ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma - LARVOL DELTA

A Comparative Evaluation of the Safety and Efficacy of Oliceridine and Sufentanil in Gastrointestinal Endoscopy: A Single-Center, Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "Additionally, the oliceridine group demonstrated lower incidence of hypotension (11.8% vs 18.2%, p=0.026), postoperative nausea and vomiting (4.6% vs 10.1%, p=0.009), and higher patient satisfaction scores (9 [9,9] vs 9 [8,9], p=0.003). The sedation success rate for GI endoscopy using remimazolam and etomidate in combination with either oliceridine or sufentanil approaches 100%, with oliceridine demonstrating superior safety and enhanced patient satisfaction."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Hypotension • Psychiatry

Model-Informed Precision Dosing of Remimazolam in General Anesthesia Patients. (PubMed, Drug Des Devel Ther) - "In addition, a web-based dashboard tool was created to offer initial personalized dosing strategies for general anesthesia procedures, enhanced by graphical representations of the PK/PD profiles associated with the recommended dosing regimens. The developed population PK/PD model effectively captured the dose-exposure-response relationship for remimazolam, allowing for the optimization of personalized dosing strategies."

Journal • Anesthesia

Feasibility and efficacy of remimazolam for anesthesia monitoring in transcatheter aortic valve implantation via femoral artery access. (PubMed, Am J Transl Res) - "Remimazolam is an effective sedative for TAVI anesthesia, associated with lower postoperative adverse reactions, thus facilitating better recovery."

Journal • Anesthesia • CNS Disorders

Effect of Remimazolam on Postoperative Nausea and Vomiting (clinicaltrials.gov) - P=N/A | N=108 | Completed | Sponsor: Inje University | Recruiting ➔ Completed | Trial completion date: Apr 2024 ➔ Oct 2024 | Trial primary completion date: Apr 2024 ➔ Oct 2024

Trial completion • Trial completion date • Trial primary completion date

Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults. (PubMed, Drug Des Devel Ther) - P1 | "These findings support its clinical utility as a safe and efficient anesthetic protocol for painless gastroscopy. Chinese Clinical Trial Registry (ChiCTR2400093416)."

Clinical • Journal • Anesthesia • Cardiovascular • Hypotension • Pain

Effect of Remimazolam and Propofol on Postoperative Delirium (clinicaltrials.gov) - P=N/A | N=82 | Recruiting | Sponsor: Inje University | Trial completion date: Aug 2025 ➔ Dec 2025 | Trial primary completion date: Dec 2024 ➔ Dec 2025

Trial completion date • Trial primary completion date • CNS Disorders • Geriatric Disorders • Immunology • Musculoskeletal Diseases • Orthopedics • Osteoarthritis • Pain • Rheumatology

Influencing Factors and Prediction Model of Postoperative Delirium for Elderly Femoral Neck Fracture Patients Under Remimazolam Intrathecal Anesthesia. (PubMed, Ann Ital Chir) - "The model constructed on the basis of multiple key influencing factors identified in this study was proved to be helpful for the early recognition of high-risk patients for POD, laying a foundation for personalized perioperative management to lessen the incidence of delirium and ameliorate the prognosis. However, this investigation has limitations, requiring optimization and improvement in the future."

Journal • Retrospective data • Anesthesia • CNS Disorders • Geriatric Disorders • Musculoskeletal Diseases • Orthopedics

Pharmacokinetic Properties and Therapeutic Effectiveness of Remimazolam in ICU Patients With Mechanical Ventilation: A Preliminary Study. (PubMed, Pharmacol Res Perspect) - P4 | "It provides mild to moderate sedation at 0.1-0.3 mg/kg/h, but caution is advised for patients with severe liver dysfunction due to its impact on drug metabolism. Trial Registration: ClinicalTrials.gov identifier: NCT05480787."

Clinical • Journal • PK/PD data • Anesthesia • Critical care • Hepatology • Liver Failure

Comparison of the recovery profiles of propofol, dexmedetomidine, and remimazolam for intraoperative sedation in patients undergoing upper limb surgery under brachial plexus blockade: a randomized controlled trial. (PubMed, Can J Anaesth) - P4 | "Patients in the propofol group exhibited the most rapid recovery time from intraoperative sedation under regional anesthesia, followed by those in the remimazolam and dexmedetomidine groups. We found no differences in the recovery-related secondary outcomes."

Journal • Anesthesia • Orthopedics

General anesthesia using remimazolam in an extremely preterm infant with myotonic dystrophy. (PubMed, Minerva Anestesiol) - No abstract available

Journal • Anesthesia • Genetic Disorders • Muscular Dystrophy • Myotonic Dystrophy

Effectiveness Analysis of Sevoflurane Combined with Propofol or Remimazolam Anesthesia in Pediatric Laparoscopic Inguinal Hernia Repair and Its Impact on Hemodynamics and Postoperative Pain. (PubMed, J Invest Surg) - "Adverse effects were lower in the sevoflurane + remimazolam group (5% vs. 12%, p = .076). Sevoflurane plus remimazolam in children receiving LIHR has minimal impact on hemodynamics, reduces pain levels within 4 h postoperatively, lowers PAED and agitation scores, and demonstrates high safety."

Clinical • Journal • Anesthesia • Gastroenterology • Pain • Pediatrics

Anesthetic efficacy with remimazolam compared with propofol: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Int J Surg) - "Remimazolam and propofol achieved comparable success rates for sedation and general anesthesia. Remimazolam reduced hypoxemia risk but prolonged awakening times during procedural sedation. It also lowered the incidence of hypotension and injection pain across both procedural sedation and general anesthesia. Additional studies are needed to further clarify its role, particularly in general anesthesia."

Journal • Retrospective data • Anesthesia • Hypotension • Pain

Remimazolam-etomidate versus remimazolam-propofol for gastrointestinal endoscopy: A randomized controlled trial. (PubMed, PLoS One) - P4 | "Remimazolam-etomidate demonstrated a superior safety profile, with reduced respiratory depression and hemodynamic instability compared to remimazolam-propofol, suggesting its potential as a safer alternative for gastrointestinal endoscopy sedation."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Movement Disorders • Pain • Psychiatry

Remimazolam Besylate Versus Propofol for Short-Term Sedation in Critically Ill Patients Receiving Mechanical Ventilation: Protocol for a Multicenter Randomized Non-inferior Trial. (PubMed, Adv Ther) - P3 | "The secondary outcomes include the percentage of time within the target sedation level of the total duration of the study drug infusion, the proportion of subjects reaching the target sedation level, the number of additional administration of the study drug, the proportion of subjects receiving additional administration of the study drug, total dosage of remifentanil, the proportion of subjects using rescue sedatives, recovery time, weaning time, successful extubation, and ICU discharge time. Adverse events occurring during the study are also recorded. ClinicalTrials.gov identifier, NCT05782894."

Journal • Anesthesia • Critical care

Remimazolam in neuroanesthesia. (PubMed, Curr Opin Anaesthesiol) - "Although remimazolam has shown promise in providing a favorable hemodynamic profile and rapid recovery in neuroanesthesia, definitive conclusions would require additional high-quality, multicenter trials with standardized methodologies. Clinicians should exercise careful judgment in dosing and monitoring till more comprehensive safety and efficacy data are available, to ensure that remimazolam's potential benefits are cautiously utilized based on evolving evidence."

Journal • Anesthesia • Hypotension

Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia (clinicaltrials.gov) - P1 | N=125 | Not yet recruiting | Sponsor: Second Hospital of Shanxi Medical University

New P1 trial • Anesthesia

The Influence of Age on the Effective Dosage of Intravenous Remimazolam for the Relief of Preoperative Anxiety in Pediatric Patients at Median and 95% Effective Doses: A Prospective Study. (PubMed, Drug Des Devel Ther) - "None of the adverse events that occurred after the use of remimazolam in this trial required the use of medication for intervention. Remimazolam can be effectively used for preoperative sedation in children aged 1-6 years with low circulatory and respiratory effects, and there was no difference in the effective dose of the drug by age."

Clinical • Journal • Anesthesia • Mood Disorders • Pediatrics • Psychiatry

Clinical application of remifentanil sevoflurane balanced anesthesia in postoperative recovery of spinal surgery (ChiCTR) - P4 | N=164 | Not yet recruiting | Sponsor: The Second Xiangya Hospital, Central South University; The Second Xiangya Hospital, Central South University

New P4 trial • Anesthesia • Orthopedics

Observation on the Clinical Effect of Remimazolam Sulfonate Combined with Afentanil in Gastric and Colon Endoscopy under Painless Condition (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Jiangxi Provincial People's Hospital; Jiangxi Provincial People's Hospital

New trial • Pain

The hemodynamic effects of remimazolam on coronary heart disease patients undergoing non-cardiac surgery (ChiCTR) - P4 | N=60 | Not yet recruiting | Sponsor: Beijing Anzhen Hospital, Capital Medical University; Beijing Anzhen Hospital, Capital Medical University

New P4 trial • Cardiovascular • Coronary Artery Disease • Heart Failure

Effect of Remimazolam on Early Perioperative Neurocognitive Disorders in Elderly Patients (ChiCTR) - P=N/A | N=106 | Recruiting | Sponsor: Wuxi Second Renmin Hospital; Wuxi Second Renmin Hospital

New trial • CNS Disorders • Cognitive Disorders • Developmental Disorders

The effect of remimazolam on diaphragm function in patients undergoing gynecological hysteroscopic surgery. (ChiCTR) - P4 | N=80 | Not yet recruiting | Sponsor: Xi'an People's Hospital (Xi'an No.4 Hospital); Xi'an People's Hospital (Xi'an No.4 Hospital)

New P4 trial • Gynecology • Women's Health

The influence of alfentanil versus remifentanil combined with propofol or remimazolam on the incidence of hypoxemia during painless colonoscopy: A multicenter, prospective, 2×2 factorial design, randomized controlled study (ChiCTR) - P=N/A | N=1032 | Not yet recruiting | Sponsor: Drum Tower Hospital; Drum Tower Hospital

New trial • Pain

Comparison of the Effects of Three Intravenous Anesthetics on Early Postoperative Recovery Quality in Elderly Patients Undergoing Thoracoscopic Lung Surgery: A Randomized Clinical Trial (ChiCTR) - P=N/A | N=459 | Not yet recruiting | Sponsor: West China Hospital, Sichuan University; West China Hospital, Sichuan University

New trial • Anesthesia

A clinical study on self-controlled sedation with remimazolam under subarachnoid block for elderly lower limb surgery (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: The Second Hospital of Shanxi Medical University; The Second Hospital of Shanxi Medical University

New trial • Anesthesia