nitroprusside / Generic mfg. - LARVOL DELTA

Pre and postharvest application of regulators enhances bell pepper quality and antioxidant levels during cold storage. (PubMed, Sci Rep) - "To evaluate the effectiveness of two ethylene regulators (1-methylcyclopropene (1-MCP) and sodium nitroprusside (SNP) as a nitric oxide donor) applied at different developmental stages on quality retention and antioxidant preservation in bell peppers during cold storage...This study establishes the timing-dependent efficacy of ethylene regulators in bell pepper preservation and provides valuable insights for developing cultivar-specific post-harvest protocols. The findings offer practical solutions for extending market life and maintaining nutritional quality of bell peppers during cold storage, with potential applications in commercial post-harvest management systems."

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Modified Ozone-Mediated Neurolysis for Resistant Hypertension in a Patient With Bilateral Renal Artery Stenosis. (PubMed, JACC Case Rep) - "Computed tomography-guided ozone-mediated neurolysis may be a promising option for RH associated with renal artery stenosis."

Journal • Cardiovascular • Hypertension • Pain

Inducing an energy management crisis to combat bacterial biofilms: The mechanism of d-proline and sodium nitroprusside. (PubMed, Water Res) - "This forced a reallocation of the remaining energy, suppressing vital protein synthesis and ultimately trapping the cell into an energy-draining cycle. This work demonstrated the inhibitors function by inducing an "energy management crisis", providing a theoretical foundation for new energy-disrupting antibiofilm strategies."

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Evaluation of silver nitroprusside nanoparticles: selective toxicity against MCF-7 cells and in vivo antitumor activity. (PubMed, Discov Nano) - "These results suggest that AgNPs have potential applications in breast cancer treatment. In this study, we focused on the development and application of silver nitroprusside nanoparticles in in vitro and in vivo models to evaluate their antitumor activity and effects in different models of breast cancer."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor

Sodium nitroprusside improves ischemia-induced neovascularization via the HO-1/NOX and AKT/eNOS signaling pathways in chronic kidney disease. (PubMed, Life Sci) - "Although further clinical studies are needed, this study highlights a theoretical basis for potential therapeutic interventions with SNP in CKD patients who also have vascular complications."

Journal • Cardiovascular • Chronic Kidney Disease • Nephrology • Peripheral Arterial Disease • Renal Disease • HMOX1 • NOS3

Salicylic acid enhances photosynthesis in Borago officinalis plants exposed to water deficit by nitric oxide-mediated boosting carbonic anhydrase and antioxidant system. (PubMed, BMC Plant Biol) - "To fill this gap, the current study for the first time, explored the impact of interplay between SA and sodium nitroprusside (SNP as a NO donor), on CA activity, photosynthetic efficiency, and the antioxidant defense system in Borago officinalis under water-deficit conditions...This research provides novel insights into the interplay between SA, NO, and CA activity in modulating photosynthesis in a C3 plant. Furthermore, it underscores the potential of combined SA and SNP application as an effective strategy to enhance the sustainable productivity of medicinal plants in arid regions."

Journal • CAT

Multidimensional Evaluation of Vascular Dysfunction in Diabetic Erectile Dysfunction: Synergistic Application of ICP Measurement, Laser Speckle Blood Perfusion Imaging, and Ex Vivo Microvascular Tension Measurement. (PubMed, Am J Mens Health) - "Sodium nitroprusside produced comparable vasodilatory responses in both groups; following incubation with N-nitro-L-arginine methyl ester, the model group demonstrated decreased vascular tension. The model group exhibited fibrosis in penile tissue, elevated levels of VCAM-1 and VEGF, and decreased expression of eNOS protein. The integration of ICP with LSBPI and vascular tensiometry enables simultaneous in vivo hemodynamic monitoring and ex vivo functional dissection of endothelial-smooth muscle interactions in DMED."

Journal • Preclinical • Erectile Dysfunction • Fibrosis • Immunology • NOS3 • VCAM1

Nitric oxide donors and gallic acid effects on amelioration of heat stress on heat shock protein 70.1 (HSP-70.1) expression and physiological traits in Viciafaba. (PubMed, Plant Physiol Biochem) - "This research focused on the potential of nitric oxide (NO) donors, specifically arginine (Arg) and sodium nitroprusside (SNP), along with gallic acid (GA), and their combinations (Arg-GA and SNP-GA), on the performance of faba beans under heat stress...The interaction between NO donors and GA enhanced its efficiency, but further research is needed to fully understand mechanisms behind this. Overall, exogenous application of NO is a promising strategy for mitigating the negative effects of heat stress, minimizing heat-induced damage and improving plant survival."

Journal • CAT

Interactive effects of H2O2 and NO on mitochondrial function and oxidative mtDNA damage in cold-stored peach fruit. (PubMed, Plant Sci) - "To investigate the effect of H2O2 on mitochondrial function and mtDNA damage in cold-stored peaches and elucidate the interactive effects of H2O2 and NO, sodium nitroprusside (SNP, an NO donor) -pretreated peaches were further treated with H2O2 and the scavenger of reactive oxygen species (N-acetyl cysteine, NAC)...It indicated that H2O2 treatment counteracted the NO-induced protection of mitochondria in cold-stored peaches. This study provides new insight for understanding the crosstalk of different signal molecules in plants."

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A Neonatal Case of Cyanide Toxicity Caused by Sodium Nitroprusside During Veno-Arterial Extracorporeal Membrane Oxygenation Management. (PubMed, J Paediatr Child Health) - No abstract available

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An antibacterial nanofiber with inflammation-suppressing, ROS-scavenging and nitric oxide-generating properties for promoting wound healing. (PubMed, Int J Pharm) - "In this study, we fabricated a novel light-activated nanofiber membrane wound dressing using Eudragit® E100 as the matrix material, propylene glycol (PG) as a plasticizer, and silver nitroprusside nanoparticles (SNP-AgNPs) as a nitric oxide (NO)-releasing component...In vitro and in vivo assessments demonstrated excellent cytocompatibility and significantly accelerated wound closure. Furthermore, immunohistochemistry and immunofluorescence analyses revealed that the treatment promoted robust angiogenesis and granulation tissue formation, while substantially attenuating inflammatory cell infiltration, ultimately leading to complete re-epithelialization with mature skin architecture."

Journal • Infectious Disease • Inflammation

Bisphenol A-Induced Vascular Endothelial Dysfunction: Protective Effects of Nigella sativa Oil and Thymoquinone. (PubMed, Food Sci Nutr) - "In addition, contractile responses to potassium chloride (KCl) and phenylephrine (PE) and relaxant responses to acetylcholine (ACh) and sodium nitroprusside (SNP) were evaluated in the rat aorta...Furthermore, NSO and TQ alone increased the vasorelaxation responses induced by ACh and SNP. These findings suggest that NSO and TQ can protect the vascular endothelium against BPA-induced damage, probably resulting from their antioxidant activity, as well as their ability to attenuate cell adhesion molecules."

Journal • NOS3 • VCAM1

Biological mechanisms of sodium nitroprusside in enhancing quality of Radix Paeoniae Rubra and Radix Paeoniae Alba. (PubMed, Front Plant Sci) - "Moreover, experiments involving combined treatment with SNP and ROS scavengers demonstrated that ROS act as the key mediator linking exogenous NO to the secondary metabolism of P. lactiflora: scavenging ROS significantly attenuated the SNP-induced accumulation of target secondary metabolites. Combined with the above findings of SNP promoting secondary metabolite synthesis, this study confirms that exogenous NO can improve the quality of cultivated RAP and RRP via ROS-mediated secondary metabolism, and clarifies the NO-ROS-secondary metabolism regulatory axis, offering insights for other medicinal plants' quality improvement."

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Early Neurovascular Adaptations in Aging Women (clinicaltrials.gov) - P1 | N=64 | Recruiting | Sponsor: University of Missouri-Columbia | Trial completion date: Jun 2027 ➔ Jun 2028

Trial completion date

External application of growth regulators modulates morpho-physiological traits and biochemical profiles of fennel. (PubMed, Sci Rep) - "To test this hypothesis, a factorial experiment was carried out with foliar applications of four plant growth regulators, including salicylic acid (SA: 1 and 2 mM), gibberellic acid (GA: 0.25 and 0.5 mM), gamma-aminobutyric acid (GABA: 5 and 10 mM), and sodium nitroprusside (SNP: 1.25 and 2.5 mM)...Among these, cis-anethole (40-75%) and limonene (6.5-19%) were identified as the predominant components in the essential oil of the leaves. These findings suggest that certain plant growth regulators, especially SNP and SA, can be used as effective agricultural tools for improving the growth and phytochemical quality of fennel."

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Foliar application of sodium nitroprusside and chitosan induced antioxidant system and alleviated drought stress in spinach. (PubMed, Sci Rep) - "The foliar application of both elicitors mitigated adverse effects of drought and promoted the spinach growth in normal condition. Cross-talk between phytohormones, signaling molecules, and osmolytes regulated the antioxidant response, turned out significant changes in the spinach morphology under each treatment."

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Nitric oxide-mediated modulation of reproductive resilience under cold stress in chickpea. (PubMed, Front Plant Sci) - "This study examined the role of sodium nitroprusside (SNP), a nitric oxide (NO) donor, in mitigating cold-induced reproductive damage in cold-tolerant (CT) and cold-sensitive (CS) chickpea genotypes...Notably, CS genotypes showed more pronounced improvements from SNP application than CT genotypes, particularly in terms of reproductive success and yield-related traits. These findings highlight the potential of NO donors, such as SNP, to enhance cold tolerance in chickpeas, with promising implications for safeguarding productivity under low-temperature stress, especially in sensitive cultivars."

Journal • CAT

Development and optimization of an engineered E. coli platform for nitrotryptophan biosynthesis. (PubMed, Enzyme Microb Technol) - "This process is supported by a nitric oxide synthetase (BsNOS) from Bacillus subtilis or its chemical alternative, sodium nitroprusside (SNP), to produce nitric oxide (NO) from L-arginine, which facilitates the direct nitration...Through systematic optimization, including pathway balancing, fermentation condition enhancement, and elimination of competing metabolic pathways, the final titer was successfully increased to 209.9 mg/L within 48 h. This work establishes a robust platform for the microbial production of valuable nitroaromatic compounds and provides key insights for future biocatalytic nitration strategies."

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A multifunctional nanosystem based on sodium nitroprusside/copper co-doped dopamine-coated Prussian blue nanoparticles with enhanced photothermal capability for combined cancer therapy. (PubMed, Colloids Surf B Biointerfaces) - "The PDA shell acts as a "gatekeeper" for pH- and thermal-responsive doxorubicin (DOX) release, enabling NO liberation under photothermal activation. In vivo evaluations demonstrate significant tumor suppression via combined PTT/chemotherapy/gas therapy/CDT, with minimal systemic toxicity, as validated by histopathology and blood biochemistry. This design exemplifies a precision nanomedicine strategy that uses endogenous stimuli and exogenous activation to effectively treat cancer combinatorially."

Journal • Oncology

Harnessing polyploidy and nitric oxide for improved arsenic tolerance in Oryza sativa. (PubMed, BMC Plant Biol) - "In brief, tetraploid rice exhibited greater As tolerance than diploid rice, with NO proving effective in regulating physiological and biochemical processes and mitigating As toxicity."

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The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming. (PubMed, Elife) - "Endogenously generated nitric oxide (NO) is highly cardioprotective, but protection is not replicated by nitroso-vasodilators (e.g., nitrates, nitroprusside) used in clinical practice, highlighting specificity in NO-based signaling and untapped therapeutic potential...Human cardiomyopathy shows reduced SCoR2 expression and an S-nitrosylation signature of metabolic reprogramming, mirroring SCoR2-/- mice. Deletion of SCoR2 thus coordinately reprograms multiple metabolic pathways-ketone body utilization, glycolysis, pentose phosphate shunt, and polyol metabolism-to limit infarct size, establishing SCoR2 as a novel regulator in the injured myocardium and a potential drug target."

Journal • Cardiomyopathy • Cardiovascular • Myocardial Infarction • Reperfusion Injury

Obesity-Induced Platelet Mitofusin-1 Expression Causes Vascular Dysfunction (ASH 2023) - "Further, endothelial-dependent- and independent- vascular relaxation was measured in both groups by stimulating aortic rings with acetylcholine (Ach) or sodium nitroprusside (SNP) using wire myography... These data demonstrate that obesity/weight gain induces platelet MFN1 expression, which drives TSP1 release from platelets to propagate vascular dysfunction. Our findings elucidate a novel platelet-centric mechanism underlying obesity-associated vasculopathy and have implications for the targeting of non-thrombotic platelet function as a therapeutic strategy for obesity-induced vasculopathy."

Cardiovascular • Genetic Disorders • Obesity • MFN1

Role of Nitric Oxide in the Antidepressant Effect of an Aqueous Extract of Punica granatum L.: Effects on GSH/GSSG Ratio and Lipoperoxidation in Adult Male Swiss Webster Mice. (PubMed, Int J Mol Sci) - "The interaction with NO signaling was examined through co-administration with an NO donor (sodium nitroprusside, SNP) and NOS inhibitors (NG-nitro-L-arginine methyl ester, L-NAME and 7-nitroindazole, 7-NI)...The results support its potential as a natural candidate for depression treatment, particularly in conditions associated with oxidative imbalance and possible NO dysregulation. Future studies should confirm these mechanisms using direct molecular assessments and include female cohorts."

Journal • Preclinical • CNS Disorders • Depression • Mental Retardation • Psychiatry

Exogenous Nitric Oxide Promotes the Growth and Cadmium Accumulation of Alfalfa (Medicago sativa) Seedlings Under Cadmium Stress. (PubMed, Plants (Basel)) - "Addition of sodium nitroprusside (SNP, as an NO donor) significantly promoted seedling growth and induced the mobilization of seed photosynthate reserves, leading to an increase in total soluble sugar (SS) and reducing sugar (RS) contents...This promoting effect of SNP depended on its concentration; the most optimal SNP concentration to promote the growth and Cd absorption of alfalfa under Cd stress was found to be 200 µM. The fresh weight (FW), dry weight (DW) and Cd accumulation of seedlings treated with 200 µM SNP increased significantly by 23.10%, 30.32% and 82.50%, respectively, on the fifth day, compared with the Cd-only treatment."

Journal • CAT

Factor H Deficiency Exacerbates Endothelial Dysfunction in CKD (KIDNEY WEEK 2025) - "Endothelium-dependent and -independent dilation were determined by dose-response curves of acetylcholine (Ach,10 −9 –10 −5 M) and sodium nitroprusside (SNP, 10 −9 –10 −5 M), respectively, on phenylephrine (PE, 10 −6 M)-induced pre-contracted vessels...Conclusion Consistent with prior observations in humans, CKD via 5/6Nx induced AP lability and endothelial dysfunction. FH deficiency further exacerbated AP dyregulation leading to AP activation and worsened endothelial dysfunction in this CKD model."

Cardiovascular • Chronic Kidney Disease • Nephrology • Renal Disease