Kagocel (copolymer of gossypol with carboxymethyl cellulose) / Nearmedic - LARVOL DELTA

Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia. (PubMed, Ther Adv Infect Dis) - "The study was conducted during the 2023-2024 influenza epidemic season and included 1867 high-risk outpatients treated with oseltamivir, umifenovir, kagocel, or imidazolyl ethanamide pentanedioic acid. The etiotropic agents oseltamivir and umifenovir demonstrated comparable efficacy in managing influenza in high-risk patients, as reflected by their impact on bacterial complication rates and disease duration. Both drugs may be recommended for the treatment of high-risk influenza patients."

Journal • Observational data • Allergy • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Influenza • Respiratory Diseases

Gene Expression Pattern of Peyer's Patch Lymphocytes Exposed to Kagocel Suggests Pattern-Recognition Receptors Mediate Its Action. (PubMed, Front Pharmacol) - "The changes in gene expression pattern and the outcomes of bioinformatics analysis suggest that pattern recognition receptors, TLRs and dectin-1, are the key mediators of kagocel immunomodulatory action, with the possible involvement of interferon autocrine loop. The genes upregulated with kagocel include diverse components of the innate immune defense system."

Journal • Immune Modulation • Immunology • Infectious Disease • Inflammation • CLEC7A • HRAS • IFNA1 • IL1B • IL5 • IRAK1 • MAP2K1 • MAP3K1 • MRC1 • NFKB1 • TLR3