CD70 CAR-T / Chongqing Precision Biotech - LARVOL DELTA

Safety and Efficacy of B Cell Maturation Antigen (BCMA)/CD70-Targeted Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Pediatric Patients with Multidrug-Resistant, Steroid-Resistant Nephrotic Syndrome (KIDNEY WEEK 2025) - P1 | "Methods In this Phase I/II study (NCT06553898), C-4-29 CAR T cells were manufactured by the PRIMCAR manufacturing platform. However, as of the latest assessment, 5 exhibited an increase in urinary protein excretion, suggesting disease relapse. Conclusion BCMA/CD70-targeted CAR T-Cell therapy demonstrates favorable safety profile in pediatric patients with MDR-SRNS while shedding light on disease pathogenesis.The expected completion time of this research is July 2027."

CAR T-Cell Therapy • Clinical • Late-breaking abstract • Glomerulonephritis • Nephrology • Pediatrics • Renal Disease • CD70

Clinical Study of BCMA/CD70-targeted CAR-T Therapy for Refractory Pediatric Rheumatic Diseases (clinicaltrials.gov) - P1 | N=11 | Recruiting | Sponsor: Chongqing Precision Biotech Co., Ltd

New P1 trial • Dermatomyositis • Idiopathic Arthritis • Immunology • Myositis • Pediatrics • Rheumatology • Scleroderma • Systemic Sclerosis • CD70

Safety and Efficacy of CD70-Targeted CAR-T Therapy in CD70-Positive Advanced Solid Tumors: A Clinical Trial (clinicaltrials.gov) - P1 | N=90 | Recruiting | Sponsor: Chongqing Precision Biotech Co., Ltd

New P1 trial • Cervical Cancer • Genito-urinary Cancer • Lung Cancer • Oncology • Ovarian Cancer • Renal Cell Carcinoma • Solid Tumor • Thymic Carcinoma • Thymus Cancer • Thyroid Gland Anaplastic Carcinoma • Thyroid Gland Carcinoma • CD70

A Clinical Study of CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors (clinicaltrials.gov) - P1 | N=30 | Recruiting | Sponsor: Weijia Fang, MD | Trial completion date: May 2025 ➔ May 2027 | Trial primary completion date: May 2024 ➔ May 2026

Trial completion date • Trial primary completion date • Cervical Cancer • Genito-urinary Cancer • Oncology • Ovarian Cancer • Renal Cell Carcinoma • Solid Tumor • CD70

Study of BCMA/CD70 CAR-T Therapy for Refractory cSLE (clinicaltrials.gov) - P1 | N=18 | Recruiting | Sponsor: The Children's Hospital of Zhejiang University School of Medicine

New P1 trial • Immunology • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus • CD70

A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Gynecologic Cancer (clinicaltrials.gov) - P1 | N=36 | Recruiting | Sponsor: Chongqing Precision Biotech Co., Ltd

Metastases • New P1 trial • Cervical Cancer • Gynecologic Cancers • Oncology • Ovarian Cancer • Solid Tumor • CD70

A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors (clinicaltrials.gov) - P1 | N=48 | Recruiting | Sponsor: Chongqing Precision Biotech Co., Ltd

Metastases • New P1 trial • Cervical Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Ovarian Cancer • Renal Cell Carcinoma • Solid Tumor • CD70 • IL6

A Clinical Study of CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors (clinicaltrials.gov) - P1 | N=36 | Recruiting | Sponsor: Weijia Fang, MD

New P1 trial • Cervical Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Ovarian Cancer • Renal Cell Carcinoma • Solid Tumor • CD70 • IL6

A Clinical Research About CD70-targeted CAR-T to Treat CD70-positive Advanced/Metastatic Solid Tumors (clinicaltrials.gov) - P1 | N=48 | Recruiting | Sponsor: Chongqing Precision Biotech Co., Ltd

New P1 trial • Cervical Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Ovarian Cancer • Renal Cell Carcinoma • Solid Tumor • CD70 • IL6

A Clinical Study of CD70-targeted CAR-T in the Treatment of Advanced/Metastatic Renal Cell Carcinoma (clinicaltrials.gov) - P1 | N=24 | Recruiting | Sponsor: Chongqing Precision Biotech Co., Ltd

New P1 trial • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • CD70 • IL6

A Clinical Study of CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors (clinicaltrials.gov) - P1 | N=36 | Recruiting | Sponsor: Chongqing Precision Biotech Co., Ltd

New P1 trial • Cervical Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Ovarian Cancer • Renal Cell Carcinoma • Solid Tumor • CD70 • IL6