cefixime / Generic mfg. - LARVOL DELTA

Aurobindo launches citalopram capsules, obtains FDA OK for generic Suprax (Drug Store News) - "Aurobindo is introducing citalopram capsules, 30 mg, which are indicated for the treatment of major depressive disorder in adults....Aurobindo also has received the green light from the FDA for cefixime capsules, which are the generic of Lupin’s Suprax."

ANDA • Depression • Infectious Disease

A CASE REPORT ON WUNDERLICH SYNDROME IN A 32-YEAR-OLD MALE: DIAGNOSTIC AND CLINICAL CHALLENGES (ISN-WCN 2026) - "Perirenal abscess formation was considered at this time and Ceftriaxone was shifted to Meropenem pending blood culture results...On hospital day 6, repeat CT scan of the whole abdomen with contrast was ordered but due to financial limitations, the patient opted to go home and continue with oral antibiotic Cefixime to complete 2 weeks.One week after discharge, CBC was done showing no further decline of hemoglobin and a follow up abdominal ultrasound showed right perinephric hematoma measuring 11.3 cm x 9.5 cm x 4.1 cm with an estimated volume of 231.51 mL with complete resolution of the pateint's fever...The characteristic Lenk triad of flank mass, a flank pain, and hypovolemic shock is appreciated in only an estimated 20% of patients with WS...Conservative management with follow-up imaging is a good approach to avoid unnecessary surgery. By delving into this rare occurence and its characteristics and clinical outcomes, the goal is to shed insights on the complexities..."

Case report • Clinical • Anorexia • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Genito-urinary Cancer • Infectious Disease • Kidney Cancer • Nephrology • Renal Calculi • Renal Cell Carcinoma • Renal Disease • Solid Tumor • Vasculitis

Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity. (PubMed, PLoS Pathog) - "Based on previous work from our lab and others, we identified a minimal set of 10 mutations that, when introduced into the β-lactam antibiotic-susceptible penA allele from FA19 (penA19), confers two-thirds of the ceftriaxone and cefixime resistance compared to the penA41 allele. These epistatic mutations change the backbone dihedral angles at position-447, which may increase flexibility of the enzyme and help maintain enzymatic function. Our results highlight the complex balance necessary for evolving cephalosporin resistance in PBP2 while also retaining sufficient transpeptidase function to support growth."

Journal • Infectious Disease

Predicting oral cephalosporin susceptibility in Escherichia coli blood isolates using parenteral cephalosporin susceptibility testing. (PubMed, J Antimicrob Chemother) - "Prediction of oral second-generation cephalosporins may warrant cefazolin MIC ≤2 mg/L, despite limitations regarding false resistance and susceptibility discordant. Ceftriaxone/cefotaxime demonstrates a more reliable surrogate for predicting oral third-generation cephalosporins susceptibility. Future investigations are necessary to clinically corroborate these findings."

Journal • Infectious Disease

Antibiotics administration during weaning ameliorates intestinal mucosal inflammation in adult mice and their offspring. (PubMed, Front Immunol) - "Three-week-old weaned male mice were used to investigate the effects of short-term (1 week) and long-term (6 weeks) administration with ampicillin and cefixime on colitis susceptibility in adulthood and in the subsequent F1 generation. Furthermore, long-term antibiotic administration significantly altered the gut microbiota of paternal males, increasing the abundance of certain beneficial bacteria, such as Lactobacillus gasseri and Parabacteroides merdae, while promoting the enrichment of antibiotic-resistant strains. Long-term antibiotic administration initiated at the weaning stage in male mice improves colitis in adulthood and in their offspring that associates with decreasing miR-10b-5p and miR-200b-3p expression, thus providing a theoretical basis for optimizing the use of antibiotics and prevention of IBD."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Mucositis • MIR10B • MIR200B • OCLN

Detection and genomic characterization of an extensively drug-resistant Neisseria gonorrhoeae ST16406 isolate identified in Italy, 2025. (PubMed, Int J STD AIDS) - "Whole-genome sequencing (WGS) was conducted using Illumina technology, and genomic characterization included MLST, NG-MAST, NG-STAR typing, resistance gene detection, and phylogenetic analysis with publicly available ST16406 genomes.ResultsThe isolate exhibited high-level resistance to tetracycline (MIC = 16 mg/L) and ciprofloxacin (MIC = 4 mg/L), very high azithromycin MIC (>256 mg/L), and resistance to both injectable and oral ESCs (ceftriaxone MIC = 0.25 mg/L, cefixime MIC = 1 mg/L). Phylogenetic analysis demonstrated close genetic relatedness to previously reported ST16406 isolates from Europe and Asia.ConclusionsThis study reports the first detection in Italy of an XDR N. gonorrhoeae ST16406 isolate carrying the penA-60.001 allele. The finding highlights the ongoing international dissemination of this resistant lineage and underscores the importance of maintaining culture-based diagnostics to ensure effective antimicrobial resistance..."

Journal • Infectious Disease • MTRR

Advancing drug allergy diagnosis in Tunisia using flow cytometry: a promising first step. (PubMed, Allergol Immunopathol (Madr)) - "By applying BAT in the Immunology Department of the Military Hospital of Tunisia, this study seeks to enhance diagnostic accuracy and contribute to personalized patient care."

Journal • Allergy • Immunology • PTGDR2

Klebsiella pneumoniae liver abscess in an adolescent with diabetes: A case report. (PubMed, Medicine (Baltimore)) - "This case review and literature review highlight the predominance of KP in pediatric pyogenic liver abscesses in Taiwan and the important role of diabetes in pediatric suppurative liver abscess. Children with DM are more likely to develop cryptogenic gas-producing abscesses and metastatic complications. Early diagnosis, timely intervention, and strict glycemic control are essential to improving the prognosis of this high-risk group."

Journal • Diabetes • Hepatology • Infectious Disease • Metabolic Disorders • Pediatrics • Pneumonia • Respiratory Diseases • Type 1 Diabetes Mellitus

Synergistic Interaction Between Alkanna tinctoria (L.) Tausch and Cefixime Enhances Antibacterial Activity Against Resistant Bacterial Strains. (PubMed, Curr Microbiol) - No abstract available

Journal

Idiopathic multifocal calcinosis cutis presenting in a cat with vestibular syndrome: clinical, radiographic and histopathological findings. (PubMed, JFMS Open Rep) - "The cat received cefixime (10 mg/kg PO q24h) and methylprednisolone (1 mg/kg PO q24h) for 2 weeks, resulting in marked improvement of vestibular signs by day 4...To the authors' knowledge, this is the first report from Türkiye describing multifocal subcutaneous idiopathic calcinosis cutis in a cat. This case emphasises the importance of thorough physical examinations to detect concurrent, clinically silent dermatological conditions during neurological evaluations."

Journal • Inflammation • Metabolic Disorders • Ophthalmology • Otorhinolaryngology • Pain

Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae (clinicaltrials.gov) - P2 | N=65 | Completed | Sponsor: University of North Carolina, Chapel Hill | Recruiting ➔ Completed | N=140 ➔ 65 | Trial completion date: Feb 2028 ➔ Feb 2026 | Trial primary completion date: Feb 2028 ➔ Feb 2026

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Infectious Disease

Superbugs Neisseria gonorrhoeae und Mycoplasma genitalium : Therapeutic challenges driven by antimicrobial resistance (PubMed, Dermatologie (Heidelb)) - "N. gonorrhoeae is showing increasing resistance to penicillins, tetracyclines, and fluoroquinolones; furthermore, there is a growing reduction in susceptibility to the macrolide antibiotic azithromycin. Resistance rates to ceftriaxone, the current first-line therapy in many international treatment guidelines, and to cefixime, the peroral treatment option frequently used in outpatient settings, remain very low in German-speaking countries. For M. genitalium, increasing resistance is observed primarily to macrolides and, less commonly, to fluocinolones; cases of infections with combined resistance to both antimicrobial classes have been reported and regularly require the use of reserve antibiotics such as pristinamycin or sitafloxacin. Enhanced surveillance, molecular resistance testing, avoidance of overdiagnosis, rational and responsible antibiotic use (preventing overtreatment), and the development and implementation of new antimicrobial agents are..."

Journal • Review • Infectious Disease

Valorisation of banana stem into N-doped activated carbon as a selective sorbent for cationic dyes and pharmaceutical contaminants. (PubMed, RSC Adv) - "Beyond synthetic dye removal, PNAC also exhibits efficient uptake of pharmaceutical contaminants, 79.8% for ciprofloxacin and 81.1% for cefixime, within 30 minutes and achieves 97% dye removal from real textile effluents within 15 minutes. The material demonstrates excellent recyclability, retaining approximately 80% efficiency after five adsorption-desorption cycles and 85% after eight cycles of acid-assisted regenerations. These findings highlight PNAC as a scalable, eco-friendly, and high-performance sorbent derived from agricultural waste, offering a promising platform for next-generation wastewater treatment and sustainable environmental remediation."

Journal

A Rare but Critical Presentation in Primary Care: A Case Report on Unilateral Ureterolithiasis Leading to Postrenal Acute Kidney Injury. (PubMed, Cureus) - "He was discharged with conservative management, including nonsteroidal anti-inflammatory drugs (NSAIDs), oral cefixime 400 mg daily, hydration advice, and follow-up instructions...Although small distal ureteral stones are often considered low risk, this case demonstrates that even a 4 mm calculus may lead to persistent obstruction and postrenal AKI. Clinicians should remain cautious for complications in patients with ongoing symptoms and consider timely reassessment and repeat imaging when clinical deterioration occurs."

Journal • Acute Kidney Injury • Nephrology • Pain • Renal Calculi • Renal Disease • Urolithiasis

Aminoglycoside Resistance Among Clinical Bacterial Isolates in Sétif, Algeria: Epidemiology, Multidrug Resistance, and Virulence Features. (PubMed, Antibiotics (Basel)) - "High resistance rates were detected for amoxicillin (83%), amoxicillin-clavulanic acid (80%), cephalexin (74.8%), cefixime (71.1%), trimethoprim-sulfamethoxazole (74.8%), and gentamicin (72.6%). Conversely, chloramphenicol (53.3%), imipenem (47.4%), amikacin (47.4%), and piperacillin-tazobactam (31.1%) remained comparatively more effective...Conclusion. In conclusion, this study revealed substantial variations in aminoglycoside resistance in Setif, shaped by demographic, clinical, and bacteriological factors."

Journal • Infectious Disease • Nephrology

Profile of Biofilm Formation and Antimicrobial Susceptibility Patterns of Escherichia coli Isolated from Adult Patients Presenting with Urinary Tract Infections at Ruhengeri Level Two Teaching Hospital, Rwanda. (PubMed, Infect Drug Resist) - "High resistance was observed for amoxicillin (100%), trimethoprim-sulfamethoxazole (93.8%), nitrofurantoin (87.5%), ampicillin (87.5%), cefixime (56.2%), gentamycin (50%), and ceftazidime (37.5%). Ciprofloxacin and meropenem were effective...A high prevalence of drug resistance was observed among biofilm-producing strains. Intervention strategies, such as frequent biofilm screening, continuous surveillance, and enhanced antimicrobial stewardship programs, are needed."

Journal • Infectious Disease • Nephrology

Neisseria gonorrhoeae in Kenya: A Systematic Review and Meta-Analysis of Prevalence, Resistance and Mitigation Strategies. (PubMed, Trop Med Int Health) - "N. gonorrhoeae poses an urgent public health threat in Kenya. Strengthening surveillance, expanding access to reliable diagnostics and enforcing antibiotic stewardship are critical. Exploration of alternative therapies including phage therapy, alongside accelerated vaccine research, will be essential for sustainable disease control."

Journal • Retrospective data • Review • Infectious Disease

Antibiotics Use Patterns in Low- and Middle-Income Countries: A Systematic Review Analysis. (PubMed, Inquiry) - "Amoxicillin, an "Access" antibiotic under the WHO AWaRe framework, was most frequently prescribed, while "Watch" antibiotics such as ceftriaxone and cefixime were also widely used. The percentage of prescriptions with antibiotics and prescribing Watch group antibiotics was found to be higher than the WHO recommendation across studies. Implementing effective antibiotic stewardship programs is recommended."

Journal • Infectious Disease

Exploring the bacterial diversity and its antibiotic resistance in Kabru Glacier ice cores, Sikkim Himalaya. (PubMed, Front Microbiol) - "Furthermore, antibiotic susceptibility testing revealed resistance to cefixime (CFM) and metronidazole (MET), along with elevated tolerance to heavy metals such as CuSO4, ZnCl2, and NiCl2, while showing lower tolerance to HgCl2. Collectively, these findings suggest that bacterial diversity in the Kabru Glacier is shaped by multiple environmental parameters. The occurrence of antibiotic-resistant and metal-tolerant bacteria underscores the need for further comprehensive investigations to better understand microbial adaptation and potential ecological implications in high-altitude glacial ecosystems."

Journal • Infectious Disease

Resistance, Ineffectiveness, and Off-Label Use Related to Cephalosporins from the Reserve Group-A Pharmacovigilance Signal Detection Study on EudraVigilance Database. (PubMed, Pharmaceuticals (Basel)) - "The aim of this study was the assessment of the resistance, ineffectiveness, and off-label use signals of all five cephalosporins belonging to the Reserve group (ceftazidime/avibactam, ceftaroline, cetolozane/tazobactam, ceftobiprole, and cefiderocol)...The resistance to ceftazidime/avibactam, cefiderocol, and ceftolozane/tazobactam was reported with a higher probability than all others, the strongest signal being observed for cefiderocol against cefixime (ROR: 171.25, 95% CI 79.64-368.27). All cephalosporins from the Reserve group (except ceftobiprole) have higher probability for reporting ineffectiveness than cephalosporins from the Watch group; the strongest signal was observed for cefiderocol-cefditoren (ROR: 14.70, 95% CI 6.73-32.11)... This analysis supplements information from clinical trials and current clinical practice, underscoring the critical need for rigorous antibiotic stewardship programs. Notably, even restricted use of cephalosporins demonstrated..."

Adverse events • Journal

Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface. (PubMed, Front Microbiol) - "Of 26 selected strains, high multi-drug resistance was detected, mainly against tetracycline and cefixime. Western blotting further identified two unique polypeptide markers (69 and 35 kDa) with diagnostic potential for detecting resistant, virulent, and biofilm-forming Salmonella. In short, these findings highlight, for the first time, duck as silent reservoirs of high-risk Salmonella strains, and propose novel protein markers to facilitate early detection at the human-animal-environment interface."

Journal

In vitro susceptibility of bovine digital dermatitis treponemes to conventional and novel antimicrobial agents, and evidence of heavy metal resistance. (PubMed, Anaerobe) - "We have identified several novel therapeutics with in vitro efficacy against BDD associated treponemes. Moreover, differences in presence of MRGs and in vitro susceptibility across lameness associated bacteria indicate heavy metal tolerance to zinc in BDD treponemes but not in other relevant ruminant lameness associated bacteria, potentially mediated by the tro metal resistance gene. These data appear to explain differences in clinical treatment responses to zinc sulphate observed for different ruminant infectious lameness diseases depending on presence or absence of treponemes and should help inform more tailored treatment approaches in the future."

Journal • Preclinical • Dermatitis • Dermatology • Immunology • Pain

Preparation of Photoclick-Crosslinked Modular Gelrite Hydrogel: Tuning Physico-Chemical Characteristics, Cytocompatibility, In Vitro Cefixime Trihydrate Release, and Antimicrobial Properties. (PubMed, Macromol Biosci) - "The lower minimum inhibitory concentration value suggests that the hydrogel formulation is more potent against E. coli (MIC = 39 µg/mL) bacteria than S. aureus (MIC = 5 mg/mL). Therefore, the prepared cytocompatible and pH-responsive Gelrite-MA hydrogel has the potential to serve as a sustained drug delivery matrix for administering cefixime trihydrate orally."

Journal • Preclinical

Analysis of gut microbiota and intestinal secondary bile acids metabolism in rats after short-term antibiotic treatment. (PubMed, J Pharm Biomed Anal) - "Four antibiotics (cefixime, clarithromycin, moxifloxacin and metronidazole) were used to treat normal rats for a short period (3 days), and then gut microbiota, intestinal bile acids profile, BSH and 7α-dehydroxylases activity mediated bile acid metabolism were measured. Collectively, our research demonstrated that different antibiotics exerted varying impacts on the production of intestinal secondary bile acids, which was related to their differential effects on the gut microbiota. This work provides novel insights into the interplay between antibiotics and microbial metabolites."

Journal • Preclinical

Detection of non-travel-associated, ceftriaxone non-susceptible Neisseria gonorrhoeae FC428-like harbouring the mosaic penA60 allele in Ontario, Canada. (PubMed, Can Commun Dis Rep) - "Agar dilution testing demonstrated reduced susceptibility to all tested agents, except for azithromycin and spectinomycin, including non-susceptibility to ceftriaxone (minimum inhibitory concentration [MIC]=0.5 mg/L) and cefixime (MIC=2 mg/L), resistance to tetracycline (MIC=2 mg/mL) and ciprofloxacin (MIC=32 mg/L), and testing intermediate to penicillin (MIC=1 mg/L). Whole-genome sequencing revealed the isolate was closely related to the FC428 clone, which harbours the mosaic penA60 allele responsible for elevated MICs to extended-spectrum cephalosporins, such as ceftriaxone or cefixime, both currently recommended as first-line or alternative treatment options for uncomplicated anogenital gonorrhea infections in Ontario. Identification of this case suggests previously unrecognized local transmission of this multidrug-resistant N. gonorrhoeae strain is occurring in Ontario and highlights the need for ongoing surveillance to monitor trends and inform treatment..."

Journal • Infectious Disease