CC-90005 / BMS - LARVOL DELTA

Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005. (PubMed, J Med Chem) - "Property-guided design enabled the identification of appropriately substituted C2 groups to afford potent analogs with metabolic stability and permeability to support in vivo testing. With exquisite general kinase selectivity, cellular inhibition of T cell activation as assessed by IL-2 expression, a favorable safety profile, and demonstrated in vivo efficacy in models of acute and chronic T cell activation with oral dosing, CC-90005 (57) was selected for clinical development."

Journal • IL2