progesterone / Generic mfg. - LARVOL DELTA

Functional luteal tissue formation and progesterone production following preovulatory follicle aspiration and follicular cell restoration in ewes. (PubMed, Domest Anim Endocrinol) - "In addition, TLA values were similar among the CO, LA, and FCR groups (0.8 ± 0.04, 0.9 ± 0.05, and 1.0 ± 0.05 cm², respectively; P = 0.50) and plasma progesterone concentrations did not differ significantly (4.0 ± 0.31, 3.7 ± 0.30, and 2.9 ± 0.30 ng/mL, respectively; P = 0.30). In conclusion, preovulatory follicle aspiration induces luteal tissue formation, which, with or without intrafollicular autologous follicular cell restoration, results in functional CL capable of producing progesterone levels consistent with those normally observed during the estrous cycle."

Journal

Exploration of common therapeutic targets for diabetic nephropathy and diabetic foot ulcers by integrated bioinformatics analysis and experimental validation. (PubMed, Mol Biol Rep) - "Notably, our study showed that sex hormones including pirinixic acid, testosterone enanthate, and progesterone were predicted to be the most promising drugs, with the combined score of the three being the highest. This finding may potentially provide common therapeutic targets for DN and DFU. Additionally, it is important to understand these networks and hub genes to advance our understanding of the multifaceted complications of DM and the future development of drugs to treat these complications."

Journal • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Diabetic Neuropathy • Gene Therapies • Inflammation • Metabolic Disorders • Nephrology • Pain • Peripheral Arterial Disease • Renal Disease • Retinal Disorders • LTBP1

Is age just a number? Oncotype DX testing and chemotherapy use in the post-TAILORx era. (PubMed, Cancer) - "In the post-TAILORx era, younger age was associated with substantially more ODX testing. The association of testing with chemotherapy varied substantially by age. The impact of age on ODX testing and use of chemotherapy is substantial and warrants further study."

Journal • Breast Cancer • Oncology • Solid Tumor

Idiopathic neutropenia after clonal and antigenic exclusion: A progesterone-dependent subtype (ASH 2025) - "After matching (n=18,561 per arm), theexogenous progesterone group had a significantly higher neutrophil count compared to non-hormonalcontraception (1.9±3.7 vs 1.5±1.7; t=3.5, p=.0004). The cohort age range was similar to our patientpopulation 44 ±19.Our observations motivate prospective evaluation of progesterone-high states as potential modifiers ofANC in otherwise idiopathic cases and particularly refractory cases Cycle-synchronized CBC with pairedprogesterone and estradiol measurements, together with controlled progesterone augmentation trials,can quantify ANC changes and clinical outcomes in this subset.We thank TriNetX and all participants for their contribution, without whom this research would not havebeen possible."

Endocrine Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Neutropenia • Rheumatology

Probiotics supplementation ameliorates bone marrow mesenchymal stem cells injury via IFN-I/STAT1 signaling pathway in immune thrombocytopenia during pregnancy (ASH 2025) - "Progesterone has been identified as a critical metabolite influencing thecomposition of gut microbiota, which in turn contributes to BM-MSCs injury in ITP during pregnancy (JThromb Haemost,2025)...Elevated levels of NOD1L and platelet countswere observed in the experimental groups.ConclusionsSupplementation with probiotics, elevation of NOD1L levels, and activation of the NOD1 receptorsignaling pathway, which subsequently triggers the IFN-I/STAT1 signaling cascade, may ameliorate thesenescence and apoptosis of MSCs in ITP during pregnancy, thereby promoting platelet production. Thisapproach represents a potentially novel therapeutic strategy for managing ITP during pregnancy."

Hematological Disorders • Immune Thrombocytopenic Purpura • Infectious Disease • Thrombocytopenia • Thrombocytopenic Purpura • CD34 • IRF3 • ITGA2B • JAK1 • NOD1 • RIPK2 • STAT1

Delayed onset of HPV-associated uterine malignancies: seven pathogenetic factors in contrast to cervical cancer. (PubMed, Rom J Morphol Embryol) - "Hormonal factors, especially prolonged unopposed estrogen exposure and progesterone-driven immune tolerance, modulate both tissue susceptibility and viral persistence...We also discuss emerging data suggesting that endometriosis and other ectopic endometrial proliferations may act as viral reservoirs. Overall, HPV appears to function as a co-factor within a multifactorial pathogenetic network, contributing to a subset of endometrial malignancies after a protracted, decades-long carcinogenic course."

Journal • Review • Cervical Cancer • Cervical Squamous Cell Carcinoma • Endometrial Cancer • Endometriosis • Gynecology • Infectious Disease • Oncology • Sarcoma • Solid Tumor • Squamous Cell Carcinoma • Uterine Cancer • Women's Health • CALD • MME • PIK3CA • PTEN

Ruhe Sanjie Tablet ameliorates depression-associated mammary gland hyperplasia by modulating estrogen receptor signaling and CDK2. (PubMed, J Ethnopharmacol) - "RST alleviates MGH and its comorbid depressive behaviors through multi-target actions involving hormonal rebalancing, suppression of estrogen receptor signaling, inhibition of CDK2-mediated cell cycle progression, and modulation of inflammatory metabolites."

Journal • Breast Cancer • CNS Disorders • Depression • Hormone Receptor Breast Cancer • Mood Disorders • Oncology • Psychiatry • Solid Tumor • CCNE1 • CDK2 • ER • IL1B • IL6 • PCNA • TNFA

LncRNA HAND2OT encoding micropeptide regulates the estradiol secretion, proliferation and apoptosis of ovarian follicular theca cells in chickens. (PubMed, Poult Sci) - "HAND2OT expression was upregulated by estradiol, while downregulated by progesterone and follicle-stimulating hormone (FSH)...The open reading frame 2(ORF2) of HAND2OT encoded a 66-amino-acid peptide (HAND2OT-66aa) exerting no effect on HAND2OT expression. Both the lncRNA HAND2OT lacking the HAND2OT-66aa and HAND2OT-66aa itself exhibited weaker effects on the cell proliferation and apoptosis of theca cells, compared with the full length HAND2OT, suggesting that HAND2OT regulates the survival and function of chicken theca cells via its RNA moiety and the HAND2OT-66aa micropeptide it encodes."

Journal

Outcomes of ultrasound-indicated cerclage in low-risk pregnancies: a retrospective observational study. (PubMed, BMC Pregnancy Childbirth) - "Ultrasound-indicated cerclage in low-risk women should be utilized with caution. Our data are limited by its retrospective nature and persistent bias, but cerclage was not associated with different outcomes compared to expectant management."

Journal • Observational data • Retrospective data

Hydration Responses to Pre-Exercise Sodium Hyperhydration at Rest and During Cycling in the Heat and Across Menstrual Cycle Phases. (PubMed, Nutrients) - "While no consistent main effects of menstrual cycle phase were observed, some phase-specific differences emerged, particularly in the early-follicular phase. These findings highlight the importance of monitoring hydration responses across the menstrual cycle and tailoring strategies to individual needs, rather than applying universal phase-specific recommendations."

Clinical • Journal

From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights. (PubMed, Iran J Med Sci) - "Our findings highlight the need for improved preclinical models to enhance translational research, ultimately aiding in the development of targeted therapies for endometriosis. This comprehensive analysis provides a framework for selecting optimal animal models in future endometriosis research."

Journal • Preclinical • Review • Endometriosis • Gynecology • Infertility • Inflammation • Pain • Sexual Disorders • Transplantation • Women's Health

Spectrum of Cervical Insufficiency: Management Strategies from Asymptomatic Shortening to Emergent Membrane Prolapse. (PubMed, J Clin Med) - "Multiple gestations show no benefit from singleton-derived interventions (RR 0.99-1.04). Optimal cervical insufficiency management emphasizes individualized approaches based on comprehensive risk stratification and objective cervical assessment, with vaginal progesterone and cervical cerclage serving as cornerstone therapies supported by robust clinical evidence."

Journal • Review • Obstetrics

Correlation Between Intrafollicular IL-10, Progesterone, and Bovine Oocyte Developmental Competence. (PubMed, Int J Mol Sci) - "Intrafollicular P4 concentration was not directly correlated with embryo development but rather with follicle size. Our findings identify intrafollicular IL-10 as a potent biomarker for predicting bovine oocyte competence and suggest that its quantification using sensitive biosensor technology could enhance the efficiency of IVEP programs."

Journal • IL10

Physiological Responses and Pregnancy Rate of Black and White Holstein Heifers During Hot and Cold Seasons in a Desert Region. (PubMed, Animals (Basel)) - "Cortisol and progesterone concentrations were higher (p < 0.01) in summer, while thyroid hormones were higher (p < 0.05) in winter...Reproductive traits were unaffected by season or coat color. Although there were some differences in physiological variables and some biochemical parameters by season and coat color, these alterations were not enough to modify reproductive responses of Holstein heifers."

Journal • Hematological Disorders

Brain Tumors in Pregnancy: A Review of Pathophysiology, Clinical Management, and Ethical Dilemmas. (PubMed, Cancers (Basel)) - "CNS tumors during pregnancy require early recognition, individualized treatment planning, and ethical vigilance. Multidisciplinary collaboration is vital to optimizing outcomes for both mother and fetus. Future efforts should focus on developing standardized protocols and expanding evidence through multicenter studies."

Journal • Review • Brain Cancer • CNS Tumor • Meningioma • Oncology • Solid Tumor

Observation of the Response to Ovulation Triggering on the Day of Intrauterine Insemination and Correlation Between Progesterone Level and Pregnancy Rate (OVUL-IIU) (clinicaltrials.gov) - P=N/A | N=158 | Completed | Sponsor: Centre Hospitalier Intercommunal Creteil | Recruiting ➔ Completed

Trial completion • Infertility • Sexual Disorders

Anti-androgenic compound Embelin ameliorates polycystic ovary syndrome by reversing the ovarian dysfunction and associated metabolic irregularities in 5α-DHT-induced PCOS rats. (PubMed, Fitoterapia) - "The anti-androgenic activity of the extracted Embelin was evaluated using the Yeast RIKILT Androgen Assay and compared against (i) 5α-dihydrotestosterone (5α-DHT), (ii) a commercially sourced Embelin standard, and (iii) flutamide, a known androgen receptor antagonist. Embelin treatment effectively reversed several hallmark features of PCOS, including ovarian dysfunction (e.g., hypo-progesteronemia, follicular cysts, and estrous cycle irregularities) as well as metabolic disturbances such as insulin resistance, weight gain, dyslipidaemia, and adipocyte hypertrophy. In conclusion, this is the first study to demonstrate the therapeutic potential of Embelin in ameliorating PCOS-related ovarian and metabolic dysfunctions."

Journal • Preclinical • Dyslipidemia • Metabolic Disorders • Polycystic Ovary Syndrome

Incidental finding of endometrial carcinoma in a first-trimester miscarriage mimicking molar pregnancy: a case report and review of literature. (PubMed, BMC Womens Health) - "Suspicious radiological findings in early pregnancy should prompt meticulous histological evaluation to rule out malignancy. Although endometrial cancer is very rare in pregnancy, it is important for clinicians and pathologists to have high index of suspicion of this possible differential diagnosis."

Journal • Endometrial Adenocarcinoma • Endometrial Cancer • Gynecologic Cancers • Gynecology • Oncology • Solid Tumor • Women's Health

Unveiling cytochrome P450 enzymes that catalyze steroid side-chain cleavage in bacteria. (PubMed, Nat Commun) - "Iterative saturation mutagenesis identified critical residues for side-chain cleavage, improving catalytic efficiency up to 6.5-fold, and computational analyses clarified sequence-function relationships. This finding of bacterial P450scc enzymes not only underscores their potential function in bacterial steroid catabolism but also lays a foundation for promising biocatalytic strategies for pregnenolone and progesterone synthesis."

Journal

Dual Impact of Estradiol Fluctuations in the Final Three Days on IVF/ICSI Outcomes: A Retrospective Cohort Analysis. (PubMed, JBRA Assist Reprod) - "Dynamic E2/P monitoring provides actionable insights for COS management. Elevated E2 in the late stimulation phase, driven by AFC and mid-cycle hormonal surge, correlates with oocyte yield but requires caution due to reduced embryo utilization. Clinically, excessive gonadotropin dosing and prolonged stimulation should be avoided to optimize outcomes. These findings support personalized hormone adjustment protocols to balance efficacy and safety in ART cycles."

Journal • Retrospective data

Effect of vitamin D deficiency on clinical pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization. (PubMed, Front Endocrinol (Lausanne)) - "Logistic regression, adjusted for endometrial thickness, progesterone, and vitamin D levels, demonstrated that serum vitamin D ≥ 20 ng/mL was independently associated with higher clinical pregnancy rates than the vitamin D deficiency group (odds ratio 1.48; 95% confidence interval, 1.02-2.32; P = 0.032)...This study suggests that vitamin D deficiency leads to lower clinical pregnancy rates in patients with PCOS undergoing IVF-ET. Furthermore, the serum vitamin D level is independently associated with clinical pregnancy rates in patients with PCOS undergoing IVF-ET."

Journal • Preclinical • Retrospective data • Gynecology • Infertility • Polycystic Ovary Syndrome • Sexual Disorders

P4R: Rescue Progesterone Supplementation During Frozen Embryo Transfer (clinicaltrials.gov) - P2 | N=150 | Suspended | Sponsor: Clinique Ovo | Trial completion date: Jun 2026 ➔ Jun 2028 | Active, not recruiting ➔ Suspended | Trial primary completion date: Sep 2025 ➔ Apr 2028

Head-to-Head • Trial completion date • Trial primary completion date • Trial suspension

Efficacy of Daily 50 mg Intramuscular Progesterone for Luteal Phase Support in Frozen Embryo Transfer Cycles: Analysis of Serum Levels and Pregnancy Outcomes. (PubMed, J Family Reprod Health) - "Endometrial preparation began with oral estradiol valerate (6 mg/day) on cycle day 2...Serum P4 levels were measured on ET day, and oral dydrogesterone (20 mg/day) was added for patients with P4 levels 27.8 ng/mL) were associated with reduced chemical pregnancy rates, the absence of significant correlations with other pregnancy outcomes highlights the multifactorial nature of embryo implantation success. These findings emphasize the need for further research to refine P4 thresholds and identify additional predictive factors influencing pregnancy outcomes in FET cycles."

Journal

Phase-dependent cytokine dynamics in multicellular in vitro models of the human endometrium. (PubMed, F S Sci) - "The phase-specific and model-dependent cytokine secretion patterns highlight the complexity of endometrial paracrine signaling and underscore the importance of multicellular in vitro models. These findings advance our understanding of cytokine dynamics during the menstrual cycle and provide a platform for future studies on endometrial receptivity and implantation."

Journal • Preclinical • BSG • CXCL8 • DKK1 • IGFBP3 • LCN2

Formulation, characterization, and toxicological evaluation of quinestrol-loaded nanoparticles for extended oral contraceptive efficacy in rodent pest management. (PubMed, Toxicol Res (Camb)) - "Quinestrol in both QNP-B (10 ppm) and QB-B (100 ppm) increased estradiol (11.59 to 32.38-41.13 pg/mL) and progesterone (4.70 to 14.42-18.25 ng/mL), while reducing FSH (0.94 to 0.42-0.45 mIU/mL) and LH (28.15 to 17.60-18.69 mIU/mL) after 15 days. QNP-B effects lasted 75 days, compared to 45 days for QB-B, demonstrating the prolonged efficacy of QNP and supporting PLGA-based delivery as a promising approach for sustained rodent fertility control."

Journal • Preclinical • Long-acting Reversible Contraceptives