33C3 / AstraZeneca - LARVOL DELTA

Post-exposure Lopinavir-Ritonavir Prophylaxis versus Surveillance for Individuals Exposed to SARS-CoV-2: The COPEP Pragmatic Open-Label, Cluster Randomized Trial. (PubMed, EClinicalMedicine) - P3 | "LPV/r for this indication merits further testing against SARS-CoV-2 in clinical trials. Swiss National Science Foundation (project no.: 33IC30_166819) and the Private Foundation of Geneva University Hospitals (Edmond Rothschild (Suisse) SA, Union Bancaire Privée and the Fondation pour la recherche et le traitement médical)."

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Retrograde intramedullary nailing of comminuted intra-articular distal femur fractures results in high union rate. (PubMed, Eur J Orthop Surg Traumatol) - "Comminuted intra-articular distal femur fractures that can be successfully treated with retrograde IMN fixation will reliably go on to union with a complication rate that is favorable to that reported for plate fixation."

Journal • Anesthesia • Fibrosis • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Knee mega-prosthesis in the management of complex knee fracture of the elderly : a case series and review of the literature. (PubMed, Acta Orthop Belg) - "Complex DFF of the elderly treated with mega knee arthroplasty exhibit good clinical outcomes scores. The patients should be selected carefully as the complication rate found in the literature remains high."

Clinical • Journal • Review • Hematological Disorders • Immunology • Musculoskeletal Diseases • Oncology • Orthopedics • Osteoarthritis • Osteoporosis • Pain • Rheumatology

Lung cancer deaths (England 2001-2017)-comorbidities: a national population-based analysis. (PubMed, BMJ Support Palliat Care) - "To deliver high-quality outcomes for the growing proportion of lung cancer patients with comorbidities, oncology teams need to work across traditional boundaries of care. Novel areas for development include integration with dementia and chronic kidney disease services."

Clinical • Journal • Alzheimer's Disease • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Cognitive Disorders • Dementia • Diabetes • Lung Cancer • Metabolic Disorders • Nephrology • Oncology • Palliative care • Renal Disease • Respiratory Diseases • Solid Tumor • Vascular Neurology

[VIRTUAL] Dysmenorrhea might be a predisposing factor of fibromyalgia (IASP 2021) - "Fibromyalgia has generalized body pain with higher prevalence rate in women, whereas the prevalence rate is positively associated with subject’s age ADDIN EN.CITE ADDIN EN.CITE.DATA..."

Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology • Women's Health • E2F2

Hybrid locked medial plating in dual plate fixation optimizes the healing of comminuted distal femur fractures: A retrospective cohort study. (PubMed, Injury) - "Hybrid locked medial plating in this study favors the healing of comminuted DFFs and reduces reoperation. Additionally, smoking and suboptimal reduction (translation) predict delayed union/nonunion."

Journal • Retrospective data • Diabetes • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics

Inequalities in lung cancer mortality trends in Brazil, 2000-2015. (PubMed, Sci Rep) - "However, the correlation between the trends in the lung cancer mortality rates and the HDI was negative in men (r = - 0.76) and women (r = - 0.58), indicating larger reductions (or smaller additions) among the Federative Units with the highest HDI, in contrast to trends reflecting a greater increase in those with the lowest HDI. Our results suggest a relevant inequality in the trends of mortality from lung cancer in Brazil."

Journal • Lung Cancer • Oncology • Solid Tumor

[VIRTUAL] A Real World DATA Analysis on Hospitalization Resource Use in Oncology across Public and Private Healthcare Systems in LATIN American Countries (ISPOR-EU 2020) - "Hospitalization resource use varies considerably across health subsystems and between countries. Study limitations are related to RWD capture as well as structural and financing differences across subsystems."

Clinical • Real-World Evidence • Oncology

Primary malignant lung tumors in children: A report from the Australian Childhood Cancer Registry, 1983-2015. (PubMed, Pediatr Pulmonol) - "Our results represent one of the largest and most complete population-based cohorts of children with primary malignant lung cancers available to date. Detection of childhood lung cancer can be difficult due to the rarity of this disease and symptoms that are typically nonspecific."

Clinical • Journal • Carcinoid Tumor • Lung Cancer • Neuroendocrine Tumor • Oncology • Solid Tumor • Thoracic Cancer

Treatment of open intraarticular distal femur fractures by Ilizarov fixator; an approach to improve the outcome with mid-term results. (PubMed, Injury) - "Ilizarov fixator was an effective treatment modality of open comminuted distal femur fractures with high union rate, adequate alignment and satisfactory functional outcomes."

Journal • Musculoskeletal Diseases • Orthopedics

Outcomes of distal femur fractures treated with the Synthes 4.5 mm VA-LCP Curved Condylar Plate. (PubMed, Int Orthop) - "In our experience, the Synthes 4.5 mm VA-LCP Curved Condylar Plate is a safe and effective implant with a relatively low mechanical failure rate."

Journal • Retrospective data

Lung cancer incidence and mortality in Split-Dalmatia County, 2003-2012. (PubMed, Cent Eur J Public Health) - "According to the indicators of incidence and mortality of lung cancer in Split-Dalmatia County, this malignant neoplasm should occupy a high place within County public health priorities measures of prevention programme, targeting risk factors responsible for their formation."

Journal

Dual plate fixation results in improved union rates in comminuted distal femur fractures compared to single plate fixation. (PubMed, J Orthop) - "Level 3. Retrospective Cohort Study."

Journal

Quality and Cost Outcomes in Chimeric Antigen Receptor T-Cell Immunotherapy in Pediatric and Young Adult Patients with Acute Lymphoblastic Leukemia from the Vizient Clinical Database (TCT-ASTCT-CIBMTR 2020) - "Since the pediatric and young adult CAR-T population is limited, synthesizing all available clinical and cost data is important to understanding and tracking outcomes and significant adverse events. Because claims data can be analyzed with only a short delay compared to other data sources, it can be a useful source for information on this population."

CAR T-Cell Therapy • Late-breaking abstract

Quality and Cost Outcomes in Chimeric Antigen Receptor T-Cell Immunotherapy in Adult Large B-Cell Cancer Patients from the Vizient Clinical Database (TCT-ASTCT-CIBMTR 2020) - "As more information on CAR-T is available with more follow-up, more information related to outcomes after receiving CAR-T immunotherapy, the good and the bad, are known. Claims data can be used to track significant adverse events, including potentially cytokine release syndrome, neurologic complications and kidney/liver failure."

CAR T-Cell Therapy

Lung Cancer Mortality Trends in a Brazilian City with a Long History of Asbestos Consumption. (PubMed, Int J Environ Res Public Health) - "The age-period-cohort model showed an increase in the risk of death from 1996 in Osasco and a reduction for Sorocaba and São Paulo State during the same period. Our results point to a need for a special monitoring regarding lung cancer incidence and mortality in areas with higher asbestos exposure."

Journal

The Olerud Extensile Anterior Approach for Complex Distal Femoral Fractures: A Systematic Review. (PubMed, J Knee Surg) - "Based on the systematic literature review, the extensile anterior approach may be a viable alternative surgical option for 33-C3 complex distal femoral fractures. Given the current literature, more comprehensive and extensive studies need to be performed to ensure the best possible outcome."

Journal • Review

Patient, tumor, and healthcare factors associated with regional variability in lung cancer survival: a Spanish high-resolution population-based study. (PubMed, Clin Transl Oncol) - "The observed geographic differences in survival between regions are due in part to the late cancer diagnosis which determines the use of less effective therapeutic options. Results from our study justify the need for promoting lung cancer early detection strategies and the harmonization of the best practice in lung cancer management and treatment."

Clinical • Journal

Investigating the burder of Cardio-Oncology comorbidity in England: A Virtual Cardio-Oncology Research Initiative (VICORI) linking national cancer and cardiovascular audits (NCRI 2019) - "36,093 of 423,935 (8.5%) patients presenting with ACS had a previous diagnosis of malignant cancer. The mean age was 76.1 (7.8 years older than ACS-only patients). The average time between first cancer diagnosis and ACS admission was 6.0 years (SD 5.0)."

Comparing Risk Factors for Lung Cancer Mortality Among Men and Women: The NHLBI Pooled Cohorts Study (ATS 2019) - "Number of cigarettes-per-day was more strongly associated with lung cancer mortality in women versus men, consistent with increased susceptibility to low-intensity smoking, which is increasingly prevalent in the contemporary US population. Longitudinal lung function and respiratory symptoms, which may index the effective doses of environmental exposures, were associated with lung cancer mortality in both sexes and may warrant further investigation with respect to risk stratification."

Clinical

Trends in incidence of lung cancer according to histological subtype among men and women in Germany : Analysis of cancer registry data with the application of multiple imputation techniques (PubMed, Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz) - "The rising incidence of adenocarcinoma of the lung is alarming. The cancer registry data do not allow risk factor analysis. In the international discussion, the introduction of filter cigarettes as well as the changing composition of cigarettes has been hypothesized as being responsible. Further epidemiologic studies are strongly needed."

Clinical • Journal

CHARACTERIZING LUNG CANCER PATIENTS IN CHINA USING EHR DATA FROM MULTIPLE HOSPITALS (ISPOR 2019) - "It may also help us monitor and understand how new treatments such as immunotherapy grow. Nevertheless, there are still issues such as data diversity and incompleteness that need to be addressed."

Clinical

Emerging Trends in Chimeric Antigen Receptor T-Cell Immunotherapy in Adults from the Vizient Clinical Database (TCT-ASBMT-CIBMTR 2019) - "...Beginning October 1, 2017, two new, unique ICD-10 procedure codes were assigned to CAR-T immunotherapy (XW033C3 for peripheral venous route and XW043C3 for central venous route), allowing for tracking of the procedure in administrative datasets... Due to the recent implementation of the unique ICD-10 codes, more time and follow-up for these adult patients is needed to determine outcomes after receiving CAR-T immunotherapy, especially to track significant adverse events, including potentially cytokine release syndrome, neurologic complications and kidney/liver failure."

CAR T-Cell Therapy

Emerging Trends in Chimeric Antigen Receptor T-Cell Immunotherapy in Young Adults and Pediatric Patients from the Vizient Clinical Database (TCT-ASBMT-CIBMTR 2019) - "...Beginning October 1, 2017, two new, unique ICD-10 procedure codes were assigned to CAR-T immunotherapy (XW033C3 for peripheral venous route and XW043C3 for central venous route), allowing for tracking of the procedure in administrative datasets... Due to the recent implementation of the unique ICD-10 codes, more time and follow-up for these young adult patients is needed to determine outcomes for pediatric cancer patients receiving CAR-T immunotherapy, especially to track significant adverse events, including potentially cytokine release syndrome, neurologic complications and kidney/liver failure."

CAR T-Cell Therapy