venlafaxine / Generic mfg. - LARVOL DELTA

Venlafaxine Removal from Water and Wastewater Using Activated Carbons from Spent Brewery Grains Produced by Conventional vs. Microwave Pyrolysis. (PubMed, Pharmaceuticals (Basel)) - "Microwave-assisted AC has shown higher efficiency than conventionally produced AC, demonstrating that this pyrolysis technique can produce materials with enhanced adsorption properties. This study evidences that microwave-assisted pyrolysis of an abundant agro-industrial residue yields high-performance materials capable of efficiently removing an antidepressant, included in the revised Urban Wastewater Treatment Directive, from complex effluents even at low doses, highlighting a sustainable route to mitigate pharmaceutical contamination in aquatic environments."

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FIGO best practice recommendations for the mental health of women at menopausal age. (PubMed, Int J Gynaecol Obstet) - "Escitalopram and venlafaxine effectively manage depressive symptoms and vasomotor instability in patients with major depressive disorder. Partner and family support helps reduce the stigma associated with mental health issues during menopause. Advocacy is required for policies that support menopause awareness and mental health."

Journal • CNS Disorders • Depression • Gynecology • Major Depressive Disorder • Mood Disorders • Obstetrics • Psychiatry

Aquatic Bacterial Community Responses to Aquatic Contaminants Revealed by 16S rRNA Metabarcoding in Field-Based Microcosms. (PubMed, Environ Microbiol Rep) - "In this study we used environmental DNA metabarcoding and field-based microcosms to assess three classes of aquatic contaminants (metals (copper), pesticides (diuron), and pharmaceuticals (venlafaxine)) and their impact on the structure of freshwater wetland sedimentary bacterial communities...We identified five phyla, 13 families, and three species which show strong potential to be either diagnostic bioindicators of one or more of the chemicals assessed or broad bioindicators of common urban contaminants, eight of which are novel bioindicators. Our study highlights the effectiveness of eDNA metabarcoding to efficiently characterise sedimentary bacterial community assemblages and emphasises its value in aquatic ecosystem assessments, particularly for the prediction of contaminants driving ecosystem change."

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Selective serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor use and sexual dysfunction: a pharmacovigilance analysis. (PubMed, Sex Med) - "Comparative analysis of antidepressant-related adverse events in the FAERS database showed that while sexual dysfunction was associated with all studied SSRIs/SNRIs (sertraline, citalopram/escitalopram, paroxetine, fluoxetine, venlafaxine, and duloxetine), symptom profiles varied markedly. But the limitation is FAERS' passive surveillance nature, which may involve underreporting or insufficient clinical context, restricting causal inference. While previous studies have not fully elucidated antidepressant-related sexual dysfunction, our findings delineate distinct sexual adverse effect profiles between SSRIs and SNRIs, contributing valuable evidence for personalized treatment approaches."

Adverse events • Journal • Sexual Disorders

Venlafaxine upregulates cortical catechol-O-methyltransferase expression and activity in rats and mice. (PubMed, Drug Metab Dispos) - "Phosphatidylinositol 3-kinase inhibitor LY294002, mammalian target of rapamycin inhibitor rapamycin, silencing P70S6K, or silencing 4EBP1 remarkably attenuated venlafaxine-induced upregulation of COMT...Furthermore, COMT inhibitor tolcapone reversed venlafaxine-induced decreases in SAM levels, H3K4me3 and H3K27me3 expression, and locomotor and exploration activities...SIGNIFICANCE STATEMENT: This study revealed that venlafaxine upregulated cortical catechol-O-methyltransferase expression and activity via activating phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway. The induction of catechol-O-methyltransferase led to depletion of cortical S-adenosylmethionine, which may partly contribute to the decreases in locomotor and exploration activities and downregulations of H3K4me3 and H3K27me3 expression in cortex of rats and mice."

Journal • Preclinical • COMT • EIF4EBP1

EVALUATION OF THE THERAPEUTIC EFFECTS OF DIFFERENT DOSES OF BOTULINUM TOXIN TYPE A IN THE TREATMENT OF DEPRESSION IN PARKINSON'S DISEASE (ADPD 2026) - "Both 50U and 100U BoNT/A demonstrate antidepressant effects comparable to venlafaxine in PD patients. The lower 50U dose may be preferable as a treatment option."

CNS Disorders • Depression • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Study to compare the effectiveness of Venlafaxine to Placebo in treating MDD or PDD in children. (clinicaltrialsregister.eu) - P3 | N=160 | Sponsor: Viatris Pharmaceutical Japan GK

New P3 trial • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Pediatrics • Psychiatry

Study to evaluate safety and efficacy of Venlafaxine in treating MDD or PDD in children who completed VENL-CAZ-3001 study (clinicaltrialsregister.eu) - P3 | N=145 | Sponsor: Viatris Pharmaceutical Japan GK

New P3 trial • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Pediatrics • Psychiatry

A Novel Approach to Estimating the Risk of Gastrointestinal Bleeding for Patients on Oral Anticoagulants and Other Medications Including Non-Steroidal Anti-Inflammatory Drugs and Antidepressants (THSNA 2026) - " Risk of GIB for OAC products obtained from pivotal studies were: 1.99% for apixaban; 3.15% for rivaroxaban; 2.99% for dabigatran; 3.31% for edoxaban; and 2.00% for warfarin. The odds of GIB for NSAIDs ranged from 1.16 (95% CI:0.84-1.61) for celecoxib to 20.67 (95% CI:14.56-29.34) for ketorolac. Odd ratios for GIB among SSRI/SNRI ranged from 1.31 (95% CI:1.07-1.62) for paroxetine to 1.50 (95% CI:1.32-1.70) for venlafaxine. Risk of GIB for other factors included: persons over 65 years of age (OR=2.50, 95% CI:1.2–5.5); previous history of GIB (OR=5.13, 95% CI:3.95–6.67); aspirin use (OR=1.31, 95% CI:0.93-1.85); antiplatelets use (OR=1.95, 95% CI:1.68-2.27); and corticosteroids use (OR=1.68, 95% CI:1.49-1.90)... The DIOAC-GIB incorporates drug interactions with OACs and had good correlation with other bleeding risk scores. DIOAC-GIB may help identify high-risk patients that benefit from tailored prescribing. No part of this publication may be reproduced, distributed, or..."

Clinical • Gastroenterology

Psychotropic drug-induced obesity in older adults: complications, preventive and therapeutic interventions (PubMed, Orv Hetil) - "Among psychotropic drugs, olanzapine, clozapine, quetiapine, mirtazapine, valproate, and lithium are associated with the most significant weight gain through complex mechanisms (H1 blockade, 5-HT2C antagonism, metabolic effects); however, other antipsychotics, mood stabilizers, and antidepressants may also contribute to weight increase...Prevention hinges on preferring agents with lower metabolic risk (e.g., aripiprazole, venlafaxine, lamotrigine), regular monitoring, and proactive lifestyle interventions. Therapeutically, switching medications, intensive lifestyle programs, metformin, or GLP1 agonists may be employed...Orv Hetil. 2026; 167(11): 410-418."

Journal • Review • Cardiovascular • CNS Disorders • Diabetes • Genetic Disorders • Geriatric Disorders • Metabolic Disorders • Obesity • Oncology • Sarcopenia

Optimized silver selenide quantum dots for surface-enhanced infrared absorption spectroscopy detecting venlafaxine. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The following SEIRA experiments comparing MD and LD QDs resulted in more repeatable signals for the MD-QDs with IR signal amplification of up to 38-fold. The lowest detectable VEN concentration via SEIRA was 0.113 mmol L-1, demonstrating the potential of SEIRA, augmented by AgxSe QDs, for monitoring pharmaceutical contaminants in aqueous matrices."

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A green nanotechnology approach based on coffee waste as a precursor for zero-valent iron in soil decontamination of venlafaxine. (PubMed, J Environ Manage) - "The greenness of the nZVI synthesis by SCG extracts was also assessed by several green analytical chemistry methods. This work represents the first application of nZVI for remediation of Vlx-contaminated soil, providing novel and valuable insights into their potential for soil decontamination strategies."

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Baihe Dihuang Decoction attenuates hippocampal neuronal injury in anxious depression by inhibiting SHP2 (PubMed, Zhongguo Zhong Yao Za Zhi) - "Sprague-Dawley rats were randomly divided into a normal group, model group, venlafaxine group(13.5 mg·kg~(-1)), and Baihe Dihuang Decoction high-, medium-, and low-dose groups(16, 8, and 4 g·kg~(-1), respectively)...In addition, SHP2 knockdown(SHP2 KD) via lentiviral transfection also mimicked the protective effects of Baihe Dihuang Decoction. In conclusion, Baihe Dihuang Decoction improves hippocampal neuronal injury in anxious depression by regulating the SHP2 signaling pathway."

Journal • CNS Disorders • Depression • Psychiatry • Napsin A

Methacrylic acid:divinylbenzene (MAA:DVB) copolymer for mixed-mode extraction of emerging contaminants from environmental waters. (PubMed, Anal Chim Acta) - "This work demonstrates, for the first time, the application of a lab-made hypercrosslinked MAA:DVB copolymer as a chemically tunable and cost-effective mixed-mode SPE sorbent for broad-spectrum EC extraction. The optimized method provides an efficient alternative to commercial sorbents, significantly enhancing the monitoring of ECs in complex environmental matrices."

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Prescription Trends and Clinical Decision-Making in Neuropathic Pain Pharmacological Treatment: Results From a Cross-Sectional Survey by the Spanish Pain Society. (PubMed, Eur J Pain) - "This nationwide survey provides the first systematic assessment of neuropathic pain management in Spain, revealing marked variability, only partial adherence to international guidelines, and persistent reliance on clinical experience over evidence. It confirms gabapentinoids, tricyclic antidepressants and duloxetine as preferred treatments, identifies continued tramadol use despite conflicting recommendations, and quantifies for the first time clinicians' perception and management of tolerance. These findings fill a major evidence gap and directly inform future national consensus, educational initiatives and clinical practice improvement."

Journal • Neuralgia • Pain

A Global Delphi-Based Expert Consensus on Relapse Prevention Strategies Following Successful Electroconvulsive Therapy for Major Depressive Disorder. (PubMed, Am J Psychiatry) - "An essential relapse prevention strategy, namely, pharmacotherapy with lithium and an antidepressant (a tricyclic antidepressant, venlafaxine, or a prior effective antidepressant), was endorsed for all patients...While pharmacotherapy and continuation ECT are core strategies, personalized adjustments based on clinical risk factors remain essential. Further empirical research is needed to refine guidelines and improve long-term outcomes."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Comparative Effectiveness and Safety of Preventive Treatments for Vestibular Migraine: A Systematic Review and Network Meta-analysis (AAN 2026) - "Propranolol ranked highest (P-score: 0.794; -7.04 attacks/month, 95% CI -12.77 to -1.31), followed by valproic acid (-5.95, 95% CI -9.01 to -2.89) and venlafaxine (-5.94, 95% CI -8.98 to -2.90). All evaluated treatments effectively reduce vertigo frequency in vestibular migraine. While propranolol showed the largest effect, this relied on indirect evidence. Galcanezumab offers the best balance of efficacy, tolerability, and evidence quality."

HEOR • Retrospective data • Review • CNS Disorders • Migraine • Otorhinolaryngology • Pain • Vertigo

Biomarker responses of marine mussels (Mytilus galloprovincialis) experimentally exposed to emerging contaminants: pharmaceuticals and microplastics. (PubMed, Environ Sci Pollut Res Int) - "The Integrated Biomarker Response (IBR) index indicated a trend of increased overall stress in mussels exposed to clarithromycin, venlafaxine and PS microplastics alone in comparison to their mixture. Results can contribute to understanding effects of pharmaceuticals and microplastics in marine organisms as well as their potential interactions."

Biomarker • Journal • Pain • CAT

Antidepressants and anxiolytics in aquatic environments as emerging contaminants and their role in antibiotic resistance. (PubMed, Sci Total Environ) - "Reported environmental concentrations reached up to 490 ng/L for diazepam and 3040 ng/L for venlafaxine. In many countries, the scarcity of recent data prevents robust conclusions, making it uncertain whether the apparent absence of these compounds actually reflects low environmental occurrence or instead results from a lack of systematic measurements and reporting in the literature. Filling this gap is essential to avoid underestimating exposure and the associated ecological and public health risks."

Journal • Review • CNS Disorders • Gene Therapies • Mental Retardation • Psychiatry

Darters (Etheostoma spp.) as indicators of antidepressant and drug of abuse exposure in an urban watershed. (PubMed, Environ Pollut) - "Of the 26 analytes monitored, only fentanyl, methadone, venlafaxine, and O-desmethylvenlafaxine were consistently detected in all species, with higher concentrations at the downstream location. Sex-specific differences in accumulation were observed, with males accumulating higher concentrations than females. This study presents a novel analytical method for detecting DoA in fish tissue and demonstrates the potential for fish exposed to treated wastewater to bioaccumulate selected DoA and antidepressants."

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A DECISION TREE ESTIMATING TOTAL COST OF CARE USING EXPOSURE-ADJUSTED DISCONTINUATION: CAPSAICIN 8% VERSUS ORAL TREATMENTS FOR PAINFUL DIABETIC NEUROPATHY IN THE UNITED STATES (ISPOR 2026) - "OBJECTIVES: To estimate 12-month total cost of care due to discontinuation for topical capsaicin 8% (HCCTS) versus oral PDPN treatments from a US payer perspective as existing PDPN economic models inadequately capture the cost of therapy withdrawal and related medical costs. A decision tree model simulated 1,000 adults initiating PDPN treatment with HCCTS or oral agents (duloxetine, pregabalin, gabapentin, amitriptyline, venlafaxine, topiramate); structurally the tree aligned to capsaicin's three-month (3M) retreatment intervals. Exposure-adjusted cost modeling using trial reported withdrawals estimated HCCTS on treatment time was up to 3x greater vs orals. HCCTS persistence meant fewer medical costs, offsetting drug acquisition costs to yield annual total cost savings of $0.7M-$25.7M vs PDPN oral alternatives for a cohort of 1,000 patients."

Cost of care • HEOR • Diabetic Neuropathy • Pain

POST-MARKETING SAFETY PROFILE OF ANTIDEPRESSANTS IN 2013 TO 2025 (ISPOR 2026) - "Findings show numerous serious AE's associated with duloxetine, milnacipran, ketamine, and venlafaxine, which can lead to other serious outcomes, including hospitalization. It is necessary to continue and systematically monitor the safety associated with antidepressants and other associated medications."

Clinical • P4 data • CNS Disorders • Insomnia • Mood Disorders • Sleep Disorder

Vulvodynia integrative approach with acupuncture – case report and study protocol for clinical applications (ISGE 2026) - "In the past years she had undergone multiple pharmacological treatments such as oral venlafaxine, amitriptyline, gabapentin. our case report regards a patient with chronic vulvodynia treated with acupuncture with satisfying results, with no concomitant treatment with opioid or neuroactive drugs. Based on this result, we decided to develop a study protocol in our clinic to be offered both to treated and non treated patients, with standardized acupuncture points and replicable outcome measurements. An integrative approach in the management of vulvodynia with acupuncture, such as for many other chronic pain diseases, appears promising, well tolerated by patients and worth for research."

Case report • Clinical • Women's Health

Association between venlafaxine use and the risk of withdrawal from nonopioid substances: a nationwide, population-based study. (PubMed, Harm Reduct J) - "This study provides strong ground for clinicians to consider the use of venlafaxine to reduce patient experiencing withdrawal symptoms from substances."

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Serum Concentration-Dependent Inhibition of CYP2D6 by Bupropion and Doxepin: Implications for Venlafaxine and Risperidone Metabolism. (PubMed, Pharmacopsychiatry) - "These effects and a phenoconversion into poor metabolizer status were detectable at subtherapeutic hydroxybupropion and therapeutic antidepressant doxepin levels. Monitoring inhibitor and victim-drug concentrations may aid in managing clinically relevant CYP2D6-mediated interactions."

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