EncorStat (OXB-202) / Oxford Biomedica - LARVOL DELTA

Safety and efficacy of OXB-202, a Genetically-Engineered Tissue Therapy for the Prevention of Rejection In High Risk Corneal Transplant Patients. (PubMed, Hum Gene Ther) - "OXB-202 (previously known as EncorStat) is a donor cornea modified prior to transplant by ex vivo genetic modification with genes encoding secretable forms of the angiostatic human proteins, endostatin and angiostatin. In conclusion, we have confirmed that angiogenesis is a valid target to prevent corneal graft rejection in a high-risk setting and demonstrated that transplanted genetically modified corneas are safe and well-tolerated in an animal model. These data support the evaluation of OXB-202 in a First-in-Man trial."

Clinical • Journal