progesterone / Generic mfg. - LARVOL DELTA

Serum Reproductive Hormone Profiles and Endometrial Expression of miR-16-5p, VEGF Gene, and Protein, and CD31-Positive Cells following Progesterone and EGCG Administration. (PubMed, Adv Biomed Res) - "Exogenous progesterone or EGCG may influence endothelial cell proliferation by altering steroid hormone concentrations, miR-16-5p synthesis, and the post-transcriptional regulation of VEGF expression. However, further studies are required, particularly to explore other angiogenesis-related factors."

Journal • CD31 • MIR16 • PECAM1 • VEGFA

Intravaginal Progesterone Application as an Efficient and Reproducible Tool for Synchronizing the Mouse Estrous Cycle. (PubMed, Reprod Med Biol) - "Successful offspring production was achieved with improved procedural consistency when this protocol was used to produce pseudopregnant females for ET. Our method reduces animal discomfort and the need for vasectomized males, offering a practical approach for enhancing reproductive efficiency and animal welfare in research settings."

Journal • Preclinical

Targeting Hormone Replacement Therapy (HRT) for the Brain in Menopause (ACTRIMS Forum 2026) - "Further, serum estriol levels correlated directly with cognitive improvement.Since 60-70% of healthy women report cognitive domain-specific symptoms of menopause, this study evaluated the effect of treatment on these symptoms using a patented blisterpack of estriol and progesterone designed for menopausal women by CleopatraRX... Given estriol’s prior neuroprotective effects in MS women ages 18-50 years of age combined with over 40 years of postmarketing experience showing safety in Europe and Asia using the hormones in the patented blisterpak, further investigation is now warranted testing this treatment for its effect on cognition in menopausal women with MS."

CNS Disorders • Cognitive Disorders • Multiple Sclerosis • ENO1 • ER • NEFL

Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Lancaster University

New trial

Progestogen Hypersensitivity in a Postmenopausal Woman on HRT: Expanding the Clinical Spectrum (AAAAI 2026) - "Progestogen hypersensitivity (PH) is a rare disorder characterized by cutaneous, respiratory, or systemic symptoms in response to endogenous or exogenous progesterone. We describe an unprecedented presentation of PH in the setting of hormone replacement therapy (HRT) in a postmenopausal woman, challenging current paradigms regarding the timing and clinical context of disease manifestation."

Clinical • Immunology • Rare Diseases

Progesterone Hypersensitivity Managed with Omalizumab and Progestin Desensitization (AAAAI 2026) - "Clinical presentation can vary widely. We present a case of PH with Type 1 hypersensitivity symptoms, requiring multiple treatment approaches."

Immunology

Unique Treatment Approach For A Patient with Severe Progesterone Hypersensitivity (AAAAI 2026) - No abstract available

Clinical • Immunology

Periovulatory neurohormone dynamics reveal an association between secretoneurin and GnRH across the mouse estrous cycle. (PubMed, Front Endocrinol (Lausanne)) - "Six upregulated TFs predicted to bind to the mouse Gnrh1 promoter were also linked to significant enrichment in ribosome-related processes, protein synthesis, and cellular component organization pathways. These findings identify a periovulatory association between SN and GnRH1 and provide a foundation for targeted studies needed to test causality in the mammalian reproductive neuroendocrine network."

Journal • Preclinical

Case Report: Pembrolizumab associated lichen planus in early stage triple negative breast cancer. (PubMed, Front Oncol) - "Triple negative breast cancer (TNBC) is a breast cancer with a poor prognosis, marked by the absence of estrogen (ER) and progesterone (PR) receptors as well as human epidermal growth factor receptor (HER2) expression. Several skin-related side effects have been documented, such as pruritus, maculopapular rashes, vitiligo, lichenoid skin reactions, psoriasis, and, in rare cases, severe and potentially life-threatening conditions. We report a rare case of pembrolizumab-associated lichen planus in a 43-year-old woman who received pembrolizumab for neoadjuvant treatment of TNBC."

IO biomarker • Journal • Breast Cancer • Dermatopathology • Immunology • Lichen Planus • Oncology • Pruritus • Solid Tumor • Triple Negative Breast Cancer • ER • HER-2 • PD-L2

Rising Star: G protein-coupled receptors (GPCRs) in Microenvironment Pharmacology and Sensory Perception Pharmacology. (PubMed, J Mol Biol) - "Using these tools, the team successfully identified membrane receptors for several critical hormones and metabolites-such as glucocorticoids, androgens, progesterone, and ceramides-resolving several long-standing questions in pharmacology...Several candidates have completed preliminary pharmacokinetic and toxicity studies, demonstrating strong translational potential. This article systematically summarizes the key scientific contributions from Professor Sun Jinpeng's laboratory over the past decade, highlighting their impact on receptor-ligand paring, signaling mechanism elucidation, tool development, and rational drug design, and discusses their implications for the future of precision medicine."

Journal • Review • Cardiovascular • Psychiatry

Safety profile of progesterone: Insights from an FDA Adverse Event Reporting System (FAERS)-based pharmacovigilance study. (PubMed, J Int Med Res) - "Newly identified preferred terms associated with progesterone included acute eosinophilic pneumonia, meningioma, and autoimmune dermatitis.ConclusionsThis study identified notable safety concerns associated with progesterone use and detected several rare adverse events. These findings underscore the need for continued monitoring, updated prescribing guidelines, and further investigation into progesterone formulations and adverse event mechanisms."

Adverse events • Journal • Observational data • Retrospective data • Brain Cancer • Dermatitis • Dermatology • Immunology • Infectious Disease • Meningioma • Oncology • Pneumonia • Respiratory Diseases • Solid Tumor

Trophoblast differentiation and embryonic development are delayed in lactating cows compared to nulliparous heifers. (PubMed, J Dairy Sci) - "Concentrations of progesterone (P4) were greater in nulliparous heifers from d 4.5 to 12, and greater P4 concentration was associated with earlier increase in PAG. In conclusion, this study demonstrates that parity influences early embryonic development, with earlier trophoblast differentiation and acquisition of PAG secretory capacity in nulliparous compared with primiparous and multiparous lactating cows."

Journal

Clinical Presentation and Management of Swyer Syndrome: A Case Report. (PubMed, Cureus) - "Following the operation, estrogen-only pubertal induction was initiated, followed later by progesterone...Our report features atypical characteristics, including partially spontaneous pubertal development and pronounced short stature, which may delay both diagnosis and treatment. Nevertheless, earlier diagnosis and comprehensive management, including early gonadectomy, hormone replacement therapy, and psychological support, remain essential for optimal outcomes."

Journal • Endocrine Disorders • Oncology • Turners Syndrome • Women's Health

SIRT1-NCOR2 Corepressor Modulates Trophoblast-Macrophage Interactions in Preeclampsia. (PubMed, Hypertension) - "cKO (trophoblast-specific Sirt1 knockout) mice were generated and treated with Rarres2 knockout or progesterone supplementation to validate the role of the SIRT1/RARRES2 axis in preeclampsia pathogenesis and prevention by progesterone...Notably, RARRES2 levels were higher and were a risk factor, whereas SIRT1 levels were lower and were a protective factor for preeclampsia in early pregnancy. This study highlights SIRT1's potential role in regulating abnormal trophoblast-macrophage interactions at the maternal-fetal interface in preeclampsia and offers a new strategy for its early prediction and prevention."

Journal • Gynecology • NCOR2 • RARRES2 • SIRT1

Antidepressant-Related Signaling Pathways of Zinc Oxide Nanoparticles in a Mouse Model of Postpartum Depression. (PubMed, Biol Trace Elem Res) - "PPD was induced in female mice via intraperitoneal injection of progesterone (5 mg/kg) for 5 days, followed by 3 days withdrawal period. Pre-treatment with L-NAME, adenosine, and MK-801 amplified the decrease in immobility duration provoked by a sub-effective dose of ZnO NPs. These findings suggest that the antidepressant-like action of ZnO NPs is likely mediated through nitrergic, serotonergic, adenosinergic, and glutamatergic pathways."

Journal • Preclinical • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Postpartum Depression • Psychiatry

A comparative pharmacokinetic evaluation of two aqueous progesterone 25 mg injections in healthy postmenopausal women under fasting conditions: An open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover bioequivalence study. (PubMed, Clin Pharmacol Drug Dev) - "AqSusten® demonstrated bioequivalence to Lubion® in healthy postmenopausal women under fasting conditions. Both formulations exhibited similar pharmacokinetic profiles, with favorable safety and tolerability, suggesting AqSusten® as a viable alternative in ART treatments."

Clinical • Journal • PK/PD data

Menopause and cardiovascular risk : a window of opportunity for women's health (PubMed, Rev Med Suisse) - "A window of opportunity exists for initiating HRT in women under 60 years old or within 10 years of menopause onset, who experience severe vasomotor symptoms, preferably using transdermal estrogen combined with micronized progesterone. HRT should be initiated at the lowest effective dose and reassessed annually."

Journal • Cardiovascular • Ischemic stroke • Women's Health

Optimizing the protocol for modified natural cycle frozen embryo transfer (mNC-FET): a multicentre, single-blinded randomized controlled trial. (PubMed, Hum Reprod Open) - P4 | "This RCT demonstrates that supplementary progesterone likely does not improve live birth rates, and that flexibility in scheduling blastocyst transfers is possible for most women undergoing mNC-FET following their first to third IVF/ICSI treatment. Our results pave the way for a less restricted approach to FET, hence reducing patient burden and costs without compromising success rates."

Journal

Salivary steroid profile investigation by high performance liquid chromatography-tandem mass spectrometry in children with congenital adrenal hyperplasia (PubMed, Probl Endokrinol (Mosk)) - "Most steroids used for diagnosis and monitoring the therapy in patients with CAH have a strong or moderate correlation between serum and saliva."

Journal • Congenital Adrenal Hyperplasia • Endocrine Disorders

The impact of endometrial fluid on single euploid frozen embryo transfers, to cancel or not? (PubMed, Hum Reprod) - "The LBR was 9.4 percentage points lower when EF resolved and 20.2 percentage points lower when EF was persistent. We identified a small cohort of subsequent cycles after initial cycle cancellation and the LBR achieved in these cycles was similar to the LBR in the index transfer cycle if the transfer was performed even in the setting of persistent EF at time of progesterone start/trigger; perhaps if EF is persistent, cycle cancellation may not confer an improved LBR. Overall, many cases of EF likely result from underlying endometrial pathology. Patients should be counseled accordingly."

Journal • Infertility • Sexual Disorders

The estrogen-progestogen-oxidative stress network in uterine fibroids: mechanistic insights and therapeutic opportunities. (PubMed, Redox Rep) - "Traditionally, it has been believed that estrogen and progesterone primarily drive the development and progression of uterine fibroids...Additionally, we summarized current clinical strategies for hormone therapy and antioxidant treatment, identified potential combination therapy approaches, and explored key challenges in their clinical translation. This aims to provide new directions and evidence for advancing the precision treatment of uterine fibroids."

Journal • Review • Gynecology • Oncology • Solid Tumor • Uterine Leiomyoma • Women's Health

Risk of progesterone elevation in patients with low ovarian reserve using long-acting FSH IVF protocol: a randomized controlled trial. (PubMed, Reprod Biomed Online) - "Ovarian stimulation with long-acting CFA plus daily 150 IU r-FSH significantly reduced the risk of PPE and increased the feasibility of fresh embryo transfer in patients with low ovarian reserve. This strategy may offer a better approach for managing PPE, and may improve overall IVF success for this specific patient population."

Journal

Changes in Menstrual Regularity and Associated Factors in Women With Obesity Without PCOS Following Bariatric Surgery. (PubMed, Obes Surg) - "The study concluded that bariatric surgery effectively improves menstrual cycle regularity in women with obesity without PCOS. C-peptide, SF, and progesterone are key factors affecting preoperative menstrual regularity, while dynamic changes influence postoperative recovery in metabolic and anthropometric indicators."

Journal • Gastrointestinal Disorder • Genetic Disorders • Obesity • Polycystic Ovary Syndrome

Immediate Post-Noise and Short-Time Systemic Elevation of Progesterone Promotes Recovery of Cochlear Synapses From Noise-Induce Synaptopathy in Mice (ARO 2026) - "Background : Female mice are generally less susceptible than males to noise-induced cochlear synaptopathy (NICS). P4 ameliorates NICS assessed by ABR amplitude and synapse counts. This appears to be due primarily to facilitating post-noise recovery rather than protection during noise. Chronic P4 delivered from an implanted pellet provides relatively little recovery from NICS relative to acutely-delivered P4 administered by injection following noise exposure."

Preclinical • CTBP2 • DLG4

A Systematic Review on GLP-1 Receptor Agonists in Reproductive Health: Integrating IVF Data, Ovarian Physiology and Molecular Mechanisms. (PubMed, Int J Mol Sci) - "Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates...Incretin signaling altered steroidogenesis by reducing the levels of StAR, P450scc, and 3β-HSD, so inhibiting FSH-induced progesterone synthesis, while simultaneously enhancing BMP-Smad signaling...Preliminary clinical data indicate improved reproductive function in PCOS, as seen by increased pregnancy rates in both natural and IVF cycles; nevertheless, animal studies reveal a potential risk of ovarian and endometrial damage. These results highlight the need for controlled human research to clarify reproductive safety, molecular pathways, and optimum therapy timing, particularly in non-PCOS patients and IVF settings."

Journal • Review • Endocrine Disorders • Infertility • Inflammation • Obesity • Polycystic Ovary Syndrome • Sexual Disorders