famotidine / Generic mfg. - LARVOL DELTA

A rare case of KIT-negative indolent systemic mastocytosis without anaphylaxis (ASH 2025) - "That same month, he began cetirizine 10mg daily for diffuse pruritus, later increased to cetirizine 10mg twice a day and 10mg famotidine daily for abdominal pain. Conclusion Clinicians should maintain a high index of suspicion for indolent systemic mastocytosis even when only a single hallmark symptom is present. Recognizing atypical presentations such as this one is essential to avoid delays in diagnosis and ensure timely care that can prevent worsening symptoms and complications."

Clinical • CNS Disorders • Dermatology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Orthopedics • Pruritus • Respiratory Diseases • CD2 • IL2RA

Motixafortide + G-CSF hematopoietic stem cell mobilization in patients with multiple myeloma following quadruplet induction therapy (ASH 2025) - P1, P3 | "All patients received"enhanced" premeds with: loratadine (10 mg, PO), famotidine (20 mg, PO) and montelukast (10 mg, PO)daily on Day 1-5; plus acetaminophen (975mg, PO), hydrocortisone (200 mg, IV), diphenhydramine (25mg, IV) and famotidine (20 mg, IV) on Day 4 (30-45 mins pre-M). Meanwhile,enhanced premeds were associated with a low rate of AEs relative to standard premeds. Ongoingextended immunophenotyping may shed insight into the mechanism of impaired HSC mobilization post-quad induction, possibly via targeted depletion of a large population of CD38+ HSCs within the CD34+graft."

Clinical • Dermatology • Hematological Malignancies • Multiple Myeloma • Pruritus • CD34

BH09 Rapid resolution of chronic spontaneous urticaria with ritlecitinib in a patient with alopecia universalis. (PubMed, Br J Dermatol) - "Initial management included high-dose fexofenadine, famotidine, montelukast and omalizumab...Pulsed dexamethasone provided modest improvement in her urticaria symptoms but did not alter the progression of her alopecia...While JAK inhibitors are not established as a standard treatment for CSU, limited case series have documented the use of tofacitinib in refractory cases...The rapid and sustained symptom resolution observed in this patient suggests the potential of ritlecitinib as a novel therapeutic option for refractory CSU. Further investigation is warranted to evaluate its broader clinical applicability and efficacy in CSU management."

Journal • Alopecia • Asthma • Chronic Spontaneous Urticaria • Dermatology • Endocrine Disorders • Immunology • Pulmonary Disease • Respiratory Diseases • Urticaria

Interdisciplinary pharmaceutical care model engaging patient participation alleviate the anticholinergic burden in community-dwelling older adults: subgroup analysis of a randomized controlled trial. (PubMed, Ther Adv Drug Saf) - "Famotidine, tramadol, alprazolam, and celecoxib were the most commonly prescribed and discontinued S-type AC drugs. This community-based interdisciplinary pharmaceutical care model, which included patient participation, was effective in reducing the burden of S-type AC drugs among older adults in rural communities."

Journal • Alzheimer's Disease • Cognitive Disorders • Xerostomia

Green synthesis of silver nanoparticles in deep eutectic solvent and their application in an electrochemical sensor for famotidine determination in pharmaceutical and biological samples. (PubMed, Talanta) - "Excellent performances were verified for repeatability, anti-interferences features, and to determine FMT in pharmaceutical and biological fluid samples. Key metrics such as the diffusion coefficient ((1.1 ± 0.5) × 10-4 cm2 s-1) and catalytic constant ((1.0 ± 0.1) × 103 mol-1 L s-1) were significantly improved with the addition of AgNPs in the sensor."

Journal • Review

T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers (clinicaltrials.gov) - P1 | N=36 | Terminated | Sponsor: National Cancer Institute (NCI) | Completed ➔ Terminated; Site plans to become a site for a multicenter study of this therapy

IO biomarker • Trial termination • Gene Therapies • Lung Cancer • Oncology • Solid Tumor

New Kinetic Investigations to Better Understand the Mechanism of Polymorphic Transformations of Pharmaceutical Materials Induced by Milling. (PubMed, Pharmaceutics) - " For each compound, the kinetics of the polymorphic transformation was found to be sigmoidal and the presence of an intermediate amorphous phase during the transition from the initial to the final polymorphic form was also identified. The kinetic data obtained for sulfamerazine and glycine, together with the detection of an amorphous intermediate during the transformations of mannitol and famotidine, support the conclusion that milling-induced polymorphic transformations in pharmaceutical materials generally proceed via an amorphization-recrystallization mechanism."

Journal

A Study to Assess the Effect of Itraconazole, Rifampin, and Acid-Reducing Agents on INCB161734 Pharmacokinetics When Administered Orally in Healthy Participants (clinicaltrials.gov) - P1 | N=63 | Completed | Sponsor: Incyte Corporation | Recruiting ➔ Completed

Trial completion

Famotidine-Induced Rash and Eosinophilia: A Case Report. (PubMed, Cureus) - "He initially received intravenous gentamicin followed by oral amoxicillin-clavulanic acid for the urinary tract infection. Oseltamivir and carbocisteine were prescribed for the flu...Considering the timing of the rash and the patient's lack of prior adverse reactions to penicillin, famotidine was identified as the most probable causative agent for the rash. The rash improved following discontinuation of famotidine, supporting the diagnosis of famotidine-induced hypersensitivity reaction."

Journal • Allergy • Cardiovascular • Eosinophilia • Heart Failure • Immunology • Infectious Disease • Influenza • Nephrology • Respiratory Diseases

Evaluating Premedication Regimens (Methylprednisolone vs Dexamethasone-based) for the Prevention of Systemic and Injection Site Reactions to Motixafortide in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization, PARADE Trial (clinicaltrials.gov) - P4 | N=94 | Recruiting | Sponsor: Emory University | Not yet recruiting ➔ Recruiting

Enrollment open • Allergy • Hematological Malignancies • Multiple Myeloma • Oncology

Identification of potential TMPRSS2 inhibitors via high-throughput screening based on oriented immobilized cell membrane chromatography technology. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "Preliminary activity validation revealed that the screened famotidine and TS0665 effectively inhibited pseudovirus infection of cells. These findings provide an experimental foundation for the subsequent development of antiviral therapeutics."

Journal • Infectious Disease • Novel Coronavirus Disease • TMPRSS2

Histamine mediates food intake, but not muscle adaptations, following 10 weeks of resistance training in humans. (PubMed, J Physiol) - "Acute study: Eight men performed three resistance training sessions with intake of either placebo, H1-receptor antihistamine (180 mg fexofenadine) or combined H1/H2-receptor antihistamine (540 mg fexofenadine/40 mg famotidine). Histaminergic crosstalk in the muscle microenvironment is involved in endurance and high-intensity interval training adaptations, but this may not be a universal mechanism across all training modalities. Histamine blockade leads to increased habitual carbohydrate intake and fat mass following 10 weeks of resistance training, possibly due to histamine's role in hypothalamic appetite regulation."

Journal • Allergy • Hypotension • Immunology

Collagenous gastritis, hyperplastic polyp, and intraepithelial duodenal lymphocytosis in a 15-year-old child: An iconographic case report. (PubMed, Medicine (Baltimore)) - "In consideration of a colon-rectal cancer diagnosis of his father at the age of 45 years, we carried out a Search Tool for the Retrieval of Interacting Genes/Proteins and Pymol-based Protein Data Bank study and found that interleukin-4 may be the key factor supporting the occurrence of hyperplastic polyps in collagenous gastritis."

Journal • Colon Cancer • Colorectal Cancer • Fatigue • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Oncology • Rectal Cancer • Solid Tumor • IL4

Preliminary efficacy and safety profile of dual histamine blockade on preventing filgrastim-associated bone pain in breast cancer patients: Randomized controlled trial. (PubMed, Br J Clin Pharmacol) - "The prophylactic dual histamine blockade strategy, when administered alongside filgrastim, could significantly ameliorate the incidence and severity of G-CSF-associated bone pain, and therefore improve patient's QoL. Further larger clinical studies are warranted to validate the clinical utility of this novel approach."

Journal • Breast Cancer • Musculoskeletal Pain • Oncology • Pain • Solid Tumor

Asparaginase-Associated Toxicities and Hypersensitivity Reactions in Pediatric and Adolescent Down Syndrome Patients with Acute Lymphoblastic Leukemia or Lymphoma (ASH 2023) - "Pegaspargase (PEG) is integral in protocols for the treatment of pediatric ALL and lymphoblastic lymphoma (LBL), and full exposure to all doses of PEG can be limited by toxicities, including hypersensitivity reactions (HSR) due to the production of anti-asparaginase antibodies rendering PEG therapy ineffective...An H1 blocker (diphenhydramine) and H2 blocker (ranitidine, famotidine or cimetidine) were administered prior to PEG administration in consolidation and subsequent cycles...Most toxicity occurred during the consolidation phase and no grade 4 or 5 toxicities were observed. Given the PEG-associated toxicity observed in DS ALL/LBL, we are conducting pharmacokinetic analysis to propose a lower dose of PEG which may minimize toxicity while maintaining therapeutic efficacy."

Clinical • Acute Lymphocytic Leukemia • Developmental Disorders • Genetic Disorders • Hematological Malignancies • Hepatology • Immunology • Leukemia • Lymphoma • Obesity • Oncology • Pediatrics

Successful Management of D816V Mutated c-KIT Systemic Mastocytosis with Chronic Imatinib: A Case Report (ASH 2023) - "When reactions did occur, she treated them at one point with a cocktail of an histamine-2 blocker (ranitidine), histamine-1 blocker (diphenhydramine), and a mast cell stabilizer (cromolyn) and without requiring the use of epinephrine...After the most recent BMB the patient altered her daily regimen due to gastric upset and found she could take of her histamine-1 blocker (diphenhydramine) once daily along with a twice daily regimen of her imatinib (split into two smaller daily doses), histamine-1 antagonist (cetirizine), her histamine-2 antagonist (famotidine), and citalopram (selective serotonin reuptake inhibitor or SSRI) with improved symptomatic control to this day. This case serves to illustrate the diagnostic and therapeutic challenges associated with SM, as well as the potential therapeutic use of imatinib in patients with D816V outside of its original FDA indication. Further characterization of the effect of imatinib on D816V mutated SM may warrant the..."

Case report • Clinical • Atrial Fibrillation • Endocrine Disorders • Gastroenterology • Gastroesophageal Reflux Disease • Hematological Disorders • Metabolic Disorders • Myeloproliferative Neoplasm • Oncology • Rare Diseases • FLT3 • IDH1 • IDH2 • KIT • NPM1

Ironing out the Wrinkles: Low Molecular Weight Iron Dextran and Premedications (ASH 2023) - "Serious infusion reactions with LMW ID were rare (n=2, 2.1%), and neither patient required epinephrine administration nor hospitalization...The incidence of AEs was compared with individual premedication, and lower incidences were seen in 64 (66.7%) patients with diphenhydramine (3.1% vs 18.8%, χ2 = 6.82; P =0.015), 50 (52.1%) with methylprednisolone (2.0% vs 15.2%, χ2 = 5.48; P =0.022), and 46 (47.9%) with acetaminophen (0.0% vs 16%, χ2 = 8.03; P =0.004)...By contrast, there was no significant difference in patients receiving famotidine, suggesting that while acetaminophen may be a useful premedication, famotidine may not be beneficial...Both our study and the prior multi-center study noted an increased incidence of infusion reactions in patients with a history of allergies, and both demonstrated the rarity of serious reactions. Based on these results and the prior studies indicating the increased cost of other IV iron formulations, consideration of reinstitution of LMW..."

Hematological Disorders • Hypotension • Immunology

Docking-MD Polypharmacy Screening Study of Loop D of Human Aquaporin 1 (KIDNEY WEEK 2025) - "The results necessitate experimental validation but could represent new adjunctive options in the treatment of some cancers and compounds to avoid in peritoneal dialysis. The best docked position of famotidine (A), carbidopa (B), lisinopril (C), and bendroflumethiazide (D) with loop D of human AQP1."

AQP1

Polypharmacy Beyond Prescriptions: A Case of Acute Interstitial Nephritis and Hyponatremia Induced by a Spanish Herbal Supplement (KIDNEY WEEK 2025) - "She had recently taken a single dose of Trimethoprim-sulfamethoxazole and intermittently used azole antifungals, loperamide, and a Spanish supplement (Feminabiane CU Flash) marketed for urinary tract symptoms...She was started on prednisone 60 mg daily, with Trimethoprim-sulfamethoxazole and famotidine for prophylaxis...Greater awareness is needed to recognize supplements as a potential and underappreciated cause of AIN. Ingredients"

Clinical • Cardiovascular • CNS Disorders • Heart Failure • Huntington's Disease • Inflammation • Insomnia • Movement Disorders • Nephrology • Renal Disease • Sleep Disorder

Population Pharmacokinetics of Atogepant for the Prevention of Migraine. (PubMed, Clin Pharmacokinet) - P3 | "The pharmacokinetics of atogepant are similar in healthy participants and patients with CM or EM. Dose adjustments owing to intrinsic factors of age, sex, race, and body weight, or owing to concomitant medications consisting of P-glycoprotein (P-gp) inhibitors, BCRP inhibitors, oral contraceptive components (ethinyl estradiol and levonorgestrel), famotidine, esomeprazole, sumatriptan, acetaminophen, and naproxen are not necessary. Atogepant's popPK model provides a valuable tool for evaluating specific questions for patients, healthcare providers, and regulatory agencies. Integration into other modeling approaches has also aided in model-informed drug development decisions."

Journal • PK/PD data • Breast Cancer • CNS Disorders • Hepatology • Migraine • Oncology • Pain • Renal Disease • Solid Tumor

Asparaginase Premedication with Hydrocortisone Decreases Hypersensitivity Reactions (ASH 2024) - "All patients who received pegaspargase were reviewed...Grade 2 reactions included the use of intravenous diphenhydramine, while grade ≥3 reactions included intramuscular epinephrine.Results : In 86 patients analyzed over a 2-year period, 48 were in the pre-intervention group given a two-drug regimen of diphenhydramine and famotidine prior to PEG or calaspargase...The incidence of HSR and IR were 16% and 13% respectively. Based on this data, rates of IR remained unchanged, while rates of HSR decreased significantly by approximately 50% (p-value 0.0411) with the addition of hydrocortisone to the pre-medication regimen.Conclusions : Universal premedication with the inclusion of hydrocortisone can significantly decrease HSR rates and serves as a useful strategy in the treatment of ALL/LL."

Acute Lymphocytic Leukemia • Cough • Dermatology • Hematological Malignancies • Immunology • Leukemia • Lymphoma • Oncology • Respiratory Diseases • Urticaria

Comparative Analysis of Dexamethasone-Enhanced Pre-Medication in Motixafortide-Induced Hematopoietic Stem Cell Mobilization for Multiple Myeloma: A Retrospective Study (ASH 2024) - "Our first 3 patients received the recommended premedication protocol which is oral doses of diphenhydramine 25 to 50 mg, famotidine 20 mg, montelukast 10 mg, and acetaminophen 650 mg, approximately 60 minutes before injection. Patients also received loratadine 10 mg daily beginning on the day of G-CSF initiation, 3 days prior to motixafortide...Subsequently, 16 patients were started on MF-DEX, which consisted of starting famotidine 20 mg, montelukast 10 mg on the day of growth factor administration and continuing until 1 day after collection (5 days total), along with IV dexamethasone 8 mg added onto the standard premedications listed previously...Although patients who received the standard premedications had no grade 4 events and all AEs were manageable with supportive care, it was a clear burden to our patients and nursing staff. After adoption of MF-DEX our center has seen less hypersensitivity reactions and patient outcomes have improved."

Retrospective data • Dermatology • Hematological Malignancies • Immunology • Multiple Myeloma • Oncology • Pruritus • Urticaria • CD34

From Reaction to Resolution: Amphotericin B Desensitization in a High-Risk Host (ACAAI 2025) - "Abstract Introduction Liposomal amphotericin B (amphoB) is a polyene antimycotic agent frequently used to treat invasive fungal diseases in immunocompromised patients...The patient underwent a 3-bag, 12-step amphoB desensitization protocol (Figure 1) in the ICU with pre-medications (diphenhydramine, famotidine and systemic steroids) with only subjective symptoms (mild facial flushing on steps 1 and 11; throat pruritus on step 12) treated with diphenhydramine...Successful administration using a 3-bag, 12-step desensitization protocol highlights the feasibility of safely reintroducing amphoB, particularly when no alternative antifungal agents are suitable. Desensitization can be consider for either IgE-mediated or cytokine release storm related anaphylaxis."

Back Pain • Dermatology • Febrile Neutropenia • Hematological Malignancies • Hypotension • Infectious Disease • Lymphoma • Musculoskeletal Pain • Peripheral T-cell Lymphoma • Pneumonia • Pruritus • Respiratory Diseases • T Cell Non-Hodgkin Lymphoma

Benefit of Up-Dosed Omalizumab in Treatment-Refractory Neutrophilic Urticaria (ACAAI 2025) - "Case Description 44 y/o Female BMI 33 presented with pruritic, painful urticaria starting on the lower extremities, becoming generalized with facial angioedema, despite cetirizine 20 mg, famotidine 40 mg BID, prednisone 60mg daily, then Kenalog 60 mg IM...Based on histology, dapsone 100 mg BID with colchicine was trialed for 1 month without improvement...The clinical significance of neutrophilia on skin biopsy remains unclear, is not well established within phenotype/endotype paradigms, and in treatment-refractory cases, broadens considerations to include other neutrophilic dermatoses. This patient demonstrated significant benefit from up-dosed omalizumab, supporting this as a therapeutic option."

Cardiovascular • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria • Vasculitis

Identifying and Managing Anaphylaxis During Hemodialysis (ACAAI 2025) - "Patient A experienced recurrent hypotension during dialysis refractory to albumin, midodrine, dialysis without ultrafiltration, and premedication with a corticosteroid, antihistamine and H2 blocker...Patient B tolerated HD with the cellulose membrane, cetirizine and famotidine premedication, and priming the tubing with 2L NS due to continued ethylene oxide exposure from the tubing. Discussion Rising numbers of patients on HD makes recognition and management of hypersensitivity reactions crucial, particularly in resource-limited situations. Though medications are the most common cause of severe reactions, providers should consider dialyzer membranes, which are associated with pseudoallergic reactions, and the sterilizing agent ethylene oxide, which is a known trigger of anaphylaxis."

Chronic Kidney Disease • Dermatology • Hematological Malignancies • Hypotension • Immunology • Multiple Myeloma • Renal Disease • Urticaria