Ukrain (NSC B238865) / Nowicky - LARVOL DELTA

Sorting nexin 3 promotes ischemic retinopathy through RIP1- and RIP3-mediated myeloid cell necroptosis and mitochondrial fission. (PubMed, Proc Natl Acad Sci U S A) - "Intriguingly, we found that W1122 effectively inhibited retinal angiogenesis in the OIR model, and combination treatment with anti-Vascular Endothelial Growth Factor (VEGF) yielded enhanced antiangiogenic effects. Collectively, our findings disclose a link between SNX3 and RIP1/3 signaling and implicate SNX3 in the development of ischemic retinopathy."

Journal • Age-related Macular Degeneration • Ophthalmology • Retinal Disorders • FGF2 • RIPK1 • SNX

Tryptophan to Tryptophan Hole Hopping in an Azurin Construct. (PubMed, J Phys Chem B) - "Electron transfer (ET) between neutral and cationic tryptophan residues in the azurin construct [Re(H126)(CO)(dmp)](W124)(W122)Cu (dmp = 4,7-Me-1,10-phenanthroline) was investigated by Born-Oppenheimer quantum-mechanics/molecular mechanics/molecular dynamics (QM/MM/MD) simulations...ET probability depends on the orientation of Re(CO)(dmp) relative to W124 and its rotation diminishes the hopping yield. Comparison with hole hopping in natural systems reveals structural and dynamics factors that are important for designing efficient hole-hopping processes."

Journal

Sour Beer as Bioreservoir of Novel Craft Ale Yeast Cultures. (PubMed, Microorganisms) - "During hopped wort fermentation, four S. cerevisiae strains and the S. cerevisiae × S. uvarum hybrid WY213 exceeded non-Saccharomyces strains in fermentative rate and ethanol production except for P. membranifaciens WY122...Among the volatile organic compounds (VOCs) produced by S. cerevisiae and the S. cerevisiae × S. uvarum hybrid, phenylethyl alcohol, which has a fruit-like aroma, was the most prevalent. In conclusion, the strains characterized here have relevant brewing properties and are exploitable as indigenous craft beer starters."

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"Powiedział to antypolski, proputinowski gniot. Właśnie takie pojeby łykają debilne pierdolenie Pieniążka i jemu podobnych. Sam narzekał że 90% antyszczepów robi nagonkę na Ukrainę ale nie pomyśli że może sam został ofiarą rosyjskiej dezinformacji" (@JozefEscriva)

"To kolejna próba wepchnięcia Polski w wojnę przez „bratnią” Ukrainę. Jaki inny cel miałoby nagłasnianie takich akcji🤯" (@DinduNuffin07)

"#russiaisaterroriststate #ukrainerussia #Ukrain #ESC2023" (@Novoyavorivsk_)

Cardiovascular

"Ukrain waterpoloteam before the World Cup match against Germany today" (@ihoepelm)

"Baccha mar gaya aur terako repurable chaiayae . Doob maro salon. ukrain falg gender confused using sunflower oil living in usa" (@WTF_1234567890a)

"Brak czynnego oporu Białorusi i jej mieszkańców, przed aneksją do Rosji, popchnie ich do wojny z Ukrainą, dość że stracą swój kraj, to jeszcze będą musieli walczyć w Ukrainie, wojna. Białoruś zniknie z mapy Świata, jako suwerenne państwo. Putin przejmie tam władze." (@ANDRZEJMADALIS5)

"Czyli wiadomo co się święci. A co z anulowaniem kontraktu na szczepionki? I czemu z prezesów wielkich korporacji robicie bohaterów, którym warto uścisnąć dłoń? Boże jak Wy nie umiecie w PR. Już lepiej jeździjcie na Ukrainę." (@Adam_Taki_Tam)

War in Ukraine and Racism: The Physical and Mental Health of Refugees of Color Matters. (PubMed, Int J Public Health) - No abstract available

Journal

"Save ukrain. Save ukrain. What about America you divisive dipshit. America first." (@winds_dusty)

"Ukraina, Gruzja i Mołdawia chcą być w UE, bo boją się Rosji. Rosja napadła na Ukrainę i boi się UE. Polska jest w UE i choć boi się Rosji, to PiS, w tym Duda, Ziobro i Kaczyński, robią wszystko, aby opuścić UE. 🤣 Zatem, kto tutaj jest niepoczytalny? NIGDY nie głosujcie na PiS." (@Grzywa_Slawomir)

"Solidarity Marathon for Ukrain #ICU e-lives Happening NOW! https://t.co/Vw40LmIv0E @ESICM" (@EricHoste)

"shoppingsite!! Bamboser. Hackers are busy: take all your financial mob. financial apps of your phone. bank hacked by??? correct Russia/Ukrain: money is needed for war. App. send requests to any other messenger, Of course you say yes => money gone to 1. Russia or 2. Ukrain? 1/n" (@renieharbers)

"Viņi vairs nevar uzturēt kovid afēru, jo krievi nogrieza kukuļu atmazgāšanas centrus ukrainā. Beidzās kukuļi, beidzās afēra." (@Berx2000)

"Anyone Could Be a Refugee No One Chooses To Be a Refugee "Treating Refugees as the Problem is the Problem" #RefugeesWelcome #RefugeesWelcome #ukrain 🇺🇦🇾🇪🇵🇸🇸🇾" (@Hlashuel)

"Exactly 1 hr ago Ukrainian forces stopped Ghanaian students to exit Ukrain saying "no non-EU allowed through" to the Slovakia border. #GeoffreyOnyeama #antonioGuttierez #GhanaGov #ukrainegov #Refugees #UNHCR" (@DrBlalanawurah)

An aspartic protease 47 causes quantitative recessive resistance to rice black-streaked dwarf virus disease and southern rice black-streaked dwarf virus disease. (PubMed, New Phytol) - "Analysis of the candidate genes underlying qRBSDV6-1 showed high expression of aspartic proteinase 47 (OsAP47) in a susceptible variety, W122, and a low resistance variety, W44...Furthermore, the resistant allele Hap1 of OsAP47 is almost exclusive to Indica, but rare in Japonica. Results suggest that OsAP47 knockout by editing is effective for improving RBSDVD and SRBSDVD resistance; This study provides genetic information for breeding resistant cultivars."

Journal • Infectious Disease

[VIRTUAL] Evolution of Diffusely Abnormal White Matter and its relationship to Progression in Primary Progressive MS (MSDC 2020) - "DAWM voxels at screening, weeks 06, 48 and 96 that transformed into FWML at the last MRI scan (w122) were segmented... DAWM voxels show a dynamic transformation into FWML over time, with volumes of DAWM-to-FWML transformation in PPMS decreasing progressively as disease duration increases. These dynamic changes are similar to those observed in SPMS. However, unlike SPMS, where previous studies have shown an association between DAWM-to-FWML transformation and CDP, this group of PPMS participants did not show such an association."

Multiple Sclerosis

Hole Hopping Across a Protein-Protein Interface. (PubMed, J Phys Chem B) - "Irradiation of {Re126WWCuII}2 or {Re126FWCuII}2 also triggers intermolecular *Re////(W122•+)' intermolecular charge recombination. Our findings shed light on the factors that control interfacial hole/electron hopping in protein complexes and on the role of aromatic amino acids in accelerating long-range electron transport."

Journal

Anticancer effects of NSC‑631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression. (PubMed, Oncol Rep) - "Moreover, NSC‑631570 suppressed the growth of all tested HNSCC cell lines, including a paclitaxel‑resistant and P‑glycoprotein (MDR1)‑overexpressing cell line. In addition, NSC‑631570 showed a high anti‑angiogenic action on the tube formation ability of human umbilical vein endothelial cells (HUVECs). In conclusion, this study highlights NSC‑631570 as a promising therapeutic approach for HNSCC."

Journal • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma of Head and Neck

Light-Induced Nanosecond Relaxation Dynamics of Rhenium-Labelled Pseudomonas Aeruginosa Azurins. (PubMed, J Phys Chem B) - "Comparing relaxation and decay kinetics of Re(dmp)124K122CuII and Re(dmp)124W122CuII suggests that ET and relaxation motions in the W122 mutant are coupled. It follows that nanosecond and faster photoinduced ET steps in azurins (and, likely other redox proteins) occur from unrelaxed systems; importantly, these reactions can be driven (or hindered) by structural and solvational dynamics."

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HAIR HEAVY METAL AND ESSENTIAL TRACE ELEMENT CONCENTRATION IN CHILDREN WITH AUTISM SPECTRUM DISORDER. (PubMed, Georgian Med News) - "...Micro-elemental status was detected in the hair, with roentgen-fluorescence spectrometer method (Method MBИ 081/12-4502-000, Apparatus ALVAX- CIP, USA - UKRAIN) .To achieve the similarity of study and control groups, pre and postnatal as well as family and social history were assessed and similar groups were selected...So, our study demonstrated alteration in levels of toxic heavy metals and essential trace elements in children with autistic spectrum disorders as compared to healthy children. This suggests a possible pathophysiological role of heavy metals and trace elements in the genesis of symptoms of autism spectrum disorders."

Clinical • Journal

Two Tryptophans Are Better Than One in Accelerating Electron Flow through a Protein. (PubMed, ACS Cent Sci) - "We have constructed and structurally characterized a Pseudomonas aeruginosa azurin mutant Re126WWCu , where two adjacent tryptophan residues (W124 and W122, indole separation 3.6-4.1 Å) are inserted between the Cu center and a Re photosensitizer coordinated to the imidazole of H126 (Re(H126)(CO)(4,7-dimethyl-1,10-phenanthroline)).- ..QM/MM/MD simulations of Re126WWCu indicate that indole solvation changes through the hopping process and W124 → *Re electron transfer is accompanied by water fluctuations that tighten W124 solvation. Our finding that multistep tunneling (hopping) confers a ∼9000-fold advantage over single-step tunneling in the double-tryptophan protein supports the proposal that hole-hopping through tryptophan/tyrosine chains protects enzymes from oxidative damage."

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