nitroprusside / Generic mfg. - LARVOL DELTA

Redox Priming Ameliorates Salinity Tolerance of Seeds and Seedlings of the Coastal Halophyte Grass Urochondra setulosa. (PubMed, Plants (Basel)) - "Redox priming, including hydrogen peroxide (H2O2), melatonin (MT), sodium nitroprusside (SNP; a nitric oxide donor), and ascorbic acid (AsA), significantly accelerated the germination rate index (GRI) and reduced mean germination time (MGT) without altering MFG under non-saline conditions...Multivariate analyses confirmed MT's consistent superiority across traits under stress. Thus, H2O2 priming optimizes germination, while MT priming improves seedling vigor and offers a practical, targeted strategy to improve early-stage salinity tolerance in U. setulosa for coastal revegetation and sustainable saline agriculture."

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Involvement of Nitric Oxide in TRPV4-Induced Relaxations of Mouse and Human Pulmonary Arteries. (PubMed, Biology (Basel)) - "In small human pulmonary arteries, ACh and sodium nitroprusside (SNP) induced concentration-dependent relaxations, blocked by endothelial cell removal, in the presence of an inhibitor of NO synthase and the KCa3.1 channel blocker TRAM-34. GSK1016790A induced relaxation of human pulmonary arteries with endothelium, but failed to relax arteries without endothelium. The findings suggest that TRPV4 channels are involved in endothelium-dependent relaxation and likely regulate pulmonary vascular tone by modulating NO release."

Journal • Preclinical • KCNN4

Unanticipated intraoperative haemodynamic challenges during adrenalectomy for a phaeochromocytoma misdiagnosed as an adrenocortical tumour. (PubMed, BMJ Case Rep) - "Intraoperatively, tumour manipulation precipitated abrupt hypertensive surges with bradycardia, necessitating nitroglycerine and sodium nitroprusside infusion. Intraoperative haemodynamic instability during adrenal manipulation should raise suspicion of catecholamine secretion, even in the absence of classical symptoms. The report emphasises the importance of invasive monitoring and anaesthetic preparedness to manage unexpected catecholamine release."

Journal • Adrenal Cortex Carcinoma • Anesthesia • Cardiovascular • Endocrine Disorders • Genito-urinary Cancer • Hypertension • Hypotension • Nephrology • Oncology • Pain • Solid Tumor • SYP

Determining biocide efficacy for treating established sulfate-reducing biofilms using flow cell systems. (PubMed, Front Microbiol) - "We used a biofilm flow cell system to examine the efficacy of sodium nitroprusside (SNP, a nitrosating compound proposed as a "green" biocide) and alkyl dimethyl benzyl ammonium chloride (ADBAC), a membrane-disrupting biocide used across many sectors, to mitigate existing SRM biofilms...The results revealed that higher doses of biocides are needed to effectively treat existing SRM biofilms compared to planktonic cells, and that biocide dosing may only be transiently effective. Studying the effects of chemical treatments on sessile rather than planktonic communities in aquatic environments may lead to more effective treatment strategies to mitigate problematic biofilms plaguing infrastructure degradation across many industries."

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Validates blood pressure control for seizure management: Jujuboside B exerts antiseizure effects via blood pressure reduction and activation of NTS-VGLUT2+ neurons. (PubMed, Phytomedicine) - "JuB exerts its antiseizure effect through the activation of vagal-mediated NTS-VGLUT2+ neurons and the inhibition of DG neurons. This reconciles cardiovascular and neurological modulation. These findings elucidate JuB's pharmacological basis, advance epileptic pathophysiology understanding, and support personalized therapeutic strategies for epilepsy with hypertension."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Hypertension • FOS

Gibberellic acid (GA) alleviates Al toxicity in rice (Oryza sativa) through a nitric oxide (NO) dependent pathway. (PubMed, Planta) - "Further research shows that GA reduced the endogenous nitric oxide (NO) levels; nevertheless, the application of an exogenous nitric oxide donor sodium nitroprusside (SNP) offset the alleviatory role of GA. In conclusion, GA accelerated the cell wall Al exclusion mechanism, probably improving rice tolerance to Al toxicity via regulating the accumulation of NO."

Journal • SLC11A1

Cyanide toxicity from high-dose nitroprusside infusion in a critically ill patient on veno-arterial extracorporeal membrane oxygenation. (PubMed, Clin Toxicol (Phila)) - No abstract available

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MaNrg1, a transcriptional regulator, negatively regulates the UV-B tolerance and governs the microcycle conidiation in Metarhizium acridum. (PubMed, Pestic Biochem Physiol) - "Genetic interaction studies indicated that MaNrg1 and MaPacC (a Rim101 homologous gene) mutually regulate expression, yet sodium nitroprusside (4 mM) rescued MC only in ΔMaNrg1 (not ΔMaPacC), demonstrating distinct regulatory mechanisms...Transcriptomics of SYA-cultured strains identified 134 and 112 differentially expressed genes (DEGs) at 8 h and 24 h, enriched in metabolic pathways (glycolysis, amino acid metabolism). Among these DEGs, two target genes that directly interact with MaNrg1 were identified through yeast one-hybrid assays."

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Inflammatory and chemotactic signals of the brainstem solitary tract mediate the morphine exacerbation of impaired reflex chronotropism in septic rats. (PubMed, Front Pharmacol) - "The baroreceptor-mediated control of chronotropic activity was assessed 24 h later in awake rats using the vasoactive method, which relates blood pressure changes caused by i.v. phenylephrine (PE) or sodium nitroprusside (SNP) to respective reciprocal changes in heart rate. These pharmacological interventions also attenuated the elevated protein expression of toll-like receptor 4 (TLR4) and monocyte chemoattractant protein-1 (MCP1) in the brainstem nucleus tractus solitarius (NTS) of morphine-treated CLP rats. Overall, morphine augments the sepsis-induced depression of reflex cardiovagal activity through an opioid receptor sensitive mechanism that engages brainstem inflammatory and chemotactic circuits related to PI3K/MAPK/NADPHox/ROCK signaling."

IO biomarker • Journal • Preclinical • Cardiovascular • CNS Disorders • Critical care • Depression • Infectious Disease • Inflammation • Pain • Psychiatry • Septic Shock • CCL2 • TLR4

Development of a dual-chamber derivatization method for the determination of cyanide in sodium nitroprusside and its preparation via HS-GC-ECD. (PubMed, J Pharm Anal) - "The method was found to be both accurate and precise, thus satisfying the requisite criteria. This method facilitates reliable cyanide monitoring in degradation-prone pharmaceuticals."

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Multi-Omics Elucidation of Edulinine's Intervention Mechanism in Hypertensive Rats. (PubMed, Curr Issues Mol Biol) - "The results demonstrated that Edu exhibited superior antihypertensive efficacy compared to sodium nitroprusside and effectively ameliorated hypertension-induced left ventricular systolic dysfunction...In summary, the potential mechanism of the protective effect and antihypertensive effect of Edu on the thoracic aorta of L-NNA-induced hypertensive rats may be inhibiting the up-regulation of OXSM and MECR expression, regulating the dynamic balance of fatty acid degradation and synthesis, and improving fatty acid metabolism disorders. These findings indicate that Edu holds substantial research value as a potential therapeutic candidate for hypertension."

Journal • Preclinical • Cardiovascular • Hypertension • Metabolic Disorders

NITROPRUSSIDE USE ASSOCIATED WITH IMPROVED SURVIVAL IN PATIENTS WITH CARDIOGENIC SHOCK WITHOUT HYPOTENSION (ACC 2026) - "Abstract is embargoed at this time."

Clinical • Cardiovascular • Hypotension

Engineering Thermoresponsive Dielectric Properties and Phase Transitions via Confinement of Polar Cations in Photoisomerizable Nitroprusside Frameworks. (PubMed, Inorg Chem) - "Notably, the [Fe(CN)5(NO)]2- units preserve reversible photoinduced nitrosyl Fe-NO ↔ Fe-ON linkage isomerization, confirmed by IR spectra, suggesting the potential for light-driven dielectric modulation. This work establishes a clear structure-dynamics-property relationship linking organic cation dynamics in confined space to macroscopic dielectric behavior and highlights the promise of nitroprusside-based frameworks as dual thermo- and photoresponsive dielectric materials."

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Integrated effects of pre-harvest high blue light and postharvest sodium nitroprusside on volatile oil composition and quality of cold-stored holy basil. (PubMed, Food Chem X) - "High blue light also maintained higher antioxidant capacity and preserved key volatile compounds, including β-caryophyllene and humulene. Integrating high blue light with optimal SNP application effectively mitigates chilling-induced oxidative damage and improves postharvest quality, offering a practical strategy to extend shelf life in holy basil."

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Effect of polyphenols on vascular dilation in rats receiving a high-fat diet (PubMed, Vopr Pitan) - "The consumption of polyphenols (resveratrol and quercetin) with excessive fat intake reduces the severity of MS: loweres visceral obesity, improves carbohydrate and lipid metabolism, prevents blood pressure rise. Data have been obtained confirming the hypothesis of the protective effect of polyphenols in HFD on the functional state of the mesenteric arteries of rats: resveratrol or quercetin intake prevents the development of endothelial dysfunction characteristic of HFD, preserving NO-dependent vasodilation mechanisms."

Journal • Preclinical • Cardiovascular • Dyslipidemia • Genetic Disorders • Metabolic Disorders • Obesity

The impact of tizanidine, thiocolchicoside, and cyclobenzaprine on vascular function in ovariectomized rats. (PubMed, Turk J Med Sci) - "Vascular reactivity was assessed using increasing concentrations of phenylephrine, acetylcholine, and sodium nitroprusside, as well as potassium chloride at a concentration of 40 mM. In high doses and for longer periods, TCC and CBZ might also have deleterious effects on vascular reactivity. These findings are noteworthy from the perspective of rational drug therapy."

Journal • Preclinical • Gynecology • Pain

norCBD disruption affects the H2-type six secretion system and multiple virulence factors in Pseudomonas aeruginosa. (PubMed, Front Microbiol) - "The effects of NO donor sodium nitroprusside (SNP) and NO scavenger carboxy-phenyl-tetramethylimidazolineoxyl (CPTIO) were also tested...Treatment with CPTIO also restored H2-T6SS expression in the PAO1(ΔnorCBD). These results indicate that NorCBD plays a critical role in maintaining NO homeostasis that is necessary for effective Dnr-mediated gene regulation and multiple virulence-related traits, highlighting the importance of redox balance in coordinating respiration and pathogenesis in P. aeruginosa."

Journal • Infectious Disease

O-GlcNAcylation of eNOS in high-salt-induced thoracic aorta endothelial dysfunction in mice. (PubMed, Front Pharmacol) - "HSD mice showed increased diastolic blood pressure and impaired acetylcholine-induced vasodilation, while sodium nitroprusside responses remained intact...Our findings suggest that high salt intake impairs endothelial function by enhancing O-GlcNAc of eNOS, thereby contributing to elevated diastolic blood pressure. The ability of OGT inhibition to reverse endothelial dysfunction highlights the therapeutic potential of targeting eNOS O-GlcNAc could be a promising approach for preventing salt-induced vascular damage and subsequent diastolic blood pressure elevation."

Journal • Preclinical • Cardiovascular • Hypertension • NOS3 • OGT

Biological studies on exogenous NO stress to improve the quality of Radix Scutellariae herbs. (PubMed, PLoS One) - "Fresh roots of S. baicalensis Georgi were treated with sodium nitroprusside (SNP) at concentrations of 0.0, 7.5, and 20 mmol/L to induce ROS bursts...This treatment also reduced serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in mice by 13.5% and 16.8% (P < 0.01), respectively. Collectively, this study confirms that exogenous NO induces ROS bursts in fresh S. baicalensis Georgi roots and improves the quality of cultivated Radix Scutellariae via ROS-mediated enhancement of secondary metabolism, and clarifies the NO-ROS-secondary metabolism regulatory axis, providing valuable insights for quality improvement strategies of other medicinal plants."

Journal • Oncology • Pain • CAT • IL6 • TNFA

Holography Meets Theranostics: DFT/TDDFT Insights into Ru-NO@M20 (M = Au, Ag) and Ru-NO@Au10Ag10(Pc) Nanohybrids as Phase-Switchable Molecular Devices. (PubMed, Int J Mol Sci) - "Frequency-dependent polarizabilities α(ω) were calculated for its ground and metastable states and compared with those of the classical holographic material [Fe(CN)5NO]2- (nitroprusside)...This enhancement reflects the cooperative effect of the Ru-NO chromophore and the Au20 nanocluster, which amplifies both polarizability and optical dispersion. The results demonstrate that coupling molecular photo-linkage isomerism with nanoplasmonic environments can significantly improve the performance of molecular systems for holography and optical-phase applications."

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Strain Engineered Co3+ Sites Promoted Electro-Generation of Active CoO2 Species for Efficient Iodide Oxidation Reaction. (PubMed, Small) - "Herein, we report strain-engineered Co3+ sites in Fe-Co(O)OH via electrochemical reconstruction of a nitroprusside-based Co-PBA precatalyst...Notably, Fe-Co(O)OH delivered 100 mA cm-2 current density at 1.35 V versus RHE potential for IOR. In situ electrochemical impedance spectroscopy (EIS) have further validated the accelerated reaction kinetics and enhanced charge transfer properties of Fe-Co(O)OH."

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Gestational Intermittent Hypoxia Programs Pregnancy-Specific Salt-Sensitive Postpartum Hypertension and Vascular Dysfunction via Disruption of NO/cGMP/PKG Pathway†. (PubMed, Biol Reprod) - "Ex vivo, arteries from IH-exposed dams showed enhanced vasocontraction to phenylephrine and impaired vasodilation to both acetylcholine (endothelium-dependent) and sodium nitroprusside (endothelium-independent)...Gestational IH induces a pregnancy-specific predisposition to postpartum salt-sensitive hypertension and vascular dysfunction, driven by disrupted PKG signaling. Early OSA detection and intervention in pregnancy may reduce cardiovascular risk."

Journal • Cardiovascular • Gynecology • Hypertension • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Chronic administration of berberine attenuates depressive-like behavior in rats subjected to chronic unpredictable mild stress combined with ACTH treatment: Role of nitrergic system. (PubMed, Behav Brain Res) - "Furthermore, the administration of sodium nitroprusside (SNP; 1mg/kg; i.p.) prior to the berberine treatment in CUMS + ACTH-treated rats blocked its positive effect. The findings suggest that berberine treatment may exert its antidepressant-like and memory-enhancing effects, at least in part, by attenuating hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, potentially through the involvement of nitrergic signaling."

Journal • Preclinical • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Nitric oxide: a strong inducer of increased production of bioactive compounds in cell and organ cultures. (PubMed, Physiol Mol Biol Plants) - "In recent years, nitric oxide (NO) donors such as sodium nitroprusside, S-introso-N-acetylpenicillamine, S-nirtosoglutathone, and diethylamine NONOate have been utilized for eliciting the plant cell, tissue, and organ cultures...The objective of the current study was to evaluate NO as an elicitor and summarize the advantages and limitations of NO for the production of specialized metabolites in vitro. The mechanism of NO-induced elicitation has been exemplified using several successful examples."

Journal • Review

A novel macrophage membrane-camouflaged ultra-small copper sulfide and photothermal-responsive nitric oxide donor nanocomposites for enhanced synergistic antitumor therapy. (PubMed, Colloids Surf B Biointerfaces) - "Ultra-small copper sulfide (CuS) nanoparticles (NPs) possess exceptional photothermal performance, Fenton-like reaction activities, and multimodal imaging characteristics, while sodium nitroprusside serves as a clinical nitric oxide (NO) donor...Thus, the MDF-SPC demonstrated high antitumor activity and biosafety when subjected to NIR laser irradiation in 4T1 tumor-bearing mice. Overall, the active tumor-targeting and retention capabilities, along with the rapid temperature elevations produced by PTT, allow the MDF-SPC to precisely and swiftly amplify chemodynamic therapy, gas therapy, and chemotherapy, providing a novel multimodal nanoplatform to promote antitumor therapy."

Journal • Oncology