ciprofloxacin oral / Generic mfg. - LARVOL DELTA

Beyond lethal doses: sub-MIC levels of multi-class antibiotics induce species- and isolate-dependent biofilm inhibition in gram-negative pathogens. (PubMed, BMC Microbiol) - "This study demonstrates that sub-MIC exposure produces heterogeneous, antibiotic-, species-, isolate-, concentration-, and method-dependent biofilm responses that diverge between structural matrix accumulation and genomic abundance. Therefore, our findings highlight that sub-MIC exposures demand a multi-assay diagnostic framework to accurately evaluate biofilm-associated drug responses."

Journal • Infectious Disease • Pneumonia

Global Genomic Analysis Reveals Spatial Patterns and Temporal Trends of Priority-Antimicrobial Resistance in Salmonellaenterica Isolates from Aquatic Animals. (PubMed, Vet Sci) - "Globally, resistance to WHO-recommended clinically important antimicrobials showed substantial variation among antibiotic classes, with resistance rates for azithromycin (2.10%), cefepime (2.89%), cefotaxime (2.71%), ceftazidime (2.71%), and ceftriaxone (0.62%). Geographical differences were observed, with isolates from Asia exhibiting higher resistance levels, particularly for ciprofloxacin (13.50%) and doxycycline (18.02%)...A total of 111 acquired ARGs and 10 resistance-associated chromosomal mutations were identified, accompanied by changes in the distribution of resistance determinants. Collectively, this study provides a global genomic perspective on priority AMR in Salmonella from aquatic animals and highlights the importance of integrating aquaculture, environmental, and public health surveillance to monitor and mitigate AMR risks within the One Health framework."

Journal

Assessment of Veterinary Antimicrobial Residues in Feedlot Soils in Argentina. (PubMed, Antibiotics (Basel)) - "Compounds absent from farm treatment records were detected in 40.7% of feedlots, correlating with antimicrobial residues not matching available AMU records, including oxytetracycline, tulathromycin, cefquinome, enrofloxacin, and ciprofloxacin among others. These findings underscore gaps in stewardship and the need for integrated environmental monitoring and improved antimicrobial usage traceability. These data provide a baseline for ecological risk assessment and resistome studies and can inform evidence-based policy and stewardship interventions in Argentine feedlot systems."

Journal

Phenotypic Susceptibility, Resistance-Associated Genomic Determinants, and Mobile-Genetic-Element Context of Canine Otitis Externa-Associated Pseudomonas aeruginosa Collected in Hungary in 2010 and 2017. (PubMed, Vet Sci) - "European Committee on Antimicrobial Susceptibility Testing epidemiological cut-off values identified non-wild-type subsets for ciprofloxacin (7/67), tobramycin (4/67), imipenem (1/67), and piperacillin-tazobactam (51/67), whereas all isolates remained within the available wild-type distributions for ceftazidime, gentamicin, and amikacin. The discordance between conserved resistance-gene repertoires and heterogeneous MICs demonstrates that sequence-based detection alone is insufficient for therapeutic inference. Integrated phenotypic and genomic surveillance is therefore required to support evidence-based antimicrobial stewardship in canine pseudomonal otitis."

Journal • Otorhinolaryngology

Phage-Antibiotic-Peptide Synergy Overcomes Biofilm-Mediated Multidrug Resistance in Serratia marcescens. (PubMed, Antibiotics (Basel)) - "These findings demonstrate that simultaneous targeting of multiple bacterial pathways can enhance antimicrobial activity against MDR S. marcescens in vitro and support further evaluation of BAP as a potential strategy for biofilm-associated infections."

Journal • Infectious Disease

Increased Prevalence of Multidrug-Resistant Escherichia coli as an Adverse Effect of Excessive Antibiotic Use in a Tertiary Care Hospital in Serbia. (PubMed, Life (Basel)) - "Total antibiotic consumption remained stable, with no correlation between consumption and MDR isolation rates, although ampicillin resistance increased significantly. Compared with 2015, resistance significantly increased to amoxicillin-clavulanic acid, cefotaxime, cefepime, ceftazidime, ciprofloxacin, and levofloxacin, while ceftriaxone resistance decreased. The blaCTX-M gene was detected in 53% of bloodstream isolates, indicating widespread dissemination of ESBL-producing E. coli and highlighting the need for continuous surveillance and antimicrobial stewardship."

Adverse events • Journal • Infectious Disease

Effects of Magnesium and Calcium Cations on Antibiotic Susceptibility of Pseudomonas aeruginosa. (PubMed, Antibiotics (Basel)) - "This study evaluated the impact of varying concentrations of Mg2+ and Ca2+ on the antibiotic susceptibility of P. aeruginosa to tobramycin and ciprofloxacin under both planktonic and biofilm growth modes... Our findings suggest that elevated concentrations of Mg2+ and Ca2+ significantly modulate bacterial antibiotic susceptibility. The results of our study has implications for limitations in standardised antibiotic susceptibility tests and to therapeutic strategies in cation-rich environments such as cystic fibrosis airways."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Isolation and Preliminary In Vitro Characterization of a Honey-Derived Bacillus licheniformis Isolate. (PubMed, Antibiotics (Basel)) - " In vitro assays revealed that Blhoney exhibits robust tolerance to simulated gastrointestinal stress, including extreme acidity (pH 1-3), bile salts (0.3-1%), pepsin, and pancreatin, maintaining viability for up to 24 h. Phenotypic antimicrobial testing demonstrated measurable inhibition zones for erythromycin, kanamycin, chloramphenicol, ampicillin, tetracycline, gentamicin, streptomycin, and spectinomycin, whereas no measurable inhibition zones were observed for penicillin G, rifampicin, ciprofloxacin, or ceftazidime. Overall, these findings indicate that the honey-derived Blhoney isolate exhibits preliminary probiotic-associated characteristics under the tested in vitro conditions. However, further strain-level genomic and safety characterization is required before its potential probiotic application can be established."

Journal • Preclinical

Health Risk Assessment of Antibiotic Residues in Normally Slaughtered, Emergency-Slaughtered, and Imported Beef in Egypt. (PubMed, Antibiotics (Basel)) - "Therefore, the current study aimed to determine ciprofloxacin, oxytetracycline, and sulphadimidine residues in beef marketed in Ismailia, Egypt. The HQ values of each antibiotic residue were higher in schoolchildren than in adults, with emergency-slaughtered beef samples exhibiting the highest HQ values for all three antibiotics. The detection of antibiotic residues, including concentrations exceeding established MRLs, particularly in emergency-slaughtered beef, highlights the crucial importance of complying with antibiotic withdrawal periods and rationalizing their use in veterinary medicine to protect public health."

Journal

Antimicrobial Resistance and Associated Genetic Determinants of Aliivibrio Colonizing the Gastrointestinal Tract of Farmed Atlantic Salmon (Salmo salar L.). (PubMed, Antibiotics (Basel)) - "Based on these results, we estimated provisional epidemiological cutoff values for several antimicrobials for Aliivibrio isolates predominant in Atlantic salmon farmed in Tasmania. Furthermore, available data show no evidence that plasmid- or integron-associated ARGs are prevalent and suggest that they are, overall, uncommon in the genus Aliivibrio. The data presented provide a foundation for monitoring AMR in Atlantic salmon gut-associated commensal bacteria."

Journal • Gastrointestinal Disorder

Mechanism of Synergistic Action of Isochlorogenic Acid C and Ciprofloxacin Against Drug-Resistant Escherichia coli. (PubMed, Biomolecules) - "ICAC may potentiate the antibacterial activity of ciprofloxacin through targeting of OmpF, which disrupts bacterial membrane integrity and energy metabolism, providing a promising candidate strategy for combating infections caused by the tested antibiotic-resistant E. coli."

Journal • Infectious Disease

Harnessing phage-ciprofloxacin synergy to overcome multidrug-resistant infections and biofilm persistence. (PubMed, Arch Microbiol) - "The combination reduced established EFR biofilm by 75% and improved embryo survival to 90-100% in an in ovo infection model compared with φR12EFP monotherapy alone. These findings indicate that φR12EFP restores CIP sensitivity in resistant E. faecalis and supports the use of phage-antibiotic regimens against multidrug-resistant enterococci."

Journal • Infectious Disease

TAPB-DHTP functionalized cotton fiber for in-syringe solid-phase extraction and determination of fluoroquinolones in food samples. (PubMed, J Chromatogr A) - "After coupling with ultra-performance liquid chromatography, the method was used for the determination of enoxacin, levofloxacin, and ciprofloxacin. The method was applied to honey, egg white, and fish samples, giving recoveries of 81.05-97.23% with RSDs below 9.77%. The results demonstrate that TAPB-DHTP COF@cotton provides a practical fibrous adsorbent for trace fluoroquinolone determination in complex food matrices."

Journal

Delafloxacin Resistance and MIC-Distribution in Ciprofloxacin-Resistant Enterobacterales: A Retrospective Evaluation of Minimum Inhibitory Concentrations. (PubMed, Antibiotics (Basel)) - "For the majority of isolates (64%), other oral options for antibiotic therapy, such as amoxicillin/clavulanic acid and trimethoprim/sulfamethoxazole, were still available. Our data suggests that, compared to CIP, DFX does not demonstrate increased in vitro efficacy against fluoroquinolone-resistant Enterobacterales. Subsequent DFX testing seems to be of limited additional value."

Journal • Retrospective data • Infectious Disease

Explainable Stacked Ensemble Learning for Predicting Antibiotic Residues in the Danube River Within the Territory of the City of Novi Sad, Serbia. (PubMed, Antibiotics (Basel)) - "Azithromycin was most prevalent (75.0%), followed by sulfamethoxazole (58.3%), trimethoprim, and ciprofloxacin (52.8% each), while wastewater generally exhibited broader antibiotic profiles and higher concentrations than surface water. Explainable STACK-RF modeling captured nonlinear, antibiotic-specific associations among residues, water-quality conditions, and microbial indicators. It may complement targeted chemical monitoring and support hypothesis generation, although larger, externally validated datasets are required before broader application."

Journal • Infectious Disease • Pneumonia

Novel Lomefloxacin-Triazole Hybrids: Design, Synthesis and In Vitro Antiproliferative Activity in Breast, Melanoma and Colon Cancer Cell Lines. (PubMed, Biomolecules) - "In recent years, extensive research has focused on fluoroquinolone-triazole hybrids, with particular emphasis on structural modifications of ciprofloxacin. A preliminary evaluation of antiproliferative activity was performed on selected human cancer cell lines using the WST-1 assay, while selectivity against normal human dermal fibroblast was assessed. The results obtained revealed promising antiproliferative activity of the tested derivatives, particularly against colorectal cancer cell lines."

Journal • Preclinical • Colon Cancer • Colorectal Cancer • Melanoma • Oncology • Solid Tumor • TOP1

Manganese Oxide-Functionalized Palm Leaf Biochar for High-Efficiency Ciprofloxacin Adsorption from Water. (PubMed, Int J Mol Sci) - "Furthermore, the regeneration study demonstrated that the MnO2/PL biochar retained 81% of its initial CIP removal efficiency after four adsorption-desorption cycles, indicating good reusability and potential for repeated application. The MnO2/PL biochar composite shows strong potential as a sustainable adsorbent for antibiotic removal from wastewater."

Journal

Ciprofloxacin Alters Cyanobacterial Competition through Extracellular Organic Matter Composition. (PubMed, Environ Toxicol Chem) - "By impairing photosynthesis and allelopathic capacity in M. aeruginosa and strengthening the stress tolerance and EOM mediated interactions of Anabaena sp., CIP shifted the direction of interference competition and reversed dominance from M. aeruginosa to Anabaena sp. These findings demonstrate that antibiotics can restructure phytoplankton communities, underscoring the need to incorporate species interactions into ecological risk assessments."

Journal

Nitrogen Vacancy Rich Tubular g-C3N4 Modified with FePc for Efficient and Reusable Photo-Fenton Degradation of Oxytetracycline. (PubMed, Molecules) - "The optimized FePc/HCNT achieved 94% oxytetracycline degradation within 60 min, with an apparent rate constant of 0.04462 min-1, approximately 11 times higher than bulk g-C3N4, and exhibited broad-spectrum degradation capability toward various organic pollutants, including rhodamine B, tetracycline, amoxicillin, and ciprofloxacin. The FePc/HCNT-PVDF membrane removed 90% of oxytetracycline within 60 min and maintained stable performance over ten cycles. This work provides insights into the integrated roles of nitrogen vacancy regulation, FePc-mediated H2O2 activation, and morphology-assisted membrane immobilization in the development of reusable g-C3N4-based photo-Fenton catalysts."

Journal

Mobile phone bacterial contamination among students and staff at Haramaya University, Eastern Ethiopia: A cross-sectional study. (PubMed, Medicine (Baltimore)) - "Among the bacterial isolates tested for antimicrobial susceptibility, susceptibility was highest to gentamicin and chloramphenicol (94.0% each), followed by clindamycin (83.4%). Resistance was highest to ampicillin (98.7%), kanamycin (88.2%), cefotaxime (71.5%), cefoxitin (54.9%), and ciprofloxacin (52.8%)...High levels of antimicrobial resistance were observed, particularly to ampicillin, kanamycin, and cefotaxime. The findings support the need to promote regular mobile-phone cleaning and improve awareness of mobile-phone hygiene."

Journal • Observational data

Batch-to-Flow Translation of β-Cyclodextrin Polymer Adsorption for Emerging Contaminant Removal: Hydrodynamic and Operational Validation. (PubMed, Polymers (Basel)) - "Under these controlled high-loading conditions, removal was strongly contaminant-dependent: cyproconazole exceeded 90%, acetaminophen reached 72-77%, hydrochlorothiazide reached 40-65%, ciprofloxacin reached 24-50%, and furosemide remained below 30%. These preliminary conditions require confirmation through replicated adsorption-desorption cycles under continuous-flow operation. These results identify laboratory-scale hydrodynamic, adsorption, matrix, and regeneration considerations that require confirmation through fixed-condition, long-term testing during subsequent process development."

Journal

Optimized Chitosan Nanoparticles for Enhanced Ciprofloxacin Delivery and Activity Against Resistant Bacteria. (PubMed, Pharmaceuticals (Basel)) - " Optimized CIP-loaded chitosan nanoparticles demonstrated improved antibacterial efficacy against resistant strains and good drug delivery properties. These findings highlight the potential of chitosan-based nanocarrier systems to improve the performance of CIP and antibiotic delivery dose-sparing antibiotic strategies."

Journal • Infectious Disease

Antibiotic Consumption Patterns in Three Romanian Hospitals: A Five-Year Retrospective Study. (PubMed, Antibiotics (Basel)) - "Cefuroxime accounted for the highest cumulative consumption, followed by ceftriaxone, meropenem, vancomycin, ciprofloxacin, and metronidazole. Antibiotic consumption differed among the participating hospitals and study years. Monitoring antibiotic consumption provides valuable information on hospital antibiotic utilization patterns and can support evidence-based antimicrobial stewardship in hospitals."

Journal • Retrospective data

Cinnamomum zeylanicum, Origanum vulgare, and Thymus vulgaris Essential Oils in Cystitis: An Alternative/Complementary Perspective. (PubMed, Antibiotics (Basel)) - "Antibacterial activity was assessed by disk diffusion assay: the efficacy of ciprofloxacin was measured, as well as the efficacy of each oil, tested both alone and in combination with ciprofloxacin... These findings suggest that cinnamon, oregano and thyme essential oils may act as multitarget phytocomplexes with antibacterial, antioxidant and bladder-modulating properties. They may represent complementary candidates for cystitis management, although further mechanistic, formulation and safety studies are required."

Journal • Infectious Disease • Nephrology

Whole Genome Characterisation of Non-O1/Non-O139 Vibrio cholerae in Wastewater Treatment Plants in the Tshwane District, South Africa. (PubMed, Microorganisms) - "Drug resistance was mostly observed to first-line antibiotics, ciprofloxacin, chloramphenicol, and trimethoprim-sulfamethoxazole. Phylogenetic analysis showed evidence of genetic diversity amongst isolates. Although the isolates lacked classical toxigenic genes, they carried other virulence determinants associated with pathogenicity, posing a potential risk for clinical infection, highlighting the need for sustained surveillance."

Journal • Cholera • Gastroenterology • Gastrointestinal Disorder • Infectious Disease