G-Pen Mini (glucagon auto-injectable rescue pen) / Xeris Biopharma - LARVOL DELTA

Modeling to Assess the Impact of Liquid, Stable Glucagon for Mini-dosing in Pediatrics—A Simulated Pharmacokinetic and Pharmacodynamic Study (ADA 2025) - "Introduction and Objective: Mini-dose glucagon can be used to treat mild or impending hypoglycemia that historically required reconstitution of lyophilized powder... Simulations of virtual pediatric populations across 5 glucagon doses and various baseline glucose levels indicated doses of 100 or 150 µg might be sufficient to provide glucose responses regardless of age/weight. Future clinical studies can validate findings."

Clinical • Late-breaking abstract • PK/PD data • Hypoglycemia • Metabolic Disorders

Effect of Mini-Dose Ready-to-Use Liquid Glucagon on Preventing Exercise-Associated Hypoglycemia in Adults With Type 1 Diabetes. (PubMed, Diabetes Care) - "Mini-dose glucagon with or without 50% reduction in CSII basal delivery rate may help to decrease EAH incidence in adults with type 1 diabetes."

Journal • Diabetes • Hypoglycemia • Metabolic Disorders • Type 1 Diabetes Mellitus