meloxicam / Generic mfg. - LARVOL DELTA

Highlighting the Anti-Inflammatory Activity of Topical Gels Loaded with Meloxicam: The Role of Different Excipients and Absorption Promoters. (PubMed, Polymers (Basel)) - "It was shown that the Fickian and chain relaxation contributions compete during MX release from PU-based hydrogels. In vitro anti-inflammatory activity was evaluated and discussed."

Journal

Anti-Inflammatory Role of Exopolysaccharides in Osteoarthritis via Modulation of Redox and Inflammatory/Catabolic Signaling Networks. (PubMed, Appl Biochem Biotechnol) - "Current pharmacological treatments, such as meloxicam (Mel), provide symptomatic relief but fail to comprehensively address the inflammatory mechanisms driving OA progression while also posing risks like liver toxicity. The study was designed to test whether exopolysaccharide (EPS) improves cartilage structural integrity in a ciprofloxacin (CIP)-induced OA-like experimental arthropathy, with inflammatory, oxidative, and signaling markers serving as supportive mechanistic outcomes...This study underscores the potential of EPS in enhancing joint health, minimizing medication-induced toxicity, and improving overall quality of life for individuals suffering from OA. Integrating EPS into OA treatment paradigms may offer a more holistic, a chondroprotective and structure-preserving effect to disability management."

Journal • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology

Effects of meloxicam administration at birth on blood gas, acid-base status, and predictive value of early cardiac autonomic variables for postnatal adaptation in Holstein-Friesian calves. (PubMed, Front Vet Sci) - "Early HRV does not provide clinically useful prediction of compromised postnatal adaptation, and adds no incremental discriminative value beyond calving difficulty; calving difficulty score is the primary determinant. These findings suggest that targeted periparturient NSAID administration may be most justified for calves born after obstetrical assistance, although the quasi-randomized design warrants confirmation in a fully randomized trial."

Journal • CNS Disorders • Metabolic Disorders • Obstetrics • Psychiatry

Analytical determination of meloxicam and tenoxicam: matrix-dependent challenges, emerging technologies, and sustainable future perspectives. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "Future progress should shift from isolated improvements in detection sensitivity toward matrix-adaptive, digitally assisted, sustainability-aware analytical systems that integrate automated sample preparation, intelligent data interpretation, robust validation, and lifecycle-based performance assessment. This integrated perspective identifies priorities for transforming the determination of MLX and TNX from fragmented, matrix-specific methodologies into more transferable, intelligent, and sustainable analytical frameworks."

Journal • Review

MR-107A-02 Demonstrates Significant Analgesic Benefit in Both Moderate and Severe Postoperative Pain: A Post-Hoc Subgroup Analysis of Two Phase 3 Studies (PAINWeek 2026) - "Background: MR-107A-02 is a novel, fast-absorbing meloxicam that has demonstrated efficacy and safety in Phase 3 trials in patients with moderate or severe postoperative pain... Patients reporting pain scores ≥4 on NRS-R and/or NRS-A were randomized to receive MR-107A-02 (15 mg BID), placebo, or tramadol (50 mg QID) in bunionectomy and herniorrhaphy studies... Across both studies,192 patients presented with moderate pain and 536 with severe pain at baseline. MR-107A-02 significantly improved SPID 0-48 versus placebo across both pain subgroups. In bunionectomy, MR-107A-02 demonstrated a LS mean SPID 0-48 of 134.94 vs 67.40 in moderate pain (LSMD: 67.54; p =0.001) and 202.25 vs 112.0 in severe pain (LSMD: 90.25; p < 0.001)."

P3 data • Retrospective data • CNS Disorders • Pain

Improvement in Pain and Functional Outcomes during the first 24 hours with Fast-Absorbing Meloxicam Following Surgery: Results from Two Phase 3 Studies (PAINWeek 2026) - "Comparisons were performed versus placebo and the active control tramadol to further characterize the early clinical benefits of MR-107A-02 in patients experiencing moderate-to-severe acute postoperative pain. A total of 410 patients undergoing bunionectomy and 579 patients undergoing herniorrhaphy were randomized, with study completion rates exceeding 95% in both trials. Baseline pain severity was comparable across treatment groups. At 24 hours after first study drug administration, MR-107A-02 demonstrated statistically significant improvements in pain reduction versus placebo across both surgical models."

P3 data • Surgery • CNS Disorders • Pain

Drugs for acute treatment of migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

A randomized field study comparing 2 cautery disbudding techniques on wound healing in dairy calves. (PubMed, J Dairy Sci) - "All calves received meloxicam (1 mg/kg BW, orally) and a cornual nerve block with 5 mL of 2% lidocaine before disbudding...Under the conditions of this study, removal of the horn bud during cautery disbudding did not affect pain sensitivity, growth performance, or time to wound healing but was associated with reduced odds of early wound discharge. These findings suggest that both techniques produce comparable long-term outcomes when appropriate analgesia is provided, and the selection of technique may be guided by early wound management considerations."

Journal • Pain

Cataract Extraction in a White-Bellied Caique (Pionites leucogaster): A Case Report. (PubMed, Vet Ophthalmol) - "Systemic enrofloxacin and meloxicam were prescribed, along with topical tobramycin. At the two-year follow-up, vision remained, as evidenced by accurate landing and normal interaction with her owner and mate. To the best of the authors' knowledge, this is the only report describing successful cataract extraction in the smallest companion bird reported to date, using a manual irrigation and aspiration technique."

Journal • Anesthesia • Cardiovascular • Cataract • Glaucoma • Ophthalmology

Preoperative Risk Factors for Opioid Use Predict Self-Reported Health and Function Up to 6 Months After Anterior Cruciate Ligament Reconstruction. (PubMed, Arthrosc Sports Med Rehabil) - "Postoperatively, patients received acetaminophen, meloxicam, tramadol, gabapentin, and oxycodone. Morphine milligram equivalents (MMEs) and VAS were assessed at multiple timepoints through 6 months...Measurements of patient resilience and anxiety show little effect on postoperative pain, opioid consumption, and PROMs requiring further study. Level III, retrospective prognostic case series."

Journal • Mood Disorders • Orthopedics • Pain • Psychiatry

Small bowel perforation secondary to swallowed denture impaction at an NSAID-induced ileal diaphragm. (PubMed, J Surg Case Rep) - "The diagnosis was confirmed histologically following a right hemicolectomy with primary stapled anastomosis. This case highlights the importance of considering diaphragm disease in patients on chronic NSAID therapy who present with signs of bowel obstruction or perforation, even when alternative diagnoses, such as Crohn's disease, are initially suspected."

Journal • Crohn's disease • Gastroenterology • Immunology • Inflammatory Bowel Disease

Efficacy and safety of a fixed-dose oral tramadol-dipyrone combination for postoperative analgesia in dogs undergoing ovariohysterectomy and unilateral mastectomy: a randomized clinical trial. (PubMed, Front Vet Sci) - "At the end of surgery, all dogs received meloxicam and the first intravenous dose of the assigned treatment...Rescue analgesia with intravenous morphine was administered when predefined thresholds were reached...The tramadol-dipyrone combination improved early postoperative pain control in dogs undergoing ovariohysterectomy and unilateral mastectomy while maintaining favorable tolerability. These findings support its clinical use as part of a multimodal postoperative analgesic protocol, particularly during the early postoperative period."

Clinical • Journal • Gynecology • Pain

Adhesion-reducing effects of meloxicam and hyaluronic acid/carboxymethyl cellulose barrier in rat hepatectomy model. (PubMed, Curr Probl Surg) - No abstract available

Journal • Preclinical

Clinical Effectiveness of Combined Arthrocentesis With Intra-articular Injection of Meloxicam in Treatment of Temporomandibular Joint Internal Derangement (clinicaltrials.gov) - P=N/A | N=50 | Active, not recruiting | Sponsor: Hussein Mohammed Ridha | Recruiting ➔ Active, not recruiting

Enrollment closed

Immobilized horseradish peroxidase hybrid biocatalysts for degradation of pharmaceuticals and other emerging micropollutants. (PubMed, PLoS One) - "For example, full degradation was achieved for MBT (100%), meloxicam (99.5%) and caffeic acid (98.6%). In contrast, prometryn and MCPA showed only partial degradation, reaching 19.2% and 20%, respectively, and no degradation was observed for fluometuron and atenolol...For instance, roxithromycin degradation increased from 0.5% to 58.2% with ZnO-HRP, and for cimetidine, TiO₂-HRP improved degradation from 0.3% to 60.1% without HOBT and from 9.0% to 66.7% with HOBT...Finally, an integrated HRP enzyme and chemical oxidation remediation strategy was applied to degrade two pollutants, trimethoprim and DEET. For trimethoprim, TiO2-HRP combined with H2O2 and UV achieved approximately 30% degradation, while for DEET, both TiO2-HRP + H2O2 + UV and ZnO-HRP + H2O2 + UV resulted in around 40% degradation, thereby highlighting a novel application for these hybrid peroxidase-photocatalysts."

Journal

Off the Beaten Limb: Remnant Duodenitis as a Rare Cause of Recurrent Melena After Roux-en-Y Gastric Bypass (ACG 2026) - "He reported development of melenic stool following an episode of heavy drinking after a period of sobriety, while also endorsing newly initiating âTawon Liarâ, an Indonesian supplement consisting of meloxicam, ketorolac, dexamethasone, and tramadol, among other herbal ingredients. Figure: Figure 1. View of pylorus and remnant stomach from retrograde approach (1a, 1b); broader view of remnant stomach (1c), partially circumferential duodenitis displayed on retrograde approach through afferent limb (1d)."

Bariatric surgery • Fibrosis • Gastroenterology • Gastroesophageal Reflux Disease • Genetic Disorders • Hepatology • Immunology • Obesity • Peptic Ulcer

Analgesic combinations to reduce the stress/pain responses in ewes submitted to non-surgical embryo recovery: butorphanol associated with meloxicam or with dipyrone/hyoscine. (PubMed, Anim Reprod) - "No significant effects were detected for the remaining parameters. Under the tested conditions, neither analgesic protocol significantly reduced physiological indicators of stress."

Journal • Anesthesia • Pain

Evaluation of Early and Delayed Meloxicam Treatment Against Regulated Cell Death Pathways and ERK1/2 Phosphorylation in a Rat Model of Renal Ischemia-Reperfusion Injury. (PubMed, Biomedicines) - "Consequently, meloxicam administration significantly reduced the elevated serum creatinine and TOS levels observed in the IR group, although serum BUN levels remained without notable alteration. The findings of this study suggest that meloxicam may extend beyond its role as a classical anti-inflammatory agent, potentially offering biochemical and functional protection against renal I/R injury in association with the modulation of specific cell death mechanisms, including necroptosis and apoptosis, as well as the MAPK signaling pathway."

Journal • Preclinical • Acute Kidney Injury • Anesthesia • Cardiovascular • Inflammation • Nephrology • Renal Disease • Reperfusion Injury • CASP3 • CST3 • IL10 • IL1B • IL6 • KIM1

EXPRESS: Attitudes and practices of veterinarians regarding feline pain management in Western versus Eastern Europe. (PubMed, J Feline Med Surg) - "Meloxicam and robenacoxib were the most used NSAIDs for chronic pain management...Reported good knowledge of pain management, pre- and intraoperative use of NSAIDs, use of pain scales and pre-operative opioids, having a specialty diploma, and working in a cat-friendly practice were associated with Western than Eastern Europe.Conclusion and relevanceImportant regional differences were found regarding feline pain management across Europe. Continuing education, wider implementation of validated pain assessment tools, and improved access to analgesics may help reduce regional disparities and improve feline welfare."

Journal • Pain

Carbon hemoperfusion markedly reduces serum meloxicam concentrations in dogs with meloxicam toxicosis. (PubMed, Am J Vet Res) - "Carbon hemoperfusion markedly reduced serum meloxicam concentrations in dogs with meloxicam toxicosis and substantially shortened meloxicam half-life. Dogs that underwent timely cHP had excellent short-term outcomes, and cHP should be considered in dogs with high-dose meloxicam ingestion."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

First UV-Based Strategies Integrating Whiteness, Greenness, and Blueness Appraisals for Estimating Meloxicam and Tramadol Concurrently in Their Veterinary Mixture. (PubMed, Arch Pharm (Weinheim)) - "Furthermore, their environmental sustainability was comprehensively assessed using the AGREEprep metric, complemented by whiteness and practicality evaluations based on the RGB12 algorithm and the BAGI tool. The results demonstrate that the proposed UV methods are sustainable, sensitive, specific, and suitable for the routine simultaneous analysis of meloxicam and tramadol in veterinary dosage forms."

Journal • Pain

Investigating the Effects of Flunixin Meglumine and Meloxicam on Humoral Immune Responses Against E. Coli and T. pyogenes in Postpartum Dairy Cows. (PubMed, Arch Razi Inst) - "The results showed a reduction in IgM and IgG titers against both pathogens after treatment with meloxicam and flunixin, respectively. However, the elevation of IgG and IgM titers suggested that the treatment affected antibody isotype switching rather than suppressing humoral immune responses."

Journal • Infectious Disease • Inflammation

Non-steroidal anti-inflammatory drugs improve bovine blastocyst formation and quality in in vitro culture. (PubMed, Arch Anim Breed) - "In the initial 3 d of the in vitro culture stage, three different NSAIDs were administered to the groups: flunixin meglumine (FM), meloxicam (Mel), and carprofen (Car)...In addition, the number of apoptotic cells and the apoptotic index were found to be lower in the FM, Car, and Mel groups compared to the control group. Consequently, it was established that the supplementation of non-steroidal anti-inflammatory drugs in the culture medium during in vitro embryo production resulted in an enhanced rate of blastocyst development and an improved quality of blastocysts."

Journal • Preclinical

Meloxicam protects against muscle and metabolic decline in ageing through Cdon restoration and oxidative stress modulation. (PubMed, Exp Mol Med) - "Activation of the Ampk-Cdon axis was associated with maintenance of mitochondrial homeostasis and redox balance. Together, these findings identify Cdon as a potential therapeutic target for age-associated skeletal muscle degeneration."

Journal • Muscular Atrophy • Sarcopenia • GPX4

Ocotea odorifera extract: antimicrobial and antibiofilm activities, phytochemical aspects, cytotoxicity and anti-inflammatory potential of an endangered plant species. (PubMed, Int Microbiol) - "The extract did not show cytotoxicity and presented anti-inflammatory activity comparable to meloxicam. Our data provides evidence on the antimicrobial activity of O. odorifera, especially its antibiofilm potential, and highlights the need of preservation of endangered species as a valuable source of bioactive metabolites of clinical interest. More studies are necessary to investigate these pharmacological properties in vivo."

Journal • Dermatology • Infectious Disease