CB201 / Crescendo Biologics - LARVOL DELTA

A novel antibody against CD300c ameliorates cognitive deficits and reduces pathology in the late-stage of APP/PS1 mouse model. (PubMed, J Alzheimers Dis) - "Histopathological analysis further revealed that CB201 treatment reduced Aβ and tau accumulation.ConclusionsCB201 exerts significant therapeutic effects on functional impairments and pathological alterations in late-stage AD. These results confirm CB201 as a potential immunotherapeutic for the treatment of AD."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Psychiatry • Solid Tumor • CD300C

Engagement of CD300c by a Novel Monoclonal Antibody Ameliorates Behavioral Deficits in a 5xFAD Mouse Model of Alzheimer's Disease. (PubMed, Biomedicines) - " These results indicate that CB201 promotes the differentiation of macrophages to MDMs and modulates AD-related inflammatory responses, thereby ameliorating the pathological features of AD. These findings identify CD300c as a potential therapeutic target for AD and indicate that CB201 is a promising candidate for its treatment."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Inflammation • CD300C

First report of Sclerotium hydrophilum causing leaf spot on Brasenia schreberi in central China. (PubMed, Plant Dis) - "OP782030, PP035994, and PP035995, respectively) and those of S. hydrophilum strain CBS201.27 (GenBank Acc...2018). To our knowledge, this is the first report of S. hydrophilum on watershield leaves in central China."

Journal

Overcoming Cabbage Crossing Incompatibility by the Development and Application of Self-Compatibility-QTL- Specific Markers and Genome-Wide Background Analysis. (PubMed, Front Plant Sci) - "...06-88 (CB201 × 96-100) yielded an excellent hybrid...The newly created line, which was designated SC96-100 and exhibited both agronomic traits that were similar to those of 96-100 and a compatibility index (CI) greater than 5.0, was successfully used in the production of the commercial hybrid 06-88. The study herein provides new insight into the genetic basis of self-compatibility in cabbage and facilitates cabbage breeding using SC lines in the male-sterile (MS) system."

Biomarker • Journal