DM107 / Dermadis - LARVOL DELTA

Transcriptome reveals Gafmt-1 and Gadlc-1-5 play positive roles in cotton resistance to Verticillium wilt. (PubMed, Plant Cell Rep) - "arboreum introgression line, DM10781, was employed to mine new resistance genes against V. dahliae from the diploid cotton species...The results indicated the two genes of Gafmt-1 and Gadlc-1-5 played positive roles in both cotton and Arabidopsis. Our study demonstrates that G. arboreum has the resistance genes to VW and can be used in future disease-resistance breeding, providing insights into the resistance of Gafmt-1 and Gadlc-1-5 against VW in cotton."

Journal • Infectious Disease

[11C]Deschloroclozapine is an Improved Pet Radioligand for Quantifying Human Muscarinic Dreadd Expression in Monkey Brain (SOBP 2023) - "Funding Source ZIAMH002795, ZIAMH002793, ZIMH002619, AMED JP20dm0107146, NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation Background [11C]deschloroclozapine([11C]DCZ) is a radioligand for Designer Receptors Exclusively Activated by Designer Drugs(DREADDs), which are a chemogenetic tool used to manipulate neuronal activity in vivo...This study further assesses the higher contrast [11C]DCZ has in comparison to its precursor [11C]clozapine([11C]CLZ)...Conclusions The greater signal-to-background ratio of [11C]DCZ was due to lower background uptake. This improves the understanding of ideal characteristics for future PET-imaging radioligand development, with higher contrast occurring as a ratio of specific to non-displaceable uptake, rather than higher specific binding overall."

Preclinical • CNS Disorders • Mental Retardation • Psychiatry

The links between microclimatic and particulate matter concentration in a multi-storey car parking: a case study iran. (PubMed, J Environ Health Sci Eng) - "This study measured the levels of emitted PM, PM, and PM by GRIMM EDM 107 laser dust monitor in a busy multi-storey parking garage located in Qom...Also, a significant positive relationship between indoor humidity and particle level was observed, while there was a meaningful, inverse relationship between temperature and particle level. The high PM concentration in the parking garage indicates the necessity of proper management and planning."

Journal • Immunology

T-TYPE CA2+ CHANNEL ENHANCER SAK3 ACTIVATES THE PROTEASOME ACTIVITIES IN BOTH AD AND DLB MODEL MICE (ADPD 2022) - "These findings strongly suggest that CaMKII/Rpt-6-dependent proteasomal activation by SAK3 ameliorates both AD and DLB pathology and inhibits progression of cognitive impairment in human. SAK3 therapy is ready for first-in-human study because the preclinical studies were completed. This research is partially supported by AMED (20dm0107071)."

Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • APP

Chemogenetic suppression of pharmacologically induced frontal lobe epilepsy in a macaque monkey (AES 2021) - "Funding: QST President's Strategic Grant (Creative Research) (to NM); MEXT/JSPS KAKENHI Grant Numbers JP19K07811, JP20H04596, (to NM), JP19K08138 (to YN), 18H04037 (to T Minamimoto); AMED Grant Numbers JP19dm0107146 (to T Minamimoto).; Rationale: Medical treatments and surgical lesions of epilepsy sometimes lead to unexpected side effects by affecting the surrounding normal tissues, and therefore, a more focused and on-demand approach is desirable... Although further study is needed, these preliminary results are the first to demonstrate in an NHP model that epilepsy can be suppressed using the DREADD system, suggesting its promising utility for future clinical applications."

Preclinical • CNS Disorders • Epilepsy • Immunology

A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models. (PubMed, EBioMedicine) - "MF 6 is a potent inhibitor of FABP5 and FABP7; targeted inhibition of the two proteins may confer potential therapeutic effects in MS via immune inhibition and oligodendrocyte protection."

Journal • Preclinical • CNS Disorders • Immunology • Multiple Sclerosis • Oncology • Solid Tumor • FABP5 • GFAP • IL1B

Detection and characterization of carbapenem resistant Gram-negative bacilli isolates recovered from hospitalized patients at Soba University Hospital, Sudan. (PubMed, BMC Microbiol) - "The frequency of carbapenemase producing bacilli was found to be high in SUH. NDM was found to be the most prevalent carbapenemase gene among clinical isolates. Close surveillance across all hospitals in Sudan is required. The relative distribution of carbapenemase genes among GNB in nosocomial infections in Africa needs to be defined."

Clinical • Journal • Complement-mediated Rare Disorders • Infectious Disease

Interim Effectiveness and Safety Comparison of Bedaquiline-Containing Regimens for Treatment of Diabetic Versus Non-Diabetic MDR/XDR-TB Patients in China: A Multicenter Retrospective Cohort Study. (PubMed, Infect Dis Ther) - "Despite some differences in baseline characteristics, Chinese patients with MDR/XDR-TB with or without DM had similar sputum culture conversion rates and favorable treatment outcomes post-24-week BDQ-containing anti-TB treatment. Low BMI but not DM is risk factor associated with unfavorable outcome of patients with MDR/XDR-TB."

Journal • Retrospective data • Diabetes • Hepatology • Infectious Disease • Metabolic Disorders • Respiratory Diseases • Tuberculosis

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons. (PubMed, EBioMedicine) - "Our findings led us to conclude that the 22q11.2 deletion causes various vulnerabilities in dopaminergic neurons, dependent on PERK dysfunction."

Journal • CNS Disorders • Mental Retardation • Psychiatry • PERK

Investigation of betaine as a novel psychotherapeutic for schizophrenia. (PubMed, EBioMedicine) - "The present study revealed the role of betaine in psychiatric pathophysiology and underscores the potential benefit of betaine in a subset of schizophrenia. FUND: This study was supported by the Strategic Research Program for Brain Sciences from AMED (Japan Agency for Medical Research and Development) under Grant Numbers JP18dm0107083 and JP19dm0107083 (TY), JP18dm0107129 (MM), JP18dm0107086 (YK), JP18dm0107107 (HY), JP18dm0107104 (AK) and JP19dm0107119 (KH), by the Grant-in-Aid for Scientific Research on Innovative Areas from the MEXT under Grant Numbers JP18H05435 (TY), JP18H05433 (AH.-T), JP18H05428 (AH.-T and TY), and JP16H06277 (HY), and by JSPS KAKENHI under Grant Number JP17H01574 (TY). In addition, this study was supported by the Collaborative Research Project of Brain Research Institute, Niigata University under Grant Numbers 2018-2809 (YK) and RIKEN Epigenetics Presidential Fund (100214-201801063606-340120) (TY)."

Journal