RT023
/ Shanghai Ruotuo Biotechnology
- LARVOL DELTA
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March 18, 2026
RT023, a first-in-class CEACAM5/EGFR targeted bispecific antibody drug conjugate (ADC) in colorectal cancer (CRC)
(AACR 2026)
- "EGFR antibodies like cetuximab are standard first-line therapy for colorectal cancer (CRC) patients with wild-type KRAS, but are less effective in those with KRAS mutations, creating an unmet clinical need. ADCs targeting CEACAM5 or EGFR, such as M9140 and MRG003, are under clinical development for CRC; however, single-target ADCs have shown limited efficacy, likely due to variable antigen expression among patients... RT023, with its unique bispecific design and differentiated features in affinity, linker-payload, has shown promising potential as a first-in-class ADC candidate for CRC treatment. Preclinical discovery studies have revealed favorable efficacy and toxicity profiles, supporting advancing RT023 into first-in-human studies."
ADC • Bispecific • First-in-human • Colorectal Cancer • Oncology • Solid Tumor • CEACAM5 • KRAS
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