nitroprusside / Generic mfg. - LARVOL DELTA

Nitric oxide and hydrogen gas synergistically promote adventitious rooting in cucumber: insights from transcriptomic and physiological analyses. (PubMed, Planta) - "This study used transcriptome sequencing to investigate cucumber explants treated with sodium nitroprusside (SNP, an NO donor) and hydrogen-rich water (HRW, an H2 donor)...Collectively, these findings systematically reveal a synergistic molecular network by which NO and H2 promote adventitious rooting. This study enhances our understanding of the regulatory mechanisms underlying adventitious root development and offers a theoretical foundation for optimizing propagation techniques in horticultural crops."

Journal

Ligand-engineered metal‒organic frameworks with atomically axial Cu-N5 sites for controlled nitric oxide delivery and enhanced tumor therapy. (PubMed, Biomaterials) - "Herein, we propose a facile ligand-engineering-induced coordination-unsaturation (LEICU) strategy to construct Cu-nitroprusside-based Prussian blue analogues single-site nanozyme (termed as CNPSE)...Both in vitro and in vivo studies demonstrate effective tumor suppression with excellent biosafety, and transcriptomic analyses reveal activation of oxidative stress, immune response, and cyclic guanosine monophosphate (cGMP) signaling pathway. This work demonstrates the potential of ligand engineering to tailor the atomic coordination environment of single-site nanozymes, offering a rational strategy for constructing coordination-unsaturated catalytic sites in multifunctional PBA-based therapeutic platforms."

Journal • Oncology

Echocardiographic Estimation of Pulmonary Artery Wedge Pressure in Advanced Heart Failure: Head-to-Head Comparison Against Right Heart Catheterization. (PubMed, Int J Cardiovasc Imaging) - "In patients undergoing sodium nitroprusside challenge, invasive and echocardiographic PAWP change (ΔPAWP) was analyzed and compared...The LAVi- and E-based equation performs best and may be used to rule in or rule out elevated filling pressures at rest when the left atrium is not severely dilated. Neither equation tracks the acute PAWP changes induced by vasodilator challenge, so RHC remains indispensable whenever the clinical question is dynamic."

Head-to-Head • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Impairment of circulating metabolites induces endothelial dysfunction in adolescents exposed to gestational diabetes in utero (ESC 2026) - "Endothelium-dependent (EDR) and -independent (EIR) relaxations to acetylcholine (10-9 to 10-4,5 M) and sodium nitroprusside (10-10 to 10-5,5 M) with and without antioxidants Tempol (10-4 M) or NAC (10-5 M) were assessed by wire myography...Levels of N-monomethylarginine (NMMA), a NO synthase inhibitor, were increased, whereas 3-hydroxyanthranilic acid (3-HAA), a metabolite with anti-inflammatory properties, was decreased... Our results demonstrate that adolescents exposed to GD in utero exhibit an altered circulating metabolome that impairs endothelial function, potentially contributing to their elevated ASCVD risk. This metabolic imbalance may represent a putative target to mitigate ASCVD risk in this population."

Atherosclerosis • Cardiovascular • NOX4

Nitric Oxide Alleviates Low-Light-Induced Photosynthetic Impairment by Improving Photosystem Coordination and Electron Transport in Tomato Seedlings. (PubMed, Plants (Basel)) - "In this study, tomato seedlings were treated with the NO donor sodium nitroprusside (SNP) and the NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (PTIO) to investigate the effects of NO-related treatments on growth, photosynthetic performance, photosystem function, electron transport, ROS accumulation, and antioxidant defense under low-light conditions...In contrast, PTIO treatment aggravated photosystem impairment under low light. These findings indicate that NO contributes to maintaining photosystem function and photosynthetic electron transport under low-light conditions, highlighting its potential role in improving low-light tolerance in tomato."

Journal

Evidence for an inflammatory contribution to cutaneous microvascular endothelial dysfunction in non-Hispanic Black women. (PubMed, Am J Physiol Heart Circ Physiol) - "Cutaneous vascular conductance was calculated (CVC=flux*mmHg-1) and normalized to site-specific maximum (28 mM sodium nitroprusside + 43 °C). Five-day salsalate treatment did not alter %FMD (p=0.28) or %FMD+HG (p=0.17). Cutaneous microvascular, but not macrovascular, function marginally improved following salsalate, indicating inflammation via NF-κB pathways contributes to impaired cutaneous microvascular function in NHB women."

Journal • Inflammation

Abscisic acid and nitric oxide confer poplar rust resistance through host defense activation and cross-kingdom regulation of effector genes. (PubMed, Tree Physiol) - "Exogenous ABA and the NO donor sodium nitroprusside synergistically enhanced rust resistance by inducing stomatal closure, modulating reactive oxygen species homeostasis, promoting lignin deposition, and increasing chitinase activity...Notably, ABA exerted cross-kingdom regulatory effects on M. larici-populina, downregulating genes involved in the spliceosome pathway and two small secreted protein effector genes (MLP105684 and MLP124543) that are critical for fungal virulence. Collectively, these findings establish a bipartite defense paradigm in which ABA and NO synergistically reinforce host basal defense while ABA suppresses fungal virulence, providing a mechanistic foundation for engineering rust resistance in poplar."

Journal

Ea/Ees and oscillatory power fraction capture complementary but distinct components of ventriculoarterial coupling: a porcine study. (PubMed, Front Physiol) - "In 14 juvenile pigs challenged with vasoactive (phenylephrine, nitroprusside) and cardioactive drugs (dobutamine, esmolol) titrated toward protocolized targets (± 40% MAP, ± 50% dP/dt), we obtained a comprehensive dataset using intracardiac conductance catheters, intraaortic pressure probes, and ascending aortic flow probes. This is consistent with the two indices reflecting predominantly steady and pulsatile aspects of arterial load, although the present data do not demonstrate that separation directly. While OPF cannot replace Ea/Ees, power-derived indices offer practical adjuncts for characterizing ventriculoarterial interactions and the effects of selected drugs at the intensive care bedside."

Journal • Preclinical • Critical care

Local endothelin-1 receptor type A antagonism improves cutaneous microvascular function in women with a history of gestational diabetes mellitus. (PubMed, Am J Physiol Heart Circ Physiol) - "Red blood cell flux was measured by laser-Doppler flowmetry (LDF) and cutaneous vascular conductance was calculated (CVC=LDF/mean arterial pressure) and normalized to maximum (28mmol/L sodium nitroprusside + 43°C)...In GDM women, ETAR antagonism increased endothelium- (vs. Ringer's; p=0.03) and NO-dependent (vs. Ringer's; p=0.01) dilation but had no effect in HC (p>0.05). These data suggest that ET-1 contributes to microvascular dysfunction following pregnancy complicated by GDM."

Journal • Cardiovascular • Diabetes • Gestational Diabetes • Metabolic Disorders • EDN1

Chronic Mixed-Allergen Exposure Induces Pulmonary Arterial Remodeling and Vascular Dysfunction in Mice. (PubMed, Am J Physiol Lung Cell Mol Physiol) - "Wire myography demonstrated enhanced serotonin (5-HT)-induced vasoconstriction and endothelial dysfunction in MA mice, evidenced by blunted endothelium-dependent relaxation to acetylcholine (ACh) with preserved endothelium-independent relaxation to sodium nitroprusside (SNP)...Collectively, chronic allergic airway inflammation drives vascular remodeling, endothelial dysfunction, and smooth muscle hyperreactivity in pulmonary arteries. This study demonstrates substantial structural and functional consequences of MA exposure to the pulmonary vasculature that models asthmatic pulmonary vascular dysfunction."

Journal • Preclinical • Asthma • Cardiovascular • Hypertension • Immunology • Inflammation • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

cAMP and cGMP pathways modulate spontaneous contractile activity in human seminal vesicle smooth muscle. (PubMed, Auton Neurosci) - "Pharmacological enhancement of cyclic nucleotide signaling reduced phenylephrine-induced hSV contractile activity. Rolipram showed the lowest apparent IC50. Mirabegron-sensitive relaxation together with ADRB3 transcript detection was compatible with possible β3-adrenoceptor involvement in hSV smooth muscle."

Journal

Progesterone alleviates vascular endothelial senescence through progesterone receptor isoform b–dependent repression of kelch-like family member 38 and stabilisation of sirtuin 1 (ESC 2026) - "Aortic relaxation to acetylcholine and sodium nitroprusside (SNP) was assessed by wire myography... OVX increased vascular senescence (SA-β-gal, acetyl-p53, p21 and p16), reduced SIRT1 and eNOS, impaired acetylcholine-mediated relaxation (SNP unaffected) and lowered serum NO, with oxidative stress (↓NRF2/PGC1α/SOD2 and ↑NOX2 expression, and ↑8-OHdG immunofluorescence) and inflammatory activation (↑serum TNF-α/IL-6/IL-1β, ↑p-p65 and MCP-1). P4 dose-dependently reversed these changes. In HAECs, P4 attenuated D-GAL–induced senescence and oxidative stress, restored SIRT1/eNOS and increased supernatant NO, whereas EX527 abrogated protection."

Cardiovascular • CDKN1A • IL1B • IL6 • NOS3 • PGR • SIRT1 • SOD2 • TNFA

Aquaporin-1 facilitates the transport of hydrogen peroxide and nitric oxide during endothelium-dependent vasorelaxation. (PubMed, Vascul Pharmacol) - "Incubation with diphenyleneiodonium (non-specific NADPH oxidase inhibitor), VAS2870 (pan-NADPH oxidase inhibitor), diethyldithiocarbamate (superoxide dismutase inhibitor), exogenous peroxidase, AgNO3 (non-selective AQP inhibitor), or bacopaside II (selective AQP1 inhibitor) significantly attenuated carbachol-stimulated endothelium-dependent relaxation...Furthermore, both AgNO3 and bacopaside II decreased relaxation mediated by the intracellular NO donor sodium nitroprusside...Collectively, these findings suggest that during endothelium-dependent vasorelaxation, AQP1 facilitates endothelial H2O2 influx and subsequent NO efflux, rather than promoting their entry into vascular smooth muscle cells. Thus, our work uncovers a coordinated H2O2-NO signaling cascade that drives endothelium-dependent relaxation in the rat aorta via AQP1-mediated transport, providing novel insights into the biophysical mechanisms governing endothelial function."

Journal • AQP1

Ruxolitinib preserves endothelial function in middle-aged and old mice after ischemia/reperfusion injury. (PubMed, Microvasc Res) - "Treatment of the aorta with the senomorphic agent ruxolitinib during ischemic storage protects the endothelial-dependent vasomotor function of the aorta in both age groups."

Journal • Preclinical • Cardiovascular • Oncology • Reperfusion Injury • CCL8 • CXCL5 • IL10 • IL13 • IL7 • TNFA

Microcirculatory responses at rest and during exercise in limited cutaneous systemic sclerosis compared to age-matched healthy adults. (PubMed, Front Sports Act Living) - P=N/A | "Microvascular function was evaluated using laser Doppler flowmetry (LDF) with iontophoresis of acetylcholine (ACh; endothelial-dependent) and sodium nitroprusside (SNP; endothelial-independent)...ClinicalTrials.gov (NCT number): NCT03058887. https://clinicaltrials.gov/ct2/show/NCT03058887?term=NCT03058887&rank=1."

Journal • Cardiovascular • Immunology • Rheumatology • Scleroderma • Systemic Sclerosis

Advances in nitric oxide donors for myocardial protection: From traditional molecules to smart responsive delivery systems. (PubMed, Eur J Med Chem) - "This review systematically examines the historical and chemical evolution of nitrogen oxide donors, ranging from classical organic nitrates and sodium nitroprusside to S-nitrosothiols, sydnonimines, diazeniumdiolates (NONOates), furoxans, metal nitrosyl complexes, and nitroxyl (HNO) donors, and further extends to contemporary stimuli-responsive delivery systems. Particular emphasis is placed on current cardioprotective strategies, including pharmacophore-NO hybrids, NO/H2S co-delivery systems, hypoxia- and enzyme-activated prodrugs, bioorthogonal enzyme-prodrug systems, hydrogels, nanocarriers, nanomotors, and implantable biomaterials. The structural design, release mechanisms, biological activities, and major limitations of these systems are critically discussed, with the aim of providing guidance and inspiration for the development of more advanced and clinically relevant therapeutic strategies."

Journal • Review • Cardiovascular • Inflammation • Myocardial Ischemia • Reperfusion Injury

Benzylguanine Induces Cellular Senescence and Decreases Relaxation of Vascular Smooth Muscle in the Rat Aorta. (PubMed, Arch Razi Inst) - "Furthermore, we observed significantly decreased relaxation response of aortic smooth muscle to sodium nitroprusside (SNP), which confirms known adverse effects of CS on the vascular system. To conclude, we found that treatment with O6-BG triggered an increase in the relative expression of p27, p21, and PCNA compared to healthy aortic tissues, acting as mediators and markers of senescence. Our findings provide new insights into the signaling of CS in a model of MGMT inhibition."

Journal • Preclinical • CDKN1A • PCNA

One Year of Endurance Exercise Training Does not Improve Vascular Function in Non-Trained Limbs in Healthy Individuals. (PubMed, Scand J Med Sci Sports) - "Forearm vascular function was assessed using intra-arterial infusions of acetylcholine (ACh; endothelium-dependent vasodilation) and sodium nitroprusside (SNP; endothelium-independent vasodilation) and flow-mediated dilation (FMD)...One year of endurance exercise training improved aerobic capacity without improving vascular function in non-trained limbs in previously untrained but healthy individuals. These findings support the idea that vascular adaptations to endurance training may reflect a region-specific training effect with vascular remodeling confined to actively engaged limbs and, thus, undetectable in vascular territories not directly involved in exercise training."

Journal • Cardiovascular

Persistent Hypertension after Adrenal Vein Clipping in Patient Undergoing Laparoscopic Adrenalectomy for Pheochromocytoma (ASA 2026) - "Sodium nitroprusside could only be discontinuated after the surgeon identified a anomalous dreinage of the right adrenal...This was not predicted during the pre operative exams. The MRI did not show any anatomical variations and the patient had no angiotomography."

Clinical • Cardiovascular • Hypertension • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Medullary Carcinoma

Effects of the Combined Treatment of NO and HVEF on the Flavor Quality of Muscat Grapes During Cold Storage. (PubMed, J Food Sci) - "This study investigated the effects of sodium nitroprusside (SNP)-mediated NO treatment, high-voltage electrostatic field (HVEF) treatment, and a combination of the two treatments on the flavor quality of refrigerated Muscat grapes during storage at 0°C for 60 days...Compared with the control group, HVEF + NO treatment exhibited higher activities of lipoxygenase (LOX), hydroperoxide lyase (HPL), alcohol dehydrogenase (ADH), alcohol acyltransferase (AAT), terpene synthase (TPS), and pyruvate decarboxylase (PDC) (p < 0.05). These findings demonstrated that HVEF treatment and SNP-mediated NO treatment effectively preserved the flavor quality of refrigerated grapes, offering a promising preservation strategy."

Journal

Refractory Coronary No-Reflow Reversed by Prolonged Intracoronary Nitroprusside Via an Innovative Microcatheter. (PubMed, JACC Case Rep) - "Localized prolonged sodium nitroprusside delivery via a stable indwelling microcatheter provides an effective bailout strategy to CNR and salvage extensive hibernating myocardium beyond the traditional reperfusion time window and help to recover the blood flow."

Journal • Acute Coronary Syndrome • Cardiovascular • Hematological Disorders • Myocardial Infarction • Thrombosis

Cooperative spin-state switching and anisotropic charge transport in two-dimensional Fe(II) Hofmann-type nitroprusside frameworks. (PubMed, Phys Chem Chem Phys) - "Conductivity calculations further reveal pronounced anisotropic charge transport and enhanced electronic delocalization in NP-Py, which exhibits stronger low-energy optical features, larger spin-dependent hybridization, and a more pronounced band gap reduction than NP-4MIso. These results provide new insight into the cooperative SCO behavior of Fe(II) nitroprusside-based polymers and highlight their potential as electronically active materials with tunable magnetic and transport responses."

Journal

Inhaled pulmonary vasodilators in pulmonary hypertension: Perioperative use and clinical considerations. (PubMed, JHLT Open) - "Traditional vasodilators such as nitroglycerin and sodium nitroprusside lack pulmonary specificity and can exacerbate systemic hypotension. Inhaled agents including nitric oxide (NO), epoprostenol (iEPO), iloprost, milrinone (iMIL) and levosimendan provide selective pulmonary vasodilation with more favorable hemodynamic profiles...Overall, iPVs represent a valuable tool in the perioperative care of patients with PH. Continued research is needed to refine clinical protocols, evaluate emerging agents, and establish outcome-based evidence for their routine use."

Journal • Anesthesia • Cardiovascular • Hypertension • Hypotension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

A Case Report of Myocardial Infarction Complicated With Blood Pressure Fluctuations Caused by Pheochromocytoma. (PubMed, J Clin Hypertens (Greenwich)) - "During percutaneous coronary intervention, blood pressure surged to 240/130 mmHg; intravenous nitroprusside caused an instantaneous drop to 95/55 mmHg, with rapid rebound to >200 mmHg upon withdrawal, showing no clear temporal relationship with drug administration...Postoperatively, the patient required no antihypertensive medications and blood pressure remained stable. This case illustrates a rare pheochromocytoma presentation as secondary hypertension manifesting as acute myocardial infarction, characterized by extreme peri-procedural hemodynamic instability during PCI and an "all-or-none" response to conventional antihypertensive therapy, ultimately cured by surgical resection."

Journal • Cardiovascular • Hypertension • Myocardial Infarction • Oncology • Solid Tumor

Mapping the immune-genetic architecture of Epstein-Barr virus-related phenotypes and multiple sclerosis through a single-cell genetic framework for target prioritization and pharmacologic hypothesis generation. (PubMed, Mult Scler Relat Disord) - "This study provides a single-cell genetic framework for prioritizing immune-cell-specific candidate targets for EBV-related phenotypes and MS, and nominates genetically supported targets and pharmacologic hypotheses for experimental investigation."

Journal • CNS Disorders • Epstein-Barr Virus Infections • Infectious Disease • Inflammation • Multiple Sclerosis