ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma - LARVOL DELTA

Remimazolam-Remifentanil versus Propofol-Remifentanil for Spontaneous Ventilation During Fiberoptic Bronchoscopy: A Randomized Controlled Trial. (PubMed, Curr Med Sci) - "Compared to propofol-remifentanil, remimazolam-remifentanil provides effective moderate sedation for FOB with superior respiratory safety and reduced hypotension requiring vasopressors, despite a numerically higher incidence of transient movement and cough. It thus represents a promising alternative for maintaining spontaneous ventilation during FOB."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Cough • Depression • Hypertension • Hypotension • Psychiatry • Respiratory Diseases

Exploration of Key Genes and Molecular Mechanisms in Mice with Perioperative Neurocognitive Disorders Treated with Remimazolam Based on Transcriptomics and Experimental Verification. (PubMed, Drug Des Devel Ther) - "Both Jph3 and Caly had good binding abilities with remimazolam (< -5.0 kcal/mol), highlighting their potential as therapeutic agents for PND. This study identified 2 validated key genes (Jph3 and Caly), providing potential therapeutic targets for PND patients."

Journal • Preclinical • Anesthesia • CNS Disorders • Cognitive Disorders • Developmental Disorders • JPH3 • MIR186

Intravenous Anesthesia with Ciprofol and Remimazolam Besylate for Painless Gastroscopy: A Prospective, Single-Center, Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "Additionally, gastroenterologist and anesthesiologist satisfaction was significantly higher in group CR than in groups P and C (all P values < 0.001). The combination of ciprofol and remimazolam exerts a lesser impact on the respiration and circulation of patients undergoing gastroscopy, and demonstrates superior safety and efficacy compared to the use of propofol or ciprofol alone."

Clinical • Journal • Anesthesia • Hypotension • Pain

Spinal augmentation for vertebral body fractures in the elderly population. (PubMed, Geroscience) - "Such efforts include pedicle screw fixation with or without fusion, intraoperative lidocaine injection, erector spinae plane block, and rehabilitation efforts, in addition to the use of dexmedetomidine or the combined use of remimazolam besylate and sufentanil analgesics. Both procedures have demonstrated efficacy in the domain of anatomical correction. PKP and PVP appear to safely restore quality of life in elderly patients, yet the finer details of each procedure must be explored with higher levels of evidence to account for potential differences in complication profiles and care options."

Journal • Musculoskeletal Diseases • Orthopedics • Pain

SEDATION IN ENDOSCOPY - PATIENT MONITORING AND EMERGENCY MANAGEMENT (UEGW 2025) - "Results/Findings: The most commonly used sedatives are midazolam and remimazolam. Sedation plays an irreplaceable role in enabling safe, effective, and comfortable gastroenterological endoscopy. For successful outcomes, it is necessary to ensure appropriate education, competence, and coordination of all healthcare team members.The nurses response in emergency situations significantly contributes to the safety and success of procedures under sedation."

Clinical • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Mood Disorders • Psychiatry

REMIMAZOLAM IN ENDOSCOPY: A GAME-CHANGER FOR SAFE AND EFFECTIVE SEDATION IN REAL-WORLD PRACTICE (UEGW 2025) - "Traditional agents like midazolam and propofol, while effective, present limitations related to recovery time, safety, and need for anesthesiologist supervision. Remimazolam provides a highly effective and safe sedation alternative for GI endoscopy in real-world NAAS settings, ensuring rapid recovery and minimal AEs, even in patients with elevated ASA status or obesity. This study was prospective real-world and had several limitations. First the number of patients was too small to accurately assess rare adverse events."

Clinical • Real-world • Real-world evidence • Anesthesia • Cardiovascular • Genetic Disorders • Hypotension • Immunology • Metabolic Disorders • Obesity • Respiratory Diseases

COMPARISON OF REMIMAZOLAM AND MIDAZOLAM FOR SEDATION DURING COLONOSCOPY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: PATIENT SATISFACTION, RECOVERY TIME, AND SAFETY (UEGW 2025) - "This prospective study suggests that remimazolam enables faster discharge from the endoscopy unit compared to midazolam, with a high level of patient satisfaction and a favorable safety profile."

Clinical • Anesthesia • Cardiovascular • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

A PROSPECTIVE, RANDOMIZED TRIAL COMPARING PROPOFOL AND REMIMAZOLAM FOR SEDATION IN ADVANCED ENDOSCOPIC PROCEDURES (UEGW 2025) - "Remimazolam appears to be a safe and effective alternative to propofol for sedation in advanced endoscopy, with a favorable safety profile regarding cardiovascular and respiratory events. These findings support its potential role in settings where anesthesiology support is limited or in patients at increased sedation risk."

Clinical • Metastases • Anesthesia • Cardiovascular • CNS Disorders • Depression • Psychiatry

Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam (clinicaltrials.gov) - P=N/A | N=24 | Recruiting | Sponsor: Pusan National University Yangsan Hospital | Trial completion date: Jun 2024 ➔ Jun 2026 | Trial primary completion date: Jun 2024 ➔ Feb 2026

Trial completion date • Trial primary completion date • Anesthesia

Reconsidering Sedation for Endoscopic Retrograde Cholangiopancreatography: The Potential of Remimazolam. (PubMed, Dig Endosc) - No abstract available

Journal • Anesthesia

Con: Remimazolam (ASA 2025) - "There is no abstract associated with this presentation."

Pro-Remimazolam (ASA 2025) - "There is no abstract associated with this presentation."

PC103. The Great Remimazolam Debate: An Evidence-Based Debate on Safety, Value, and Scope of Practice (1 CME) (ASA 2025) - "It seeks to combine the anxiolytic, amnestic, sedative, and hemodynamically stable properties of midazolam with the pharmacokinetics profile of remifentanil. Speakers in this 60-minute point/counterpoint session will debate the use of remimazolam in terms of clinical impact, patient safety, value, and perioperative outcomes, reviewing the latest literature as well as discussing their own extensive clinical experience with the drug. SessionLearningObjective1: Describe the pharmacokinetic advantages and disadvantages of remimazolam within different areas of perioperative practice.SessionLearningObjective2: Determine the value or risk of incorporating remimazolam into regular practice including implications for cost and workflow efficiency.SessionLearningObjective3: Forecast the scope of remimazolam use in anesthesia and perioperative medicine."

Clinical • Anesthesia

Remimazolam, An Ultra-fast Benzodiazepine: Safe in Elderly, Cognitive Impairment, or Neurosurgery? (ASA 2025) - "There is no abstract associated with this presentation."

Clinical • Surgery • Alzheimer's Disease • Cognitive Disorders

PN407. Medicine Over Mind: Understanding the Neurological Impact of Newer Perioperative Drugs (1 CME) (ASA 2025) - "Attendees should gain practical insights into integrating these medications into clinical practice while optimizing brain health. SessionLearningObjective1: Describe the pharmacologic mechanisms and perioperative utility of remimazolam, GLP-1 agonists, and tranexamic acid.SessionLearningObjective2: Discuss the latest evidence-based outcome data of these new drugs in specific neurosurgical populations or in patients with underlying neurologic disease.SessionLearningObjective3: Explain how remimazolam and GLP-1 agonists can impact cognitive function."

Anesthesia • CNS Disorders

Feasibility of Remimazolam Use in Lumbar Spine Surgery: A Pilot Study on MEP Signal Preservation and Immediate Recovery (ASA 2025) - "Abstract is embargoed at this time."

Clinical • Surgery • Orthopedics

The effect of desflurane versus remimazolam anesthesia on postoperative delirium in elderly patients with hip fractures (ASA 2025) - "Abstract is embargoed at this time."

Clinical • Anesthesia • CNS Disorders • Geriatric Disorders • Musculoskeletal Diseases • Orthopedics

Prediction Model for Remimazolam Dosing Based on Patient Characteristics to Enhance Anesthesia Management (ASA 2025) - "Abstract is embargoed at this time."

Clinical • Anesthesia

Pharmacodynamic Interaction between Remimazolam and Remifentanil for Loss of Consciousness (ASA 2025) - "Abstract is embargoed at this time."

PK/PD data

Remimazolam for Pediatric Lymphoma (ASA 2025) - "Current modalities such as midazolam/other longer-acting sedatives have an increased risk of respiratory depression.This case presents a 12-year-old with suspected Hodgkin lymphoma who underwent a lymph node biopsy using remimazolam for sedation. In contrast, remimazolam's rapid onset, predictable sedation, and favorable hemodynamic properties contribute to advantageous outcomes in managing difficult airways. Further exploration of its applications in airway management is warranted to optimize outcomes in challenging cases."

Clinical • Anesthesia • CNS Disorders • Depression • Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Pediatrics • Psychiatry

Remimazolam for Hemodynamic Stability and Burst Suppression in Complex STA-MCA Bypass: A Case Report on Innovative Anesthetic Use in High-Risk Craniotomy (ASA 2025) - "In a 68-year-old patient requiring burst suppression and high vasopressor support, remimazolam was used to maintain cerebral perfusion pressures while minimizing hypotension compared to traditional propofol-based regimens. This approach facilitated stable hemodynamics with lower vasopressor requirements and effective burst suppression, demonstrating remimazolam's potential advantages in high-risk neurosurgical patients."

Case report • Clinical • Anesthesia • Hypotension

Anesthetic Management of Awake MRI-Guided Laser Ablation for Right Frontal Glioblastoma: A Case Report (ASA 2025) - "The patient confirmed intact motor function throughout. This approach highlights remimazolam's effectiveness in awake neurosurgery, offering a reliable method for patient comfort and real-time neurological assessment."

Case report • Clinical • Anesthesia • Brain Cancer • Glioblastoma • Solid Tumor

Usage of Remimazolam for ALS patients undergoing IR gastrostomy tube placement (ASA 2025) - "One of these strategies is the approval of Remimazolam, a benzodiazepine with a similar time to onset when compared to Midazolam, but with a faster time to peak alertness. Our aim is to utilize Remimazolam in conjunction with multimodal analgesia to improve patient satisfaction and minimize respiratory complications. This presentation seeks to illustrate usage of Remimazolam since its approval at our institution."

Clinical • Amyotrophic Lateral Sclerosis

Safe Emergence in a High-Risk Patient with Remimazolam (ASA 2025) - "Extubation was smooth, with airway reflexes intact. Postoperatively, she reported no pain, nausea, or recall, and experienced a rapid, uneventful recovery."

Clinical • Anesthesia • CNS Disorders • Gastroenterology • Gastroesophageal Reflux Disease • Genetic Disorders • Mood Disorders • Obesity • Obstructive Sleep Apnea • Psychiatry • Respiratory Diseases • Sleep Disorder

Anesthetic Management Using Remimazolam in a High-Risk Patient Undergoing Complex Endovascular Aortic Repair: A Case Report Highlighting Hemodynamic Stability and Fluid Management Considerations (ASA 2025) - "Rising CVP prompted initiation of milrinone. Iatrogenic fluid overload from remimazolam infusion volume (250 mL NS) may have contributed to acute decompensated heart failure and pulmonary edema. This case highlights the risks of fluid burden in patients with severe cardiomyopathy undergoing remimazolam-based anesthesia."

Case report • Clinical • Anesthesia • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Respiratory Diseases