ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma - LARVOL DELTA

Actualities in Procedural Sedation: Remimazolam (clinicaltrials.gov) - P4 | N=200 | Active, not recruiting | Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy | Recruiting ➔ Active, not recruiting

Enrollment closed • Anesthesia • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Patient-Controlled Sedation with Remimazolam Enables More Precise Intraoperative Sedation in Elderly Patients Under Spinal Anesthesia: A Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "It ensures a higher proportion of optimal sedation depth while reducing drug consumption, accelerating recovery, and enhancing patient comfort and satisfaction. Under the conditions of this study, this approach constitutes a safe, effective, and individualized sedation strategy."

Clinical • Journal • Anesthesia • Hypotension

Age-dependent electroencephalogram alterations under remimazolam anesthesia. (PubMed, Korean J Anesthesiol) - "Older patients exhibited decreased alpha and beta powers, increased delta and theta dominance, and decreased frontal coherence under remimazolam anesthesia guided by the PSI. These findings suggest age-specific alterations in cortical dynamics that may affect EEG monitoring during remimazolam anesthesia."

Journal • Anesthesia • CNS Disorders

The effects of remimazolam on emergence agitation in patients undergoing nasal surgery: a clinical randomized controlled trial. (PubMed, PeerJ) - "However, there were no significant differences between the two groups in terms of adverse effects such as bradycardia, postoperative wound bleeding, and postoperative nausea and vomiting. Remimazolam holds significant clinical application value and potential in surgeries with a high incidence of EA."

Clinical • Journal • Anesthesia • Cardiovascular • Hypotension • Otorhinolaryngology • Pain

Comment on "Effect of intraoperative remimazolam infusion on postoperative sleep disturbance in elderly patients after gynecological laparoscopy: A randomized clinical trial". (PubMed, Anaesth Crit Care Pain Med) - No abstract available

Clinical • Journal • CNS Disorders • Sleep Disorder

Comparative analysis of esketamine versus remimazolam in adult and pediatric surgical patients: a multimodal monitoring evaluation. (PubMed, Am J Transl Res) - "Remimazolam offers faster onset and recovery but carries higher cardiorespiratory risks. Esketamine provides superior hemodynamic stability and is associated with less restlessness. The anesthetic effects show significant age-dependent variations, necessitating individualized drug selection based on patient age, physiological status, and surgical type."

Journal • Anesthesia • CNS Disorders • Depression • Pediatrics • Psychiatry

Remimazolam for hemodynamic stabilization in patients with perioperative arrhythmia: report of two cases. (PubMed, Am J Transl Res) - "Therefore, remimazolam may be a viable anesthetic alternative for patients with preexisting or newly developed arrhythmias, providing stable cardiovascular control during the induction and maintenance phases. Although larger prospective studies are warranted, these cases demonstrate the clinical utility of remimazolam in high-risk cardiac patients requiring surgical intervention."

Journal • Anesthesia • Atrial Fibrillation • Cardiovascular

Remimazolam and Postoperative Delirium in Patients with Hyperlipidemia: A Retrospective Cohort Study with Target Trial Emulation Analysis. (PubMed, Drug Des Devel Ther) - "Remimazolam significantly reduced POD incidence and severity in patients with hyperlipidemia and improved cognitive function at 6 months postoperatively. However, prospective studies are needed to confirm these findings."

Journal • Retrospective data • Alzheimer's Disease • Anesthesia • CNS Disorders • Cognitive Disorders • Dyslipidemia • Inflammation

KPD: Ketamine for Veterans With Parkinson's Disease (clinicaltrials.gov) - P2 | N=80 | Recruiting | Sponsor: VA Office of Research and Development | Trial completion date: Jun 2029 ➔ Sep 2029 | Trial primary completion date: Jun 2029 ➔ Sep 2029

Trial completion date • Trial primary completion date • CNS Disorders • Depression • Inflammation • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Remimazolam and Emergence Delirium in Children: Encouraging Signals, Incomplete Certainty. (PubMed, Paediatr Anaesth) - No abstract available

Journal • CNS Disorders

Sex-related differences in blood concentrations and emergence profiles following total intravenous anesthesia with remimazolam and remifentanil. (PubMed, Sci Rep) - No abstract available

Journal • Anesthesia

Roc'd by Anaphylaxis, Saved by Sugammadex (SCCM 2026) - "Awake fiberoptic intubation was performed with lidocaine, fentanyl, and remimazolam. Sugammadex avoided the need for additional epinephrine, IV fluids, and complex airway procedures. Our findings add to the limited literature and suggest a novel consideration of including sugammadex with epinephrine as first line treatment for rocuronium-induced anaphylaxis."

Aesthetic Medicine • Hypotension • Immunology • Infectious Disease • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder • Squamous Cell Carcinoma

Postoperative recovery with remimazolam versus propofol in elderly patients undergoing daytime ocular fundus surgery under general anesthesia: a multicenter randomized non-inferiority trial. (PubMed, Minerva Anestesiol) - "Remimazolam was non-inferior to propofol regarding postoperative recovery among elderly patients receiving ocular fundus daytime surgery. Compared to propofol, remimazolam facilitated more stable hemodynamics and shorter recovery times."

Clinical • Head-to-Head • Journal • Anesthesia

Remimazolam alleviates blood-brain barrier damage by regulating the PI3K/AKT signaling pathway in sepsis-associated encephalopathy mice. (PubMed, Brain Res Bull) - "Notably, co-administration of LY294002 abolished the protective effects of remimazolam, indicating a critical role for PI3K/AKT signaling in mediating its neuroprotective actions. These findings suggest that remimazolam may represent a promising therapeutic candidate for targeting the pathogenesis of SAE."

Journal • Preclinical • CNS Disorders • Infectious Disease • Inflammation • Septic Shock • IL1B • IL6 • OCLN • TJP1

The Influence of Pharmacological Agents Used During General Anesthesia on the Intensity of Postoperative Pain and the Occurrence of Post-Anesthetic Delirium-A Scoping Review. (PubMed, J Clin Med) - "Analysis of clinical trial outcomes conducted in pediatric populations undergoing various surgical procedures suggests that dexmedetomidine (administered intranasally and intravenously) and alfentanil were associated with lower incidence and severity of emergence delirium compared to standard care or other agents (e.g., midazolam)...Hydromorphone was reported in the included trials to be associated with better postoperative pain control than sufentanil, whereas remimazolam, although associated with reduced delirium incidence in some trials, did not influence the length of stay in the post-anesthesia care unit...Ketamine, while commonly used for analgesic therapy, did not demonstrate a consistent association with delirium prevention and, in some studies, was associated with increased neuropsychiatric events. Further research is required to more precisely define optimal perioperative delirium prevention protocols."

Journal • Review • Anesthesia • CNS Disorders • Cognitive Disorders • Insomnia • Pain • Pediatrics • Psychiatry • Sleep Disorder

Optimal Insertion Time During Remimazolam-Remifentanil Anesthesia for Painless Gastroscopy (clinicaltrials.gov) - P=N/A | N=342 | Completed | Sponsor: Huizhou First People's Hospital

New trial • Anesthesia • Pain

Update on total intravenous anesthesia in children. (PubMed, Curr Opin Anaesthesiol) - "Pediatric TIVA is moving toward greater precision, safety, and sustainability. Moderate effect-site targets, opioid titration, and early down-titration remain central, particularly in neonates. Propofol infusion syndrome is exceedingly rare, and organ-protective effects of TIVA are reported in major surgery. Despite clinical and environmental advantages, adoption varies globally due to limited training, variable pump availability, and regulatory barriers. Expanding structured education and pediatric-specific TCI tools is essential for broader implementation."

Journal • Anesthesia • CNS Disorders • Pediatrics

In vitro effects of remimazolam on human platelet function and a possible flumazenil-sensitive and non-sensitive pathway. (PubMed, J Anesth) - "Remimazolam (Anerem®) did not affect human platelet function at clinically relevant concentrations. However, it inhibited platelet aggregation at supra-clinical concentrations and this effect was partially mediated by a flumazenil-sensitive pathway. These findings provide pharmacological insight into the effects of remimazolam on platelets; however, the clinical relevance of these observations requires further evaluation in future in vivo and clinical studies."

Journal • Preclinical • Hematological Disorders

ED90 of Remimazolam for Moderate Sedation in Children Undergoing Neurosurgery. (PubMed, Drug Des Devel Ther) - "This study reported the ED90 of remimazolam for moderate sedation in neurosurgical children. These results provided important information for the use of remimazolam in children with neurologic disease."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Pediatrics • Psychiatry

Review of clinical advances in the procedural sedation application of remimazolam. (PubMed, Front Pharmacol) - "This systematic review of its clinical applications provides scientific evidence for the rational and standardized use of remimazolam in clinical practice. Future research should focus on expanding its application in more complex clinical scenarios and conducting long-term safety and efficacy studies to further promote the widespread use of remimazolam in procedural sedation."

Journal • Review • Anesthesia • Palliative care

Aquatic toxicity of propofol vs. remimazolam: an in-silico comparison. (PubMed, Anaesthesia) - No abstract available

Journal

The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy (clinicaltrials.gov) - P=N/A | N=60 | Not yet recruiting | Sponsor: Fu Jen Catholic University Hospital

New trial • Anesthesia • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Bypro: A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy (clinicaltrials.gov) - P4 | N=90 | Recruiting | Sponsor: Clinical Hospital Centre Zagreb

New P4 trial • Anesthesia • Colonic Polyps • Gastroenterology

Reply to Commentary: Finsterer, J. Outcome of General Anesthesia With Remimazolam in a m.3243A>G Carrier. Anesthesia Progress. 2026;73(1):51. doi: 10.2344/25-0017. (PubMed, Anesth Prog) - No abstract available

Journal • Anesthesia

Outcome of General Anesthesia With Remimazolam in a m.3243A>G Carrier. (PubMed, Anesth Prog) - No abstract available

Journal • Anesthesia