amoxicillin/sulbactam / Generic mfg. - LARVOL DELTA

Molecular and phylogenetic characterization of Staphylococcus aureus isolated from primary pyoderma in a goat from tropical India: an emerging zoonotic threat. (PubMed, Vet Res Commun) - "The isolate was catalase positive and exhibited sensitivity to tetracycline, gentamicin, amoxicillin-sulbactam, ceftriaxone-tazobactam, and streptomycin, but showed resistance to multiple antibiotics. The genetic proximity to human pathogenic strains across diverse regions highlighted the broad host range of the bacterium. The findings of present study underscore the need for molecular surveillance, antimicrobial stewardship, and integrated One Health strategies to mitigate emerging zoonotic threats, particularly in regions with frequent human-livestock contact."

Journal • Infectious Disease • Septic Shock • CAT

Antimicrobial susceptibility of Porphyromonas spp. isolated from dogs with periodontal disease in South Korea. (PubMed, Front Vet Sci) - "Resistance was detected in six isolates (15%) to penicillin, three (7.5%) to imipenem, three (7.5%) to meropenem, 15 (25%) to clindamycin, and seven (17.5%) to ampicillin. No resistance was observed to ampicillin/sulbactam, amoxicillin/clavulanic acid, cefotetan, cefoxitin, metronidazole, chloramphenicol, piperacillin, tetracycline, mezlocillin, or piperacillin/tazobactam. These findings provide crucial insights into the antimicrobial susceptibility patterns of canine oral Porphyromonas spp. and highlight the importance of judicious antimicrobial use in veterinary dentistry."

Journal • Dental Disorders • Periodontitis

Clinical epidemiological characteristics and antibiotic sensitivity of Escherichia coli urinary tract infection. (PubMed, PLoS One) - "Urinary tract infections caused by E. coli are predominantly community acquired, accounting for 84.5%(339/401), and most cases involved ESBL-negative strains. Therefore, third-generation cephalosporins remain the preferred choice for empirical treatment, while quinolones and second-generation cephalosporins are not recommended. Subsequently, the treatment regimen can be de-escalated based on confirmed infection type and patient condition, an approach that has been associated with reduced hospitalization."

Journal • Infectious Disease • Nephrology

Clinical characteristics and influencing factors of severe influenza A virus pneumonia in children coinfected with gram-negative bacteria: A retrospective analysis. (PubMed, J Int Med Res) - "In the observation group, all H. influenzae isolates were sensitive to ceftriaxone, cefotaxime and meropenem, while resistance rates to ampicillin, trimethoprim-sulfamethoxazole, cefuroxime and ampicillin/sulbactam were 60.4%, 75%, 27.8% and 6.2%, respectively. All M. catarrhalis isolates were sensitive to ampicillin/sulbactam, amoxicillin/sulbactam and ciprofloxacin, whereas resistance rates to ampicillin and trimethoprim-sulfamethoxazole were 67.9% and 10.7%, respectively.ConclusionSevere influenza A virus pneumonia complicated by gram-negative bacterial infection is more common in children aged <5 years. Younger age and the presence of underlying diseases increase the likelihood of gram-negative bacterial coinfection. Persistent fever, wheezing and significant elevations in C-reactive protein level, procalcitonin level, platelet count and monocyte count are important early warning signs for the clinical identification of gram-negative bacterial infection."

Journal • Retrospective data • Critical care • Infectious Disease • Influenza • Pediatrics • Pneumonia • Respiratory Diseases • CRP

False equivalence: differences in the in vitro activity of ampicillin-sulbactam and amoxicillin-clavulanate in several Enterobacterales species. (PubMed, JAC Antimicrob Resist) - "Isolates of E. coli, K. pneumoniae group and P. mirabilis with susceptibility profiles consistent with ESBL production (ceftriaxone resistant and cefoxitin susceptible) were more likely to be susceptible to AMC but not susceptible to SAM than isolates without this susceptibility phenotype (E. coli, 38% versus 27%, P < 0.0001; K. pneumoniae group: 40% versus 10%, P < 0.0001; P. mirabilis: 24% versus 6%, P < 0.0001). The high prevalence of SAM-not susceptible, AMC-susceptible isolates supports reporting AST results for both SAM and AMC to maximize options for antimicrobial therapy and to support antimicrobial stewardship."

Journal • Preclinical • Infectious Disease • Pneumonia

The correlation between antibiotic usage and antibiotic resistance: a 3-year retrospective study. (PubMed, Front Cell Infect Microbiol) - "Cefoperazone/sulbactam, amoxicillin/clavulanic acid, ceftriaxone, and ceftazidime showed significant changes in susceptibility for K. pneumoniae over time. Regarding the correlation between antibiotic usage and antibiotic resistance, Pearson's correlation was 0.777 (p = 0.433), which is suggestive of a strong positive correlation between third-generation cephalosporin usage and extended-spectrum beta-lactamase (ESBL), whereas Pearson's correlation was 0.762 (p = 0.448), which also suggests strong positive correlation between carbapenem usage and CREs. The correlation between the use of third-generation cephalosporins and ESBL rate, as well as the use of carbapenems and CRE rate, further suggests that controlling certain antibiotic usage could help mitigate the rise in MDR microorganisms."

Journal • Retrospective data • Infectious Disease • Pneumococcal Infections • Pneumonia

Antimicrobial Resistance Profile of Escherichia coli Isolated from Raw Chicken Meat in a Selected Wet Market in Manila City, Philippines. (PubMed, Acta Med Philipp) - "High resistance rates were observed against ampicillin (92%), tetracycline (88%), trimethoprim-sulfamethoxazole (83%), chloramphenicol (79%), ampicillin-sulbactam (75%), amoxicillin-clavulanic acid (67%), fosfomycin (67%), and streptomycin (54%). The majority of the E. coli isolates were still susceptible to a wide range of selected antimicrobial agents, including carbapenems (100%), ceftriaxone (100%), cefepime (100%), cefuroxime (96%), cefotaxime (96%), ceftazidime (96%), piperacillin-tazobactam (96%), aztreonam (96%), cefoxitin (92%), and nitrofurantoin (83%), among others...This study suggests that chickens in wet markets can potentially serve as reservoir hosts for drug-resistance genes, which could transfer to other bacteria and contaminate humans, animals, and the environment within the food production and supply chain. These findings emphasize the need for AMR surveillance and strategies to combat AMR in the Philippines through the One Health approach."

Journal • Infectious Disease

Pulmonary Actinomycosis Causing an Unusual Presentation in a Patient with COPD: A Case Report. (PubMed, Ethiop J Health Sci) - "The patient was initially treated with intravenous amoxicillin/sulbactam, later switched to oral amoxicillin. This case highlights a rare clinical presentation of pleural effusion in a patient with pulmonary actinomycosis."

Journal • Chronic Obstructive Pulmonary Disease • Cough • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Characterization of bla NDM-5-carrying plasmids in two clinical Salmonella isolates from Jiaxing city, China. (PubMed, Front Microbiol) - "Both isolates were multidrug resistant, with insusceptibility to ampicillin, ampicillin/sulbactam, amoxicillin/clavulanic acid, cefuroxime, ceftiofur, cefazolin, cefoxitin, cefotaxime, ceftazidime, cefepime, ceftazidime/avibactam, meropenem, imipenem, ertapenem, tetracycline, gentamicin, trimethoprim/sulfamethoxazole, florfenicol, chloramphenicol, ciprofloxacin, colistin, and polymixin B. The bla NDM-5-carrying plasmids in 2023JX045 and 2024-406 were named p23045-NDM5 and p2024406-NDM5, respectively, with both belonging to the incompatibility (Inc)HI2/IncHI2A group and sequence type ST3. IS26-flanked composite transposons appeared to play an important role in the formation of this region. The dissemination of blaNDM in Salmonella isolates and the complexity of the bla NDM-5 region highlight the urgent need to monitor carbapenem-resistant S. enterica."

Journal • Infectious Disease

Has the COVID-19 pandemic affected Vulvovaginitis in Prepuberty and Adolescent Females in China? A retrospective study of 4 644 cases during 2018-2021. (PubMed, J Pediatr Adolesc Gynecol) - "Our findings provide evidence-based guidance for appropriate antibiotic use and facilitate the optimization of therapeutic strategies and lifestyle recommendations for prepubertal and adolescent girls with VV."

Journal • Retrospective data • Infectious Disease • Influenza • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Vaginitis

Drug prescribing pattern in upper respiratory tract infections among the pediatric population attending outpatient clinics in pediatric hospitals. (PubMed, World J Clin Pediatr) - "Overprescription of antibiotics is a significant issue among clinicians in pediatric outpatient clinics. Stewardship of drugs, particularly antibiotics, is a must to prevent the development of drug resistance. Most cases of URTIs were treated in accordance with the existing national treatment guidelines."

Journal • Infectious Disease • Pediatrics • Respiratory Diseases

The Accuracy of Empirical Antibiotic Treatment for Periprosthetic Joint Infections in Total Shoulder and Knee Arthroplasties. (PubMed, Antibiotics (Basel)) - " The most administered postoperative empirical antibiotics were cefuroxime and amoxicillin-sulbactam. Furthermore, a statistically significant difference was observed in the sensitivities of pathogens to metronidazole (p < 0.001) and erythromycin (p = 0.014). This study demonstrates microbiological and antimicrobial resistance differences between PJI TSA and TKA cases."

Journal • Infectious Disease • Mood Disorders • Orthopedics

Detection of rare β-lactamase bla SCO-1 from a Klebsiella pneumoniae high-risk clone in Peru. (PubMed, JAC Antimicrob Resist) - "Susceptibility to amoxicillin/clavulanic acid, amoxicillin/sulbactam, piperacillin/tazobactam, aztreonam, ceftriaxone, cefotaxime, ceftazidime, ceftazidime/avibactam, cefepime, imipenem, meropenem, ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, amikacin and tigecycline was determined using the Kirby-Bauer disc diffusion method...Illumina WGS showed the presence of bla SCO-1 and bla OXA-1, bla SHV-28, bla TEM-1, bla CTX-M-15, as well as genes associated with resistance to quinolones, fosfomycin, aminoglycosides, sulphonamides, trimethoprim and phenicols...Phylogenetic relationships were established by comparisons with 19 K. pneumoniae genomes carrying bla SCO-1 from other countries in the Americas, revealing at least three different clades. This study highlights the importance of genomic surveillance of uncommon antimicrobial resistance genes such as bla SCO-1, which might contribute to further antimicrobial resistance levels in this country."

Journal • Infectious Disease • Pneumonia

Genomic Characterization and Antimicrobial Resistance of ESBL-Producing, Escherichia coli Isolates in Suzhou, China. (PubMed, Infect Drug Resist) - "No predominant blaCTX-M subtypes were detected, while the coexistence of different ESBL types was strongly linked to resistance to amoxicillin/sulbactam, cefepime, ceftazidime, and aztreonam, suggesting the widespread circulation of diverse blaCTX-M genes within the Suzhou community. In clinical cases of ESBL resistance, carbapenem therapy is recommended as most (>90%) isolates were susceptible."

Journal

Microbiology and antibiotic-therapy in patients admitted to a Community Hospital according to days of hospitalization, 2022-2023 (PubMed, Medicina (B Aires)) - "Indications for amoxicillin/sulbactam decreased from G3. Carbapenems and colistin increased from G3. Piperacillin/tazobactam and vancomycin were widely used in all periods. This simple weekly control allowed us to know the microbiology in the hospital, its antibiotic sensitivity patterns, detect outbreaks, and adjust the rational use of antibiotics, especially empirical, notably in the abuse of ciprofloxacin in urinary or abdominal foci; and compare the isolations and therapeutic behaviors with national and international patterns."

Journal • Infectious Disease • Pneumonia • Urology

Machine learning models for coagulation dysfunction risk in inpatients administered β-lactam antibiotics. (PubMed, Front Pharmacol) - "The incidence of coagulation disorders related to cefazolin sodium, cefoperazone/sulbactam sodium, cefminol sodium, amoxicillin/sulbactam sodium, and piperacillin/tazobactam sodium was 2.4%, 5.4%, 1.5%, 5.5%, and 4.8%, respectively. The study findings suggest that machine learning classifiers can serve as valuable tools for identifying patients at risk of coagulation dysfunction associated with β-lactam antibiotics and intervening based on high-risk predictions. Enhanced access to administrative and clinical data could further enhance the predictive performance of machine learning models, thereby expanding pharmacovigilance efforts."

Journal • Machine learning • Hematological Disorders

A Newly Incompatibility F Replicon Allele (FIB81) in Extensively Drug-Resistant Escherichia coli Isolated from Diseased Broilers. (PubMed, Int J Mol Sci) - "They shared resistance to ampicillin, ampicillin/sulbactam, amoxicillin/clavulanate, doxycycline, cefotaxime, and colistin. These findings suggest that broilers are a significant reservoir of IncF replicons with highly divergent IncF-FIB plasmid incompatibility groups circulating among XDR Enterobacterales. Supporting these data with additional comprehensive epidemiological studies involving replicons other than the IncF can provide insights for implementing efficient policies to prevent the spreading of new replicons to humans."

Journal

Piperacillin-Tazobactam versus Cefotaxime as Empiric Treatment for Febrile Urinary Tract Infection in Hospitalized Children. (PubMed, Infect Chemother) - "In Korea, escalating resistance to empirical antibiotics has led to the adoption of broad-spectrum empirical treatment. TZP emerged as a viable alternative to CTX for hospitalized children aged ≥3 months with UTIs. Consideration of ESBL-positive strains and individualized approaches for those <3 months are crucial."

Journal • Infectious Disease • Nephrology • Pediatrics

Severe Complicated Pelvic Inflammatory Disease: A Presentation of Unusual Polymicrobial Pathogens (ATS 2024) - "Piperacillin/Tazobactam was initiated...Antimicrobials were transitioned to Ceftriaxone, Doxycycline and Metronidazole...The patient was transitioned to oral Amoxicillin/Sulbactam on discharge...Despite this, P. asaccharolyticus is rarely implicated in development of PID, and F. necrophorum even more so. Due to this, anaerobic coverage during PID treatment is imperative."

Asthma • Cardiovascular • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Hypotension • Infectious Disease • Infertility • Inflammation • Pain • Pulmonary Disease • Respiratory Diseases • Septic Shock • Sexual Disorders

A Comprehensive Study to Determine the Residual Elimination Pattern of Major Metabolites of Amoxicillin-Sulbactam Hybrid Molecules in Rats by UPLC-MS/MS. (PubMed, Molecules) - "These results showed that the total quantity of amoxicillin, amoxicilloic acid, and amoxicillin diketopiperazine was eliminated more slowly in the liver and kidney of the AS group than those of the mixture group and that the excretion rate through urine and feces was essentially the same for both groups. The residual elimination pattern of the hybrid molecule in rats determined in this study provides a theoretical basis for the in-depth development and application of hybrid molecules, as well as guidelines for the development of similar drugs."

Journal • Preclinical

Genetic determinants underlying the progressive phenotype of β-lactam/β-lactamase inhibitor resistance in Escherichia coli. (PubMed, Microbiol Spectr) - "Currently, whole-genome sequencing (WGS) data have not shown strong concordance with Escherichia coli susceptibility profiles to the commonly used β-lactam/β-lactamase inhibitor (BL/BLI) combinations: ampicillin-sulbactam (SAM), amoxicillin-clavulanate (AMC), and piperacillin-tazobactam (TZP)...The diversity of β-lactam resistance mechanisms, including non-ceftriaxone hydrolyzing bla variants, bla, and ampC and bla strong promoter mutations, was greater in AMC- and TZP-non-susceptible strains but rarely observed within SAM- and AMP-non-susceptible isolates...We were able to characterize the complexity of the genetic mechanisms underlying progressive BL/BLI resistance including the critical role of β-lactamase encoding gene amplification. For the diverse array of AMR phenotypes with complex mechanisms involving multiple genomic factors, our study provides an example of how composite risk scores may improve understanding of AMR genotype/phenotype correlations."

Journal • Infectious Disease

Point prevalence probing of antimicrobial prescription patterns from a developing country. (PubMed, Expert Rev Anti Infect Ther) - "Most commonly prescribed antimicrobial was ceftriaxone (21.7%), followed by metronidazole (17.3%), cefoperazone-sulbactam (8.4%), amoxicillin-clavulanate (6.3%), and piperacillin/tazobactam (5.9%). Findings demonstrate high consumption of broad-spectrum antimicrobials and emphasize the importance of expanding antimicrobial stewardship programs among hospitals. Mentoring clinical teams could help rationalize antimicrobial use."

Journal • Infectious Disease

Combining the Real-Time Vial Sharing Strategy with Daily-Rate Charge Mode for Antimicrobial Drugs of Inpatients: An Economical and Practical Method for Patients and Hospitals. (PubMed, Risk Manag Healthc Policy) - "The top 5 drugs saved by the real-time vial-sharing strategy were cefoperazone-sulbactam, vancomycin, amoxicillin-sulbactam, ceftazidime, and meropenem. Taken the price into consideration, the top five payment-saved drugs were vancomycin (¥ 1,522,385), meropenem (¥ 1,311,475), cefoperazone-sulbactam (¥ 736,697), imipenem-cilastatin (¥ 406,092), and amoxicillin-sulbactam (¥ 51,394)...The real-time vial sharing strategy combined with the daily-rate charge mode greatly reduces drug wastage and patients' payments. It may be useful for hospitals with PIVAS to achieve vial-sharing while protecting the best interest of inpatients."

Journal • Pediatrics

Prevalence and resistance profile of bacteria isolated from wound infections among a group of patients in upper Egypt: a descriptive cross-sectional study. (PubMed, BMC Res Notes) - "The prevalence of MRSA isolated from various wound infections and MDR is a warning issue in Upper Egypt. It should implement a health education strategy and hygiene measures to prevent the spread of wound infection-causing organisms in the community."

Journal • Observational data • Infectious Disease

Brumadinho dam collapse induces changes in the microbiome and the antibiotic resistance of the Paraopeba River (Minas Gerais, Brazil). (PubMed, Sci Total Environ) - "Antibiotic resistance increased significantly to amikacin, ampicillin, ampicillin/sulbactam, amoxicillin/clavulanate, ceftriaxone, cefalotin, and meropenem among isolates obtained in May after the disaster. The effects of toxic mud on microbiomes were felt at all points sampled up to Anguereta. The ore mud may have exacerbated the growth of different antibiotic-resistant, metal-resistant, and faecal-indicating bacteria in the Paraopeba River."

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