DepoDur (morphine liposomal) / Pacira - LARVOL DELTA

Nanotechnology for pain management in orthopedic surgery. (PubMed, World J Orthop) - "This narrative review evaluated the potential of nanotechnology platforms (DepoFoam bupivacaine®, DepoDur®, Exparel®, Zynrelef®, NeuroCuple™) in the control of postoperative pain following orthopedic procedures...All EREM dosages diminished the mean fentanyl usage vs placebo and delayed the median time to first dose of fentanyl...Opioid consumption was reduced by 37% in the Zynrelef® PR cohort vs 25% in the bupivacaine HCl cohort. In individuals experiencing total knee arthroplasty and total hip arthroplasty, the use of a nanotechnology-based NeuroCupleTM device diminished postoperative pain at rest by 34% and reduced pain with movement by 18%."

Journal • Review • Anesthesia • Orthopedics • Pain

Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures (clinicaltrials.gov) - P1 | N=200 | Active, not recruiting | Sponsor: University of Utah | Enrolling by invitation ➔ Active, not recruiting

Enrollment closed • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

Nanotechnology for Pain Management. (PubMed, J Clin Med) - "This formulation is the base of DepoDur™, which comprises a combination of liposomes and extended-release morphine, and Exparel™, which comprises a combination of liposomes and extended-release bupivacaine...The use of liposome led to the development of DepoDur™, bupivacaine Exparel™ and a mixture of bupivacaine and meloxicam (Zynrelef™) and more recently lidocaine liposome formulation... Increasing evidence supports the concept that nanotechnology may represent a valuable tool as a drug transporter including liposomes and as a nanocapacitor-based device/patch to reduce or even eliminate the use of opioids in surgical patients. However, more studies are required to confirm this concept, especially with the use of nanotechnology incorporated in devices/patches."

Journal • Review • Addiction (Opioid and Alcohol) • Gastroenterology • Orthopedics • Pain

Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures (clinicaltrials.gov) - P1 | N=200 | Enrolling by invitation | Sponsor: University of Utah | Trial completion date: May 2023 ➔ May 2026 | Trial primary completion date: May 2023 ➔ May 2026

Trial completion date • Trial primary completion date • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures (clinicaltrials.gov) - P1 | N=150 | Active, not recruiting | Sponsor: University of Utah | Enrolling by invitation ➔ Active, not recruiting | Trial completion date: Mar 2023 ➔ Mar 2026 | Trial primary completion date: Mar 2023 ➔ Mar 2026

Enrollment closed • Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics • Pain

Depodur vs Fentanyl Infusion for Post-C/S Analgesia (clinicaltrials.gov) - P=N/A | N=0 | Withdrawn | Sponsor: Goodman, Evan, M.D. | N=300 ➔ 0 | Not yet recruiting ➔ Withdrawn

Enrollment change • Trial withdrawal

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures (clinicaltrials.gov) - P1; N=150; Enrolling by invitation; Sponsor: University of Utah

New P1 trial • Musculoskeletal Diseases • Orthopedics • Pain

Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures (clinicaltrials.gov) - P1; N=200; Enrolling by invitation; Sponsor: University of Utah

New P1 trial • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

Effect of Regional Analgesia Techniques on Opioid Consumption and Length of Stay After Thoracic Surgery. (PubMed, Semin Cardiothorac Vasc Anesth) - "Multimodal analgesia involving regional anesthetic alternatives to TEA could help manage postoperative pain in thoracic surgery patients."

Journal • Anesthesia • Pain

Liposomal bupivacaine (Exparel®) administration in open radical cystectomy is associated with decreased post-operative pain, length of stay, and opioid use (AUA 2019) - "Our data shows that use of LB in radical cystectomy is well tolerated and may significantly reduce LOS, decrease perioperative opioid requirements, and improve patient-reported pain scores when compared to historical controls. Additional patient enrollment and evaluation is needed to demonstrate continued benefit of LB."

Pain

The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision (clinicaltrials.gov) - P=N/A; N=0; Withdrawn; Sponsor: University of Texas Southwestern Medical Center; N=500 ➔ 0; Active, not recruiting ➔ Withdrawn

Clinical • Enrollment change • Trial withdrawal • Pain

Intrathecal Morphine Versus Extended-Release Epidural Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion. (PubMed) - Anesth Analg - "There was no difference in total morphine consumption or time until first PCA demand between the EREM and IT morphine groups. EREM provides a longer duration of analgesia after posterior spinal fusion for scoliosis and may be associated with less opioid-induced pruritus."

Journal • Biosimilar • CNS Disorders • Depression • Pain

Liposomal Bupivacaine Efficacy for Post-Operative Pain Following Posterior Vaginal Surgery: A Randomized, Double-Blind, Placebo Controlled Trial. (PubMed, Am J Obstet Gynecol) - "The use of extended-release liposomal bupivacaine in posterior vaginal wall surgeries, injected into the lateral posterior vaginal wall and perineal body, does not provide a significant decrease in post-operative pain or decrease narcotic medication usage when compared to saline."

Clinical • Journal