imipramine / Generic mfg. - LARVOL DELTA

Synthesis and Biological Evaluation of Novel Chalcone-Based SERT Inhibitors as Potential Antidepressants using the Chronic Unpredictable Mild Stress (CUMS) Model (Neuroscience 2026) - "Group 1: olive oil (10 mL/kg, p.o), group 2: CUMS (Chronic Unpredictable Mild Stress) only, groups 3-5: QC (Quinoline Chalcone) + CUMS (5, 10, 20 mg/kg, p.o), groups 6-8: IC (Indole Chalcone) + CUMS (5, 10, 20 mg/kg, p.o), and group 9: imipramine + CUMS (25 mg/kg, p.o)...QC and IC treatments (5, 10, and 20 mg/kg) significantly reduced immobility time in FST and TST and increased grooming time in SST compared with CUMS-only mice. Additionally, there was a significant increase in antioxidant parameters (CAT, SOD, and GST), a decrease in oxidative and nitrosative stress biomarkers (MDA and NO), suppression of inflammatory mediators and cytokines (TNF-α, IL-6, MPO, and arginase), elevation of monoamine levels (5-HT), and reduction in acetylcholinesterase activity in QC and IC-treated mice, compared to controls.This study showed that both QC and IC have antidepressant-like effects in mice with CUMS via antioxidant, anti-inflammatory, and increased serotonin signaling..."

CNS Disorders • Depression • IL6 • TNFA

iMOSS: An integrated open-source tail suspension test platform for high-resolution immobility scoring and synchronization with neural activity (Neuroscience 2026) - "Additionally, both tools reliably detected changes in behavioral dynamics induced by antidepressant imipramine, confirming sensitivity to pharmacological manipulations. Finally, we demonstrate the platform's utility for systems neuroscience by seamlessly integrating iMOSS behavioral metrics with simultaneous fiber photometry recordings of medial septal glutamatergic calcium activity. Together, the iMOSS platform provides an efficient, user-friendly, and bias-minimized solution for high-throughput behavioral profiling, enabling seamless alignment of physical movement with high-resolution neural dynamics."

CNS Disorders

Chronopharmacology and implications for the safety and efficacy of anticonvulsants, antipsychotics, and antidepressants: A systematic review. (PubMed, J Psychopharmacol) - "Current evidence provides preliminary support that circadian rhythm may differentially affect the pharmacology of select psychotropic agents. Whether the foregoing translates into clinically meaningful differences in efficacy, tolerability, and/or posology of the evaluated agents/classes requires systematic evaluation. Given that evidence is predominantly preclinical, further studies using clinically relevant repeated-dose regimens and disease-relevant animal models are required."

Journal • Review • CNS Disorders • Epilepsy

Multimodal Pharmacologic Strategies for Chronic Cancer Pain: A Systematic Review. (PubMed, Cureus) - "In one trial, duloxetine was associated with clinically meaningful pain-response rates, although its primary mean pain-score analysis was not statistically significant. Low-dose gabapentin plus imipramine reduced pain and rescue-morphine use. Pregabalin reduced the morphine dose required to maintain pain control in one crossover trial, while other pregabalin studies showed numerical or non-significant benefits. Neither nabiximols trial met its primary efficacy endpoint, and nefopam did not significantly improve pain response or morphine consumption...Overall, the evidence remains heterogeneous and insufficient to support a standard multimodal pharmacological regimen. Selected antidepressant and gabapentinoid strategies, particularly in neuropathic cancer pain, may benefit selected patients."

Journal • Review • Addiction (Opioid and Alcohol) • Oncology • Pain

Reduced intra-frontal functional connectivity during a verbal fluency task in depressed individuals with autistic traits: an fNIRS study. (PubMed, Front Hum Neurosci) - "Between-group FC differences were evaluated using ANOVA for the Control versus depressive-state comparison, and medication-adjusted ANCOVA for the DP_AQ-high versus DP_AQ-low comparison, with diazepam-equivalent anxiolytic dosage and imipramine-equivalent antidepressant dosage as covariates. Within the depressive-state group, the DP_AQ-high subgroup consistently demonstrated increased interhemispheric frontoparietal FC across both chromophores, accompanied by localized intra-frontal FC reductions, compared with the DP_AQ-low subgroup. These findings suggest that autistic traits modulate task-evoked large-scale network organization within a clinically relevant depressive-state cohort and support the utility of fNIRS-based network analysis for characterizing neurobiological heterogeneity associated with depressive symptoms."

Journal • Autism Spectrum Disorder • CNS Disorders • Depression • Genetic Disorders • Psychiatry

A hERG blocker facilitates K+ channel current by promoting pore opening while blocking. (PubMed, J Gen Physiol) - "A process that may counteract arrhythmogenic hERG block, termed facilitation, is common to many clinically approved hERG blockers, including nifekalant, amiodarone, promethazine, imipramine, nortriptyline, haloperidol, verapamil, carvedilol, metoprolol, propranolol, quinidine, fluoxetine, and chlorpheniramine. Voltage-clamp measurements revealed that agonism-while-blocking can result in nifekalant block and facilitation. We speculate that this agonism-while-blocking mechanism contributes to the relative safety of hERG blockers that induce facilitation."

Journal • Cardiovascular

FSCN1 promotes rheumatoid arthritis progression via inhibiting TRIM38-mediated ubiquitination of IGF2BP1 in fibroblast-like synoviocytes. (PubMed, Arthritis Rheumatol) - "Pharmacological inhibition of FSCN1 restrains synovial inflammation and joint destruction by suppressing the aggressive phenotype change of FLS, representing a promising therapeutic strategy against RA."

Journal • Immunology • Inflammation • Inflammatory Arthritis • Osteoarthritis • Pain • Rheumatoid Arthritis • Rheumatology • Targeted Protein Degradation • Fascin • FSCN1 • IGF2BP1 • TRIM38

Aromatic thioamides as photo-proxies: Enabling synergistic photocatalytic (sp3)C–(sp3)C coupling reactions with diverse functionalities | Poster Board #1595 (ACS-Fall 2026) - "Under photocatalytic conditions, the thioamides were directly employed to convert alkyl/allyl/benzyl/heterocyclic halides into a diverse range of photoproducts with attractive properties, including the conversion of a few to natural products such as Brittonin A, Imipramine, Honokiol analogs, and bisphenols. My presentation will detail the novel photosynthetic method and highlight the key/elementary photochemical steps."

Macropinocytosis inhibition attenuates fibroblast activation and bleomycin-induced skin fibrosis. (PubMed, J Invest Dermatol) - No abstract available

Journal • Fibrosis • Immunology • Scleroderma • Systemic Sclerosis

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial (clinicaltrials.gov) - P=N/A | N=202 | Recruiting | Sponsor: Mayo Clinic | N=120 ➔ 202

Enrollment change • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor

Tricyclic Antidepressant Poisoning: A 6-year Retrospective Observational Cross-sectional Analysis of Emergency Department Presentation, Clinical Severity, and Hospital Outcomes in a Tertiary Academic Center. (PubMed, Indian J Crit Care Med) - "Amitriptyline was the most common drug (69.3%), followed by imipramine (17.3%). Tricyclic antidepressant overdose, predominantly involving amitriptyline, was commonly triggered by interpersonal issues and frequently presented with altered mental status. Poor outcomes were associated with a higher amitriptyline dose and need for intubation."

Journal • Retrospective data

Beyond rodents: A systematic review of antidepressant-like effects in Drosophila melanogaster as an alternative model in psychopharmacology. (PubMed, Altern Lab Anim) - "Most studies involved adult flies (k = 131), males (k = 56), fluoxetine treatment (k = 109) and courtship outcomes (k = 85). Some studies involved larvae (k = 15), females (k = 39), treatment with other antidepressants (citalopram, k = 12; desipramine, k = 6; amitriptyline, k = 2; imipramine, k = 2) and other outcomes (locomotion, k = 11; sucrose preference, k = 5; light preference, k = 2; aggression, k = 2; climbing, k = 1)...In addition, incomplete reporting precluded an accurate risk-of-bias assessment. These findings highlight the need for standardisation and transparent reporting, in order to establish flies as a reproducible, ethically acceptable alternative to vertebrates in antidepressant research."

Journal • Preclinical • Review • Psychiatry

The gut microbiota mediates the antidepressant effects of imipramine: Evidence from fecal microbiota transplantation and prebiotic inulin intervention. (PubMed, Psychopharmacology (Berl)) - "Imipramine partially exerts its antidepressant activity through microbiota modulation, with putative A. muciniphila and L. reuteri emerging as important mediators. The superior efficacy of the imipramine-inulin combination highlights a promising microbiota-targeted strategy for advancing antidepressant therapy."

Journal • CNS Disorders • Depression • Psychiatry • Transplantation • BDNF • OCLN • TJP1

Imipramine Reverses Sorafenib Resistance in Hepatocellular Carcinoma by Targeting the BLOC1S5/FOXO1 Signaling Axis. (PubMed, Biomed J) - "Clinically, elevated BLOC1S5 expression correlated with poor prognosis, whereas higher FOXO1 levels were associated with favorable outcomes in HCC patients. Collectively, these results highlight the repurposing of imipramine as a promising therapeutic strategy to sensitize HCC cells to sorafenib via modulation of the BLOC1S5/FOXO1 signaling axis."

Journal • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor • FOXO1

Second- and third-line treatment options for refractory monosymptomatic enuresis in children: a scoping review. (PubMed, Eur J Pediatr) - "The results showed that, following first-line treatment, a combination of biofeedback, electrical nerve stimulations, anticholinergics (e.g. oxybutynin, tolterodine, solifenacin), β3-adrenoceptor agonists (e.g. vibegron), tricyclic antidepressants (e.g. imipramine) and selective serotonin reuptake inhibitor (e.g. fluoxetine) improved both partial response (PR) and complete response (CR) at varying rates across highly heterogeneous interventions and study populations...Furthermore, reports on electro-acupuncture, furosemide, onabotulinumtoxin A injections or the herbal medicine 'shokenchuto' were considered unreliable for pure refractory MNE, despite improvements in PR and CR occurring at different rates...Some second- and third-line treatment options may improve PR and CR rates, despite the limited available evidence to support a treatment algorithm. However, further research is needed to confirm these benefits."

Clinical • Journal • Review • Pediatrics • Urinary Incontinence

From Visceral Pain to Emotional Distress: Comparative Effectiveness of Antispasmodics and Antidepressants in Irritable Bowel Syndrome - Systematic Review and Network Meta-analysis. (PubMed, J Gastrointestin Liver Dis) - "Imipramine and alverine/simethicone were superior for reducing abdominal pain, whereas flupentixol-melitracen, peppermint oil, fluoxetine, and vortioxetine demonstrated the strongest anxiolytic effects. Effective options for depression included imipramine, venlafaxine, flupentixol-melitracen, desipramine, and vortioxetine. Notably, amitriptyline uniquely improved overall IBS severity scores, while otilonium bromide, venlafaxine, amitriptyline, and cumin sofouf provided the greatest benefits for QoL. These findings clarify comparative efficacy and may guide tailored pharmacotherapy strategies for IBS patients."

HEOR • Journal • Retrospective data • Review • CNS Disorders • Depression • Gastrointestinal Disorder • Mood Disorders • Pain • Psychiatry

Antidepressant-like effects of Nidus vespae fraction: Evidence from monoamine uptake inhibition, behavioral, biochemical, and histopathological studies. (PubMed, J Neuroimmunol) - "The findings suggest that Nidus vespae fraction exerts antidepressant effects through dual monoaminergic modulation and antioxidant mechanisms, supporting its potential as a natural antidepressant candidate."

Journal • CNS Disorders • Depression • Mental Retardation • Psychiatry • CAT

Repurposing tricyclic drugs as cancer therapeutics: comparative analysis of antitumorigenic effects of chlorpromazine, amitriptyline and imipramine. (PubMed, Front Oncol) - "In contrast, all three drugs exhibited little or no antitumorigenic effect on A375 cells in both in vitro and in vivo experiments.. These findings further the efforts to repurpose the FDA-approved tricyclic drugs CPZ, AmiT, and ImiP for cancer treatment."

Journal • Breast Cancer • Melanoma • Neuroblastoma • Oncology • Solid Tumor • Triple Negative Breast Cancer

Prevalence of Psychotropic Drug Treatment Interventions in Patients Undergoing Metabolic and Bariatric Surgery: A Retrospective Study. (PubMed, Obes Surg) - "Although only a minority of patients required psychotropic drug treatment interventions, monitoring psychotropic drug treatment is essential for safe and effective treatment post-MBS. Greater attention is needed regarding altered drug exposure, and plasma concentration monitoring may help optimize psychotropic pharmacotherapy in these patients."

Journal • Retrospective data • CNS Disorders • Mental Retardation • Pain • Psychiatry

CYP450-based reclassification of urinary metabolic ratio cutoffs for pain management and substance abuse treatment drugs. (PubMed, J Opioid Manag) - "These pairs include dextrorphan/dextromethorphan, oxymorphone/oxycodone, hydromorphone/hydrocodone, O-desmethyltramadol/tramadol, hydromorphone/-morphine, norbuprenorphine/buprenorphine, norfentanyl/-fentanyl, -noroxycodone/-oxycodone, norhydrocodone/hydrocodone, -7-aminoclonazepam/clonazepam, α-hydroxyalprazolam/alprazolam, norquetiapine/quetiapine, meprobamate/carisoprodol, N-desmethyltapentadol/tapentadol, norketamine/ketamine, -2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine/methadone, -desipramine/imipramine, and nortriptyline/amitriptyline. MR-derived phenotype classifications aligned with the phenotype frequencies reported in Zhu et al., indicating that population-level MR distributions reflect known CYP450 genetic variability. Incorporating CYP-specific cutoffs alongside traditional 95 percent RIs may improve identification of expected genetic metabolism, reduce misclassification, and enhance the interpretive accuracy of MR analysis in clinical UDT."

Journal • Pain • Substance Abuse • CYP2C19 • CYP2C9 • CYP3A4

Evaluation of [18F]MFPBG: a novel automatically radiolabeled probe for NET PET imaging. (PubMed, EJNMMI Res) - "[1⁸F]MFPBG demonstrates NET-mediated uptake, stable cardiac retention, low background noise, and suitability for automated radiolabeling, establishing it as a promising agent for cardiac sympathetic nerve imaging with favorable characteristics that warrant further preclinical validation, including in vivo metabolic profiling, to fully assess its clinical translatability."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Imipramine Can Block Human Cardiac H1-Histamine Receptors. (PubMed, J Cardiovasc Pharmacol) - "We conclude that imipramine can antagonize H1-histamine receptor mediated positive inotropic effects in the mammalian atrium in general and, of note, in the human atrium. This may explain cardiac side effects of imipramine."

Journal

Deacetyl xylopic acid exhibits synergistic antidepressant-like effects and augments fluoxetine activity in a chronic restraint-induced depression model in mice. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "The interaction index (γ), together with the significantly lower ED50mix compared to the ED50add, for the dXA combinations, with fluoxetine, sertraline, imipramine and ketamine is indicative of synergistic effect. The present study demonstrates that deacetyl xylopic acid (dXA) exerts synergistic antidepressant-like effects with selective antidepressants and augments the antidepressant effects of fluoxetine in a mouse model of chronic restraint stress-induced depression. These findings suggest that dXA may represent a promising adjunctive agent for improving antidepressant efficacy, particularly in stress-related depressive disorders."

Journal • Preclinical • CNS Disorders • Depression • Mood Disorders • Psychiatry

Imipramine inhibits feline infectious peritonitis virus infection by targeting host cholesterol metabolism via NPC1. (PubMed, Antimicrob Agents Chemother) - "Notably, in an in vivo model, imipramine treatment reduced viral loads and alleviated clinical signs in FIPV-infected cats. These findings collectively identify imipramine as a promising, host-targeted therapeutic candidate for FIP."

Journal • Infectious Disease

Sex differences in antidepressant serum levels (CINP 2026) - " Serum levels of amitriptyline, nortriptyline, citalopram, clomipramine, fluoxetine, fluvoxamine, imipramine, mirtazapine, paroxetine, sertraline, and venlafaxine, along with their active metabolites, were collected from the laboratory information system (GLIMS) database of the University Medical Centre Groningen (UMCG) between January 2016 and October 2024. Under current treatment guidelines, women are exposed to significantly higher antidepressant serum levels than men for citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, clomipramine, imipramine, nortriptyline, and venlafaxine. Subgroup analyses confirmed that the observed sex differences are unlikely to result from dosing practices but instead reflect sex differences in underlying mechanisms such as pharmacokinetic variations or sex-specific epigenetic regulation of hepatic drug-metabolizing enzymes. Whereas most antidepressants investigated are prescribed using standardized dosing regimens, dosing of..."

CNS Disorders • Depression • Mood Disorders • Psychiatry