verapamil / Generic mfg. - LARVOL DELTA

Effects of GS-967, GS-6615 and ranolazine on the responses of the rabbit aorta to adrenergic nerve stimulation. (PubMed, Front Physiol) - "Electrical Field Stimulation (EFS) (2, 4 and 8 Hz) induced frequency-dependent contractions that were abolished by tetrodotoxin, prazosin, or guanethidine (10-6 M)...Concentration-response curves to GS-967, GS-6615 or RAN were constructed in rings precontracted with noradrenaline, endothelin-1 or KCl with or without specific inhibitors (L-NAME, nimesulide, SC-560, verapamil, nifedipine, apamin or charybdotoxin)...Taken together, our results indicate that GS-967, GS-6615 and RAN decrease vasoconstrictor responses due to both neural and noradrenaline-induced adrenergic stimuli. We can suggest that the use of GS-967, GS-6615 and Ranolazine may be interesting in clinical procedures involving hyperstimulation of the adrenergic nervous system."

Journal • Preclinical • EDN1

Antifungal Activity of Lipophilic Bisphosphonates. (PubMed, ACS Infect Dis) - "The lipophilic bisphosphonates were ∼20-fold more potent against C. glabrata than the most potent hydrophilic bisphosphonate, zoledronate...Some combinations of lipophilic bisphosphonates had synergistic activity with FICI values in the ∼0.3-0.5 range, and similar synergies were observed with fluconazole, implicating ergosterol biosynthesis inhibition leading to compromised membrane structure and function...There was also synergy with other antifungals but very strong antagonism with verapamil (FICI ∼4), which blocks calcium channels. Unlike hydrophilic bisphosphonates, which target farnesyl diphosphate synthase, lipophilic bisphosphonates also target squalene synthase, suggesting that the combination of multitargeting bisphosphonates is one origin of the synergistic interactions observed. Given that one of the lipophilic bisphosphonates studied here (BPH-1237) has been shown to have activity against many other human fungal pathogens, combinations with the compounds..."

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Comparative Efficacy and Safety of Vasodilators Used to Prevent Internal Thoracic Artery Spasm in Coronary Artery Bypass Grafting: A Systematic Review. (PubMed, Cureus) - "This review systematically evaluates the comparative efficacy and safety of vasodilators used to prevent ITA spasm, including papaverine, glyceryl trinitrate-verapamil (GV) solution, systemic diltiazem, and efonidipine. Delivery method influenced efficacy, with topical or intraluminal administration providing rapid, direct vasodilation. Overall, combination therapy (GV solution) offers a practical and safe approach for intraoperative ITA spasm prevention."

Journal • Review

Delayed Progressive Multifocal Cerebral Vasculopathy Following Fat Liquefaction in the Setting of Postsurgical Meningitis (ISC 2026) - "About two weeks later, she developed recurrent symptomatic bilateral supraclinoid internal carotid artery (ICA) vasospasm with adherent small clots treated repeatedly with intra-arterial verapamil as well as hydrocephalus ultimately requiring placement of a ventriculoatrial shunt...Cerebrospinal fluid analysis demonstrated elevated protein, however, an extensive evaluation for infectious, rheumatologic, and genetic etiologies was unrevealing. Thus these delayed, progressive changes may be secondary to irritation and inflammation from fat liquefaction causing ongoing in situ vasospasm and remodeling, rather than a primary vasculopathic process."

Brain Cancer • CNS Disorders • Infectious Disease • Inflammation • Rheumatology • Solid Tumor • Ventriculomegaly

Transradial Access Without Radial Cocktail for Mechanical Thrombectomy is Safe and Feasible (ISC 2026) - "Three groups are divided: full dose cocktail (Heparin 2000 units, Verapamil 2.5mg, and Nitroglycerin 200mg), half dose cocktail (Heparin 1000 units or none, Verapamil 2.5mg, and Nitroglycerin 200mg) and none cocktail. In the modern era of mechanical thrombectomy the fast procedural time may make the need of intra-arterial radial cocktail unnecessary during transradial access. These findings should be corroborated with a larger prospective multicenter data."

Hematological Disorders

Hypotensive Agents for Controlled Hypotension in Endoscopic Sinus Surgery: A Systematic Review and Network Meta-Analysis. (PubMed, JAMA Otolaryngol Head Neck Surg) - "Randomized clinical trials of patients undergoing ESS and receiving dexmedetomidine, clonidine, esmolol, labetalol, bisoprolol, metoprolol, diltiazem, nifedipine, or verapamil vs placebo. In this systematic review and network meta-analysis, controlled hypotension improved surgical field quality in ESS with comparable safety. Diltiazem, esmolol, dexmedetomidine, labetalol, and clonidine were effective; dexmedetomidine was associated with reduced MAP the most, and esmolol favored recovery."

Clinical • Journal • Retrospective data • Hypotension • Otorhinolaryngology

Engineering Human 3D Cardiac Tissues for Predictive Functional Drug Screening. (PubMed, Pharmaceutics) - "Contractile performance, defined by beat rate and contraction amplitude, was quantified using video-based motion analysis. The platform was applied to evaluate the dose-dependent effects of various cardioactive compounds, including β-adrenergic agonists ((-) epinephrine and dopamine), a cardiotoxic chemotherapeutic (doxorubicin), a sinus node inhibitor (ivabradine), a calcium channel blocker (verapamil), and a β-adrenergic antagonist (metoprolol)... This human-relevant, scalable platform enables sensitive, multiparametric functional assessment of cardiac tissues, offering a cost-effective and predictive tool for preclinical drug safety testing. By bridging the gap between in vitro assays and human physiology, it holds promise to enhance translational accuracy while reducing reliance on animal models."

Journal • Cardiovascular

LEFT VENTRICULAR DIASTOLIC ALTERATIONS IN RESPONSE TO BISOPROLOL AND VERAPAMIL TREATMENT IN NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (ACC 2026) - "Abstract is embargoed at this time."

Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Non-obstructive Hypertrophic Cardiomyopathy

Role of Perindopril in Mitigating Doxorubicin's Vascular Toxicity in a Rat Model. (PubMed, Cardiovasc Toxicol) - "Vascular reactivity was evaluated in isolated aortal rings using phenylephrine (PE), acetylcholine (ACh), L-N-Nitro arginine methyl ester hydrochloride (L-NAME), and verapamil (VER). PER mitigates DOX-induced vascular toxicity, likely through endothelial protection and reduction of oxidative stress. These findings support the potential use of ACEIs as prophylactic agents in patients undergoing anthracycline-based chemotherapy and highlight the need for further translational studies in cardio-oncology."

Journal • Preclinical • Cardiovascular • Oncology

Pharmacological evidences for the blood pressure lowering and cardiovascular inhibitory actions of the essential oil of Thymus serrulatus hochst. Ex benth. (PubMed, Front Pharmacol) - "Preincubation with a lower concentration (0.1 mg/mL) produced a rightward shift in PE-mediated concentration-response curves (CRCs) without reducing maximal response, similar to prazosin-like competitive antagonism. A higher concentration (0.3 mg/mL) suppressed the maximal PE response, consistent with non-competitive antagonism comparable to verapamil...serrulatus essential oil exhibits hypotensive, cardiac-depressant, and vasodilatory effects, likely mediated through α-adrenergic antagonism and Ca++ channel blockade. These findings provide pharmacological support for its traditional use in cardiovascular disorders, including hypertension."

Journal • Anesthesia • Cardiovascular • Hypertension

A Case of Transient Central Hypothyroidism Coinciding With Reversible Cerebral Vasoconstriction Syndrome. (PubMed, Cureus) - "She was treated with levothyroxine and verapamil, leading to gradual improvement in both thyroid function and neurological deficits. We hypothesize that transient vasoconstriction of small pituitary arteries, undetectable on imaging, may have contributed to reversible pituitary dysfunction. This case cautiously indicates a possible association between RCVS and CH, suggesting that endocrine evaluation would be helpful when managing patients with RCVS."

Journal • Cardiovascular • CNS Disorders • Endocrine Disorders • Vascular Neurology

Na+ Uptake Triggered in Adrenal Chromaffin Cells by a 5-ns Electric Pulse is Facilitated by Ca2+ Influx Via an L-Type-Like Ca2+ Channel Independent of Changes in Membrane Potential. (PubMed, J Membr Biol) - "A 5-ns, 5 MV pulse elicited a tetrodotoxin-insensitive rise in ING-2 fluorescence that exhibited a similar electric field dependency and response to pulse-pair stimulation as the inward current...Full inhibition was achieved with the selective L-type voltage-gated Ca2+ channel (VGCC) inhibitors nitrendipine, verapamil, or diltiazem but not the broad-spectrum inhibitor Cd2+...These results provide evidence that nanoelectropulse-induced Na+ influx into chromaffin cells involves several Na+ influx pathways that are facilitated by Ca2+ influx via an L-type-like Ca2+ channel associated with cholesterol-rich membrane domains. Investigating such membrane effects is essential for developing nanosecond electric pulse technologies for stimulating and/or modulating excitable cells."

Journal • CD2 • NALCN

Physiologically based pharmacokinetic (PBPK) modeling of drug-drug interactions between suraxavir marboxil and CYP3A4 inhibitors: Quantitative prediction of pharmacokinetic effects on active metabolite GP1707D07. (PubMed, Pharm Sci Adv) - "Simulations using the validated model predicted a substantial increase in GP1707D07 exposure when co-administered with moderate inhibitors fluconazole (AUC ratio 2.820; Cmax ratio 1.509) and verapamil (AUC ratio 2.347; Cmax ratio 1.645), comparable to the effect of itraconazole. Consequently, clinical monitoring and potential dose adjustment of GP681 are recommended when co-administered with strong inhibitors and the moderate inhibitors. The study demonstrates the utility of PBPK modeling for efficient and predictive DDI assessment of complex prodrug systems, guiding the safe clinical use of GP681."

Journal • PK/PD data • Infectious Disease • Influenza • Respiratory Diseases

Verapamil and venlafaxine combined as an effective and well-tolerated adjunct for cancer pain management. (PubMed, Am J Transl Res) - "Compared with verapamil alone, combined therapy of verapamil and venlafaxine significantly relieves pain, improves psychological outcomes, and enhance patients' quality of life without increasing adverse events. These findings support its potential as an effective and well-tolerated adjunctive strategy for cancer pain management."

Journal • CNS Disorders • Depression • General Anxiety Disorder • Mood Disorders • Oncology • Pain • Psychiatry

RaP-AF: Rate Control in Patients With Atrial Fibrillation (clinicaltrials.gov) - P=N/A | N=13 | Completed | Sponsor: National Taiwan University Hospital | Active, not recruiting ➔ Completed | N=50 ➔ 13

Enrollment change • Trial completion • Atrial Fibrillation • Cardiovascular

Concurrent Reversible Cerebral Vasoconstriction Syndrome and Bilateral Vertebral Artery Dissection in the Postpartum Period: A Case Report. (PubMed, Clin Case Rep) - "She was transferred to a tertiary hospital and treated with verapamil and aspirin, and triptans were ceased. Following her index event, the patient recovered well with no neurological sequelae apart from chronic migraine. Three years later, with effective management that included routine preeclampsia prevention, she had a safe subsequent pregnancy and birth."

Journal • CNS Disorders • Gynecology • Migraine • Musculoskeletal Pain • Obstetrics • Pain

In Vitro Evaluation of 5-Fluorouridine as an Adjuvant to Antifungal Drugs and Molecular Insights into Resistance to This Compound in Candida Species. (PubMed, Int J Mol Sci) - "The antifungal activity of 5-FUrd alone and in combination with amphotericin B, fluconazole, voriconazole, caspofungin, and flucytosine was assessed using the checkerboard microdilution method. Efflux pump activity was evaluated using two inhibitors: carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and verapamil...This study highlights the potential of 5-FUrd, alone or combined with azoles or caspofungin, as an adjunct therapy against Candida infections. It also suggests that reduced susceptibility may be linked to efflux pump activity in certain strains."

Journal • Preclinical • Candidiasis • Gynecology • Infectious Disease

Management of Ablation-Refractory Atrial Fibrillation During Pregnancy. (PubMed, Case Rep Med) - "Two years earlier, during her previous pregnancy, she was hospitalized for AF, where she experienced labetalol-related hypotension and failed therapy with verapamil and digoxin. She was then managed with flecainide pill-in-pocket therapy until delivery...These episodes were unresponsive to her scheduled regimen, prompting an increase in her beta-blocker dose. However, the patient developed syncope and persistent palpitations prompting her presentation to the emergency department (ED)."

Journal • Atrial Fibrillation • Cardiovascular • Hypotension

Atogepant in episodic cluster headache: A case report on efficacy and tolerability (EHF-EHC 2025) - "Previous preventive therapies with high-dose verapamil (240 mg twice daily) and topiramate (50 mg/day) offered limited benefit, with 1-2 bouts of the disease each year. This case suggests that atogepant may represent a promising preventive approach for selected patients with episodic cluster headache, particularly when conventional treatments fail. Although adverse effects limited its use in this case, the rapid and complete response warrant further investigation. Controlled studies are warranted to assess its efficacy, safety and potential role in the management of cluster headache."

Case report • Clinical • Anorexia • Pain

Refractory chronic cluster headache: A new therapeutic option (EHF-EHC 2025) - "Acute therapy with oral zolmitriptan 5 mg, subcutaneous sumatriptan 6 mg, and oxygen were used, with moderate effect. Preventive treatment included prednisolone and occipital nerve block during exacerbations, and verapamil, both as monotherapy and in combination with topiramate and lithium in various regimens... Treating refractory chronic cluster headache is challenging, as it is highly disabling for the patient. Although other therapies targeting CGRP have not shown clear benefit in clinical trials, especially in chronic forms, atogepant may offer a promising alternative."

Anorexia • Cardiovascular • Chronic Cluster Headache • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Hypertension • Migraine • Pain

Use of gepants in the acute treatment and bout modulation of cluster headache: A retrospective case series (EHF-EHC 2025) - "Notably, no traditional preventive therapies (e.g., verapamil, corticosteroids) were used during the reported bout Retrospective case series of six CH patients who used gepants during a recent cluster bout...Rimegepant 70 mg (every other day, 16–28 days) was used by four patients; two used atogepant 60 mg/day (28 days)... Gepants may represent a promising and well-tolerated therapeutic option for both acute treatment and bout modulation in episodic CH, even in the absence of traditional preventive therapies. Their efficacy in chronic CH remains uncertain. These preliminary findings warrant confirmation in prospective, controlled studies"

Retrospective data • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Migraine • Pain

Integrative Human Genomic and Pharmacological Analyses Identify CACNB4 as a Druggable Target for Periodontitis. (PubMed, J Periodontal Res) - "Through MR analysis, we identified CACNB4 as a potential druggable gene for periodontitis. Among the drugs targeting CACNB4, verapamil and safinamide emerged as the most promising candidates for periodontitis treatment. Pharmacological studies further demonstrated that these agents may inhibit osteoclast differentiation by targeting CACNB4, thereby offering potential therapeutic options for periodontitis."

Journal • Dental Disorders • Periodontitis • ADAM12 • FGF2

Using Physiologically Based Pharmacokinetic Modeling and Simulations to Predict Antihypertensive Drug Doses in Cirrhotic Patients. (PubMed, J Clin Pharmacol) - "The model predicted that the healthy doses of nifedipine 20 mg three times daily (TID), verapamil 80 mg TID, nebivolol 10 mg once daily, and diltiazem 60 mg TID should be adjusted to 44%, 41%, 49.8%, and 51% of these doses, respectively, in the mild cirrhosis population. Among the studied drugs, nifedipine was the most affected and diltiazem was the least affected by cirrhosis, highlighting variability in hepatic impact across antihypertensive drugs. In the absence of dedicated clinical trials in cirrhosis for these drugs, validated PBPK models offer evidence-based insights to support clinicians in evaluating antihypertensive dosing options."

Journal • PK/PD data • Cardiovascular • Fibrosis • Gastroenterology • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis

POs-Ca Drives Osteogenic Differentiation of Human Dental Pulp Stem Cells Via AMPK-Dependent Autophagy Activation and Reciprocal Calcium-Autophagy Crosstalk. (PubMed, Stem Cells Int) - "Mechanistic studies employed verapamil (Ca2+ channel blocker), Compound C (CC;AMPK inhibitor), and chloroquine (CQ;autophagy inhibitor)...In conclusion, POs-Ca might promote hDPSCs osteogenesis via a calcium influx-driven AMPK-autophagy axis, providing a foundation for novel biomaterials that exploit physiological calcium signaling. These findings offer immediate translational potential for developing minimally invasive, cost-effective strategies in dental pulp regeneration and bone defect repair."

Journal • AMPK • RUNX2

Modeling Metabolite Kinetics with a Partial Differential Equation-Based Hepatic Sinusoidal Model and MALDI-Mass Spectrometry Imaging of Verapamil and Its Metabolites. (PubMed, J Med Chem) - "Consistent with previous reports, the observed decrease in the sinusoidal verapamil concentration toward the central vein is consistent with increasing intrinsic clearance along the sinusoid. Incorporation of microphysiology and zonation may provide improved predictions of sequential metabolism, drug-drug interactions, and liver toxicities within specific liver anatomical regions."

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