BE CAR33 T / Great Ormond Street Hospital for Children - LARVOL DELTA

Base edited CAR T cells for combinatorial strategies against acute myeloid leukaemia (ESGCT 2024) - "Base edited “universal” TCRa/b- CD7- CD52- BE-CARCLL-1, BE-CAR33 and BE-CAR7 effectors were generated from peripheral blood mononuclear cells by lentiviral transduction following activation, and electroporation with base-editor mRNA alongside multiplexed base editing single guide RNAs...Disruption of CD7 was included to enable BE-CAR7 production and allow co-infusion of other BE-CAR products, and CD52 editing conferred resistance to Alemtuzumab...Therapeutic strategies envisage ‘pick & mix’ applications of universal CAR T cell combinations determined by patient-specific target selection after flow-based disease immunophenotyping. Combinations of fratricide-resistant, lymphodepletion insensitive, co-infusion compatible CAR T cells would be harnessed for leukaemic eradication and deep preparative conditioning ahead of programmed, donor-derived reconstitution following allogeneic haematopoietic stem cell transplant (HSCT)."

CAR T-Cell Therapy • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Aplastic Anemia • Bone Marrow Transplantation • Chronic Lymphocytic Leukemia • Graft versus Host Disease • Hematological Malignancies • Immunology • Leukemia • Oncology • Pediatrics • T Acute Lymphoblastic Leukemia • T-cell Acute Lymphoblastic Lymphoma • CD33

CARAML: Base Edited CAR T Cells Against AML: Deep Conditioning Ahead of Allogeneic Stem Cell Transplantation (clinicaltrials.gov) - P1 | N=10 | Recruiting | Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust | Not yet recruiting ➔ Recruiting

CAR T-Cell Therapy • Enrollment open • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Hematological Malignancies • Leukemia • Oncology • Transplantation • CD33

CARAML: Base Edited CAR T Cells Against AML: Deep Conditioning Ahead of Allogeneic Stem Cell Transplantation (clinicaltrials.gov) - P1 | N=10 | Not yet recruiting | Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

CAR T-Cell Therapy • New P1 trial • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Hematological Malignancies • Leukemia • Oncology • Transplantation • CD33