TD-0714
/ Zymeworks
- LARVOL DELTA
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June 09, 2020
Safety, Pharmacokinetics and Pharmacodynamics of TD-0714, a Novel Potent Neprilysin Inhibitor in Healthy Adult and Elderly Subjects.
(PubMed, Clin Transl Sci)
- "The TD-0714 PK-PD relationship and safety profile was similar in elderly vs. younger adult subjects. The TD-0714 PK and PD profiles support further clinical development of TD-0714 and suggest the potential for once-daily administration and predictable exposure in patients with cardiorenal diseases regardless of their renal function."
Clinical • Journal • PK/PD data • Cardiovascular • Congestive Heart Failure • Heart Failure • Renal Disease
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