verapamil / Generic mfg. - LARVOL DELTA

Regulation of Calcium Homeostasis by PIEZO1 Drives NETosis and Fibrosis in Bronchopulmonary Dysplasia. (PubMed, J Cell Mol Med) - "Experimental validation confirmed elevated NETosis markers (PADI4, MPO, dsDNA) in BPD patients and further demonstrated that PIEZO1 overexpression promotes NET formation via calcium overload, which was inhibited by verapamil. Additionally, using a co-culture system, we showed that PIEZO1-induced NETosis exacerbates pulmonary fibrosis in lung epithelial cells. These findings highlight PIEZO1 as a key regulator of NETosis in BPD and a promising therapeutic target for mitigating lung injury and fibrosis."

Journal • Bronchopulmonary Dysplasia • Fibrosis • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • IL6

The antihypertensive and cardiovascular effects of lawsone methyl ether in high salt-induced hypertensive rats are mediated through multiple pathways. (PubMed, Biochem Pharmacol) - "Nonetheless, LME completely reversed the phenylephrine (PE), high K+ and angiotensin-II-induced contractions, causing a rightward shift in Ca+2 concentration response curves, identical to that of verapamil. This vasorelaxant activity was substantially ameliorated by 4-aminopyridine...In isolated atrial strips, LME induced atenolol-sensitive negative inotropic and chronotropic effects. Molecular docking suggested cardiovascular targets for LME, including nitric oxide synthase, muscarinic receptors, voltage-dependent calcium channels, beta-adrenergic receptors, potassium channels, and angiotensin-converting enzyme, supporting its potential role as a multi-target antihypertensive agent. Concludingly, herein, LME delivered promising antihypertensive and cardio-suppressive effects by reducing peripheral resistance via muscarinic receptor-linked NO release, Ca+2 antagonism, inhibiting Ca+2 efflux, and reducing cardiac output."

Journal • Preclinical • Cardiovascular

The QUEEN-IVF trial: Quinidine versus verapamil in short-coupled idiopathic ventricular fibrillation: An open-label, randomized crossover pilot trial (clinicaltrialsregister.eu) - P1/2 | N=24 | Recruiting | Sponsor: Amsterdam UMC | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular

Predicting the potential for organic cation transporter 1-mediated drug-drug interactions with fenoterol by amitriptyline, fluoxetine, selegiline, metformin, and verapamil. (PubMed, Expert Opin Drug Metab Toxicol) - "An in vitro OCT1 inhibition assay using fenoterol as probe substrate was validated and identified that verapamil may pose a clinically relevant interaction risk, predicting a minimum 2-fold increase in fenoterol exposure. This highlights the need for caution when coadministrating verapamil with fenoterol and supports incorporating OCT1 inhibition profiling into preclinical evaluation of new drug entities to better inform clinical development and ensure patient safety."

Journal • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases • SLC22A1

Multimodal Management of Keloid and Hypertrophic Scars: A Review of Current Therapeutic Strategies (AAD 2026) - " Comprehensive literature synthesis examined treatment modalities including intralesional injectables (triamcinolone acetonide [TAC], 5-flurouracil [5-FU], botulinum toxin-A [BTX-A], verapamil, platelet-rich plasma [PRP]), energy-based devices (laser, radiotherapy), and surgical options with adjuvant therapies... Multimodal, individualized approaches combining injectables, energy-based devices, in addition to surgical excision with adjuvant therapy yield optimal outcomes for keloid and hypertrophic scars, improving characteristics and reducing recurrence with acceptable safety."

Review • Fibrosis

12-Hydroxystearic Acid (12-HSA) enhances autophagy and lysosome-Mediated skin processes thus promotes melanosome degradation and improves skin barrier in vitro (AAD 2026) - "Autophagy activity, barrier marker and melanosome degradation were further evaluated in HaCaT keratinocytes Treatments included 12-HSA, Verapamil (autophagy agonist), and Hydroxychloroquine (HCQ, autophagy inhibitor). In silico analysis of RNA seq data suggests that 12-HSA may modulate autophagy through PPAR signalling. These findings suggest that 12-HSA promotes autophagy and lysosomal function, in keratinocytes thus facilitating melanosome degradation and enhancing skin barrier properties."

Preclinical • FLG

Comparative efficacy of intralesional therapies for keloid scars: A Network Meta-Analysis of clinical trials (AAD 2026) - "Results From 51 studies (3,234 participants, 23 interventions), 5-fluorouracil (5-FU) + Corticoids significantly improved keloid reduction compared to corticoids alone...Regarding adverse effects, a significant risk reduction was found for BTX-A (RR = 0.29; 95% CI: 0.09–0.95; p = 0.04) and Verapamil (RR = 0.35; 95% CI: 0.14–0.84; p = 0.01) compared to corticoids; others showed no significant effects. Conclusion This NMA provides a comparative overview, indicating that combination therapies, most notably 5-FU+ corticoids + YAG: Laser, offer the greatest benefit. While data for novel agents (insulin and BTX-A) suggest potential, further research with standardized methodologies and longer-term follow-up is crucial to define optimal treatment algorithms."

Retrospective data • Fibrosis • Immunology • Pruritus

Overcoming acquired doxorubicin resistance of ovarian carcinoma cells by verapamil‑mediated promotion of DNA damage‑driven cytotoxicity. (PubMed, Int J Oncol) - "A2780ADR cells revealed cross‑resistance to multiple compounds, including anticancer drugs [cisplatin (CisPt) and etoposide (Eto)] and DNA repair/DNA damage response (DDR) inhibitors (olaparib, niraparib, entinostat, prexasertib and rabusertib). However, combination treatment with Doxo and Ver also increased the cytotoxic response of non‑malignant murine cardiomyocytes, murine embryonic stem cells and human induced pluripotent stem cells. Taken together, the present study suggested inhibition of MDR1‑mediated Doxo efflux by Ver a useful approach to overcome acquired drug resistance of A2780ADR cells by stimulating DDR‑related cytotoxicity, yet at the price of a potentially increased risk of normal tissue toxicity."

Journal • Oncology • Ovarian Cancer • Solid Tumor • ABCB1 • RAC1

Early clinical pharmacology evaluation of the novel anti-inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions. (PubMed, Br J Clin Pharmacol) - "Glasmacinal was well tolerated in single doses up to 750 mg and repeat doses up to 375 mg. Glasmacinal may be a victim of selected drugs that impact CYP3A4 and/or P-gp but is unlikely to be a perpetrator of clinically relevant DDIs."

Clinical • First-in-human • Journal • PK/PD data • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

BEYOND THE HEURISTIC: ADENOSINE FAILURE AND AV-NODAL BLOCKER TERMINATION DO NOT EXCLUDE SUPRAVENTRICULAR TACHYCARDIA (ACC 2026) - "Intravenous diltiazem restored sinus rhythm; a second episode terminated after metoprolol 5 mg...Decision-Making: With structural heart disease, adenosine non-response, and apparent verapamil sensitivity, fascicular VT was suspected and ICD considered... Adenosine-refractory WCT that terminates with AV-nodal blockade does not confirm fascicular VT. In patients with conduction disease, atrial tachycardia with aberrancy can mimic VT. EP study is essential before committing to device therapy."

Cardiomyopathy • Cardiovascular • Chronic Obstructive Pulmonary Disease • CNS Disorders • Congestive Heart Failure • Diabetes • Heart Failure • Immunology • Infectious Disease • Metabolic Disorders • Pneumonia • Respiratory Diseases • Ventricular Tachycardia

TAKOTSUBO CARDIOMYOPATHY WITH DYNAMIC LEFT VENTRICULAR OUTFLOW TRACT OBSTRUCTION PRESENTING AS STEMI TRIGGERED BY DUCK FLOWER DETOX (ACC 2026) - "Angiography showed reversible coronary vasospasm relieved by nitroglycerin and verapamil...Hypotension was managed with fluids and midodrine; inotropes were avoided... This first reported case of Takotsubo cardiomyopathy from a "duck flower" cleanse highlights the risk of unregulated herbal products and the need to avoid inotropes in dynamic obstruction."

Acute Coronary Syndrome • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Vascular Neurology

VENTRICULAR TACHYCARDIA WITHOUT STRUCTURAL HEART DISEASE: UNMASKING A PRE-WORKOUT PROVOCATION (ACC 2026) - "This case highlights stimulant-containing pre-workout supplements as potential VT triggers in structurally normal hearts. Early recognition of ECG features and verapamil responsiveness are critical in diagnosis and management of fascicular VT."

Cardiovascular • Heart Failure • Ventricular Tachycardia

MEDICAL MANAGEMENT OF CONCURRENT HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY AND AORTIC STENOSIS (ACC 2026) - "Decision-Making: The patient remained asymptomatic for five years on verapamil with routine echocardiography. Despite fluctuations in obstruction and symptoms over the next year, initiation of mavacamten as sole therapy resulted in symptomatic and hemodynamic improvement... This case illustrates successful medical management of dual obstruction, prioritizing HOCM while monitoring AS. Further investigation is needed to establish evidence-based strategies for treating concurrent conditions."

Cardiomyopathy • Cardiovascular • Dyslipidemia • Hypertension • Hypertrophic Cardiomyopathy • Obstructive Hypertrophic Cardiomyopathy

A FISHY SITUATION: A-FIB DURING PREGNANCY (ACC 2026) - "She was given verapamil and omega-3 was discontinued... It is important to ask about supplements, especially in pregnant patients as these are not frequently disclosed. Omega 3 has been commercialized as a benign supplement, and this case highlights potential arrhythmogenic effect of high-dose omega-3 use possibly through altered ion channel activity and the importance of identifying reversible causes in new-onset AF."

Cardiovascular

A TOXIC TRIGGER: 5-FLUOROURACIL INDUCED STEMI (ACC 2026) - "Decision-Making: Intra-coronary nitroglycerin was given, leading to complete reversal, thereby confirming vasospasm...The patient was treated with verapamil and isosorbide mononitrate... 5-FU induced STEMI is a rare but serious complication arising from coronary vasospasm due to endothelial dysfunction. Prompt recognition is essential, as management differs from atherothrombotic STEMI and relies on discontinuation of 5-FU with vasodilator therapy, thereby avoiding unnecessary percutaneous coronary interventions."

Colon Cancer • Colorectal Cancer • Myocardial Infarction • Solid Tumor

CORONARY NO-REFLOW TREATED WITH SUPERSATURATED OXYGEN (ACC 2026) - "Intracoronary adenosine and verapamil failed to restore reperfusion (limited to TIMI 1 flow)... No reflow is a critical predictor of poor outcomes with limited rescue options. This case demonstrates SSO2 as a possible rescue treatment, successfully overcoming severe MVO. SSO2 warrants dedicated research as a targeted intervention for no reflow refractory to conventional management."

Cardiovascular • Congestive Heart Failure • Heart Failure

Arthrospira platensis prevents impairment of intestinal smooth muscle relaxation in diet-induced obesity via modulation of nitric oxide, prostanoid and oxidative stress pathways. (PubMed, J Ethnopharmacol) - "These findings provide mechanistic support for the traditional use of A. platensis, demonstrating that its protective effects on intestinal smooth muscle function are mediated by the modulation of convergent inflammatory and redox pathways. The results highlight A. platensis as an ethnopharmacologically relevant natural product with potential for preventing obesity-associated gastrointestinal dysmotility."

Journal • Genetic Disorders • Metabolic Disorders • Obesity

Pharmacokinetic Insights and Therapeutic Potential of Calcium Channel Blockers in Cardiovascular and Non-Cardiovascular Disorders. (PubMed, Curr Pharm Des) - "Since the introduction of verapamil in the 1960s, newer drugs with improved selectivity and safety, such as cilnidipine and azelnidipine, have been developed. This review provides an updated overview of the pharmacokinetics, pharmacodynamics, and therapeutic applications of dihydropyridine and non-dihydropyridine CCBs, while identifying research gaps and future directions to enhance their clinical utility. By integrating established pharmacological knowledge with recent advances, this study underscores the continued relevance of CCBs in modern medicine."

Journal • PK/PD data • Cardiovascular • CNS Disorders • Genito-urinary Cancer • Hypertension • Oncology • Vascular Neurology

Positron emission tomography-based radiopharmaceuticals for imaging the expression and function of multidrug resistance P-glycoprotein. (PubMed, J Pharmacol Exp Ther) - "It highlights the significance of various radiolabeled tracers, including verapamil, metoclopramide, and MC225, in assessing P-gp-mediated drug delivery to the brain and its role in various neurodisorders. It may help clinicians decide whether a patient is suitable for chemotherapy. Positron emission tomography imaging can provide information on P-gp activity, which can be assessed before and during chemotherapy."

Journal • Review • Alzheimer's Disease • CNS Disorders • Epilepsy • Oncology

Digital Subtraction Angiography as the First Clue to CNS Intravascular Large B-cell Lymphoma (AAN 2026) - "Digital subtraction angiography demonstrated multifocal cortical arterial irregularities within the quaternary distal cortical segments of bilateral MCA and ACA arteries that did not resolve with intraarterial verapamil administration, consistent with a small vessel arteriopathy...The patient was treated with methotrexate and CHOP chemotherapy, resulting in an improvement in mental status... Although IVLBCL is often described as "angio occult" because it preferentially involves vessels below the resolution of conventional angiography, this case demonstrates that careful review of distal cortical branches can reveal multifocal irregularities that CTA and MRA may miss. Higher resolution imaging, like vessel wall MRI may sensitively detect vasculitic changes, but such imaging remains limited to larger academic centers. A prior case report has also documented angiographic abnormalities in IVLBCL, recognition of such subtle findings may expedite biopsy and treatment."

B Cell Lymphoma • Hematological Malignancies • Large B Cell Lymphoma • Lymphoma • Non-Hodgkin’s Lymphoma • Vasculitis

Atypical Episodic Hypotonia Responsive to Verapamil in a Child with RYR1 and GNAS Variants (AAN 2026) - "Between episodes, the patient is developmentally appropriate with mild hypotonia.Electrodiagnostic testing revealed decreased amplitude and slowed conduction in the motor median nerve. This case highlights a possible novel phenotype or overlap syndrome involving RYR1 and GNAS variants with features reminiscent of AHC. The positive response to calcium channel blockade supports further exploration of this therapeutic approach and expands the differential diagnosis for episodic hypotonia in our pediatric patients."

Clinical • Metabolic Disorders • GNAS

Beta-Blocker (Bisoprolol) vs Calcium-Channel Blocker (Verapamil) in Nonobstructive Hypertrophic Cardiomyopathy: A Randomized Triple-Crossover Physiologic Trial. (PubMed, J Am Coll Cardiol) - "In nonobstructive HCM, treatment with bisoprolol reduced pVO2, whereas it was unchanged with verapamil. There were a number of significant differences in exercise response, structural changes, myocardial function, symptoms, and biomarkers. This study provides new insights into the mechanisms of these drugs that might be taken into consideration in management of nonobstructive HCM."

Clinical • Journal • Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Non-obstructive Hypertrophic Cardiomyopathy • Ventricular Tachycardia

The role of Ca2+-calcineurin signaling pathway on the antifungal activity of Murrayone against Botrytis cinerea. (PubMed, Pest Manag Sci) - "Murrayone significantly decreases the cytosolic Ca2+ concentration and disrupts Ca2+ homeostasis in B. cinerea. Its antifungal mechanism is linked to the Ca2+-calcineurin signaling pathway, potentially through acting as a calcium channel blocker. This work provides a theoretical foundation for developing Murrayone as a promising antifungal candidate and promotes its further application."

Journal

Optimisation of verapamil hydrochloride loaded polyhydroxyalkanoate nano and microparticles using response surface methodology. (PubMed, Sci Rep) - No abstract available

Journal

Bifrontal Decompressive Craniectomy in the Management of Aneurysmal Subarachnoid Hemorrhage-associated Refractory Intracranial Hypertension (AAN 2026) - "Two weeks later, the patient experienced symptomatic vasospasm of the right middle cerebral artery and bilateral supraclinoid internal carotid arteries, which was successfully treated with intra-arterial verapamil and milrinone. The case outlines the potential use of BDC as a feasible salvage therapy in aSAH with associated refractory intracranial hypertension. Although evidence outside of TBI is limited, careful assessment of neurological exams, ICP trends, imaging, and outcomes may justify individual therapeutic application in specific patient populations. Multidisciplinary care remains essential for patient selection and improved outcomes."

Cardiovascular • CNS Disorders • Hematological Disorders • Hypertension • Subarachnoid Hemorrhage • Vascular Neurology