cefixime / Generic mfg. - LARVOL DELTA

99mTc-labeled antibiotics for infection imaging along with diagnostic potential: a comparative study of cephalosporin and fluoroquinolone. (PubMed, Nucl Med Commun) - "This study examines 99mTc labeling of cefixime, ceftriaxone, and ciprofloxacin, achieving high binding efficiency. It compares their potential in infection imaging, distinguishing infections from inflammation, and exploring therapeutic applications."

Clinical • Journal • Infectious Disease • Inflammation

Lactococcus lactis subsp. lactis as a biocontrol agent against phytopathogens causing rice bacterial leaf blight. (PubMed, Sci Rep) - "Metabolomic analysis of RBX7 identified antimicrobial compounds such as cefixime, cinchonidine, antimycin A, and bufalin. Finally, in planta assays revealed that both RBX7 CFS and the live culture effectively suppressed BLB symptoms in rice seedlings. This study highlights a safer and more sustainable approach for controlling BLB in rice by utilizing RBX7 as a biocontrol agent, advancing efforts toward achieving sustainable development goals in rice farming."

Journal

Antimicrobial Resistance Patterns and Prevalence of Salmonella Species in Blood Samples: Insights From a Tertiary Care Center in Nepal. (PubMed, Interdiscip Perspect Infect Dis) - "No multidrug resistance was observed, and all isolates were susceptible to third- and fourth-generation cephalosporins (e.g., cefixime, ceftriaxone, and cefepime) and β-lactamase inhibitors (e.g., piperacillin-tazobactam).Salmonella Paratyphi showed 100% sensitivity to ampicillin, amoxicillin, and cotrimoxazole, while susceptibility to chloramphenicol was high for both S. Typhi (88.9%) and S. Paratyphi (92.9%)...High resistance to ciprofloxacin and gentamicin was observed, while susceptibility to ampicillin, chloramphenicol, and cotrimoxazole re-emerged, suggesting their potential for reintroduction in treatment. No multidrug resistance or resistance to third- and fourth-generation cephalosporins (e.g., cefixime, ceftriaxone, cefepime) and β-lactamase inhibitors (e.g., piperacillin-tazobactam) was noted, supporting their reliability for empirical therapy. These findings underscore the need for ongoing antimicrobial surveillance to guide effective treatment strategies."

Journal • Infectious Disease

Surveillance of Antimicrobial Resistance in Neisseria gonorrhoeae in Alberta from 2016-2022. (PubMed, Antibiotics (Basel)) - "Ongoing antimicrobial susceptibility surveillance in Alberta is crucial for identifying resistance trends and informing the development of effective treatment strategies for gonorrhea."

Journal • Infectious Disease

Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity. (PubMed, bioRxiv) - "Based on previous work from our lab and others, we identified a minimal set of 10 mutations that, when introduced into the β-lactam antibiotic-susceptible penA allele from FA19 ( penA19 ), confers two-thirds of the ceftriaxone and cefixime resistance compared to the penA41 allele. Three mutations (A311V, I312M, and V316P) are in the"

Journal • Infectious Disease

Enhanced surface modification of Fe-metal organic gel with cold plasma as an eco-friendly alternative for the separation of antibiotics. (PubMed, J Environ Manage) - "Fe-MOG modified with plasma (Fe-MOG/plasma) exhibited increased active sites and enhanced affinity toward Cefixime (FIX) and Ceftriaxone (CTX) antibiotics compared to the bare Fe-MOG. Subsequently, the adsorbent was regenerated using methanol and DBD-plasma, demonstrating the potential for repeated use. The results showed that the cold plasma is a practical and eco-friendly method for the surface modification and regeneration of the adsorbents based on metal-organic gels."

Journal

Burden of antibiotic resistance in urinary isolates: a retrospective cross-sectional study from a tertiary center in Far-Western Nepal. (PubMed, BMC Infect Dis) - "This study highlights the burden and evolving pattern of antibiotic resistance with high XDR rates in an area with limited resources and a lack of prior surveillance data. These findings reinforce the need for escalating antimicrobial stewardship, strengthening surveillance systems in the region, while also contributing to national infection control strategies."

Journal • Observational data • Retrospective data • Infectious Disease • Nephrology

Preclinical evaluation of Lactiplantibacillus plantarum as a probiotic alternative against multidrug-resistant avian pathogenic Escherichia coli in chickens. (PubMed, Front Immunol) - "Multidrug resistance was common, including complete resistance to cefixime and aztreonam. plantarum ATS1 provides protective and immunomodulatory effects against APEC by supporting intestinal colonization, surviving in macrophages, and enhancing humoral immunity. These findings highlight its potential as a probiotic strategy to improve broiler health and reduce dependence on antibiotics."

Journal • Preclinical

High prevalence and emerging cephalosporin resistance of penicillinase-producing Neisseria gonorrhoeae in Meizhou, China (2022-2024). (PubMed, BMC Infect Dis) - "The high prevalence of PPNG and emerging cephalosporin resistance, including blaTEM-135 variants with potential ESBL activity, highlights the need to strengthen regional surveillance and develop appropriate control measures for resistant gonorrhea in this area."

Journal • Infectious Disease

Development of a carbon cloth electrochemical sensor for the detection of cefixime. (PubMed, Biosens Bioelectron) - "The CC electrode showed good linearity in the concentration range from 2 to 100 μM cefixime with a limit of detection around 1 μM. Cefixime was also measured in the presence of different concentrations of horse serum using the CC electrode without any loss of sensitivity due to surface fouling."

Journal

Antibiotic susceptibility pattern and resistance genes in Salmonella strains isolated from cattle. (PubMed, BMC Vet Res) - "This study provides insights into the antibiotic susceptibility pattern and prevalence of antibiotic resistance genes in Salmonella isolates from Pakistani cattle. The high resistance to oxytetracycline and doxycycline highlights the need for alternative treatment strategies. However, the findings should be interpreted with caution due to the limited sample size and the absence of serotyping, which restricted identification of specific Salmonella serovars. Continued surveillance and targeted control measures remain essential to mitigate the spread of resistant strains."

Journal

Antimicrobial drug-resistant Neisseria gonorrhoeae (GC) infections in men using doxycycline postexposure prophylaxis. A substudy of the ANRS 174 DOXYVAC trial. (PubMed, Clin Infect Dis) - "DoxyPEP use was associated with a significant increase in high-level tetracycline resistance and decreased susceptibility to cefixime in GC. AMR should therefore be closely monitored when using this strategy."

Journal • Human Immunodeficiency Virus • Infectious Disease

Adverse events associated with third-generation cephalosporins: Analysis of the FDA adverse event reporting system database. (PubMed, Medicine (Baltimore)) - "The most reported adverse events of cefotaxime were pain, eosinophilia, and ineffective drugs. Ineffective medication, pyrexia, and sepsis were the most frequently reported adverse effects of ceftazidime. The most reported events of cefdinir were diarrhea, drug hypersensitivity, and rash. The most reported events of ceftriaxone included off-label use, ineffective drugs, and eosinophilia...The most reported adverse events of cefixime included diarrhea, clostridium colitis, and ineffective drugs. This study highlights that gastrointestinal issues, hypersensitivity reactions, and inadequate medication responses are the most commonly reported adverse effects of third-generation cephalosporins. Despite their effectiveness in treating various infections, healthcare professionals must remain vigilant about the potential side effects of these drugs."

Adverse events • Journal • Anorexia • Dermatology • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Pain • Pruritus • Septic Shock

Biogenic synthesis of magnetic nanozymes with peroxidase-like activity for water remediation. (PubMed, Sci Rep) - "UV-Vis spectroscopy showed more than 99% removal of crystal violet and methylene blue in the batch experiments in the presence of FIONPs, while HPLC analysis revealed more than 98% degradation of antibiotic cefixime and chlorpyrifos pesticide. Degradation mechanism of chlorpyrifos was further studied by LC-MS analysis and biocompatibility of degradation products was evaluated in vitro. The overall results indicated high potential of FIONPs for pollutant removal from water."

Journal

Evaluating cefixime for the prevention of congenital syphilis: a multiple-dose pharmacokinetic study (Study 2 of 3) (ANZCTR) - P3 | N=32 | Not yet recruiting | Sponsor: World Health Organization

New P3 trial • Infectious Disease

Evaluating cefixime for the prevention of congenital syphilis: a single-dose pharmacokinetic study (Study 1 of 3) (ANZCTR) - P3 | N=64 | Not yet recruiting | Sponsor: World Health Organization

New P3 trial • Infectious Disease

Evaluating cefixime for the prevention of congenital syphilis: a transplacental transfer study (Study 3 of 3) (ANZCTR) - P3 | N=64 | Not yet recruiting | Sponsor: World Health Organization

New P3 trial • Infectious Disease

The Enteric Fallout of a Systemic STI: New-Onset Inflammatory Bowel Disease After Disseminated Gonococcal Infection (ACG 2025) - "Two months earlier, he was treated for urethral gonorrhea with IM ceftriaxone and oral cefixime. This case underscores the need to consider immune-mediated disease in patients with persistent GI symptoms after systemic infection.Figure: Figure 1. Images acquired during colonoscopy show abnormal patches of inflammation with friable, erythematous, and nodular mucosa at the following locations:Row 1 – Inflammation at the cecum extending into the ascending colon.Row 2 – Inflammation at the hepatic flexure extending into the proximal transverse colon.Row 3 – Inflammation at the descending colon extending into the sigmoid colon."

Anemia • Crohn's disease • Dermatitis • Dermatology • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Rheumatology • Septic Shock

Ofloxacin, paracetamol and cefixime induced Stevens-Johnson syndrome - toxic epidermal necrolysis in an adult female patient: a case report. (PubMed, J Pharm Health Care Sci) - "This case highlights the necessity for clinicians to maintain high suspicion for SCARs in patients presenting with mucocutaneous symptoms and recent drug exposure-even with commonly used medications not frequently associated with SJS-TEN. The unique presentation involving synchronous ocular, nasal, oral, and genital erosions alongside use of a rare drug combination strengthens the need for early recognition, comprehensive clinical assessment, and cautious prescription practices. Individualized treatment and close monitoring are crucial in preventing mortality and minimizing complications. This case underscores the importance of pharmacovigilance and personalized care in managing drug-induced hypersensitivity reactions, especially in resource-limited or polypharmacy scenarios."

Journal • Hematological Disorders • Immunology • Ophthalmology • Pain • Steven-Johnson Syndrome

A case report on urethral prolapse. (PubMed, Oxf Med Case Reports) - "She was managed conservatively with oral cefixime suspension (4 mg/kg/day), ibuprofen, sitz baths, and topical estrogen cream. The prolapsed mass was significantly reduced in size after two weeks and resolved entirely by the sixth week, without residual symptoms. This case highlights the importance of considering urethral prolapse as a differential diagnosis in cases with vaginal bleeding in prepubertal girls."

Journal • Pediatrics

ANTIMICROBIAL SUSCEPTIBILITY PROFILE OF INFECTIOUS AGENTS ISOLATED DURING FEBRILE NEUTROPENIA (FN) EVENTS OF ACUTE LYMPHOBLASTIC LEUKEMIA (AL) PATIENTS FROM PAKISTAN (SIOP 2025) - "Antimicrobial susceptibility testing showed high resistance among Gram negative organisms, with Enterobacteriaceae exhibiting susceptibility rates below 25% for commonly used Beta Lactams, including Cefixime, and Ceftriaxone, whereas carbapenems demonstrated only 40% susceptibility. Pseudomonas aeruginosa displayed susceptibility of around 70% to piperacillin tazobactam, fluoroquinolones, and carbapenems. All Staphylococcus species were susceptible to Vancomycin while Enterococcus species displayed resistance to Ampicillin and Vancomycin in 75% of the isolates, however 100% of them were susceptible to Chloramphenicol and Tigecycline. The above susceptibility results reveal that meropenem monotherapy for gram negative organisms may be suboptimal, suggesting that a combination treatment could enhance coverage. Additionally, vancomycin remains appropriate for targeting gram positive organisms, except for vancomycin-resistant Enterococci."

Clinical • Acute Lymphocytic Leukemia • Febrile Neutropenia • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia

Antibiotic use and adherence to the WHO AWaRe guidelines among patients with influenza-like illness in Bangladesh, 2022-2025 (ASTMH 2025) - "The top five antibiotics were azithromycin (47.8%, 1,428), cefixime (25.5%, 760), amoxicillin (5.2%, 155), levofloxacin (4.2%, 125), and ciprofloxacin (4.1%, 123), accounting for 86.8% of all prescriptions. This study highlights the overuse of Watch group antibiotics and the underuse of Access group antibiotics among ILI patients in Bangladesh, falling substantially below the United Nations General Assembly's 2030 target of 70% Access group use. These findings underscore the urgent need for national antimicrobial stewardship programs to reduce inappropriate antibiotic use and combat antimicrobial resistance in Bangladesh."

Adherence • Clinical • Infectious Disease • Influenza • Respiratory Diseases

Outcome and management of children with chest indrawing pneumonia at primary health care settings in Pakistan: an observational cohort study (ASTMH 2025) - "Oral amoxicillin was prescribed and used by 282 (62.4%) and 236 of those (83.7%) adhered to five or more days of oral amoxicillin treatment. Oral cefixime was prescribed and used by 114 children (25.2%). Our findings support using the IMCI protocol for treating chest indrawing pneumonia without danger signs in children aged 2-59 months with oral antibiotics on an outpatient basis. It can potentially reduce childhood pneumonia deaths, increase access to treatment, improve treatment coverage, reduce referrals and reduce costs for the health system and families in resource-limited settings."

Clinical • Observational data • Cough • Infectious Disease • Pneumonia • Respiratory Diseases

Scrub typhus: A significant and underrecognized cause of acute febrile illness in Kathmandu (ASTMH 2025) - "Azithromycin was the main prescribed antibiotic, followed by cefixime. The observed seasonal, climate-influenced trends and high rates of antibiotic use prior to diagnosis highlight the need for early clinical suspicion. Timely diagnosis and appropriate treatment may help reduce unnecessary antibiotic exposure and improve outcomes."

Cough • Dengue Fever • Pediatrics • Respiratory Diseases

Effectiveness of Antibiotic Regimens in Reducing White Blood Cell Count Within Three to Five Days in Febrile Leukocytosis Treated With Ambulatory Therapy. (PubMed, J Clin Med Res) - "Patients received one of three regimens: (A) single-day intravenous (IV) ceftriaxone followed by oral cefixime, (B) 3-day IV ceftriaxone followed by oral cefixime, or (C) 3-day IV ceftriaxone plus oral doxycycline from day 1. After adjustment, regimen C showed a median WBC reduction of -6.9 × 103 cells/mm3 (95% confidence interval (CI): -7.5 to -6.3), compared with -6.8 × 103 (95% CI: -7.2 to -6.5) for regimen B and -6.6 × 103 (95% CI: -7.0 to -6.2) for regimen A. Differences were not significant (Wald test, P = 0.484), but graphical analysis suggested the steepest decline with regimen C. Though regimen C showed the steepest WBC decline and fewer failures, the study was markedly underpowered (< 10%). Larger multicenter studies are required to confirm these findings."

Journal • Infectious Disease • Septic Shock