cefixime / Generic mfg. - LARVOL DELTA

K1: The Key to a Pyogenic Liver Abscess (ACG 2026) - "Figure: Figure 2. Axial view of interval CT 3 weeks after discharge and after completion of Cefixime course demonstrating near complete resolution of abscess."

Endometriosis • Gynecology • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Pneumonia • Women's Health

Repurposing of non-steroidal anti-inflammatory drugs as adjunct therapies against biofilm-forming Staphylococcus aureus isolated from camel milk. (PubMed, Trop Anim Health Prod) - "Furthermore, In-Vitro combination therapy trials showed synergistic effect of amoxicillin and trimethoprim+sulphamethoxazole with flunixin meglumine and cefixime with meloxicam. This study will provide baseline data on biofilm-forming S. aureus persistence in the camel population, along with devising an effective therapy against biofilm-forming S. aureus infections."

Journal • Infectious Disease

Global genomic surveillance uncovers emergence and spatiotemporal patterns of World Health Organization priority antibiotic resistance in invasive Salmonella. (PubMed, Nat Commun) - "29 (37.7%) of 77 countries identified at least one isolate with resistance or decreased susceptibility to ciprofloxacin, 25 (32.5%) and 29 (37.7%) countries resistance or decreased susceptibility to ceftriaxone and cefixime, 8 (10.4%) countries resistance to azithromycin, 15 (19.5%) countries resistance to fosfomycin, 10 (13.0%) countries resistance to colistin. We generated a global map of clinically key antibiotic resistance genes in invasive Salmonella infections worldwide. This retrospective, global, longitudinal genomic epidemiology study on invasive Salmonella provides evidence-based data for clinical guidelines, genomic surveillance, AMR control, and public health policies."

Journal • Infectious Disease

An AI-Driven Chemogenomics Knowledgebase for Human-Transmissible Pathogens: A Platform for Antimicrobial Drug Discovery. (PubMed, J Chem Inf Model) - "In wet-lab validations, four approved drugs (cefixime, ceftazidime, saquinavir, and rilapladib) identified via virtual screening show binding activity to SARS-CoV-2 nucleoprotein in affinity assays and inhibit SARS-CoV-2 replication in Vero E6 cells, demonstrating HPM-CKB's potential in drug repurposing. Meanwhile, two anti-Staphylococcus aureus lead compounds with novel scaffolds (CYC-HXL-9124 and CYC-HXL-9126) are identified via deep learning, and the potential target protein, cell division protein FtsZ, is subsequently prioritized using HPM-CKB (http://cgai.asia/g/pathogenDB) and experimentally validated by affinity assays. Collectively, these findings establish HPM-CKB as both a chemogenomic knowledgebase and a systematic drug development platform against EIDs."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CKB

Expanding treatment options for syphilis during pregnancy: a review of alternatives to penicillin. (PubMed, Front Glob Womens Health) - "We conducted a review of potential alternatives to penicillin for treating syphilis during pregnancy when penicillin is not available or cannot be used, including ceftriaxone, amoxicillin, doxycycline, cefixime, and linezolid. Going forward, evaluation of new and existing medications for treating syphilis and preventing congenital syphilis should include a pregnancy investigation plan. Where possible, efforts should be made to ensure that high-quality pregnancy safety and efficacy or effectiveness data on drug candidates are generated in carefully designed studies to ensure that pregnant women and their infants are able to benefit from the full range of treatment options."

Journal • Review • Allergy • Immunology • Infectious Disease

Isolation, antibiogram and whole genome sequence analysis of Pasteurella multocida type A from layer birds. (PubMed, PLoS One) - "Phenotypic analyses showed resistance to cefixime, ceftriaxone, ertapenem, and meropenem, while the highest sensitivity was observed for ciprofloxacin, doxycycline, tetracycline, and levofloxacin. These findings highlight the genomic basis of virulence and antimicrobial resistance in P. multocida type A from Bangladeshi layer for the first time. The isolate characterized in this study provides valuable genomic insights and the selection of targeted antimicrobials to improve fowl cholera control strategies."

Journal • Cholera

Antimicrobial Resistance in Neisseria gonorrhoeae Isolates from Men with Urethral or Urogenital Infection: A Systematic Review and Meta-Analysis. (PubMed, Medicina (Kaunas)) - "Cefixime resistance was reported in 748 of 13,154 isolates, corresponding to an aggregate proportion of 5.69%; however, the random-effects estimate was unstable because three studies reported no resistant isolates and events were concentrated in two large datasets. Ceftriaxone resistance varied from 0% to 5.17%, with a pooled estimate of 0.32% (95% CI 0.05-2.15; I2 = 97.8%). Resistance was high but heterogeneous for ciprofloxacin (71.84%, 95% CI 7.53-98.77; I2 = 97.3%) and penicillin (62.47%, 95% CI 36.87-82.58; I2 = 98.1%). Spectinomycin resistance was 2.57% (95% CI 1.58-4.16; I2 = 0%), while azithromycin resistance was 6.38% (95% CI 4.38-9.21; I2 = 94.9%)...The pooled estimates should be interpreted as exploratory summaries rather than current global prevalence values or an independent basis for treatment selection. Standardized reporting of sex, anatomical site, breakpoints, MIC distributions, and resistant/tested counts is needed to improve future surveillance..."

Clinical • Journal • Retrospective data • Review • Infectious Disease • Urology

Natural Polymer-Inspired Thiolated Chitosan Nanoparticles for Improving the Solubility and Antimicrobial Efficacy of Cefixime (ACS-Fall 2026) - "Antimicrobial evaluation demonstrated that the cefixime-loaded thiolated chitosan nanoparticles exhibited significant activity against Staphylococcus aureus, Escherichia coli, and Salmonella typhi, with minimum inhibitory concentration (MIC) values of 50, 6.25, and 0.7 µg/mL, respectively. These findings highlight the potential of natural polymer-inspired nanomaterials as effective platforms for improving drug solubility and combating antimicrobial resistance, reinforcing the role of natural products in driving new discoveries in chemical sciences."

Clinical

Azithromycin with or without cefixime for suspected or culture-confirmed uncomplicated typhoid fever in Nepal, Bangladesh, and Pakistan (ACT-South Asia): a double-blind, parallel-group, randomised, placebo-controlled, phase 4 trial. (PubMed, Lancet Infect Dis) - P4 | "This study supports the WHO recommendation of oral azithromycin alone for treatment of clinically suspected or culture-confirmed uncomplicated typhoid fever,providing no evidence to support addition of cefixime, which has important implications for antimicrobial stewardship."

Journal • P4 data • Dengue Fever • Infectious Disease • Malaria • Novel Coronavirus Disease • CRP

Repurposing Success: Real-World Validation of a Novel Cephalosporin Decontamination Protocol Using Chlorine Dioxide and Disc Diffusion Testing. (PubMed, Appl Biosaf) - "Antimicrobial susceptibility discs (ASDs) contaminated with cephalosporins (Cefalexin, Cefaclor, Cefixime, Cefuroxime) were exposed to both aqueous (400 ppm for 24 h) and gaseous ClO2 (5 mg/L for >5 h) in separate cycles, achieving a minimum cumulative exposure of 9600 ppm-hours in both. Analysis confirmed that cephalosporin residues were degraded to levels below the acceptable limits (<1 μg/disc) with microbial challenge testing supporting the success of the cycle, with no significant biological activity remaining in the discs placed throughout the facility. This study presents the first successful protocol for cephalosporin facility decontamination using gaseous ClO2 in a real-world setting."

Journal • Real-world evidence

Efficient degradation and detoxification of the emerging pollutants antibiotics including sulfonamides and cefixime by the LAC-48-2 laccase/mediator system. (PubMed, J Hazard Mater) - "This study systematically investigated the degradation and abolishment of antibiotic potency and phytotoxicity of 6 sulfonamide antibiotics (sulfadiazine, sulfapyridine, sulfamethoxazole, sulfathiazole, sulfameter, and sulfadimethoxine) and a cephalosporin, cefixime, using purified LAC-48-2 laccase. The LAC-48-2 laccase/ABTS system also efficiently degraded the sulfonamide + cefixime mixture, as laccase treatment could significantly decrease or even completely abolish the antibiotic potency (bacteriostatic activity) of the sulfonamide + cefixime mixture. Treatment with laccase demonstrated strong detoxification capabilities against the phytotoxicity of this mixed antibiotics."

Journal

Carbapenem-Resistant Klebsiella pneumoniae in Clinical Specimens at the University Teaching Hospital of Butare, Rwanda: Antimicrobial Resistance Profiles and Carbapenemase Genes. (PubMed, Am J Trop Med Hyg) - "As a result, Klebsiella isolates exhibited high resistance rates to trimethoprim-sulfamethoxazole (78%), cefuroxime (71.3%), cefixime (72%), and ceftriaxone (66.7%). Moderate resistance to ciprofloxacin (30%) and amoxicillin-clavulanate (42.7%) was observed. In contrast, lower resistance to amikacin (9.3%), imipenem (12%), meropenem (13.3%), and ertapenem (14%) was observed. Of the Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates, 8 (38.1%) tested positive for the blaNDM gene, whereas none harbored the blaKPC gene. This study found a high resistance rate in K. pneumoniae to a widely used antibiotic and confirms the presence of blaNDM, highlighting the need for antimicrobial stewardship and strengthened local surveillance."

Journal • Infectious Disease • Pneumonia

Antibiotic Resistance of Profiles of Escherichia coli Strains From Imported Chicks and Eggs in the Semi-Intensive Poultry Sector of Kinshasa, Democratic Republic of the Congo. (PubMed, Vet Med Int) - "Antibiotic susceptibility testing revealed high resistance to amoxicillin (76%), trimethoprim/sulfamethoxazole (75%), and ampicillin (69%), but little to no resistance to cefuroxime (0%), gentamicin (20%), and cefixime (24%). All imported batches were resistant to at least one antibiotic, with the strains from Belgium and Zambia exhibiting two and five different resistance profiles, respectively. This study demonstrates that the importation of chicks and fertilized eggs into the DRC can lead to the introduction of multidrug-resistant E. coli strains."

Journal

Predicting pH-Dependent Solubility Enhancement and Precipitation Suppression in Drug-Cyclodextrin-Arginine Formulations. (PubMed, Pharmaceutics) - "The approach was applied to representative ternary systems containing repaglinide, sulfadiazine, cefixime, and meloxicam. These observations support the importance of pH and multicomponent interactions in controlling formulation performance in cyclodextrin-containing systems. The obtained profiles may support preliminary optimization of formulation pH and excipient composition before experimental screening."

Journal

Determination of worst-case cephalosporin residues in laboratory glassware using a validated low-level RP-HPLC method. (PubMed, Sci Rep) - "The aim of this study was to assess the efficiency of cleaning laboratory glassware procedures by identifying the level of residual contamination of a worst-case cephalosporin antibiotic, cefixime...Conductivity measurements were used to demonstrate the effective removal of detergent residue, that could not be adequately detected at 254 nm. The integrated analytical method provides a scientifically grounded and regulatory-applicable approach to holistic cleaning validation of laboratory glassware, which facilitates the control of contamination in pharmaceutical analytical facilities without violating the postulates of green analytical chemistry."

Journal

Enhanced gonococcal antimicrobial surveillance programme in India. Insights for Neisseria gonorrhoeae AMR for FY 2025 (AIDS 2026) - "Gentamicin demonstrated complete susceptibility in all tested isolates. EGASP data indicate a high burden of gonococcal infection among symptomatic males with widespread ciprofloxacin resistance. While ceftriaxone and cefixime remain largely effective, for azithromycin there is need for continuous surveillance. Ongoing monitoring through EGASP is critical to guide evidence-based policies for treatment and to prevent the emergence and spread of antimicrobial resistance."

Human Immunodeficiency Virus • Infectious Disease

Occurrence of Salmonella, Listeria monocytogenes, and Escherichia coli O157:H7 in goat and sheep milk from four rural and tribal regions, Fars province, Iran. (PubMed, Iran J Vet Res) - "The E. coli O157:H7 isolates exhibited full or intermediate resistance to ampicillin, cefixime, and chloramphenicol, but they were susceptible to gentamicin, kanamycin, streptomycin, tetracycline, ciprofloxacin, trimethoprim-sulfamethoxazole, and trimethoprim. Despite the low occurrence, the presence of foodborne pathogens in raw milk reinforces the need to control the sale and consumption of raw milk dairy products in rural and tribal regions where goat and sheep farming is of great economic importance."

Journal

Short Course Cefixime to Prevent Irinotecan-Associated Diarrhea in Children With Solid Tumors: A Retrospective Analysis. (PubMed, Pediatr Blood Cancer) - "A 5-day course of prophylactic cefixime, starting on the day of irinotecan initiation, was safe, increased provider ordering compliance, and did not lead to increased irinotecan toxicity."

Journal • Retrospective data • Infectious Disease • Oncology • Pediatrics • Solid Tumor

Molecular determinants of antimicrobial resistance in Klebsiella pneumoniae isolates among geriatric patients in Chattogram, Bangladesh: a cross-sectional study. (PubMed, Microbiol Spectr) - "KPN exhibited high resistance to ceftazidime (96%), cefuroxime (92%), and cefixime (83%), but sensitivity to colistin (79%) and amikacin (75%). Analyzing whole genomes of two KPNs, Kpn007 (ST277) was identified as a hypervirulent strain with aerobactin and yersinia siderophores, contributing to virulence, and Kpn016 (ST420) carried fluoroquinolone (qnrS1), ESBL (blaCTX-M-15 and blaSHV-27) resistance. Both genomes contained K antigens (K20 and K46) and O antigens (O1 and O3b)."

Journal • Observational data • Geriatric Disorders • Infectious Disease • Pneumonia

A robust cd-based coordination polymer with high sensitivity for fluorescent detection of cefixime in environmental water and milk samples. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "Furthermore, when applied to the detection of CEX in environmental water and milk samples, CP 1 achieved satisfactory recovery rates and low relative standard deviations. This study confirms that CP 1, as a fluorescent probe material, holds significant potential for CEX detection in food safety monitoring and environmental analysis."

Journal

A dual-response ratiometric fluorescent probe based on Tb3+/Eu3+-functionalized MOF-membrane on silica microspheres: highly selective detection of cefixime and tetracyclines via a built-in self-calibration strategy. (PubMed, Mikrochim Acta) - "Subsequently, an intelligent detection platform integrating a smartphone and the probe is developed, enabling qualitative and quantitative analysis for the target antibiotics by color gradient recognition. The research presents a sensitive and accurate sensing platform for in situ and visual monitoring of antibiotics by using the dual-mode sensing to eliminate cross-interference among different analytes."

Journal

Aging and aggregation enhance antibiotics persistence and sequestration on polyethylene microplastics. (PubMed, Sci Rep) - "The findings demonstrate that environmental transformation of polyethylene microplastics enhance molecular adsorption of cefixime on polyethylene, with potential implications for contaminant transport, persistence, and ecological exposure in aquatic systems. The results provide mechanistic insight into the role of polymer ageing and aggregation in antibiotic adsorption and contribute to the understanding of antibiotic microplastic interactions."

Journal

Detection and Zoonotic Implications of Shiga Toxin-Producing Escherichia coli in Black Bengal Goats in Bangladesh. (PubMed, Vet Med Sci) - "These findings, although representing a low overall prevalence, demonstrate the presence of diverse virulence profiles in Black Bengal goats, including markers associated with severe human disease in LEE-negative strains. The detection of saa and subA suggests that these goats may serve as a reservoir for atypical STEC strains with zoonotic potential, necessitating broader surveillance strategies."

Journal

Bacterial profiles, antibiotic resistance, and recurrence of UTIs during pregnancy: a prospective cohort study from Palestine. (PubMed, BMC Infect Dis) - "Pregnant women in Palestine face a high burden of UTIs, dominated by E. coli and S. aureus, with alarming levels of multidrug resistance. Strengthening culture-based diagnosis, local resistance surveillance, and antimicrobial stewardship in antenatal care is crucial to improving maternal outcomes and mitigating the spread of antimicrobial resistance."

Journal • Infectious Disease • Nephrology • Obstetrics • Pain

Pharyngeal gonorrhea in Ugandan men with urogenital gonorrhea: differences in antimicrobial resistance and strain types between anatomical sites. (PubMed, J Infect Dis) - "phNG is common in Ugandan men with uNG, both displaying high rates of AMR. Different strains at the two anatomical sites were common, supporting the need for pharyngeal testing and phNG susceptibility testing as the pharynx is a critical site for AMR emergence."

Journal • Human Immunodeficiency Virus • Infectious Disease