cefixime / Generic mfg. - LARVOL DELTA

Resistance, Ineffectiveness, and Off-Label Use Related to Cephalosporins from the Reserve Group-A Pharmacovigilance Signal Detection Study on EudraVigilance Database. (PubMed, Pharmaceuticals (Basel)) - "The aim of this study was the assessment of the resistance, ineffectiveness, and off-label use signals of all five cephalosporins belonging to the Reserve group (ceftazidime/avibactam, ceftaroline, cetolozane/tazobactam, ceftobiprole, and cefiderocol)...The resistance to ceftazidime/avibactam, cefiderocol, and ceftolozane/tazobactam was reported with a higher probability than all others, the strongest signal being observed for cefiderocol against cefixime (ROR: 171.25, 95% CI 79.64-368.27). All cephalosporins from the Reserve group (except ceftobiprole) have higher probability for reporting ineffectiveness than cephalosporins from the Watch group; the strongest signal was observed for cefiderocol-cefditoren (ROR: 14.70, 95% CI 6.73-32.11)... This analysis supplements information from clinical trials and current clinical practice, underscoring the critical need for rigorous antibiotic stewardship programs. Notably, even restricted use of cephalosporins demonstrated..."

Adverse events • Journal

In vitro susceptibility of bovine digital dermatitis treponemes to conventional and novel antimicrobial agents, and evidence of heavy metal resistance. (PubMed, Anaerobe) - "We have identified several novel therapeutics with in vitro efficacy against BDD associated treponemes. Moreover, differences in presence of MRGs and in vitro susceptibility across lameness associated bacteria indicate heavy metal tolerance to zinc in BDD treponemes but not in other relevant ruminant lameness associated bacteria, potentially mediated by the tro metal resistance gene. These data appear to explain differences in clinical treatment responses to zinc sulphate observed for different ruminant infectious lameness diseases depending on presence or absence of treponemes and should help inform more tailored treatment approaches in the future."

Journal • Preclinical • Dermatitis • Dermatology • Immunology • Pain

Preparation of Photoclick-Crosslinked Modular Gelrite Hydrogel: Tuning Physico-Chemical Characteristics, Cytocompatibility, In Vitro Cefixime Trihydrate Release, and Antimicrobial Properties. (PubMed, Macromol Biosci) - "The lower minimum inhibitory concentration value suggests that the hydrogel formulation is more potent against E. coli (MIC = 39 µg/mL) bacteria than S. aureus (MIC = 5 mg/mL). Therefore, the prepared cytocompatible and pH-responsive Gelrite-MA hydrogel has the potential to serve as a sustained drug delivery matrix for administering cefixime trihydrate orally."

Journal • Preclinical

Analysis of gut microbiota and intestinal secondary bile acids metabolism in rats after short-term antibiotic treatment. (PubMed, J Pharm Biomed Anal) - "Four antibiotics (cefixime, clarithromycin, moxifloxacin and metronidazole) were used to treat normal rats for a short period (3 days), and then gut microbiota, intestinal bile acids profile, BSH and 7α-dehydroxylases activity mediated bile acid metabolism were measured. Collectively, our research demonstrated that different antibiotics exerted varying impacts on the production of intestinal secondary bile acids, which was related to their differential effects on the gut microbiota. This work provides novel insights into the interplay between antibiotics and microbial metabolites."

Journal • Preclinical

Detection of non-travel-associated, ceftriaxone non-susceptible Neisseria gonorrhoeae FC428-like harbouring the mosaic penA60 allele in Ontario, Canada. (PubMed, Can Commun Dis Rep) - "Agar dilution testing demonstrated reduced susceptibility to all tested agents, except for azithromycin and spectinomycin, including non-susceptibility to ceftriaxone (minimum inhibitory concentration [MIC]=0.5 mg/L) and cefixime (MIC=2 mg/L), resistance to tetracycline (MIC=2 mg/mL) and ciprofloxacin (MIC=32 mg/L), and testing intermediate to penicillin (MIC=1 mg/L). Whole-genome sequencing revealed the isolate was closely related to the FC428 clone, which harbours the mosaic penA60 allele responsible for elevated MICs to extended-spectrum cephalosporins, such as ceftriaxone or cefixime, both currently recommended as first-line or alternative treatment options for uncomplicated anogenital gonorrhea infections in Ontario. Identification of this case suggests previously unrecognized local transmission of this multidrug-resistant N. gonorrhoeae strain is occurring in Ontario and highlights the need for ongoing surveillance to monitor trends and inform treatment..."

Journal • Infectious Disease

Enhancing the Susceptibility of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics Through the Use of 4-Methoxysalicyl Aldehyde. (PubMed, FASEB J) - "The combination of HMB and cefixime effectively protected host cells from MRSA-induced damage in a co-culture system...Additionally, HMB significantly accelerated skin wound healing in those infected with S. aureus USA300. These findings identify HMB as a novel β-lactamase inhibitor with the potential to combat β-lactamase-producing bacteria."

Journal • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases

Cefixime for the Treatment of Neisseria gonorrhoeae Infections in a Setting With Increased Antimicrobial Resistance: A Retrospective Study in Hanoi, Vietnam. (PubMed, Clin Infect Dis) - "Among N. gonorrhoeae infections treated with oral cefixime, we found no positive cultures at follow-up. Higher NAAT positivity among those treated with cefixime could reflect slower clearance at pharyngeal sites. However, persistent detection by NAATs at pharyngeal sites suggests the presence of nonviable bacteria, a limitation of the tests."

Journal • Retrospective data • Infectious Disease

Prevalence, Risk Factors, and Antibiogram Analysis of Bovine Mastitis in Northern Bangladesh. (PubMed, Vet Sci) - "Gentamicin (100%) and Streptomycin (92.20%) were the most effective antibiotics, whereas Cefixime (100%) and Amoxicillin (87.40%) showed the highest resistance rates. In contrast, breed, age, and parity were not significant. These findings highlight a high prevalence of mastitis, predominance of Staphylococcus spp., and rising antimicrobial resistance, identify associated risk factors, and rising antimicrobial resistance profiles in Northern Bangladesh."

Journal

Antibiotic Resistance of Campylobacter Species Isolated From Foods, Animals and Humans in Iran Through One Health Approach: A Systematic Review and Meta-Analysis. (PubMed, Vet Med Sci) - "isolates in Iran have high resistance proportions to beta-lactams (including cefixime (0.97), cephalothin (0.84), ceftriaxone (0.76), cephalexin (0.63), ceftazidime (0.53) and carbenicillin (0.38)), fluoroquinolones (including ofloxacin (0.79), nalidixic acid (0.51) and ciprofloxacin (0.52)), sulfonamides like trimethoprim-sulfamethoxazole (0.68) (potentiated sulfonamides), florfenicol (0.62), tetracycline (0.57) and macrolides (including erythromycin (0.12) and azithromycin (0.17))...showed low resistance rates to aminoglycosides (including neomycin (0.08), amikacin (0.08), meropenem (0.06), spectinomycin (0.04), gentamicin (0.04) and imipenem (0.02)) and chloramphenicol (0.07). Regarding Campylobacter coli and Campylobacter jejuni isolates, resistance to erythromycin (0.18-0.09), and gentamycin (0.08-0.04) was higher in C. coli than C. jejuni isolates, respectively, whereas resistance to ciprofloxacin (0.56) and tetracycline (0.56) was higher in C. jejuni...were tetO..."

Clinical • Journal • Retrospective data • Review

Microbial PHB/PCL Nanofibrous Scaffolds for Controlled Drug Delivery and Enhanced Wound Healing: Comprehensive In Vitro and In Vivo Evaluation. (PubMed, ACS Appl Bio Mater) - "The study explores the fabrication and evaluation of an electrospun nanofibrous scaffold composed of microbial poly-3-hydroxybutyrate (PHB) and polycaprolactone (PCL) loaded with a dual drug combination of cefixime (CFX) and azithromycin (AZM) for controlled drug delivery (CDD) in wound healing. Additionally, in vivo studies displayed improved wound closure, reepithelialization, neovascularization, and collagen remodeling in treated wounds. These results suggest that a dual drug-loaded PHB/PCL nanofibrous scaffold, designed for CDD, offers a promising platform for wound healing management."

Journal • Preclinical • Infectious Disease

Design, Synthesis, and Evaluation of β‑Lactamase Inhibitors as Potential Therapeutics for Antimicrobial Resistance. (PubMed, ACS Omega) - "In-depth investigation revealed that 4-(2-(tert-butyl)-thieno-[2,3-d]-pyrimidin-4-yl)-morpholine demonstrated exceptional results compared to cefixime (control). To evaluate the compound's potency in combination therapy, synergistic effects were observed when imipenem was administered alongside our potent compound, resulting in a significantly enhanced minimum inhibitory effect against clinical isolates of S. aureus. The findings from this study hold substantial pharmacological significance in addressing the growing threat of bacterial resistance, particularly associated with β-lactamase enzymes."

Journal • Infectious Disease

Effect of Vitamin E Supplementation on Recovery and Recurrence Prevention in Women with Lower Urinary Tract Infections: A Triple-Blind Randomized Clinical Trial. (PubMed, Clin Nutr ESPEN) - "Supplementing women with lower UTI with 100 IU of vitamin E daily to the antibiotic regimen significantly reduces recovery time, improves urinary symptoms (frequency and dysuria), and lowers UTI recurrence rates. However, further randomized clinical trials with large sample size are recommended to confirm these findings."

Clinical • Journal • Infectious Disease • Nephrology

Dual mode fluorescence and spectrophotometric cefixime sensing using onion juice nitrogen doped carbon dots with smartphone and paper strip readouts. (PubMed, Sci Rep) - No abstract available

Journal

99mTc-labeled antibiotics for infection imaging along with diagnostic potential: a comparative study of cephalosporin and fluoroquinolone. (PubMed, Nucl Med Commun) - "This study examines 99mTc labeling of cefixime, ceftriaxone, and ciprofloxacin, achieving high binding efficiency. It compares their potential in infection imaging, distinguishing infections from inflammation, and exploring therapeutic applications."

Clinical • Journal • Infectious Disease • Inflammation

Lactococcus lactis subsp. lactis as a biocontrol agent against phytopathogens causing rice bacterial leaf blight. (PubMed, Sci Rep) - "Metabolomic analysis of RBX7 identified antimicrobial compounds such as cefixime, cinchonidine, antimycin A, and bufalin. Finally, in planta assays revealed that both RBX7 CFS and the live culture effectively suppressed BLB symptoms in rice seedlings. This study highlights a safer and more sustainable approach for controlling BLB in rice by utilizing RBX7 as a biocontrol agent, advancing efforts toward achieving sustainable development goals in rice farming."

Journal

Antimicrobial Resistance Patterns and Prevalence of Salmonella Species in Blood Samples: Insights From a Tertiary Care Center in Nepal. (PubMed, Interdiscip Perspect Infect Dis) - "No multidrug resistance was observed, and all isolates were susceptible to third- and fourth-generation cephalosporins (e.g., cefixime, ceftriaxone, and cefepime) and β-lactamase inhibitors (e.g., piperacillin-tazobactam).Salmonella Paratyphi showed 100% sensitivity to ampicillin, amoxicillin, and cotrimoxazole, while susceptibility to chloramphenicol was high for both S. Typhi (88.9%) and S. Paratyphi (92.9%)...High resistance to ciprofloxacin and gentamicin was observed, while susceptibility to ampicillin, chloramphenicol, and cotrimoxazole re-emerged, suggesting their potential for reintroduction in treatment. No multidrug resistance or resistance to third- and fourth-generation cephalosporins (e.g., cefixime, ceftriaxone, cefepime) and β-lactamase inhibitors (e.g., piperacillin-tazobactam) was noted, supporting their reliability for empirical therapy. These findings underscore the need for ongoing antimicrobial surveillance to guide effective treatment strategies."

Journal • Infectious Disease

Surveillance of Antimicrobial Resistance in Neisseria gonorrhoeae in Alberta from 2016-2022. (PubMed, Antibiotics (Basel)) - "Ongoing antimicrobial susceptibility surveillance in Alberta is crucial for identifying resistance trends and informing the development of effective treatment strategies for gonorrhea."

Journal • Infectious Disease

Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity. (PubMed, bioRxiv) - "Based on previous work from our lab and others, we identified a minimal set of 10 mutations that, when introduced into the β-lactam antibiotic-susceptible penA allele from FA19 ( penA19 ), confers two-thirds of the ceftriaxone and cefixime resistance compared to the penA41 allele. Three mutations (A311V, I312M, and V316P) are in the"

Journal • Infectious Disease

Enhanced surface modification of Fe-metal organic gel with cold plasma as an eco-friendly alternative for the separation of antibiotics. (PubMed, J Environ Manage) - "Fe-MOG modified with plasma (Fe-MOG/plasma) exhibited increased active sites and enhanced affinity toward Cefixime (FIX) and Ceftriaxone (CTX) antibiotics compared to the bare Fe-MOG. Subsequently, the adsorbent was regenerated using methanol and DBD-plasma, demonstrating the potential for repeated use. The results showed that the cold plasma is a practical and eco-friendly method for the surface modification and regeneration of the adsorbents based on metal-organic gels."

Journal

Burden of antibiotic resistance in urinary isolates: a retrospective cross-sectional study from a tertiary center in Far-Western Nepal. (PubMed, BMC Infect Dis) - "This study highlights the burden and evolving pattern of antibiotic resistance with high XDR rates in an area with limited resources and a lack of prior surveillance data. These findings reinforce the need for escalating antimicrobial stewardship, strengthening surveillance systems in the region, while also contributing to national infection control strategies."

Journal • Observational data • Retrospective data • Infectious Disease • Nephrology

Preclinical evaluation of Lactiplantibacillus plantarum as a probiotic alternative against multidrug-resistant avian pathogenic Escherichia coli in chickens. (PubMed, Front Immunol) - "Multidrug resistance was common, including complete resistance to cefixime and aztreonam. plantarum ATS1 provides protective and immunomodulatory effects against APEC by supporting intestinal colonization, surviving in macrophages, and enhancing humoral immunity. These findings highlight its potential as a probiotic strategy to improve broiler health and reduce dependence on antibiotics."

Journal • Preclinical

High prevalence and emerging cephalosporin resistance of penicillinase-producing Neisseria gonorrhoeae in Meizhou, China (2022-2024). (PubMed, BMC Infect Dis) - "The high prevalence of PPNG and emerging cephalosporin resistance, including blaTEM-135 variants with potential ESBL activity, highlights the need to strengthen regional surveillance and develop appropriate control measures for resistant gonorrhea in this area."

Journal • Infectious Disease

Development of a carbon cloth electrochemical sensor for the detection of cefixime. (PubMed, Biosens Bioelectron) - "The CC electrode showed good linearity in the concentration range from 2 to 100 μM cefixime with a limit of detection around 1 μM. Cefixime was also measured in the presence of different concentrations of horse serum using the CC electrode without any loss of sensitivity due to surface fouling."

Journal

Antibiotic susceptibility pattern and resistance genes in Salmonella strains isolated from cattle. (PubMed, BMC Vet Res) - "This study provides insights into the antibiotic susceptibility pattern and prevalence of antibiotic resistance genes in Salmonella isolates from Pakistani cattle. The high resistance to oxytetracycline and doxycycline highlights the need for alternative treatment strategies. However, the findings should be interpreted with caution due to the limited sample size and the absence of serotyping, which restricted identification of specific Salmonella serovars. Continued surveillance and targeted control measures remain essential to mitigate the spread of resistant strains."

Journal

Antimicrobial drug-resistant Neisseria gonorrhoeae (GC) infections in men using doxycycline postexposure prophylaxis. A substudy of the ANRS 174 DOXYVAC trial. (PubMed, Clin Infect Dis) - "DoxyPEP use was associated with a significant increase in high-level tetracycline resistance and decreased susceptibility to cefixime in GC. AMR should therefore be closely monitored when using this strategy."

Journal • Human Immunodeficiency Virus • Infectious Disease