venlafaxine / Generic mfg. - LARVOL DELTA

Clinical outcomes in patients with multiple myeloma and antidepressant use: A retrospective cohort study (ASH 2025) - "Adult patients with multiple myeloma since 2010 and prescribed antidepressants (sertraline, escitalopram, citalopram, paroxetine, fluoxetine, fluvoxamine, venlafaxine, duloxetine, trazodone, mirtazapine, or bupropion) were identified using ICD-10 diagnostic and RxNorm codes. While some associations were modest in magnitude, the consistent pattern of increased risk suggests that pre-existing depression and its treatment may identify a more vulnerable subgroup of multiple myeloma patients. Further prospective studies are needed to clarify underlying mechanisms and to evaluate the potential impact of early psychiatric intervention."

Clinical data • Retrospective data • Chronic Kidney Disease • CNS Disorders • Depression • Hematological Malignancies • Infectious Disease • Major Depressive Disorder • Multiple Myeloma • Musculoskeletal Diseases • Nephrology • Renal Disease

Upcycling Coffee Waste into Sustainable Nano Zerovalent Iron for Environmental Contaminant Remediation: Characterization, Applicability and Cytotoxicity. (PubMed, Nanomaterials (Basel)) - "Preliminary remediation assays were conducted with seven contaminants, with venlafaxine selected for detailed pH and kinetic studies...Compared with chemically synthesized nZVI, the green version exhibited enhanced stability, attributed to the presence of surface-bounded organic matter. Overall, this sustainable and cost-effective approach to produce nZVI from SCG provides an innovative method for waste valorization and environmental remediation."

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Management of Small Fiber Neuropathy: A Clinical Perspective. (PubMed, Muscle Nerve) - "First-line medications include amitriptyline, nortriptyline, gabapentin, and pregabalin. Second-line treatments can include serotonin-norepinephrine reuptake inhibitors and selective serotonin reuptake inhibitors such as duloxetine and venlafaxine, as well as lidocaine patches and capsaicin."

Journal • Diabetes • Immunology • Infectious Disease • Metabolic Disorders • Neuralgia • Pain

Sustainable photolyzers for activation of peroxosulfuric acids in the reclaiming treatment of municipal wastewater. (PubMed, J Environ Manage) - "Results demonstrate that it can completely eliminate the presence of pathogens such as E. coli, resistant genes such as sul1, and emerging contaminants like iopromide, diclofenac, sulfamethoxazole, and venlafaxine, with oxidant doses like those proposed in other studies on the subject. This research highlights some of the problems presented by using sulfate-based oxidants for the treatment of these effluents and warns that future work will need to consider process intensification in order to minimize the problem of secondary saline contamination, which results from the accumulation of sulfate from the electrochemical generation and the subsequent dosing of peroxosulfuric acids to wastewater effluents."

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Bioaccumulation of Psychoactive Contaminants and Their Effects on Brain-Gonad-Sperm Neurotransmitter Networks in Fish. (PubMed, Environ Sci Technol) - "Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. No significant changes were observed in gonadal histopathology or sperm-quality parameters; however, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain-gonad-sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology."

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The Efficacy and Safety of Pregabalin Combined With Venlafaxine in Patients With Fibromyalgia (clinicaltrials.gov) - P=N/A | N=750 | Recruiting | Sponsor: Beijing Tiantan Hospital | N=384 ➔ 750

Enrollment change • Monotherapy • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology

Severe venlafaxine poisoning successfully rescued with veno-arterial extracorporeal membrane oxygenation: A case report. (PubMed, World J Clin Cases) - "In cases of massive venlafaxine ingestion, continuous intensive monitoring, particularly of QTc, is essential for at least 24 hours, even when initial clinical signs are mild. If refractory ventricular arrhythmias occur, prompt initiation of veno-arterial extracorporeal membrane oxygenation should be considered."

Journal • Cardiovascular • CNS Disorders • Depression • Epilepsy • Major Depressive Disorder • Mood Disorders • Psychiatry • Ventricular Tachycardia

Connectional diaschisis associated with acute psychosis after right thalamic stroke: A case report. (PubMed, Cortex) - "The patient was treated with risperidone and venlafaxine, leading to an improvement in psychotic symptoms at both discharge and follow-up. Understanding these network-level disruptions may offer valuable insights into therapeutic approaches and prognostic evaluation."

Journal • Cardiovascular • CNS Disorders • Psychiatry

Adjustment for dispensed doses does not explain higher antidepressant concentrations in post-mortem toxicology. (PubMed, Br J Clin Pharmacol) - "Dose adjustment generally did not improve the separation of poisoning vs non-poisoning suicides, indicating that post-mortem concentrations may not have clear dose-concentration relationships."

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Hyperfiltration and Metabolism Before and After a Low-Calorie, Pre-Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs. (PubMed, Basic Clin Pharmacol Toxicol) - "The greater the individual weight loss, the greater the concentration increase in hydrophilic drugs that undergo glomerular filtration, for example, pregabalin and gabapentin, suggesting that this reflects decreased glomerular hyperfiltration. By contrast, for highly lipophilic drugs, for example, mirtazapine and sertraline, the greater the individual creatinine and cystatin C loss, the greater the decrease in drug concentration, interpreted as increased drug metabolism based on decreased liver inflammation and steatosis. Venlafaxine/O-desmethylvenlafaxine displayed a complicated pattern suggesting the involvement of both glomerular filtration and metabolism. Serum concentrations of modestly lipophilic drugs, for example, duloxetine and (es)citalopram, were not significantly affected by the diet. In conclusion, hydrophilicity- and lipophilicity-related changes in drug concentrations over the diet period covary with markers of changes in hyperfiltration and metabolism,..."

Journal • Genetic Disorders • Inflammation • CST3

Use of oral neuromodulators in chronic pelvic painNumber 8 - 2025. (PubMed, Rev Bras Ginecol Obstet) - "•Pregabalin is the medication with the best pharmacokinetic profile; nortriptyline has the best adverse effects profile; duloxetine is the most widely used and has the lowest risks; and venlafaxine should be used as a second-line inhibitor. •Although the drug classes can be combined to reduce the total doses and minimize side effects, maximizing the analgesic effect, monotherapies are recommended as the first line to avoid polypharmacy."

Journal • Review • Gynecology • Musculoskeletal Pain • Neuralgia • Pain

Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea (clinicaltrials.gov) - P4 | N=45 | Completed | Sponsor: China Medical University Hospital | Recruiting ➔ Completed | N=132 ➔ 45

Enrollment change • Trial completion • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Migraine worsening after excellent initial response to galcanezumab (EHF-EHC 2025) - "Several prophylactics were tried (topiramate, amitriptyline, and atogepant) with no improvement...However, in the last few months of treatment, she experienced recrudescence of symptoms – she's now awaiting treatment with eptinezumab...While he tried several preventive medications (topiramate, amitriptyline, venlafaxine and valproic acid), he was also medicated with corticosteroids...Recent literature and medical experience refer to Galcanezumab as a good sustained treatment to refractory migraine. However, these cases highlight the situations in which, despite the initial response being great, there's no prolonged effect on pain relief."

Cardiovascular • CNS Disorders • Complement-mediated Rare Disorders • Hepatology • Hereditary Angioedema • Migraine • Pain

Comparative efficacy and safety of venlafaxine versus amitriptyline for migraine prophylaxis: A systematic review and meta-analysis (EHF-EHC 2025) - "Safety profiles were similar, suggesting venlafaxine may be a clinically appropriate alternative for migraine prophylaxis. Further trials are needed to confirm these findings."

Retrospective data • Review • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Migraine • Pain • Xerostomia

Evaluating the efficacy of combined treatment in patients with Persistent Idiopathic Facial Pain (PIFP) (EHF-EHC 2025) - "All patients received combinations of medications targeting neuropathic pain and musculoskeletal tension, antidepressants (e.g., duloxetine, venlafaxine), anticonvulsants (e.g., carbamazepine, gabapentin) and COX-2 inhibitors. Treatment response often required dose titration. Combined pharmacological approaches targetting both neuropathic and affective components may provide meaningful symptom control in PIFP."

Clinical • CNS Disorders • Dental Disorders • Epilepsy • Migraine • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Novel Coronavirus Disease • Pain

Middle meningeal artery lidocaine infusion for refractory migraine: First case report in Portugal (EHF-EHC 2025) - "Various pharmacologic classes were tried without benefit: antihypertensives and calcium channel blockers (propranolol, candesartan, flunarizine), antiepileptics (valproic acid, topiramate, oxcarbazepine), antidepressants (amitriptyline, nortriptyline, venlafaxine, fluvoxamine, sertraline, clomipramine), other preventives (prednisolone, oxitriptan, melatonin), cycles of botulinum toxin (PREEMPT protocol), monoclonal antibodies (galcanezumab, fremanezumab, erenumab), and atogepant. At the time of the procedure, the patient was on eptinezumab 100 mg and botulinum toxin every three months but continued to have daily headaches, with severe intensity and reliance on eletriptan for acute relief...It constitutes an invasive therapeutic approach that should be considered only as a rescue option for carefully selected patients with severely refractory migraine. Further studies and long-term follow-up are needed to assess efficacy and safety."

Case report • Clinical • Anorexia • CNS Disorders • Migraine • Pain

Clinical characterisation and treatment patterns in tension-type headache: A retrospective study from a public hospital cohort (EHF-EHC 2025) - "The most prescribed preventives were amitriptyline, duloxetine, and venlafaxine. Identifying these patterns may help optimise individualised and multidisciplinary treatment approaches. The small and selected cohort, limited to a tertiary care setting, restricts generalisability and further correlation."

Retrospective data • CNS Disorders • Depression • Fibromyalgia • Migraine • Mood Disorders • Musculoskeletal Pain • Pain • Rheumatology

Venlafaxine-associated priapism: Case report and review of priapism linked to psychotropic medications. (PubMed, Urol Case Rep) - "Priapism is a Urological emergency that manifests as penile erection lasting more than 4 hours and is commonly reported with antipsychotics and a few antidepressants like Trazodone due to their alpha-adrenergic blockade. Here we report a 52-year-old male with a history of Chronic Venlafaxine intake who presented with low-flow ischemic Priapism. In conclusion, clinicians should recognize that venlafaxine, though rarely, can cause ischemic priapism and may present with atypical features."

Journal • CNS Disorders

Optimizing Venlafaxine Therapy in Pregnancy: A Maternal-Fetal PBPK Modeling Approach. (PubMed, Drug Des Devel Ther) - "These findings should be interpreted with caution, given the limited sample size in pregnant women (n= 7 for plasma and n=9 for cord blood). A venlafaxine dose of 150 mg/day is recommended during pregnancy, balancing efficacy with the risk of toxicity in both mother and fetus."

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An Efficient Neural Network of Cooperating Serotonergic and Noradrenergic Neurons in Modulating SUDEP (AES 2025) - "Clinical Translation PotentialWith its unique integration of circuit neuroscience and translational pharmacology, this work promises to redefine clinical approaches to SUDEP prevention. Using the SUDEP-prone DBA/1 mouse model, we employed integrated approaches: pharmacological interventions (5-hydroxytryptophan, atomoxetine, venlafaxine), in vivo calcium imaging, and optogenetics. Targeted microinjections of receptor antagonists (ketanserin: 5-HT2A; prazosin: NE α-1) into the pre-Bötzinger complex (PBC) assessed local receptor contributions. We demonstrate, for the first time, a robust synergistic interaction between 5-HT and NE in mitigating S-IRA and preventing SUDEP... This study establishes the DR-LC-PBC pathway as a critical network for the synergistic protective action of 5-HT and NE against S-IRA and SUDEP. We identify 5-HT2A and NE α-1 receptors within the PBC as key therapeutic targets. These findings provide a mechanistic foundation for developing novel..."

Late-breaking abstract • CNS Disorders • Epilepsy

Evaluation of Three Sample Preparation Methods for LC-HRMS Suspect Screening of Contaminants of Emerging Concern in Effluent Wastewater. (PubMed, Anal Chem) - "Compound prioritization, based on abundance, persistence, mobility, bioaccumulation potential, and toxicity, identified the antibiotics clindamycin and tiamulin, the analgesic flufenamic acid, the musk fragrance metabolite galaxolidone, and the antidepressant venlafaxine metabolite, O-desmethyl venlafaxine, as top priority. These results highlight the importance of applying an appropriate SP method to obtain a comprehensive CEC footprint in suspect screening analysis and demonstrate the suitability of lyophilization for wastewater characterization."

Journal • Anesthesia • Pain

Clinical relevance of venlafaxine ER for generalized anxiety disorder. (PubMed, Psychiatry Clin Neurosci) - "Methodological factors-including the exclusion of placebo responders, the inclusion of participants with comorbid depressive disorders, and a higher rate of discontinuation due to adverse events-further diminish the clinical significance of the findings. Overall, although venlafaxine achieved statistical efficacy, it may lack a clinically meaningful risk-benefit balance."

Clinical • Journal • CNS Disorders • Depression • General Anxiety Disorder • Mood Disorders • Psychiatry

Degradation by-products of pharmaceuticals in a tropical Estuary: Identification and ecotoxicological insights via DIMS and molecular modeling. (PubMed, Sci Total Environ) - "We detected six pharmaceuticals (caffeine, ibuprofen, paracetamol, lidocaine, venlafaxine, and ractopamine) and twenty-two associated by-products. Notably, 13 of the 22 by-products (approximately 59 %) became more lipophilic and less polar than their parent compounds, 6 (approximately 27 %) became more hydrophilic, and 3 (approximately 14 %) remained essentially unchanged, potentially heightening ecotoxicological risks even when the parent compounds are not observed. This integrative approach proved effective for tracing contamination sources and assessing potential impacts on aquatic ecosystems."

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The Efficacy and Safety of Pregabalin Combined With Venlafaxine in Patients With Fibromyalgia (clinicaltrials.gov) - P=N/A | N=384 | Recruiting | Sponsor: Beijing Tiantan Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Monotherapy • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology

The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia (clinicaltrials.gov) - P=N/A | N=400 | Recruiting | Sponsor: Beijing Tiantan Hospital

New trial • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology