled and sustained release over 72 h, indicating their potential as drug delivery carriers. This study concludes that Dennettia tripetala-mediated ZnONPs have promising applications in pharmaceutical and biomedical fields."

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Carpensterol: a new steroid from the ethyl acetate fraction of the fruits of Solanum aculeastrum Dunal (Solanaceae) with antimicrobial activities. (PubMed, Nat Prod Res) - "The evaluation of their antimicrobial activities using the broth microdilution method revealed that, compound 4 (MIC = 4.8 µg/mL) exhibited the greatest activity against Escherichia coli, with an MIC value lower than that of the reference drug, ciprofloxacin (MIC = 256 µg/mL). Additionally, compounds 1 and 4 exhibited moderate activity against Staphylococcus aureus and Salmonella thyphi (MIC = 78.125 μg/mL). These results provide baseline information for the potential use of the isolated steroids."

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Optimization and kinetic modeling of ciprofloxacin adsorption and photocatalytic degradation in water. (PubMed, Sci Rep) - "The novelty of this work lies in the application of dual-function Ni-Al LDH for the removal of a pharmaceutical pollutant, demonstrating rapid adsorption kinetics and an enhanced photocatalytic activity, a solar-driven, and a green approach involving ethanol and plant-based reagents for material regeneration, aligning with the sustainable water treatment goals. These findings highlight the material's promise as an eco-friendly and efficient candidate for practical wastewater treatment applications."

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