PF 2413873 / Pfizer - LARVOL DELTA

Progesterone Antagonizes Dexamethasone-Regulated Surfactant Proteins In Vitro. (PubMed, Reprod Sci) - "The inhibitory effect of progesterone could be imitated by the GC and progesterone receptor (PR) antagonist RU-486, but not by the specific PR antagonist PF-02413873, indicating that progesterone acts as a competitive antagonist of DXM. The present study highlights a new action of progesterone as a potential physiological inhibitor of GC-dependent SP expression in lung epithelial cells. The clinical relevance of this in vitro finding is currently unknown."

Journal • Preclinical