CAStem (human embryonic stem cell-derived M cells) / Chinese Academy of Sciences, Wuhan Jinyintan Hospital - LARVOL DELTA

New insights on mesenchymal stem cells therapy from the perspective of the pathogenesis of nonalcoholic fatty liver disease. (PubMed, Dig Liver Dis) - "Increasingly, studies suggest that mesenchymal stem cells hold promise in the treatment of chronic liver injury diseases. This review focuses on investigating the role of mesenchymal stem cells in chronic metabolic liver diseases, such as non-alcoholic fatty liver disease, and delves into their specific functions."

Journal • Review • Fibrosis • Hepatology • Immunology • Liver Failure • Metabolic Dysfunction-Associated Steatotic Liver Disease • Oncology • Transplantation

Phase II clinical trial of CAStem cell injection in the treatment of acute graft-versus-host disease (ChiCTR) - P2 | N=18 | Recruiting | Sponsor: West China Hospital of Sichuan University; Beijing Zephyrm Biotechnology Co., LTD | Not yet recruiting ➔ Recruiting

Enrollment open • Acute Graft versus Host Disease • Graft versus Host Disease • Immunology

PGE2 Overexpressing Human Embryonic Stem Cell Derived Mesenchymal Stromal Cell Relieves Liver Fibrosis in an Immuno-suppressive Manner. (PubMed, Stem Cell Rev Rep) - No abstract available

Journal • Stroma • Fibrosis • Hepatology • Immunology • Liver Cirrhosis

Human embryonic stem cell-derived mesenchymal stromal cells suppress inflammation in mouse models of rheumatoid arthritis and lung fibrosis by regulating T-cell function. (PubMed, Cytotherapy) - "Transplantation of hESC-MSCs represents a promising therapeutic strategy for RA, potentially regulating T-cell proliferation and differentiation."

Journal • Preclinical • Stroma • Fibrosis • Immunology • Inflammation • Inflammatory Arthritis • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Transplantation

Clinical-grade human embryonic stem cell-derived mesenchymal stromal cells ameliorate diabetic retinopathy in db/db mice. (PubMed, Cytotherapy) - "The findings of our study indicated that intravenous transplantation of hESC-MSCs ameliorated retinal neural and microvascular dysfunctions, regulated body weight and FBG and modulated peripheral blood and retinal inflammation responses in a mouse model of DR. These results suggest that hESC-MSCs could be a potentially effective clinical-grade cell source for the treatment of DR."

Journal • Preclinical • Stroma • Diabetic Retinopathy • Inflammation • Ocular Inflammation • Retinal Disorders • Transplantation • CCL2 • IL10

Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects. (PubMed, Med Res Rev) - "To avoid human error and reduce the risk of contamination, an automatic, closed system that allows real-time monitoring of QC should be considered. We also highlight potential advantages of pluripotent stem cells as an alternative source for MSC and exosomes generation and manufacture."

Journal • Metastases • Review • Immunology

One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. (PubMed, Neural Regen Res) - "Importantly, midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts. Overall, our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation."

Journal • Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease • Transplantation

Scalable preparation of osteogenic micro-tissues derived from hESC-derived immunity-and-matrix-regulatory cells within porous microcarriers in suspension culture. (PubMed, Cell Prolif) - "In this study, we demonstrated for the first time that human embryonic stem cell-derived MSCs, also known as immunity-and-matrix-regulatory cells (IMRCs), could be inoculated into microcarriers to create osteogenic micro-tissues appropriate for scalable production in 250 mL bioreactor...Furthermore, the expression levels of osteogenic biomarker genes/proteins such as alkaline phosphatase (ALP), osteocalcin (OCN), runt-related transcription factor 2 (RUNX2), osteopontin (OPN) and osterix (OSX) were significantly higher than osteogenic micro-tissues derived from UCMSCs-seeded microcarriers. Our findings imply that IMRCs could potentially serve as seed cells for the scalable production of osteogenic micro-tissues for BD treatment."

Journal • Orthopedics • RUNX2 • SPP1

Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model. (PubMed, Cell Death Dis) - "Our iPSCs model showed enhanced expression of autophagy proteins, attenuated the expression and toxic effects of mutant ataxin-3 on neurons, and alleviated the effects of ataxin-3 on autophagy. Therefore, MSCs are associated with autophagy-inducing therapy and compared to animal models, our MSCs co-culture could be used as a novel and potential therapeutic approach to study SCA3 disease and other neurodegenerative diseases."

Journal • Ataxia • CNS Disorders • Movement Disorders • ATXN3 • BECN1 • TFEB

Current status of clinical trials assessing mesenchymal stem cell therapy for graft versus host disease: a systematic review. (PubMed, Stem Cell Res Ther) - "In this study, we attempted to analyze the clinical trials for MSCs in GVHD, identify the most suitable group of patients for MSC therapy, and provide a new perspective for the design of such trials in the future."

Journal • Review • Bone Marrow Transplantation • Graft versus Host Disease • Immune Modulation • Immunology • Inflammation • Transplantation

MSCLCTWPOI: Mesenchymal Stem Cells (MSCs) - Like Cell Transplantation in Women With Primary Ovarian Insufficiency (clinicaltrials.gov) - P1; N=28; Active, not recruiting; Sponsor: Chinese Academy of Sciences; Recruiting ➔ Active, not recruiting

Enrollment closed • Endocrine Disorders • Transplantation • Women's Health

Safety and Efficacy of CAStem for Severe COVID-19 Associated With/Without ARDS (clinicaltrials.gov) - P1/2; N=9; Recruiting; Sponsor: Chinese Academy of Sciences

Clinical • New P1/2 trial