progesterone / Generic mfg. - LARVOL DELTA

Differences in Reproductive Performance Between Shiqi and Dabao Pigeons: Insights from Multi-Omics Analysis. (PubMed, Genes (Basel)) - " Dabao pigeons had higher serum progesterone concentrations than Shiqi pigeons (1.35 ± 0.49 vs. 0.32 ± 0.19 ng/mL, p < 0.001) and larger mature follicles (2.25 ± 0.31 vs. 1.08 ± 0.56 mm, p = 0.034), whereas follicle numbers were not significantly different... Shiqi and Dabao pigeons differed mainly in ovarian physiological and molecular characteristics, whereas short-term flock-level reproductive records were broadly similar. Metabolomic differences were limited but concentrated in bile-acid- and lipid-related features."

Journal • Metabolic Disorders • TGFB1

Formulation Screening and Characterization of PLGA-Based Injectable In Situ Gel Loaded with Progesterone. (PubMed, Pharmaceuticals (Basel)) - " The screened PLGA-based progesterone in situ gel resolves critical drawbacks of traditional progesterone dosage forms. This low-irritation, sustained-release injectable platform provides a scalable industrial formulation candidate for long-acting hormone therapy."

Journal • Inflammation • Pain

Melatonin Supplementation Increases Oocyte Recovery and Quality Associated with Altered Follicular Steroidogenesis and Redox Status in Dairy Cows. (PubMed, Antioxidants (Basel)) - "These improvements were accompanied by reduced local and systemic oxidative stress, enhanced glutathione metabolism, and lower serum progesterone concentrations at the measured time points, coinciding with a more favorable endocrine environment for follicular development...These findings provide promising experimental evidence for the potential application of MT in dairy breeding and offer insights into the associated molecular pathways. However, further functional validation is required to fully elucidate the underlying mechanisms and establish its large-scale applicability."

Journal • Metabolic Disorders

Presentation and Management of Progestogen Hypersensitivity in a Male Patient in the Emergency Department and Intensive Care Unit. (PubMed, Cureus) - "Progestogen hypersensitivity (PH), historically termed autoimmune progesterone dermatitis, is an exceedingly rare condition documented almost exclusively in reproductive-age women...He presented to the emergency department with a diffuse rash, facial angioedema, and nausea, and received intravenous fluids, epinephrine, antihistamines, and corticosteroids...Inpatient management consisted of dexamethasone, cromolyn sodium, testosterone cypionate, analgesia, and supportive care, with rapid improvement and discharge on hospital day three. This report describes a symptom-directed approach to the management of PH in a male patient in the critical care setting and considers the comorbidities and possible mechanisms that may underlie his presentation. Given the rarity of the condition and the limited literature in men, effective management currently depends on an individualized, symptom-directed strategy."

Journal • Carcinoid Tumor • Cardiovascular • Coronary Artery Disease • Critical care • Dermatitis • Dermatology • Immunology • Oncology • Pain • Solid Tumor

Effect of Melatonin Supplementation on Reproductive Performance, Hormonal Profile and Antioxidant Status in Sheep Under Subtropical Conditions. (PubMed, Animals (Basel)) - "Progesterone concentration increased significantly (p < 0.05) on day 30 following 10 and 20 mg melatonin treatment during both seasons. Antioxidant enzyme activities, including glutathione peroxidase, superoxide dismutase, and catalase, were significantly enhanced following melatonin treatment. In conclusion, subcutaneous administration of melatonin improved reproductive performance, hormonal profile, and antioxidant status in sheep under subtropical conditions, with 20 mg melatonin/animal producing the most favorable responses, particularly during the non-breeding season."

Journal • CAT

Optimizing the Endometrial Factor in Recurrent Implantation Failure: From Established Diagnostics to Mechanism-Informed Management. (PubMed, J Clin Med) - "Progesterone resistance, impaired decidualization, chronic endometritis, microbiome dysbiosis, displacement of the window of implantation, and immune dysregulation represent proposed mechanisms contributing to implantation failure in selected patients... RIF is best regarded as a heterogeneous clinical outcome rather than a single disease entity, reflecting multiple disturbances in endometrial receptivity. Overall, current evidence supports a mechanism-informed approach that integrates targeted diagnostics with individualized, evidence-based therapeutic strategies."

Journal • Review • Endometriosis

Whole-Transcriptome Landscape Deciphers a ceRNA-Mediated "De-Repression-Activation" Circuit Governing Continuous Estrus in Ovine. (PubMed, Animals (Basel)) - "ceRNA network analysis further revealed a clear functional stratification: conserved core miRNAs targeted "sensor" pathways (cAMP, PI3K-Akt, MAPK), whereas accelerator miRNAs specifically targeted "executor" pathways (estrogen signaling, progesterone-mediated oocyte maturation, Hippo signaling)...(4) Taken together, our findings redefine the molecular basis of year-round estrus-moving beyond single-gene mutations or overexpression to an enhanced global transcriptomic responsiveness of the ovary. This work provides a fresh conceptual framework for understanding the divergence of reproductive strategies in sheep and offers actionable candidate targets for genetic improvement of continuous estrus traits."

Journal • MIR199A • MIR199B • MIR204

Effects of Age Category and eCG Dose on Reproductive Performance in Ile-de-France Ewe Lambs and Adult Ewes Under Seasonal-Transition Field Conditions. (PubMed, Vet Sci) - "A total of 914 animals were assigned to four groups according to age category and eCG dose: ewe lambs receiving 400 IU (EL400, n = 173) or 500 IU eCG (EL500, n = 169), and adult ewes receiving 400 IU (AE400, n = 301) or 500 IU eCG (AE500, n = 271), following a 7-day intravaginal progesterone-based synchronization protocol...These results indicate that age category and eCG dose were associated with different aspects of reproductive performance. Under the specific seasonal-transition field conditions of this single-breed, single-farm study, selecting the eCG dose according to the reproductive objective may represent a practical management consideration."

Journal

Molecular Signaling Pathways, Regulatory and Coactivator Networks, and Emerging Mechanisms in Hepatocellular Carcinoma. (PubMed, Biomedicines) - "Molecular profiling studies have identified key oncogenic pathways involved in HCC progression, including MAPK/ERK (mitogen-activated protein kinase/extracellular signal-regulated kinase), Wnt/β-catenin, PI3K/AKT/mTOR (Phosphoinositide 3-kinase/Protein Kinase B/mechanistic Target of Rapamycin), Hippo-YAP/TAZ, (Yes-associated protein/transcriptional co-activator with PDZ-binding motif) cell cycle regulators, and p53-mediated tumor suppression...Additionally, recent bioinformatic analyses suggest a potential role for progesterone-mediated oocyte maturation pathways in HCC, although their functional relevance remains unclear. A thorough understanding of these interconnected mechanisms could lead to novel therapeutic targets and the development of more effective, personalized treatment strategies for HCC. This review discusses key signaling pathways and emerging mechanisms in HCC and their roles in disease development and treatment."

Journal • Review • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor • CTNNB1

Efficacy of aglepristone for the treatment of pyometra in dogs: A multicenter field clinical study. (PubMed, Theriogenology) - "Clinical signs, transabdominal ultrasonography, and serum C-reactive protein (CRP) and progesterone concentrations were monitored through Day 14...Serum CRP concentrations decreased from 6.1 mg/dL at baseline to 1.4 mg/dL on Day 14. The standardized three-injection aglepristone protocol (10 mg/kg subcutaneously) represents a therapeutically valid non-surgical strategy for preserving reproductive capacity or managing dogs with elevated surgical risks."

Journal • Gynecology • CRP

Integrative Methylome and Transcriptome Analysis of DNA Methylation and Sex-Biased Gene Expression in Northern Pike (Esox lucius). (PubMed, Animals (Basel)) - "Pathway enrichment analyses implicated TGF-β signaling, Wnt signaling, and progesterone-mediated oocyte maturation pathways, suggesting crosstalk between sex differentiation and metabolic regulation/signal transduction. Our results reveal associations between promoter methylation and the expression of core sex-related genes, including dmrt1 (male-biased) and rspo1 (female-biased), which may be relevant to sex differentiation. The potential link between these epigenetic patterns and sexual growth dimorphism remains speculative and requires direct validation using growth-related phenotypic data and tissues."

Journal • DMRT1 • RSPO1 • TGFB1

Menopause Hormone Therapy in Women With Cardiovascular Risk Factors or Established Ischemic Heart Disease: A Joint FIGO and WHF Position Paper. (PubMed, Glob Heart) - "For those at high thromboembolic risk, transdermal estrogen, with micronized progesterone or dydrogesterone when needed, is considered the safest regimen. All primary and secondary prevention measures, including statins, should be continued. Managing the most complex cases warrants the adoption of a multidisciplinary approach between cardiologists, gynecologists, internists and primary care providers to offer the best possible care."

Journal • Review • Cardiovascular • Coronary Artery Disease • Gynecology • Heart Failure • Obstetrics • Women's Health

Renin-Angiotensin-Aldosterone Axis Activity in Women with Chronic Endometritis: A Prospective Observational Study. (PubMed, Int J Mol Sci) - "Fasting blood samples were collected 48 h before hysteroscopy (t1) and approximately 2.5 h before the procedure (t2) to assess plasma renin, serum aldosterone, the aldosterone-to-renin ratio (ARR), sodium, potassium, progesterone, thyroid-stimulating hormone (TSH), and IL-6...No consistent RAAS or inflammatory differences emerged according to plasma-cell burden or CE persistence after treatment. These findings suggest that CE is not associated with measurable systemic RAAS activation or IL-6 changes, supporting the hypothesis of local CE alterations."

Journal • Observational data • Endometriosis • Gynecology • Infertility • Inflammation • Sexual Disorders • IL6 • SDC1

Protein Supplementation During Luteal Phase to Stop Protein Degradation (clinicaltrials.gov) - P=N/A | N=34 | Recruiting | Sponsor: Sam Houston State University

New trial • Muscular Atrophy • Targeted Protein Degradation

A Sleep Intervention for Improving Sleep and Lifestyle (Diet, Physical Activity and Sedentary Behaviour) in Women with Polycystic Ovary Syndrome (ANZCTR) - P=N/A | N=40 | Completed | Sponsor: Monash University | Not yet recruiting ➔ Completed

Trial completion • Polyendocrine Metabolic Ovarian Syndrome

Integrated smart flock monitoring of reproductive parameters for lambing date prediction in merino sheep. (PubMed, Front Vet Sci) - "Sixty ewes underwent an 11-day progesterone-sponge synchronization protocol followed by PMSG administration and were allocated to two mating-management groups...Singleton pregnancy and maternal body weight were associated with absolute prediction error, whereas offspring sex was associated with gestation duration, although both regression models had limited explanatory power. Integrated smart flock monitoring can generate biologically meaningful reproductive datasets and may support practical lambing-date prediction, but the regression findings require confirmation in larger independent populations."

Journal

CCR5 blockade inhibits menstrual-driven proinflammatory T cell infiltration into the cervicovaginal mucosa of women. (PubMed, Sci Adv) - "Across the menstrual cycle, we identified dynamic changes consistent with an immune response during the time frame of progesterone withdrawal. Notably, maraviroc treatment in women led to prolonged receptor antagonism, substantially reducing this immune response. These data demonstrate that menstrual-driven proinflammatory CD4 T cell infiltration into the FRT can be inhibited by CCR5 blockade, which may provide an immunomodulatory approach to treating associated diseases and conditions affecting women."

Journal • Infectious Disease • Inflammation • CD4

Case Report: Multiple mammary carcinomas in a young dog with estrus-associated hyperglycemia: clinicopathological findings and glycemic normalization after ovariohysterectomy. (PubMed, Front Vet Sci) - "The temporal association between reproductive hormonal status and the observed metabolic alteration suggests a possible hormone-related insulin resistance rather than a direct metabolic effect of the tumors themselves. This case highlights the potential interaction between mammary neoplasia, reproductive hormonal status, and glucose metabolism in dogs and emphasizes the importance of comprehensive clinical and metabolic evaluation in young patients presenting with mammary tumors."

Journal • Breast Cancer • Diabetes • Gynecology • Hematological Disorders • Oncology • Solid Tumor

Long-Term Use of Oral Contraceptives Is Associated With Increased Risk of Small Intestinal Bacterial Overgrowth in Premenopausal Women (ACG 2026) - "Propensity-score matching (1:1) balanced demographics, BMI, race/ethnicity, metabolic and gynecologic variables, GI comorbidities, and medication exposures including PPIs, opioids, anticholinergics, GLP-1 agonists, metformin, corticosteroids, and prokinetics...Both estrogen-only and progesterone-containing formulations showed similar associations... After matching, 200,685 OCP users and 200,685 controls were included. OCP users had consistently higher SIBO rates across all time intervals. At 5 years, 141 OCP users versus 81 controls developed SIBO (HR 1.469, 95% CI 1.118â1.931; RR 1.742, 95% CI 1.325â2.289)."

Clinical • Addiction (Opioid and Alcohol)

Hormone Replacement Therapy and Severe Portal Vein Thrombosis: A Clinical Dilemma in Menopause Management (ACG 2026) - "Further history revealed initiation of hormone replacement therapy (HRT) approximately six months prior for menopausal symptoms, consisting of oral progesterone 200 mg daily and transdermal estrogen 0.05 mg/day. Anticoagulation with apixaban was initiated and HRT was discontinued...Further research is needed to better define the relationship between HRT and splanchnic vein thrombosis and to guide safe management in this population. Figure: Figure 1: PVT"

Clinical • Cardiovascular • Gastroenterology • Hematological Disorders • Thrombosis

Acute Antral Mucosal Injury After Norethisterone Initiation in a Patient With a Long-Standing Intragastric Balloon (ACG 2026) - "She denied non-steroidal anti-inflammatory drug (NSAID), aspirin, herbal, alcohol, or tobacco use for 30 days prior...Norethisterone was stopped and omeprazole increased to 40 mg twice daily, with clinical resolution within 72 hours...Direct human evidence that norethisterone delays gastric emptying is absent, cycle-phase studies have not shown a consistent progesterone effect on emptying, and animal data are mixed and species-dependent...Figure: Higher-magnification view of the ulcer margin demonstrating heaped, irregular edges with surrounding inflamed mucosa. Biopsies showed acute inflammation without Helicobacter pylori, dysplasia, or malignancy."

Clinical • Addiction (Opioid and Alcohol) • Genetic Disorders • Infectious Disease • Obesity

Raloxifene and progesterone neuroprotection in a female mouse model of Parkinson's disease. (PubMed, Front Neurosci) - "Striatal glial fibrillary acidic protein (GFAP), an astrogliosis marker, levels were elevated in MPTP-lesioned mice and this was similarly prevented with the hormonal treatment alone or in combination. Raloxifene and progesterone treatment was neuroprotective without excessive uterine stimulation in OVX mice supporting repurposing of these drugs for PD and their high translational value."

Journal • Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease • GFAP

Exposure to a mixture of long-chain PFAS disrupts ovarian follicle development, ovulation, and luteinization in female mice. (PubMed, bioRxiv) - "PFASmix-high suppressed the periovulatory expression of Areg, Ereg, Tnfaip6, and Adamts1 and impaired corpus luteal (CL) development and function, as evidenced by reduced CL spheroid growth and cell survival, decreased expression of Star, Cyp11a1, Hsd3b1, and Lhcgr, and reduced progesterone secretion...Benchmark dose modeling identified estrous cyclicity and follicle rupture as sensitive in vivo and in vitro endpoints, respectively. Together, these findings demonstrated that exposure to the mixture of long-chain PFAS disrupts multiple stages of ovarian function, from follicular development, oocyte maturation to ovulation and luteal development and function and provided mechanistic and quantitative evidence for the reproductive toxicity of PFAS mixtures."

Journal • Preclinical • ADAMTS1 • AREG • EREG • HSD3B1 • PPARG • STAR • TNFAIP6

Progesterone regulates lipid synthesis and secretion in bovine uterine epithelial cells. (PubMed, Biol Reprod) - "Immunohistochemistry of endometrial biopsies collected from the cow uterus on days 1 and 11 of the cycle showed that the lipid storage and esterification enzymes LPIN1 and DGAT2 were significantly higher in the glandular epithelium on day 11. These results suggest that progesterone increases lipid synthesis and secretion by the uterine epithelium when progesterone concentrations are high, such as in the luteal phase or early pregnancy."

Journal • LPIN1

ERBB2 establishes the timing of progesterone priming required for uterine receptivity. (PubMed, bioRxiv) - "High-dose progesterone fails to rescue the phenotype; advancing progesterone priming by 24 hours restores stromal PGR, HAND2, Bmp2 , and on-time implantation. Collectively, the present study provides evidence that ERBB2 directs the temporal window of stromal progesterone priming by setting the threshold for PGR induction, thereby synchronizing the maternal-fetal interface and safeguarding pregnancy."

Journal • BMP2 • HER-2