ION717 / Ionis - LARVOL DELTA

Therapeutic Trajectories in Human Prion Diseases. (PubMed, Subcell Biochem) - "The chapter also highlights the progress in clinical trials, such as the PrProfile trial for ION717, which tests a novel treatment based on an antisense oligonucleotide (ASO). As we look toward the future, the chapter underscores the need for a multifaceted approach to treating prion diseases. Furthermore, early detection methods, innovative drug delivery systems, and collaborative interdisciplinary research efforts will be essential for translating scientific discoveries into practical clinical breakthroughs."

IO biomarker • Journal • Review • CNS Disorders • PRNP

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717 (clinicaltrials.gov) - P1/2 | N=56 | Active, not recruiting | Sponsor: Ionis Pharmaceuticals, Inc. | Trial primary completion date: Mar 2025 ➔ Jul 2025 | Recruiting ➔ Active, not recruiting

Enrollment closed • Trial primary completion date • CNS Disorders

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717. (clinicaltrials.gov) - P1/2 | N=56 | Recruiting | Sponsor: Ionis Pharmaceuticals, Inc. | Trial completion date: Oct 2025 ➔ Jun 2027

Trial completion date • CNS Disorders

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717. (clinicaltrials.gov) - P1/2 | N=56 | Recruiting | Sponsor: Ionis Pharmaceuticals, Inc. | Active, not recruiting ➔ Recruiting

Enrollment open • CNS Disorders

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717. (clinicaltrials.gov) - P1/2 | N=56 | Active, not recruiting | Sponsor: Ionis Pharmaceuticals, Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed • CNS Disorders

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717. (clinicaltrials.gov) - P1/2 | N=56 | Recruiting | Sponsor: Ionis Pharmaceuticals, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders