inactivated VZV vaccine (V212) / Merck (MSD) - LARVOL DELTA

Genetic or Epigenetic CR1 Deficiency Defines Catastrophic Antiphospholipid Syndrome (CAPS) and Response to Complement Inhibition (ASH 2024) - "Notably the one thrombotic event on C5i occurred in the postoperative period in the setting of delayed C5i administration (1 week late). Conclusion : CR1 deficiency, due to genetic or epigenetic down-regulation identifies a subset of CAPS that is particularly responsive to C5i."

Atypical Hemolytic Uremic Syndrome • Cardiovascular • Complement-mediated Rare Disorders • Genetic Disorders • Gynecology • Hematological Disorders • Hematological Malignancies • Leukemia • Nephrology • Oncology • Thrombosis • CR1

Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis. (PubMed, Cell Res) - "We also detected sTF in the plasma of human COVID-19 patients and showed that SARS-CoV-2 pseudovirus induced sTF production. Our findings demonstrated that the sTF plays a major role in thrombosis under necroptosis-related pathological conditions and provided a diagnostic marker and potential therapies for treating thrombosis without affecting hemostasis."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases • Thrombosis

Genetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome. (PubMed, Ann Rheum Dis) - "Genetic or epigenetic-mediated CR1 deficiency is a potential hallmark of CAPS and predicts response to C5 inhibition."

Journal • Cardiovascular • Complement-mediated Rare Disorders • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • Thrombosis • CR1

Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS). (PubMed, medRxiv) - "Five patients were treated with C5 inhibition which mitigated thrombosis. Genetic or epigenetic-mediated CR1 deficiency is a potential hallmark of CAPS and predicts response to C5 inhibition."

Journal • Cardiovascular • Complement-mediated Rare Disorders • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • Thrombosis • CR1

Impact of Heat Treatment Parameters on the Plastic Properties of 6061 Aluminum Alloy. (PubMed, Materials (Basel)) - "Additionally, the elongation of 6061 aluminum alloy initially decreases and then increases as the aging time increases. Based on the experiments, a Hansel-Spittel constitutive model was developed, incorporating temperature, strain rate, and strain effects to accurately predict the flow stress of 6061 aluminum alloy under varying heat treatment conditions."

Journal

Regulate catalytic performance by engineering non-regular structure of extradiol dioxygenase: An entrance to bottom strategy. (PubMed, Int J Biol Macromol) - "kcat value of P183S/V186L (SL) towards monocyclic catechols significantly surpasses any other combinatorial mutants around Tcu3516 active sites. Moreover, the synergetic effects on conformational plasticity were analyzed by molecular dynamic simulations to shed light into the interplay between structural changes and catalytic performance."

Journal

Engineering non-conservative substrate recognition sites of extradiol dioxygenase: Computation guided design to diversify and accelerate degradation of aromatic compounds. (PubMed, Int J Biol Macromol) - "Except for 2,3-DHB (the mutant V186L/D285A gave the best catalytic performance), the triple mutant prevailed all other 5 catecholic compounds for their degradation; affording the catalytic efficiency kcat/Km value increase by 10-30 folds, protein Tm (structural rigidity) increase by 15 °C and the half-life time enhancement by 10 times compared to the wild type Tcu3516. The molecular dynamic simulation suggested that a stabler core and a more flexible entrance are likely accounting for enhanced catalytic activity and stability of enzymes."

Journal

Sulfate reduction behavior in response to changing of pressure coupling with temperature inside landfill. (PubMed, Waste Manag) - "Key SRB (Desulfosporosinus-ASV212, Desulfitibacter-ASV1744) mediated differentiated sulfate reduction behavior in the pressure-bearing environment at 25 °C, while key SRB (Dethiobacter-ASV177, Desulfitibacter-ASV2355 and ASV316) were involved at 50 °C. This study provides a theoretical basis for the formulation of landfill gas management and control strategies."

Journal

Enhancing the Catalytic Activity of Glycolate Oxidase from Chlamydomonas reinhardtii through Semi-Rational Design. (PubMed, Microorganisms) - "The semi-rational design of the fusion enzyme GST-Gly-Ser-Gly-CreGO led to the superior variant GST-Gly-Ser-Gly-CreGO-Y27S/V111G/V212R with the k/K value of 29.2 s·mM, which was six times higher than that of the wild type. In contrast to GST-Gly-Ser-Gly-CreGO, 5 mg/mL of crude enzyme GST-Gly-Ser-Gly-CreGO-Y27S/V111G/V212R together with 25 μg/mL of catalase catalyzed the oxidation of 300 mM of methyl glycolate for 8 h, increasing the yield from 50.4 to 93.5%."

Journal • CAT • GLRX

Hemophilia A subjects with an intron-22 gene inversion mutation show CD4 T-effector responses to multiple epitopes in FVIII. (PubMed, Front Immunol) - "Furthermore, the FVIII region encoded by the exon 22-23 junction sequence was not remarkably immunoreactive and is therefore unlikely to contain an immunodominant, promiscuous CD4 T-cell epitope. Our results indicate that putative intracellular expression of partial FVIII proteins does not confer T-cell tolerance to FVIII regions encoded by inverted F8 mRNA or F8B mRNA."

Journal • Hematological Disorders • Hemophilia • Rare Diseases • CD4

A novel 7-base pair deletion at a splice site in MS-2 impairs male fertility via premature tapetum degradation in common bean (Phaseolis vulgaris L.). (PubMed, Theor Appl Genet) - "The ms-2 mutant plants produce many small parthenocarpic pods, and the size of the pods can be doubled by external application of 2 mM indole-3-acetic acid (IAA). Our results demonstrate that a novel mutation in PvTKPR2 impairs male fertility through premature degradation of the tapetum."

Journal

SAFETY, TOLERABILITY, EFFICACY, AND IMMUNOGENICITY OF INACTIVATED VZV VACCINE (ZVIN) IN RECIPIENTS OF AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTS (AUTO-HSCTS) (MASCC-ISOO 2017) - P3; "These results of the pivotal Phase III study (V212-001; NCT01229267) demonstrate that ZVIN is efficacious and well-tolerated when administered to adult recipients of auto-HSCT."

Adverse events • Clinical • Serious adverse event • Biosimilar • Demo Pain • Oncology • Pain

A case of siblings with juvenile retinitis pigmentosa associated with NEK1 gene variants. (PubMed, Ophthalmic Genet) - "According to the guidelines of the American College of Medical Genetics and Genomics, both variants were classified as likely pathogenic. This is the first report of RP patients with NEK1 variants not associated with skeletal abnormalities."

Journal • Ankylosing Spondylitis • Genetic Disorders • Immunology • Inherited Retinal Dystrophy • Ocular Inflammation • Ophthalmology • Orthopedics • Retinal Disorders • Retinitis Pigmentosa • NEK1

Puberty disorders among ART-conceived singletons: a Nordic register study from the CoNARTaS group. (PubMed, Hum Reprod) - "This large, register-based study suggests that ART-conceived children have a higher risk for puberty disorders. However, the mechanisms of infertility and pubertal onset are complex, and ART is a rapidly advancing field with various treatment options. Studying the pubertal disorders of ART-conceived offspring is a continuing challenge."

Journal • Cardiovascular • Developmental Disorders • Diabetes • Gestational Diabetes • Gynecology • Hypertension • Infertility • Metabolic Disorders • Obstetrics • Sexual Disorders • Small for Gestational Age

Development of Fermented Shrimp Shell Product with Hypoglycemic and Hypolipidemic Effects on Diabetic Rats. (PubMed, Metabolites) - "In conclusion, a biorefinery process for waste SS was established through mixed strain fermentation. The in vitro and in vivo data reveal that the fermented SS is a promising functional food for the management of diabetic hyperglycemia and hyperlipidemia."

Journal • Preclinical • Diabetes • Dyslipidemia • HK1 • TNFA

"There are places like northern Ireland already rebounding https://t.co/zT8iov212P" (@itosettiMD_MBA)

Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning. (PubMed, Inform Med Unlocked) - "T > GA, C > GA, and A > TC are not anticipated in the future. Since SARS-CoV-2 is mutating continuously, our findings will facilitate the tracking of mutations and help to map the progression of the COVID-19 intensity worldwide."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

"@SaludAmerica @PublicHealthMap @wellmedgives @CaregiverSOS @LatinaStrongDr @dr_shaps @TheWellnessBee1 @PMontenegroDC @psosa077 @AleRiv212 @FlorenciaDrumw1 @therapy4latinx @latinxpitch @CaregiverAction @AlzheimersLA @alzheimerssoc @alzassociation @NHMAmd @fridasgardenphx" (@latinxvocesllc)

Clinical • Alzheimer's Disease • CNS Disorders

Rare Germline Mutations in Complement Regulatory Genes Make the Antiphospholipid Syndrome Catastrophic (ASH 2019) - "APS serum activates complement in vitro shown by a functional assay (mHam) and increased C5b-9 deposition on the cell surface. A positive mHam test strongly associates with both recent thrombosis and triple positive APS. Purified human anti-B2GPI antibody from APS patients activates complement when added to normal human serum, suggesting that complement activation plays a pathophysiologic role in APS associated thrombosis."

Cardiovascular • Genetic Disorders • Hematological Disorders • Immunology • Lupus • Paroxysmal Nocturnal Hemoglobinuria • Systemic Lupus Erythematosus • Thrombosis • CD59

"#AlejandroSolís @ev212 #MoreNadaDeNada https://t.co/AFZqI7zopS" (@orazioaguirre)

"#Pandemonios #AlejandroSolís @ev212 https://t.co/LlKO7rGo7y" (@orazioaguirre)

Discovery, characterisation and genomic variation of six novel gammapapillomavirus types from penile swabs in South Africa. (PubMed, Papillomavirus Res) - "A retinoblastoma binding domain (pRB) binding domain in E7 protein was additionally identified in HPV214. This study expands the knowledge of the rapidly growing Gammapapillomavirus genus."

Journal

A Study to Test the Safety and Antibody Response of V212 in Healthy Adults (V212-004)(COMPLETED) (clinicaltrials.gov) - P1; N=290; Completed; Sponsor: Merck Sharp & Dohme Corp.; N=160 ➔ 290

Enrollment change

Unique surface-exposed hydrophobic residues in the C1 domain of Factor VIII contribute to cofactor function and Von Willebrand Factor binding. (PubMed, J Thromb Haemost) - "The surface-exposed hydrophobic residues in C1 domain contribute to cofactor function and VWF binding. These findings provide novel information on the fundamental role of the C1 domain in FVIII life-cycle."

Journal

"🤝 @Boehringer Ingelheim y Universitat Internacional de Catalunya (UIC Barcelona) crean una #cátedra centrada en #liderazgo #enfermero. https://t.co/ilV212nNeK" (@PMFarma)