human umbilical cord derived mesenchymal stem cells / Shandong University - LARVOL DELTA

An Emodin-Depot Microsphere-in-Hydrogel Reprograms the Immuno-myogenic Niche to Enable Volumetric Muscle Loss Repair Revealed by Single-Cell Profiling. (PubMed, Research (Wash D C)) - "In vitro, E-AMs@GM showed excellent cytocompatibility and attenuated intracellular reactive oxygen species in human bone-marrow-derived mesenchymal stem cells under oxidative challenge...Mechanistically, scRNA sequencing revealed that E-AMs@GM enriches a reparative Mmp12 + macrophage subset and rewires macrophage-muscle satellite cell interactions through SPP1-CD44 and SPP1-integrin signaling, consistent with accelerated transition from inflammatory clearance to tissue reconstruction. Together, this depot-enabled hydrogel provides an instructive biomaterial strategy for functional VML repair."

Journal • Fibrosis • Immunology • Inflammation • IL10 • SPP1

Umbilical cord-derived mesenchymal stem cells synergize with biomimetic collagen scaffolds to drive structural cervical regeneration. (PubMed, Biomaterials) - "Here, we developed a composite graft by seeding human umbilical cord-derived mesenchymal stem cells (UC-MSCs) onto a biomimetic, bilayer collagen scaffold (CS)...Notably, compared with the scaffold alone, the composite yielded a smaller cervical diameter and denser morphology, and improved biomechanical strength over six months. These results demonstrate that UC-MSCs synergize with a decellularized collagen scaffold to support structural cervical regeneration, offering a clinically translatable, "off-the-shelf" strategy for reconstructing severe cervical defects."

Journal

HOXA7 Impairs Osteogenic Differentiation via p38/JNK Signaling: Implications for Osteoporosis. (PubMed, J Musculoskelet Neuronal Interact) - "HOXA7 reduces osteogenesis and osteoblast proliferation and promotes osteoblast apoptosis via the p38 MAPK/JNK pathway, suggesting potential therapeutic avenues against OP."

Journal • Osteoporosis • Rheumatology • RUNX2

Ultrasound-driven wireless piezoelectric hydrogel synergizes with cotransplantation of NSCs-hUCMSCs for structural and functional recovery in spinal cord injury. (PubMed, Mater Today Bio) - "Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) possess powerful paracrine and immunomodulatory properties, providing a supportive niche that improves the engraftment and function of NSCs...In a rat SCI model, wireless piezoelectric hydrogel synergized with cotransplanting NSCs-hUCMSCs and modulated the immune microenvironment during the acute phase, thereby restructuring scar cavities during the chronic phase, suppressing scar formation, accelerating neurogenesis, and facilitating axonal regeneration. These results emphasize the potential of synergizing stem cell therapies with wireless piezoelectric stimulation as a promising strategy for SCI repair, providing novel insights into the clinical translation of regenerative treatments."

Journal • CNS Disorders • Orthopedics • Transplantation

Therapeutic effect of three-dimensional hanging drop cultured human umbilical cord mesenchymal stem cells on osteoarthritis in rabbits. (PubMed, Stem Cell Res Ther) - "The above experimental results illustrated that 3D hanging drop culture method could enhance the therapeutic effect of hUC-MSCs, and showed a good clinical application prospect in the treatment of OA."

Journal • Preclinical • Immunology • Osteoarthritis • Pain • Rheumatology • IL10 • IL6 • IL7 • TGFB1 • TNFA

The function and mechanism of Human nasal mucosa-derived mesenchymal stem cells in allergic rhinitis in mice. (PubMed, Inflamm Res) - "Our findings suggest that hNMSCs can ameliorate allergic rhinitis in mice, with a certain advantage in anti-inflammatory effects compared to hUCMSCs. The NF-κB pathway is likely involved in the anti-inflammatory regulation process by hNMSCs.Therefore, hNMSCs might represent a novel therapeutic approach for allergic rhinitis."

Journal • Preclinical • Allergic Rhinitis • Immunology • Inflammation • IL4

A new strategy for the treatment of middle ear infection using ciprofloxacin/amoxicillin-loaded ethyl cellulose/polyhydroxybutyrate nanofibers. (PubMed, Int J Biol Macromol) - "MTT assay was performed by culturing human adipose-derived mesenchymal stem cells (hAD MSCs) on the scaffolds. At the highest drug concentration, a better repair effect was observed. Results were promising and showed potential for novel treatment."

Journal • Infectious Disease • Otorhinolaryngology

Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice. (PubMed, Stem Cell Res Ther) - "Our study highlights the beneficial effects of hUC-MSC treatment on PND and provides a justification to consider the potential use of hUC-MSCs in the perioperative period."

Journal • Preclinical • Alzheimer's Disease • Anesthesia • CNS Disorders • Cognitive Disorders • Developmental Disorders • Inflammation • Metabolic Disorders

Mesenchymal stem cells-derived exosomal miR-24-3p ameliorates non-alcohol fatty liver disease by targeting Keap-1. (PubMed, Biochem Biophys Res Commun) - "Here in our study, in vitro results initially showed that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs)-derived Exo treatment significantly suppressed lipid accumulation, reactive oxygen species (ROS) generation and inflammatory response in palmitate (PA)-stimulated mouse hepatocytes...In addition, the effects of MSCs-derived exosomal miR-24-3p to restrain lipid accumulation, ROS generation and inflammation in vitro were largely Keap-1 dependent via Keap-1 depression. Collectively, our study demonstrated that MSCs-derived exosomal miR-24-3p had hepaprotective effects through targeting Keap-1 signaling, providing a potential therapeutic value for NAFLD treatment."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Hepatology • Immunology • Inflammation • Liver Failure • Metabolic Disorders • Non-alcoholic Fatty Liver Disease • Psychiatry • KEAP1

Exosomes from Human Omental Adipose-Derived Mesenchymal Stem Cells Secreted into Ascites Promote Peritoneal Metastasis of Epithelial Ovarian Cancer. (PubMed, Cells) - "Finally, our clinical studies provided evidence that ascites from ovarian cancer patients enhance EOC cell line proliferation, migration, and invasion in vitro. The present study indicated that HO-ADSC exosomes are secreted into ascites and exert a tumor-promoting effect on EOC growth and metastasis, providing a new perspective and method to develop future novel therapeutic strategies for the treatment of ovarian cancer."

Journal • Oncology • Ovarian Cancer • Solid Tumor • FOXM1 • KIF20A

Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways. (PubMed, World J Stem Cells) - "iT hUC-MSCs administration ameliorates hyperoxia-induced lung, heart, and kidney injuries by activating HO-1 expression and JAK/STAT signaling. The therapeutic benefits of local iT and iP administration are equivalent."

Journal • Bronchopulmonary Dysplasia • Inflammation • Oncology • Pulmonary Disease • Respiratory Diseases • HMOX1 • IL10 • IL6 • JAK2 • MPO • STAT3 • TNFA

Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression. (PubMed, Bioengineered) - "These findings largely explain the mechanisms underlying the inhibition of ECM production in keloids by adMSC-Exos. In conclusion, our results revealed that adMSC-Exos effectively inhibited the production of ECM in keloids, which provides a new potential alternative for the systemic treatment of keloids."

Journal • Fibrosis • FN1 • NOTCH1 • SMAD3 • TGFB1

Study on a 3D-Bioprinted Tissue Model of Self-Assembled Nanopeptide Hydrogels Combined With Adipose-Derived Mesenchymal Stem Cells. (PubMed, Front Bioeng Biotechnol) - "Objective: This study aimed to observe the cell growth status and multidirectional differentiation ability in a 3D-bioprinted tissue model of self-assembled nanopeptides and human adipose-derived mesenchymal stem cells (Ad-MSCs)...Self-assembled nanopeptide hydrogel is a good tissue engineering material that can serve as an extracellular matrix. Ad-MSCs in the 3D-printed tissue model using a biological ink consisting of a mixed solution of self-assembled nanopeptides and Ad-MSCs grew well and still had strong differentiation ability."

Journal • CD31 • CD34 • ITGB1 • PTPRC • THY1