meloxicam / Generic mfg. - LARVOL DELTA

When Pain Outlasts Our Drugs: The Case for Sustained-Release Analgesia in Sheep. (PubMed, Animals (Basel)) - "Advancing SR meloxicam formulations could support widespread uptake of welfare-focused innovations in the sheep industry. Although not yet widely available, sustained-release meloxicam represent a promising step towards making routine husbandry procedures more humane and efficient."

Journal • Pain

Reduced-Resistances Model for Enhanced Drug Permeation via a Solubilizing Receiver Medium: A Mechanistic Study with Hollow Fiber Membranes. (PubMed, Mol Pharm) - "The impact of nine solubilizing receiver additives, including surfactants, cyclodextrins, and bovine serum albumin, on the flux of griseofulvin was investigated. Additional drug cocktail permeability studies with antipyrine, phenytoin, and meloxicam confirmed the broader applicability of this model. These findings provide a framework for informed receiver selection in permeability assays and underscore the importance of considering the receiver medium when comparing results across experiments."

Journal

Survey describing the perspectives and practices of Australian veterinarians to pain management in horses. (PubMed, Aust Vet J) - "This survey demonstrates that demographic factors influence the attitudes of Australian equine veterinarians regarding pain and there may be opportunities to educate and optimise pain assessment and protocol choices."

Journal • Pain

The Assessment of TECAR Therapy Efficacy to Manage Lateral Epicondylitis: A Randomized Clinical-Trial. (PubMed, Adv Biomed Res) - "The current double-blinded randomized clinical trial has been conducted on 46 patients with lateral epicondylitis who were allocated into two groups of controls (treatment with 15 mg meloxicam and cock-up brace for the period of 2 weeks) and intervention who received similar treatment as well as five sessions of TECAR therapy (every other day in a week)...Based on the findings of the current study, TECAR therapy is an effective modality for the treatment of lateral epicondylitis considering its remarkable influence on both pain relief and functional rehabilitation. Further studies are recommended."

Clinical • Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

A comparative study of some NSAIDs with natural products: integrating in vitro anticancer efficacy, in vivo antiulcerative effect, histochemistry, and in silico analysis. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Herein, dose- and time-dependent in vitro anticancer activity studies of anti-inflammatory drugs, including celecoxib (C), indomethacin (I), and meloxicam (M), in combination with natural products (taxifolin (T), quercetin (Q), and rutin (R)) and doxorubicin (Dox), were carried out in MDA-MB-231, BT-20, MCF-7, and HT-29 human cancer cell lines. The obtained results highlight that drug C and T may be potential inhibitor candidates as SphK1 inhibitors for targeted cancer therapy. Overall, the combination of drug C with T has shown promising results, anticancer effects in breast and colon cancer cells and antiulcerative effects in rats."

Journal • Preclinical • Breast Cancer • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • SPHK1

Iguratimod for Knee Osteoarthritis: A Study on Efficacy and Safety (ChiCTR) - P=N/A | N=600 | Not yet recruiting | Sponsor: Beijing Jishuitan Hospital, Capital Medical University; Beijing Jishuitan Hospital, Capital Medical University

New trial • Immunology • Osteoarthritis • Pain • Rheumatology

Comparison of the processes photo-Fenton and photocatalysis with TiO2 supported on non-woven fabric using a LED radiation in the degradation of the pharmaceutical meloxicam. (PubMed, Environ Sci Pollut Res Int) - "Moreover, photocatalysis required 32% less energy than the photo-Fenton process under the same conditions. The photocatalysis with TiO2sup and LED radiation, therefore, proved to be effective for the degradation of meloxicam."

Journal

The combination of rosuvastatin and meloxicam enhances the radiotherapy efficacy of MCF7, T-47D, and MDA-MB-231 breast cancer cell lines. (PubMed, Res Pharm Sci) - "The combination of rosuvastatin and meloxicam at specific concentrations increased the radiation sensitivity of MCF-7, T-47D, and MDA-MB-231 cells. Combined pretreatment with rosuvastatin 10 μM and meloxicam 50 μM notably enhanced genotoxicity while reducing colony formation, catalase activity, and SOD activity compared to radiotherapy alone in MCF-7, T-47D, and MDA-MB-231 cell lines."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor • CAT

Successful management of protracted anaphylaxis-induced severe acute respiratory distress syndrome masquerading as non-ST elevation myocardial infarction: a rare case report. (PubMed, BMC Cardiovasc Disord) - "Protracted anaphylaxis, especially when complicated by ARDS and myocardial injury mimicking NSTEMI, requires careful diagnostic consideration. Clinicians must thoroughly evaluate patient history, particularly recent medication use, to avoid misdiagnosis. Epinephrine remains a crucial treatment in such cases, and prompt administration can be life-saving. This case highlights the diagnostic challenges of protracted anaphylaxis and the importance of comprehensive clinical assessment and timely intervention."

Journal • Acute Respiratory Distress Syndrome • Allergy • Cardiovascular • Myocardial Infarction • Pain • Pulmonary Disease • Respiratory Diseases

Evaluation of Urinary Tissue Inhibitor of Metalloproteinase-2 (TIMP-2), Insulin-Like Growth Factor-Binding Protein-7 (IGFBP-7), and Kidney Injury Molecule-1 (KIM-1) as Biomarkers for the Detection of Meloxicam-Induced Kidney Injury in Cats. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "Urinary IGFBP-7 and KIM-1 increase in cats that develop acute kidney injury after repeated meloxicam administration. Further studies are needed before the clinical utility of these molecules as biomarkers for early acute kidney injury detection in cats can be determined."

Biomarker • Journal • Acute Kidney Injury • Inflammation • Nephrology • Renal Disease • IGFBP7 • KIM1 • TIMP2

Opioid-Sparing Joint Replacement (clinicaltrials.gov) - P3 | N=120 | Not yet recruiting | Sponsor: Emory University

New P3 trial • Orthopedics • Pain

Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis. (PubMed, J Clin Invest) - "While dexamethasone and meloxicam prolonged fPOP, PDX shortened the pain duration. Finally, PDX rapidly modulated nociceptor neuron responses by suppressing C-fiber-induced muscle reflex in vivo and calcium responses in DRG neurons ex vivo and by reducing TRPA1/TRPV1-induced acute pain and neurogenic inflammation in vivo. Our findings highlight multiple benefits of PDX to manage postoperative pain and promote perioperative recovery."

Journal • Preclinical • Inflammation • Musculoskeletal Diseases • Orthopedics • Pain • GPR37 • PD-1 • TRPA1 • TRPV1

The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair (clinicaltrials.gov) - P4 | N=130 | Recruiting | Sponsor: Montefiore Medical Center | Trial completion date: Dec 2025 ➔ Jun 2026 | Trial primary completion date: Dec 2025 ➔ Jun 2026

Trial completion date • Trial primary completion date • Pain

Linear IgA Bullous Dermatosis in an Elderly Patient Following Meloxicam and Candesartan Use: A Case Report. (PubMed, Cureus) - "Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune blistering disorder characterized by subepidermal blisters and linear IgA deposition along the dermo-epidermal junction (DEJ). After discontinuation of the suspected culprit drug and adjustment of her antihypertensive therapy, she was treated with oral dapsone 1 mg/kg (50 mg) daily for two weeks, resulting in clinical improvement. This case underscores the importance of thorough drug history taking and early recognition of drug-induced LABD, particularly in patients on multiple medications, where identifying the true offending agent may be challenging."

Journal • Dermatology • Immunology • Orthopedics

Reduced Opioid Prescription After Laparoscopic Hysterectomy (clinicaltrials.gov) - P=N/A | N=120 | Active, not recruiting | Sponsor: Johns Hopkins University | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Gynecology • Pain

Ways to optimize the management of lower back pain patients at the outpatient stage (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "In the treatment of patients with LBP, it is advisable to use chondroprotectors containing disease-modifying molecules, such as CS, GS, and UC-II, in addition to ST."

Journal • Back Pain • Immunology • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology

Reclassification of NSAID hypersensitivity according to the WAO 2025 guidelines: insights from a cohort of 527 patients. (PubMed, Allergol Immunopathol (Madr)) - "The WAO 2025 classification successfully reallocated previously blended cases, particularly into NIUA, mixed NECD, and mixed NERD, thereby improving diagnostic clarity. This updated framework reduces ambiguity and may enhance patient management by better reflecting clinical heterogeneity."

Journal • Retrospective data • Allergy • Asthma • Cardiovascular • Dermatology • Immunology • Inflammation • Nasal Polyps • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Urticaria

Meloxicam Eluting 3D Printed 316L Stainless Steel Implants for Targeted Delivery in Bone Fixation Surgeries. (PubMed, AAPS PharmSciTech) - "The multilayer coatings developed in this study have the potential to improve adhesion at the implant-bone interface and thus might prevent implant rejections in patients undergoing orthopedic surgery. Moreover, this method can be applied to other drugs and polymers to address the issues related to implant failure, pain management, and surgical site infections."

Journal • Infectious Disease • Inflammation • Orthopedics • Pain

Ultrasound-guided coronoid approach to the trigeminal nerve block in a dog undergoing orbital exenteration. (PubMed, Vet Anaesth Analg) - "After negative aspiration, 1.35 mL of 0.75% ropivacaine was injected, with anechoic fluid observed during injection along the fascial plane and around the artery...A multimodal analgesic plan (methadone, paracetamol and meloxicam) was implemented and continued postoperatively...This case suggests that the coronoid approach to the trigeminal nerve block is feasible and may be effective as part of a multimodal analgesic approach. Further studies are warranted to evaluate its safety and efficacy in dogs undergoing craniofacial surgery."

Journal • Anesthesia • Oncology • Pain

Comparative Efficacy of Opioid-Free and Opioid-Sparing Anesthesia in Dogs Undergoing Dental Procedures: A Prospective Study of Perioperative Analgesia and Hemodynamic Stability. (PubMed, J Vet Dent) - "All dogs received intramuscular medetomidine (10 µg/kg) as premedication, followed by intraoperative constant rate infusions according to group assignment: OFA1 (ketamine 0.6 mg/kg/hr), OFA2 (ketamine 0.6 mg/kg/hr and lidocaine 1.5 mg/kg/hr), or OSA (ketamine 0.6 mg/kg/hr and hydromorphone 0.05 mg/kg intravenous bolus)...Subcutaneous meloxicam (0.2 mg/kg) was also administered at the end of surgery...Postoperative pain scores were not significantly different among groups. Overall, OFA protocols provided effective analgesia and nociceptive control, supporting the clinical feasibility of OFA in dental procedures while highlighting the value of opioids for autonomic modulation."

Journal • Anesthesia • Pain

Association of transversus abdominis plane and superficial serratus block for postoperative analgesia in dogs undergoing unilateral radical mastectomy. (PubMed, Aust Vet J) - "Local anaesthesia was successful in providing postoperative pain management for at least 6 h after mastectomy in dogs."

Journal • Anesthesia • Oncology • Pain

A comparison of short-term analgesic effects of xylazine alone or combined with levomethadone or ketamine in calves after hot-iron disbudding. (PubMed, J Dairy Sci) - "All calves received subcutaneous meloxicam (0.5 mg/kg) and a local anesthetic (procaine hydrochloride, 4.5 mg/kg) 15 min before heat cauterization of the horn buds. The findings from this preliminary study suggest that the combination of levomethadone with low-dose xylazine provided superior short-term pain control and improved postdisbudding comfort compared with ketamine-xylazine or xylazine alone. However, given the limited sample size, these results should be interpreted with caution, and larger-scale studies are needed to confirm whether incorporating opioids into sedation protocols can reliably enhance calf welfare following disbudding."

Journal • Anesthesia • Pain

A 36-Year-Old Black Male With Sickle Cell Disease and Coexisting Psychiatric Comorbidity: Utilizing Open Dialogue Practices to Overcome Stigma and Enhance Patient-Centered Care. (PubMed, Case Rep Psychiatry) - "Pharmacologic treatment was initiated with sertraline titrated to 150 mg daily, and his pain was managed with buprenorphine-naloxone 1 mg twice daily, meloxicam 15 mg daily, and acetaminophen 650 mg every 6 h as needed. This case illustrates the potential for integrating OD principles to promote transparency and collaborative decision making that could help mitigate the detrimental effects of stigma and structural racism for black patients with SCD. Developing and testing standardized OD protocols could potentially further enhance patient-centered care and reduce healthcare disparities."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Genetic Disorders • Hematological Disorders • Inflammation • Major Depressive Disorder • Mood Disorders • Obsessive-Compulsive Disorder • Pain • Psychiatry • Sickle Cell Disease • Suicidal Ideation

Role of Cytokines in Wound Healing Following Wound Catheter Analgesia in Rats. (PubMed, Vet Sci) - "Meloxicam and buprenorphine increased TGF-β1 expression, but their vascular effects differed considerably. Meloxicam induced a marked increase in angiogenesis, but the newly formed vessels were structurally immature, displaying uniformly narrow lumina and poor architectural organisation, which led to their subsequent regression. In contrast, buprenorphine supported the formation of more mature vascular structures, characterised by wider vessel lumina and a more organised vascular network. These findings demonstrate that adjuvants used with levobupivacaine can significantly modify angiogenic and apoptotic responses and should be carefully considered when selecting multimodal local analgesia strategies after surgery."

Journal • Preclinical • Pain • CASP3 • TGFB1

Epidural and quadratus lumborum blocks with 1% lidocaine provide comparable analgesia while maintaining cardiovascular and respiratory stability in dogs undergoing ovariohysterectomy. (PubMed, J Am Vet Med Assoc) - "All dogs were premedicated with dexmedetomidine and meloxicam, anesthetized with propofol, and maintained with sevoflurane under spontaneous ventilation...The number of fentanyl boluses did not differ between groups...EP and QL blocks with 1% lidocaine provided comparable anesthetic stability and postoperative analgesia in dogs premedicated with dexmedetomidine and meloxicam undergoing OVH. EP and QL blocks with 1% lidocaine provided similar anesthetic and analgesic effects, with the EP technique requiring less equipment and patient manipulation."

Journal • Anesthesia • Cardiovascular • Gynecology • Pain