meloxicam / Generic mfg. - LARVOL DELTA

A randomized trial of bupivacaine liposomal injectable suspension shows reduced need for postoperative analgesic rescue in dogs undergoing enucleation. (PubMed, J Am Vet Med Assoc) - "Dogs were premedicated with hydromorphone and acepromazine, induced with propofol, and maintained with isoflurane...Oral meloxicam was administered after the 8-hour time point...Treatment with BLIS reduced the need for rescue analgesia, and these dogs were more likely to have lower pain scores. BLIS may be useful as part of a multimodal pain management plan in dogs undergoing enucleation when administered as a peri-incisional eyelid block."

Journal • Pain

Dramatic Response to Lidocaine Infusion Therapy for Chronic Generalized Pain Secondary to Multiple Large Keloids. (PubMed, Cureus) - "Conventional treatments, including surgical excision with intralesional corticosteroids, duloxetine, meloxicam, amitriptyline, and acupuncture, provided only transient relief. Moderate pain relief was achieved with pregabalin, nortriptyline, topical lidocaine, and medical marijuana, resulting in a visual analog scale (VAS) score of 8/10. The subsequent addition of intravenous (IV) lidocaine infusions (5 mg/kg administered over one hour) produced significant pain reduction (VAS 3/10) and notable improvements in quality of life and functional capacity, enabling her to maintain employment. The interval between infusions was later extended to every four months while maintaining pain relief, without neuroexcitatory or cardiac complications. This case suggests that periodic IV lidocaine infusions may offer a safe and effective therapeutic option for sustained analgesia in patients with chronic keloid-related pain."

Journal • Fibrosis • Infectious Disease • Mood Disorders • Musculoskeletal Pain • Neuralgia • Pain • Varicella Zoster

Survey of German veterinarians' approaches to pain assessment and management of perioperative pain in pet rabbits. (PubMed, Vet Rec) - "Respondents used different indicators to detect pain in rabbits. Analgesic therapy in ovariohysterectomies, as reported by participants, can be considered suboptimal in several cases."

Journal • Preclinical • Anesthesia • Gynecology • Pain

Anti-arthritic appraisal of Acorus calamus L. extracts in complete Freund's adjuvant‑induced arthritic Wistar rats via regulating inflammatory cytokines and OPG/RANKL pathway. (PubMed, Inflammopharmacology) - "Fifty-four female Wistar rats were divided into nine groups (n = 6) and orally treated with meloxicam (MEL; 3 mg/kg) and three doses (125, 250, and 500 mg/kg/day) of MEAC and HEAC for 28 days...Our findings suggest that A. calamus exerts anti-arthritic activity by inhibiting inflammation, potentiating antioxidant defense mechanisms, and subsequently modulating the OPG/RANKL pathway. Thus, A. calamus rhizomes may be a potential natural alternative for the treatment of inflammatory and autoimmune diseases."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • IL10 • IL17A • IL1B • IL4 • IL6 • TNFA

Comparison of genicular nerve block and its combination with IPACK block for analgesia and recovery after total knee arthroplasty: a randomized trial. (PubMed, BMC Anesthesiol) - P=N/A | "In patients undergoing Total knee arthroplasty, adding IPACK block to GNB provides the best optimal analgesia and enhancing recovery compared to GNB alone."

Journal • Anesthesia • Orthopedics • Pain

Evaluation of buprenorphine as optimisation of postoperative analgesia in feral cats undergoing ovariohysterectomy under field conditions. (PubMed, J Small Anim Pract) - "These findings suggest that a single subcutaneous dose of buprenorphine may not consistently enhance analgesia over standard multimodal protocols under field conditions."

Journal • Anesthesia • Gynecology • Pain

Pharmacokinetic Parameters of Oral Firocoxib, Oral Meloxicam, and Transdermal Flunixin in Meat Type Goats. (PubMed, J Vet Pharmacol Ther) - "Transdermal flunixin showed mean plasma T1/2 of 16.5 (range: 10.7-62) at 3.3 mg/kg, 22.0 (range: 16.6-67.4) at 4.2 mg/kg, and 17.8 (range: 7.4-56.3) at 5.0 mg/kg. These results highlight significant variability in drug disposition and suggest that further research is warranted to optimize dosing regimens for oral firocoxib, oral meloxicam, and transdermal flunixin in goats."

Journal • PK/PD data

Urothelial cell carcinoma of the bladder causing severe hemorrhage and hypovolemic shock in a cat. (PubMed, JFMS Open Rep) - "The biopsies were consistent with urothelial cell carcinoma, and meloxicam was prescribed...However, severe hemorrhage caused by this tumor resulting in hypovolemic shock has been poorly reported in cats. Treatment with electrocautery and sclerotherapy can lead to long-term control of bleeding when definitive treatment is not pursued."

Journal • Bladder Cancer • Cardiovascular • Genito-urinary Cancer • Hematological Disorders • Oncology • Solid Tumor • Thrombosis • Urothelial Cancer

Effects of varenicline as an adjunct to analgesic and anti-inflammatory therapy in acute nerve injury. (PubMed, Injury) - "Varenicline, as an adjunct to meloxicam, enhances neuroprotection, reduces inflammation, and promotes histological and biochemical indicators of regeneration in rats with acute sciatic nerve injury. Future studies should explore its long-term effects and potential as a monotherapy for peripheral nerve injuries."

Journal • Fibrosis • Immunology • Inflammation • Neuralgia • Pain • IL6

Use of Activated Carbon Hemoperfusion and Hemodialysis in the Treatment of a Meloxicam Overdose in a Dog. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "Eight weeks after HP/HD treatment, follow-up bloodwork showed a relatively static, mild azotemia. This is the first clinical report to describe the successful use of activated carbon HP and HD in veterinary medicine and the first to document the use of HP to treat meloxicam toxicosis."

Journal • Nephrology

Meloxicam may induce nephrotoxicity in California sea lions (Zalophus californianus) with chronic domoic acid toxicosis. (PubMed, J Am Vet Med Assoc) - "This is the first report of meloxicam-associated nephrotoxicity in pinnipeds. While multiple factors such as dehydration, nutrition, other medication, and/or compromised immune function may have contributed to the development of nephrotoxicity, further evaluation of renal effects of domoic acid as well as effects of NSAIDs is warranted in CSLs."

Journal • Nephrology • Renal Disease

Design, In Silico, and Experimental Evaluation of Novel Naproxen-Azetidinone Hybrids as Selective COX-2 Inhibitors. (PubMed, Molecules) - "Molecular docking revealed high COX-2 binding affinities (-11.93 to -9.72 kcal/mol), while MM/GBSA analysis identified compound N4c (ΔG = -62.27 kcal/mol) as the most stable complex, surpassing meloxicam and naproxen. In vivo anti-inflammatory testing using an egg-white-induced rat paw edema model showed that N4d, N4e, and N4f achieved higher inhibition (19.22%, 16.98%, and 16.98%) than naproxen (4.3%). These results highlight 2-azetidinone-naproxen hybrids as promising selective COX-2 inhibitors with enhanced pharmacokinetic and electronic properties."

Journal

Free And Nanoencapsulated Meloxicam As An Adjuvant In Intraoperative And Postoperative Analgesia In Bicthes Undergoing Ovariohysterectomy. (PubMed, Top Companion Anim Med) - "Both free meloxicam and the new formulation of nano-encapsulated meloxicam promoted satisfactory postoperative analgesia in healthy dogs submitted to OH when administered orally, in a single dose, four hours before the surgical procedure. Only animals treated with free meloxicam had side effects related to the gastrointestinal tract in the postoperative period, indicating that the nanostructured formulation may be is safe and effective as an alternative to commercial products."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Gynecology • Pain

Pilot Studies Testing Novel Minimized Pan-Coronavirus (CoV) Vaccines in Feline Immunodeficiency Virus-Infected Cats With or Without Feline CoV Serotype-1 (FCoV1) Coinfection and in Specific-Pathogen-Free Cats Against Pathogenic FCoV2. (PubMed, Vaccines (Basel)) - "However, 100 μg pan-CoV vaccine-1 caused fever 24 h later, which was resolved by a single Meloxicam treatment...In Pilot Study 2, the FCoV1-based B-cell vaccine(s) induced low levels of XNAbs against FIPV2 and delayed challenge infection against high-dose FIPV2. The high-dose FIPV2 infections in the vaccinated and control cats started to clear, by single housing at 23-26 weeks post-challenge, whereas two cats in Pilot Study 1 cleared natural FCoV1 transmission by 26 weeks post-infection."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • Vasculitis • OPTN

Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis. (PubMed, bioRxiv) - "While dexamethasone and meloxicam prolonged fPOP, PDX shortened the pain duration. Finally, PDX rapidly modulates nociceptor neuron responses by suppressing C-fiber-induced muscle reflex in vivo and calcium responses in DRG neurons ex vivo and reducing TRPA1/TRPV1-induced acute pain and neurogenic inflammation in vivo . Our findings highlight multiple benefits of PDX to manage postoperative pain and promote perioperative recovery."

Journal • Preclinical • Inflammation • Musculoskeletal Diseases • Orthopedics • Pain • GPR37 • PD-1 • TRPA1 • TRPV1

The dual role of the COX-2/PGE2 Axis in multiple sclerosis: From pathogenesis to pharmacological inhibition. (PubMed, Clin Immunol) - "In experimental models, inhibiting COX-2 (using celecoxib or meloxicam) or blocking pro-inflammatory receptors (EP1/EP3) alleviates disease pathology by reducing immune cell infiltration and cytokine production and protecting oligodendrocytes via both COX-2-dependent and independent mechanisms. This review discusses the potential of selectively targeting the detrimental effects of the COX-2/PGE2 axis (such as EP1/EP3 signaling) while preserving protective pathways as a sophisticated therapeutic strategy for MS. However, cardiovascular risks limit the clinical translation of COX-2 inhibitors, necessitating the development of safer, more precise modulation of this pathway."

Journal • Review • Cardiovascular • CNS Disorders • Inflammation • Multiple Sclerosis • Solid Tumor

The Analgesic Effect of Two Different Extended-Release Meloxicam Formulations for Attenuation of Hypersensitivity in Rats (Rattus norvegicus). (PubMed, J Am Assoc Lab Anim Sci) - "Under isoflurane anesthesia, a 1-cm longitudinal skin incision was made on the plantar hind paw 5 minutes after drug administration. No abnormal clinical signs were noted, but injection site reactions were noted in the Melox, Melox-ER, and Melox-XR groups. Further research is needed to evaluate rat meloxicam analgesic dosages for incisional pain."

Journal • Preclinical • Anesthesia • Immunology • Pain

Use of a surgical drain for continuous postoperative trigeminal nerve block in a dog. (PubMed, Vet Anaesth Analg) - "Preoperative pain management consisted of methadone 0.2 mg kg-1 intravenously and an ultrasound-guided trigeminal nerve block with bupivacaine. The dog began eating voluntarily 4 hours after surgery without signs of pain or discomfort. The drain was removed after 24 hours and the dog was discharged 24 hours postoperatively with oral meloxicam."

Journal • Anesthesia • Oncology • Pain • Squamous Cell Carcinoma

Additive Accelerated Meloxicam Release from Poly(Ester Urea) Fiber Implants for Acute Pain Management. (PubMed, Adv Healthc Mater) - "Biopsies of muscle tissue surrounding the fracture, one day post-treatment, possessed high meloxicam concentrations relative to plasma and significantly reduced Ptgs2 expression and COX-2 inhibition. This work demonstrates the extended performance of local meloxicam-loaded PEU implants with significant pain and inflammation suppression."

Journal • Anesthesia • Inflammation • Musculoskeletal Diseases • Orthopedics • Pain • PACERR • PTGS2

Draft genome sequence of the meloxicam-degrading Gordonia alkanivorans IEGM 1277 strain. (PubMed, Microbiol Resour Announc) - "We report the draft genome sequence of Gordonia alkanivorans IEGM 1277, an actinomycete strain exhibiting a pronounced ability to degrade the pharmaceutical pollutant meloxicam-an emerging environmental contaminant. Utilizing the acquired sequence, identify candidate genes that encode enzymes implicated in the degradation of meloxicam."

Journal

Herbal analgesic patches versus NSAIDs in soft tissue injury management: real-world comparative effectiveness from a 35-center chinese prospective cohort of 1378 participants. (PubMed, Int J Surg) - "GTP is a safe NSAIDs alternative, especially for patients with comorbidities. Monotherapy or a 2-week SCI-to-GTP transition is recommended because of the lack of combination synergy."

HEOR • Journal • Real-world evidence • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Early Anti-Inflammatory Effect of Bupivacaine-Meloxicam Therapy in a Rabbit Model of Arthrofibrosis. (PubMed, Tissue Eng Part C Methods) - "Gene expression analysis, however, revealed significant reduction in inflammatory genes but not profibrotic genes. In summary, bupivacaine and meloxicam combination therapy did not exert antifibrotic effects in a rabbit model of arthrofibrosis but significantly reduced the expression of inflammatory markers in the local environment of the posterior capsule."

Journal • Preclinical • Anesthesia • Orthopedics • Pain

Drug-induced fixed urticaria because of hypersensitivity to non steroidal anti-inflammatory drugs. (PubMed, Allergol Immunopathol (Madr)) - "An oral provocation test (OPT) was performed with ibuprofen, acetylsalicylic acid, and metamizole, which also caused the same fixed-location wheals and subsequent spontaneous resolution. She, however, tolerated an OPT with meloxicam...In this case, as in those of DIFU described in the literature, the hives appeared shortly after the drug was administered and resolved rapidly. This feature distinguishes it from FDE, and it resembles acute drug urticaria, as in the patient's father, which raises questions concerning the pathophysiology of DIFU."

Journal • Conjunctivitis • Dermatology • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Pediatrics • Urticaria

Prophylactic effects of non-steroidal anti-inflammatory drugs on heterotopic ossification after total hip arthroplasty: a Bayesian network meta-analysis of randomized controlled trials using cumulative logistic regression. (PubMed, BMC Musculoskelet Disord) - "Considering the efficacy of preventing HO following THA observed in our research, together with analgesic effect and gastrointestinal tract safety from previous literature, etoricoxib 90 mg/d is recommended as the optimal choice for patient undergoing THA. More head-to-head and long-term studies are needed."

Journal • Retrospective data • Review • Gastrointestinal Disorder • Orthopedics • Pain

From Proteinuria to Platelet Crisis: Nonsteroidal Anti-Inflammatory Drug (NSAID)-Triggered Minimal Change Disease Complicated by Thrombotic Thrombocytopenic Purpura (KIDNEY WEEK 2025) - "She reported recent use of meloxicam, methocarbamol, and botox injections for migraine management...She was treated with rituximab and prednisone, leading to remission of nephrotic syndrome, although ADAMTS13 activity remained persistently decreased...NSAID use may have triggered MCD and concurrent COVID-19 infection further disturbed immune regulation, contributing to autoantibody development against ADAMTS13 and precipitating TTP. Given the scarcity of cases linking MCD and TTP, particularly in the setting of NSAID use and infection, this case highlights the need for clinical vigilance and further research into the immunological interplay between glomerular diseases and TMAs."

Anemia • Cardiovascular • CNS Disorders • Glomerulonephritis • Hematological Disorders • Immune Thrombocytopenic Purpura • Immunology • Infectious Disease • Migraine • Nephrology • Novel Coronavirus Disease • Renal Disease • Thrombocytopenia • Thrombocytopenic Purpura