famotidine / Generic mfg. - LARVOL DELTA

CR16: Real-World Incidence of Infusion-Related Reactions with Sacituzumab Govitecan and Opportunities for Premedication De-escalation (HOPA 2026) - "Most patients also received the appropriate pre-medications, including diphenhydramine (98.8%), famotidine (97.6%), and acetaminophen (97.6%), along with dexamethasone (98.8%) already included in their antiemetic regimen. In this real-world cohort, no IRRs were observed with SG, suggesting greater tolerability than reported in clinical trials. Some patients tolerated premedication de-escalation, with de-escalation occurring as early as dose 3. Given the low incidences of IRRs, these findings support further investigation into developing protocols to safely reduce premedication requirements and potentially shorten observation times."

Clinical • Real-world • Real-world evidence • Breast Cancer • Solid Tumor

Infusion-Related Reactions in Patients Treated With Axatilimab for Chronic Graft-Versus-Host Disease in the AGAVE-201 Study (HOPA 2026) - P2 | "At the time of the IRR, 13 patients (56.5%) were receiving concomitant medications, mainly prednisone (26.1%), prednisolone (21.7%), topical hydrocortisone (13.0%), famotidine (13.0%), hydrocortisone (8.7%), and diphenhydramine (8.7%). Of the 239 patients who received axatilimab during AGAVE-201, 23 patients (9.6%) experienced 38 IRRs. IRR incidence by group was 11/79 patients (13.9%) for 0.3 mg/kg Q2W, 5/81 patients (6.2%) for 1 mg/kg Q2W, and 7/79 patients (8.9%) for 3 mg/kg Q4W. Among these 23 patients, cGVHD most commonly involved the eyes (69.6%), skin (69.6%), and lungs (56.5%)."

Clinical • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Urticaria

Real-World Incidence of Infusion-Related Reactions With Sacituzumab Govitecan and Opportunities for Premedication De-Escalation (HOPA 2026) - "Most patients also received the appropriate premedications, including diphenhydramine (98.8%), famotidine (97.6%), and acetaminophen (97.6%), along with dexamethasone (98.8%) already included in their antiemetic regimen. In this real-world cohort, no IRRs were observed with sacituzumab govitecan, which suggests greater tolerability than in clinical trials. Some patients tolerated premedication de-escalation, with de-escalation occurring as early as dose 3. Given the low incidences of IRRs, these findings support further investigation into developing protocols to safely reduce premedication requirements and potentially shorten observation times."

Clinical • Real-world • Real-world evidence • Breast Cancer • Solid Tumor

A Study to Learn How Different Preparations of Osivelotor Taste and Enter the Blood With Food or Liquids or With an Antacid in Healthy Adults (clinicaltrials.gov) - P1 | N=52 | Not yet recruiting | Sponsor: Pfizer | Trial completion date: Oct 2026 ➔ May 2027 | Trial primary completion date: Oct 2026 ➔ Feb 2027

Trial completion date • Trial primary completion date • Pediatrics

POSITIVE OUTCOMES AMONG PEDIATRIC HCT PATIENTS TREATED WITH DARATUMUMAB FOR AUTO-IMMUNE HEMOLYTIC ANEMIA (EBMT 2026) - "Premedication for daratumumab infusion included diphenhydramine, solumedrol, acetaminophen and famotidine. The majority of patients with AIHA post-HCT were refractory to initial treatment with corticosteroids and rituximab. Daratumumab was well tolerated in this patient cohort. All patients with refractory AIHA treated with daratumumab achieved resolution."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Immunology • Metabolic Disorders • Pediatrics • Primary Immunodeficiency

POSITIVE OUTCOMES AMONG PEDIATRIC HCT PATIENTS TREATED WITH DARATUMUMAB FOR AUTO-IMMUNE HEMOLYTIC ANEMIA (EBMT 2026) - "Premedication for daratumumab infusion included diphenhydramine, solumedrol, acetaminophen and famotidine. The majority of patients with AIHA post-HCT were refractory to initial treatment with corticosteroids and rituximab. Daratumumab was well tolerated in this patient cohort. All patients with refractory AIHA treated with daratumumab achieved resolution."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Immunology • Metabolic Disorders • Pediatrics • Primary Immunodeficiency

SEVERE HYPOMAGNESEMIA IN A DIABETIC PATIENT ON MULTIPLE LONG-TERM MEDICATIONS (ISN-WCN 2026) - "Vonoprazan, metformin, and semaglutide were discontinued, and intravenous magnesium and calcium supplementation was initiated with concomitant oral alfacalcidol...Vonoprazan was replaced with famotidine...Following withdrawal of the causative drugs and magnesium repletion, both magnesium and calcium levels normalized promptly and remained stable thereafter.Conclusion In diabetic patients on long-term polypharmacy, clinicians should be alert to drug-induced hypomagnesemia. Regular and long-term monitoring of serum magnesium is essential, particularly in those receiving medications that may alter intestinal absorption or hormonal regulation of magnesium homeostasis."

Clinical • Anorexia • Diabetes • Endocrine Disorders • Gastrointestinal Disorder • Metabolic Disorders • Nephrology • Type 2 Diabetes Mellitus

Fluorescence Quenching-Based Quantification of Famotidine in Pharmaceutical Formulations and Biological Fluids Using Eosin Y. (PubMed, Luminescence) - "The environmental sustainability of the proposed method was evaluated using AGREE and the analytical Eco-Scale. The ICH guideline was used to test the validity of the method provided, and it can therefore be employed to evaluate famotidine in commercial dosage forms, yielding acceptable results."

Journal

Lung Abscess in a COVID-19 Patient: A Case Report. (PubMed, Adv Biomed Res) - "A treatment regimen, including dexamethasone, enoxaparin, piperacillin/tazobactam, and famotidine intravenous remdesivir was started. The HRCT scan was repeated on the 6th day of admission and showed the same ground-glass opacity as before but the lung abscess had become smaller in size. Altogether, we should be aware of lung abscess as one of the COVID-19 manifestations and complications."

Journal • Infectious Disease • Novel Coronavirus Disease • Pain • Pulmonary Disease • Respiratory Diseases

Rivaroxaban, colchicine and famotidine/loratadine with integrated clinical care for Long COVID, a multi-site, open-label randomised controlled trial (ESCMID Global 2026) - No abstract available

Clinical • Late-breaking abstract • Novel Coronavirus Disease

Harnessing metabolomics and proteomics in a clinical trial for pulmonary arterial hypertension: insights from post-hoc analysis of the REHAB-PH trial. (PubMed, EBioMedicine) - "Integrating multi-omics into a prospective clinical trial is feasible and yields stable longitudinal profiles in the absence of intervention. While famotidine did not yield clinical benefit, associated proteomic changes illustrate how molecular profiling can reveal treatment-related biology and inform future trial design. These findings highlight the broader utility of multi-omics for evaluating drug responses and identifying molecular endotypes in PAH and beyond."

Journal • Retrospective data • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Preventable Life-Threatening Severe Hypocalcemia: The Importance of Medication Reconciliation (SCCM 2026) - "Her pantoprazole was switched to famotidine. While severe hypocalcemia from denosumab use is relatively rare, the presence of additional risk factors can significantly increase its likelihood, most notably, CKD, PPI usage, vitamin D deficiency, and low-normal calcium level at baseline, as each of these conditions impair either absorption or regulation of calcium, compounding the effect of denosumab. There are no current guidelines recommending earlier checks even in potentially higher risk patient population. This case highlight the importance of risk factors optimization includes vitamin D and calcium supplementation if needed and thorough medication reconciliation."

Breast Cancer • Chronic Kidney Disease • CNS Disorders • Endocrine Disorders • Epilepsy • Gastroenterology • Gastroesophageal Reflux Disease • Nephrology • Renal Disease • Solid Tumor

Drug-Induced Thrombocytopenia from Proton Pump Inhibitors and H₂ Blockers: A Systematic Review and Comparative Analysis of Published Case Reports (THSNA 2026) - "Representative PPI reports (pantoprazole, lansoprazole, omeprazole/esomeprazole) and classical H₂RA reports (cimetidine, ranitidine, famotidine) were abstracted for onset (days), recovery (days), bleeding and ICU status. Case-level evidence indicates both PPIs and H₂RAs can cause abrupt, reversible thrombocytopenia with onset within days and recovery within 1–2 weeks; PPI reports show a trend toward earlier onset and higher bleeding documentation. Findings are limited by reporting bias and small numbers; prospective pharmacovigilance and mechanistic testing are needed to confirm class-specific risks. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author."

Case report • Clinical • Review • Hematological Disorders • Thrombocytopenia

I-SPY_COVID: I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients (clinicaltrials.gov) - P2 | N=1500 | Active, not recruiting | Sponsor: QuantumLeap Healthcare Collaborative | Recruiting ➔ Active, not recruiting

Enrollment closed • Infectious Disease • Novel Coronavirus Disease

NAVIGATING PROTAMINE-INDUCED ANAPHYLAXIS IN CARDIAC SURGERY: DECISION MAKING, RESUSCITATION AND OPEN CHEST MANAGEMENT (ACC 2026) - "Case: A 49-year-old woman with hypertension, hyperlipidemia, coronary artery disease, prior deep vein thrombosis on apixaban, obesity, and type 1 diabetes mellitus underwent elective CABG with left atrial appendage occlusion...Despite diphenhydramine, methylprednisolone, and famotidine, the patient required cardiac massage and return to bypass... Protamine anaphylaxis can complicate CABG with life-threatening hemorrhage and shock. Rapid recognition, multidisciplinary decision making, and staged operative management are essential for survival."

Surgery • Cardiovascular • Cognitive Disorders • Coronary Artery Disease • Diabetes • Dyslipidemia • Genetic Disorders • Hematological Disorders • Hypertension • Hypotension • Metabolic Disorders • Obesity • Thrombosis • Type 1 Diabetes Mellitus

MID CAVITY TAKOTSUBO CARDIOMYOPATHY IN ANTISYNTHETASE SYNDROME TRIGGERED BY RITUXIMAB INDUCED ANGIOEDEMA (ACC 2026) - "In the ED she received IV diphenhydramine, solumedrol, famotidine, fluids and IM epinephrine. This case highlights the intersection of autoimmune disease, biologic infusion reactions, and catecholamine toxicity. To our knowledge, this is the first reported case of mid-cavity TCM in ASS triggered by rituximab-induced angioedema treated with epinephrine."

Cardiomyopathy • Cardiovascular • Hypertension • Hypotension • Immunology • Rare Diseases

CORONARY ARTERY BYPASS GRAFTING IN COLD-INDUCED URTICARIA USING PREMEDICATION AND STRICT THERMAL MANAGEMENT: A CASE REPORT (ACC 2026) - "Premedication included fexofenadine, cetirizine, famotidine, montelukast, prednisolone, and diphenhydramine. Omalizumab was administered preoperatively. Epinephrine pen was available during the procedure... CABG can be safely accomplished in patients with cold-induced urticaria by combining structured premedication with vigilant thermal control. This case adds intraoperative temperature and cardioplegia parameters demonstrating safe on-pump CABG with moderate systemic cooling, cold cardioplegia, and elimination of topical ice, supported by structured premedication."

Case report • Clinical • Cardiovascular • Dermatology • Dyslipidemia • Hypertension • Hypotension • Immunology • Nicotine Addiction • Peripheral Arterial Disease • Urticaria

PULSELESS ELECTRICAL ACTIVITY CARDIAC ARREST SECONDARY TO ANAPHYLAXIS FOLLOWING LUMASON CONTRAST ECHOCARDIOGRAPHY (ACC 2026) - "Cardiopulmonary resuscitation was initiated with intravenous epinephrine, methylprednisolone, diphenhydramine, famotidine, and fluids, achieving return of spontaneous circulation within two minutes. Although rare, UEAs can provoke life-threatening anaphylaxis despite prior tolerance. This case illustrates progressive immune sensitization across structurally distinct UEAs, culminating in cardiac arrest. To our knowledge, this is the tenth documented Lumason-induced anaphylaxis and the first with cross-reactivity resulting in cardiac arrest."

Asthma • Back Pain • Cardiovascular • Complement-mediated Rare Disorders • Coronary Artery Disease • Dyslipidemia • Hereditary Angioedema • Hypertension • Hypotension • Immunology • Musculoskeletal Pain • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Finding the Root Cause: Licorice Root Extract Induced Posterior Reversible Encephalopathy Syndrome (AAN 2026) - "The patient's wife revealed that, on a naturopathic provider's recommendation, the patient recently replaced famotidine with licorice root extract for GERD treatment, in addition to already taking excessive amounts of calcium carbonate for his GERD... This patient was diagnosed with PRES caused by secondary hyperaldosteronism and milk-alkali syndrome with hypercalcemic crisis. Licorice contains glycyrrhizic acid which inhibits 11-hydroxysteroid dehydrogenase, responsible for converting cortisol to cortisone. Elevated cortisol levels produce a pseudo-hyperaldosteronism state, causing secondary hypertension."

Acute Kidney Injury • Cardiovascular • CNS Disorders • Endocrine Disorders • Epilepsy • Gastroesophageal Reflux Disease • Hypertension • Metabolic Disorders • Nephrology • Renal Disease

Use of Unsupervised Learning to Identify Patients with Chronic Spontaneous Urticaria from Electronic Health Record Data (AAAAI 2026) - "Medications for treatment include H1 antihistamines, and anti-IgE omalizumab for unresponsive patients...Of the top 10 features that differentiated the clusters best, eight were medications (prednisone, cetirizine, diphenhydramine, epinephrine, methylprednisolone, famotidine, dexamethasone, fexofenadine), one laboratory test (Antinuclear Antibody) and one comorbidity (chronic obstructive pulmonary disease)...Medications were the key features that differentiated between subgroups of patients with urticaria. This method shows promise in identifying patients most in need of advanced therapeutic interventions including immunosuppressants."

Clinical • Chronic Obstructive Pulmonary Disease • Chronic Spontaneous Urticaria • Dermatology • Immunology • Pulmonary Disease • Respiratory Diseases • Urticaria

Emergency Department Management of Anaphylaxis in Pediatric Patients (AAAAI 2026) - "Methods A single educational session was held for ED providers focusing on preferential use of second-generation antihistamines, post-epinephrine observation times, reducing use of systemic steroids in the ED and at discharge, reducing use of H2 blockers...Patients seen post-intervention were administered less diphenhydramine (17%, p = 0.001), famotidine (33%, p <0.001), or steroids (28%, p <0.001), and more cetirizine (13%, p = 0.002)...We found appropriately increased use of second-generation antihistamines and decreased use of H2 blockers and steroids in the ED. Length of stay shortened significantly though unchanged steroid prescribing at discharge highlights the need for further intervention."

Clinical • Pediatrics

299IG301: A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN) ( PREVAIL ) (clinicaltrialsregister.eu) - P2/3 | N=201 | Recruiting | Sponsor: Biogen Idec Research Limited

New P2/3 trial • Glomerulonephritis • IgA Nephropathy • Renal Disease

Chronic Histamine Exposure Promotes Melanogenesis via ORAI1-STIM1-Mediated Calcium Signaling Remodeling. (PubMed, Int J Mol Sci) - "Histamine (10-30 μM) significantly increased melanin content (2.5-2.8-fold), an effect specifically abolished by the H2 antagonist famotidine...Histamine-induced melanogenesis was significantly suppressed by intracellular Ca2+ chelation, pharmacological inhibition of ORAI1 (BTP-2 or Synta-66), and siRNA-mediated silencing of ORAI1 or STIM1, but not ORAI2, ORAI3, or STIM2. Our findings demonstrate that chronic histamine exposure drives hyperpigmentation through ORAI1-STIM1-mediated SOCE remodeling, establishing this complex as a promising therapeutic target for the treatment of PIH and related inflammatory pigmentary disorders."

Journal • Dermatitis • Melanoma • Oncology • Solid Tumor • STIM1

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response. (PubMed, Adv Sci (Weinh)) - "Using deep learning-based screening, we find that H2 receptor antagonists (ebrotidine, ranitidine and famotidine) can act as dual inhibitors of MCR and YqgB proteins, thus exhibiting excellent synergistic activity with colistin against mcr-positive bacteria under both neutral and acidic conditions. In animal models infected with mcr-positive pathogens, the co-administration of ranitidine and colistin demonstrates superior therapeutic outcomes against both systemic and intestinal infections. Our findings highlight the potential of targeting the bacterial acid stress response system to counteract mcr-mediated colistin resistance and offer a promising therapeutic strategy for the treatment of MDR bacterial infections."

Journal • Infectious Disease

Vocal Cord Palsy in Neonates and Infants after Cardiac Surgery Carries Significant Burden of Care (STS 2026) - "Medications included Famotidine (23, 30%), Gabapentin (7, 9%), Budesonide (12, 16%), Furosemide (26, 34%), and Digoxin (14, 18%), suggesting a spectrum of residual cardiac, respiratory, gastrointestinal, and neurologic needs. Conclusions These findings highlight the substantial clinical burden associated with VCP in pediatric cardiac surgery patients including prolonged ventilation and hospitalization, delayed feeding, frequent reliance on tube feeds, and considerable home care needs, which underscores the importance of early recognition and multidisciplinary management. Table Image"

Surgery • Cardiovascular