salmeterol xinafoate (LIPO-202) / Evofem Biosci - LARVOL DELTA

Determination of the enantiomers of salmeterol xinafoate in salmeterol fluticasone powder inhalant by chiral nonaqueous capillary electrophoresis (PubMed, Se Pu) - "The results showed that the percentage of labeled quantities was 98.7% for both enantiomer 1 and enantiomer 2, with RSDs of 2.5% and 2.7%, respectively. Thus, this method is simple, feasible, accurate, and inexpensive, and can be applied for the determination of SalX enantiomers in commercially available salmeterol fluticasone powder inhalants."

Journal • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Incidence of oral thrush in patients with COPD prescribed inhaled corticosteroids: Effect of drug, dose, and device. (PubMed) - Respir Med - "ICS use increases oral thrush incidence in COPD and this effect is dose-dependent for FP/SAL therapies. Of the therapies assessed, FP/SAL pMDI and BUD/FOR DPI may be more protective against oral thrush."

Journal • Biosimilar • Chronic Obstructive Pulmonary Disease • Immunology

Detection and pharmacokinetics of salmeterol in thoroughbred horses following inhaled administration. (PubMed) - J Vet Pharmacol Ther - "Salmeterol xinafoate (Serevent Evohaler(®) ) was administered (0.1 mg twice daily for 4.5 days) via inhalation to six horses. Average estimated urine concentration at steady-state was obtained via PK modelling and used to estimate a urine concentration of 59 ± 34 pg/mL as a marker of effective lung concentration. From this, potential detection times were calculated using a range of safety factors."

Journal • Biosimilar

Study to Evaluate the Safety and Efficacy of LIPO-202 for the Reduction of Submental Subcutaneous Fat (clinicaltrials.gov) - P2; N=162; Active, not recruiting; Sponsor: Neothetics, Inc; Recruiting ➔ Active, not recruiting

Enrollment closed • Biosimilar

Extension Study to Evaluate the Post-Treatment Safety and Duration of Clinical Effect of LIPO-202 (clinicaltrials.gov) - P3; N=100; Terminated; Sponsor: Evofem Inc.; N=1077 ➔ 100

Clinical • Enrollment change

Clinical and inflammatory phenotypic features of asthmatic patients sensitive to cold stimulation (PubMed, Nan Fang Yi Ke Da Xue Xue Bao) - "The cold-sensitive asthmatic patients experience frequent recurrent and/or aggravated symptoms and have obvious lung function impairment. Different from that in patients with classic asthma, the airway inflammatory phenotype in these patients is characterized by the domination by neutrophilic subtype."

Clinical • Journal

Evaluating the Safety and Efficacy of LIPO-202 for the Reduction of Central Abdominal Bulging Due to Subcutaneous Fat (AbCONTOUR2) (clinicaltrials.gov) - P3; N=793; Completed; Sponsor: Evofem Inc.; Active, not recruiting ➔ Completed

Clinical • Trial completion