liatermin (r-metHuGDNF) / MedGenesis, Parkinson's Society of the United Kingdom - LARVOL DELTA

Single-Cell Transcriptome Analyses of Four Pain Related Genes in Osteosarcoma. (PubMed, Cancer Inform) - "In addition, all four genes showed deferential pattern of expression in 16 OS cell lines. Future studies should investigate the potential to target deferentially expressed pain-related genes in specific cell types of OS for therapeutic benefit to improve the quality of life for patients living with pain caused by OS."

Journal • Oncology • Osteosarcoma • Pain • Sarcoma • Solid Tumor

Berberine Improves Depression-Like Behaviors and Gastrointestinal Dysfunction in 6-Hydroxydopamine-Induced Parkinson's Disease Rats. (PubMed, Neurogastroenterol Motil) - "These findings suggested that BBR ameliorated the colonic dysfunction in 6-OHDA rats and modulated changes in enteric neurotransmitters and EGCs. Moreover, BBR regulated monoamines in the midbrain and OXA and CRF in the hypothalamus, which are associated with depression-like behaviors in 6-OHDA rats. This study provides a theoretical and experimental foundation for the potential application of BBR in treating non-motor symptoms of PD."

Journal • Preclinical • CNS Disorders • Depression • Gastrointestinal Disorder • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry • CHAT • GFAP

Effects of 1,25-Vitamin D3 and 24,25-Vitamin D3 on Corneal Nerve Regeneration in Diabetic Mice. (PubMed, Biomolecules) - "CD45+ cells and macrophage numbers were significantly decreased, and vitamin D increased CD45+ cell and macrophage recruitment in these wounded diabetic mouse corneas. The accelerated nerve regeneration observed in these corneas following topical 1,25 Vit D and 24,25 Vit D administration may be related to the vitamin D-stimulated expression, secretion of neurotrophic factors, and recruitment of immune cells."

Journal • Preclinical • Diabetes • Metabolic Disorders • PTPRC

Biological Activity In Vitro, Absorption, BBB Penetration, and Tolerability of Nanoformulation of BT44:RET Agonist with Disease-Modifying Potential for the Treatment of Neurodegeneration. (PubMed, Biomacromolecules) - "The micellar nanoformulation of BT44 exhibited improved absorption (after subcutaneous injection) and blood-brain barrier (BBB) penetration, and no acute toxic effects in mice were observed. In conclusion, herein, we have developed an ultrahigh BT44-loaded aqueous injectable nanoformulation, which can be used to pave the way for its preclinical and clinical development for the management of neurodegenerative disorders."

Journal • Preclinical • CNS Disorders

MRI-Guided Focused Ultrasound-Induced Blood Brain Barrier Disruption to Deliver Glial Cell Line Derived Neurotropic Factor Proteins into Brain to Treat Rat Depression. (PubMed, J Biomed Nanotechnol) - "Behavioral tests demonstrated the increased GDNF could reverse the depressive-like behaviors induced by chronic mild stress, improve the expression of 5-HT 1B receptor and the protein p11, and increase the number of 5-HT or TPH2 immunoreactive neurons. In conclusion, our study provided an effective approach to deliver GDNF proteins into brain to treat rat depression through MRI-guided focused ultrasound-induced destruction of blood-brain barrier."

Journal • Preclinical • CNS Disorders • Depression • Mood Disorders • Psychiatry

Intracerebral administration of ultrasound-induced dissolution of lipid-coated GDNF microbubbles provides neuroprotection in a rat model of Parkinson's disease (Brain Res Bull) - "We found that GDNF levels were increased in the striatum of PD rats after lipid-coated GDNF microspheres administration following low frequency ultrasound stimulation (20kHz, 5min per day, daily for 4 weeks). Moreover, GDNF microspheres reduced apomorphine-induced rotations, and increased striatal dopamine and nigral tyrosine hydroxylase (TH) levels in PD rats."

Preclinical • Parkinson's Disease

Transport of glial cell line-derived neurotrophic factor into liposomes across the blood-brain barrier: In vitro and in vivo studies (Int J Mol Sci) - "The results indicated that the liposomes could enhance transport of GDNF across the BBB and GDNF-SSL-T had achieved the best transport efficacy. The distribution of GDNF liposomes was studied in vivo. Free GDNF and GDNF-L were eliminated rapidly in the circulation. GDNF-SSL-T has a prolonged circulation time in the blood and favorable brain delivery."

Preclinical • Parkinson's Disease

6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo (Neurosci Lett) - "In both striatal and medial forebrain bundle (MFB) lesion models, striatal levels of GDF5 mRNA increased at 10 days post-lesion, while GDNF mRNA levels in the nigrostriatal system decreased after 10 and 28 days. Midbrain mRNA levels for both GDF5 receptors transiently increased after striatal lesion, whereas those of two GDNF receptors decreased at later time-points in both models."

Preclinical • Parkinson's Disease

Histological and clinical effects of GDNF expressing human mesenchymal stem cells in the 6-OHDA rat model or Parkinson's disease (ADPD 2013) - Presentation time: NA; "MSCs can be safely transplanted into Parkinsonian rats and they survive until six months, with continous changes in markerexpression."

Preclinical • Parkinson's Disease

Performance on the Wisconsin card-sorting test and serum levels of glial cell line-derived neurotrophic factor in patients with major depressive disorder (Asia Pac Psychiatry) - P=NA, N=64; "Performance on the WCST in MDD patients was significantly poorer than that in controls. Serum GDNF levels in MDD patients were significantly decreased compared to that of the control subjects (P < 0.001). Furthermore, the decrease in the serum GDNF levels positively correlated with performance in the WCST-% CONC and negatively with performance in the WCST-P in MDD patients."

Clinical data • Parkinson's Disease

Dopaminergic induction of human dental pulp stem cells by photobiomodulation: comparison of 660nm laser light and polychromatic light in the nir. (PubMed, J Photochem Photobiol B) - "In conclusion, the expression of dopaminergic neuron protective protein mRNAs in hDPSCs was increased by photobiomodulation in defined conditions. However, the cells were not able to differentiate into functional dopaminergic neurons either in control or in photobiomodulated groups that are prone to cell death and exhibit immature dopaminergic neuron characteristics."

Journal • BDNF • NR4A2

Scaffold protein Lin7 family in membrane skeletal protein complex in mouse seminiferous tubules. (PubMed, Histochem Cell Biol) - "In cultured spermatogonial stem cells maintained with glial cell line-derived neurotropic factor (GDNF), Lin7 was clearly expressed and immunolocalized along cell membranes, especially at cell-cell junctions. Thus, Lin7 protein is expressed in germ cells, and Lin7, particularly Lin7c, is a useful marker for early spermatogenesis."

Journal • Preclinical

Long-term culture of undifferentiated spermatogonia isolated from immature and adult bovine testes. (PubMed, Mol Reprod Dev) - "These cell lines have characteristics resembling those of previously reported male mouse germ cell lines as confirmed by their botryoidally aggregated morphology, as well as the expression of germ-cell-specific markers and pluripotent stem cell markers. These findings could be useful for the development of long-term culture of undifferentiated spermatogonia, which could aid in conservation of species and improvement of livestock production through genome editing technology."

Journal