5-Hydroxytriptolide / Shanghai Pharma - LARVOL DELTA

(5R)-5-Hydroxytriptolide inhibits immune activation in SIV-infected ART-treated rhesus macaques (IAS-HIV 2023) - "LLDT-8 treatment significantly inhibited CD8 + T cell activation in SIV-infected RMs and human PBMCs, providing a potential therapeutic option for PLWH."

IO biomarker • Human Immunodeficiency Virus • Infectious Disease • Ophthalmology • CD4 • CD8 • MKI67

A randomized controlled trial of (5R)-5-hydroxytriptolide in HIV INRs receiving ART (IAS-HIV 2023) - P2 | "LLDT-8 enhanced CD4 recovery and alleviated inflammation in long-term suppressed INRs, providing them a potential therapeutic option."

Clinical • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Ophthalmology • CD4

(5R)-5-hydroxytriptolide for HIV immunological non-responders receiving ART: a randomized, double-blinded, placebo-controlled phase II study. (PubMed, Lancet Reg Health West Pac) - P2 | "LLDT-8 enhanced CD4 recovery and alleviated inflammation in long-term suppressed INRs, providing them a potential therapeutic option. Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences, Shanghai Pharmaceuticals Holding Co., Ltd., and the National key technologies R&D program for the 13th five-year plan."

Clinical • Journal • P2 data • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Ophthalmology • CD4 • IFNG

Safety and Efficacy of T8 on Treating Chronic Abnormal Immune Activation in AIDS Patients (clinicaltrials.gov) - P2 | N=151 | Completed | Sponsor: Shanghai Pharmaceuticals Holding Co., Ltd | Active, not recruiting ➔ Completed | Trial completion date: Mar 2022 ➔ Jul 2022 | Trial primary completion date: Sep 2021 ➔ Jul 2022

Trial completion • Trial completion date • Trial primary completion date • Human Immunodeficiency Virus • Infectious Disease • CD4

Safety and Efficacy of T8 on Treating Chronic Abnormal Immune Activation in AIDS Patients (clinicaltrials.gov) - P2; N=160; Active, not recruiting; Sponsor: Shanghai Pharmaceuticals Holding Co., Ltd; Recruiting ➔ Active, not recruiting

Clinical • Enrollment closed • Human Immunodeficiency Virus • Infectious Disease • CD4 • CRP • IL6