Influenza antibody / iBio - LARVOL DELTA

The multipurpose stick: A complete and low-cost technique for remote sample collection in pinnipeds. (PubMed, Res Vet Sci) - "The recent outbreak of highly pathogenic avian influenza (HPAI) H5N1 among southern elephant seals (Mirounga leonina) in Argentine Patagonia, resulting in the deaths of thousands of animals, highlights the urgent need for health monitoring strategies among free-ranging pinnipeds...This non-invasive approach significantly reduces stress for the animals and logistical burdens for researchers. It is an ideal tool for monitoring the health of wild pinniped populations and has promising applications for the early detection of outbreaks, surveillance of zoonotic diseases, and assessment of ecosystem health."

Journal • Anesthesia • Infectious Disease • Influenza • Respiratory Diseases

The association between community solidarity and adoption of public health preventive measures during the COVID-19 pandemic in a cross-sectional, multi-national sample. (PubMed, PLoS One) - "The findings underscore the potential of fostering community solidarity to enhance prosocial actions amid widespread emergencies."

Journal • Infectious Disease • Influenza • Novel Coronavirus Disease • Respiratory Diseases

Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter. (PubMed, Elife) - "We have previously reported the structures of SiaQM, a membrane-embedded component of the Haemophilus influenzae TRAP transport system, (Currie et al., 2024)...Neu5Ac primarily interacts with residues in the elevator domain of the protein, thereby supporting the elevator with an operator mechanism. The residues interacting with Neu5Ac are conserved, providing fundamental information required to design inhibitors against this class of proteins."

Journal • Infectious Disease • Influenza • Respiratory Diseases

Searching for high pathogenicity avian influenza virus in Antarctica. (PubMed, Nat Microbiol) - No abstract available

Journal • Infectious Disease • Influenza • Respiratory Diseases

Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia. (PubMed, Nat Commun) - "Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that gradually undergo transition to tissue-resident alveolar macrophages (TR-AM) in the inflamed lung...We reveal that Plet1 is released from alveolar macrophages, and acts as important mediator of macrophage-epithelial cross-talk during lung repair by inducing proliferation of alveolar epithelial cells and re-sealing of the epithelial barrier. Intratracheal administration of recombinant Plet1 early in the disease course attenuated viral lung injury and rescued mice from otherwise fatal disease, highlighting its therapeutic potential."

Journal • Infectious Disease • Influenza • Pneumonia • Respiratory Diseases

The Dual Role of CCR5 in the Course of Influenza Infection: Exploring Treatment Opportunities. (PubMed, Front Immunol) - "While discordant data in literature regarding this CCR5 mutation and influenza severity, the association of CCR5delta32 and HIV resistance fostered the development of different CCR5 inhibitors, now being tested in lung inflammation therapy. The potential use of CCR5 inhibitors to modulate the inflammatory response in severe human influenza infections is to be addressed."

Journal • Review • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases • CCL3 • CCR5 • CD4 • CD8

Accessible LAMP-Enabled Rapid Test (ALERT) for Detecting SARS-CoV-2. (PubMed, Viruses) - "ALERT (Accessible LAMP-Enabled Rapid Test) incorporates the following features: (1) increased shelf-life and ambient temperature storage, compared to liquid reaction mixes, by using wax layers to isolate enzymes from other reagents; (2) improved specificity compared to other LAMP end-point reporting methods, by using sequence-specific QUASR (quenching of unincorporated amplification signal reporters); (3) increased sensitivity, compared to methods without purification through use of a magnetic wand to enable pipette-free concentration of sample RNA and cell debris removal; (4) quality control with a nasopharyngeal-specific mRNA target; and (5) co-detection of other respiratory viruses, such as influenza B, by multiplexing QUASR-modified RT-LAMP primer sets. The flexible nature of the ALERT workflow allows easy, at-home and point-of-care testing for individuals and higher-throughput processing for labs and hospitals. With minimal effort, severe acute respiratory syndrome..."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • PCR