BI 1026706 / Boehringer Ingelheim - LARVOL DELTA

The effect of bradykinin 1 receptor antagonist BI 1026706 on pulmonary inflammation after segmental lipopolysaccharide challenge in healthy smokers. (PubMed, Pulm Pharmacol Ther) - P1 | "Treatment with BI 1026706 for four weeks was safe and well-tolerated in healthy smoking subjects. BI 1026706 100 mg bid did not provide evidence for anti-inflammatory effects in the human bronchial LPS challenge model."

Clinical • Journal • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • CXCL8

Quantification of Drugs in Distinctly Separated Ocular Substructures of Albino and Pigmented Rats. (PubMed, Pharmaceutics) - "Following oral administration, we applied the tissue separation method, in order to determine the ocular concentrations of dexamethasone and levofloxacin, as well as two in-house molecules BI 113823 and BI 1026706, compounds differing in their melanin binding. Additionally, clear differences were observed in the BN rat tissue partitioning compared to the WH rat. Overall, the developed method enables a reliable determination of small molecule drug concentrations in ocular tissues to support ocular drug research and development."

Journal

BI 1026706, a Bradykinin 1 Antagonist, Did Not Reduce Pulmonary Inflammation Upon Segmental Endotoxin Challenge in Healthy Current Smoker Subjects Compared with Placebo (ATS 2019) - "Unexpectedly, there was a trend towards an increase in most types of inflammatory cells and soluble biomarkers in the BAL following BI 1026706 versus placebo. The clinical relevance of the findings remains unknown."

Clinical

Safety and Tolerability of Four Weeks' Treatment with a Bradykinin 1 Receptor Antagonist (BI 1026706) in Patients with COPD (GOLD I-III) (ATS 2019) - "CONCLUSION BI 1026706 was safe and well tolerated in patients with COPD treated for 4 weeks on top of LABD(s) with dose proportional PK. A numerical but not statistical significant increase in induced sputum neutrophil counts was observed."

Clinical