XmAb412
/ Xencor
- LARVOL DELTA
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February 25, 2026
Xencor is on track to present the preclinical characterization of XmAb412 in a poster...at DDW in May 2026...
(Xencor Press Release)
- "...to initiate a first-in-human study of XmAb412 in 2H26."
First-in-human • New trial • Preclinical • Inflammatory Bowel Disease
January 08, 2026
Two Differentiated, Potentially Best-in-Class Therapeutic Options for Inflammatory Bowel Disease
(FinancialContent)
- "Present final results from the Phase 1 study of XmAb942 in healthy volunteers in 1H26; Provide an update on progress achieved in the XENITH-UC study near year-end 2026...Present preclinical characterization of XmAb412 in 1H26; Initiate a first-in-human study of XmAb412 in 2H26."
First-in-human • New trial • Preclinical • Trial status • Ulcerative Colitis
May 07, 2025
Xencor Reports First Quarter 2025 Financial Results
(Businesswire)
- "XmAb TL1A x IL23p19: Xencor is conducting lead selection studies and has begun good manufacturing practice (GMP) production campaigns for a TL1A x IL-23p19 bispecific antibody, that is designed to target two important inflammatory pathways for autoimmune and inflammatory disease while avoiding the complexities of dosing and formulary access for two separate TL1A and IL23 targeted drugs. In vitro studies show that several lead candidates match the target inhibition potency of monospecific antibodies to these targets, in a simple IgG bispecific format. Xencor anticipates initiating first-in-human studies during 2026."
New trial • Preclinical • Immunology • Inflammation
February 27, 2025
Upcoming Clinical Study Initiation Plans
(Businesswire)
- "XmAb657 (CD19 x CD3), a potent, extended half-life B-cell depleting bispecific T-cell engager for development in autoimmune disease. Xencor plans to initiate a first-in-human study in the second half of 2025; TL1A x IL23 Program: a bispecific antibody for dual targeting of important inflammatory pathways in autoimmune and inflammatory disease, while avoiding the complexities of dosing and formulary access for two separate TL1A and IL23 targeted drugs. Xencor anticipates selecting a lead candidate in 2025 and initiating first-in-human studies during 2026."
New trial • Pipeline update • Immunology • Inflammation
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