CSL888 / CSL Behring - LARVOL DELTA

Exploring hemoglobin dynamics and scavenging mechanisms in preterm infants and preterm rabbits with cerebral intraventricular hemorrhage. (PubMed, Pediatr Res) - "The aim of this study was to characterize the dynamics of hemoglobin and haptoglobin in the cerebrospinal fluid of preterm infants with severe IVH and to evaluate the translational validity of a preterm rabbit pup IVH model. By directly comparing hemoglobin and haptoglobin concentrations across species, this study revealed a profound imbalance between hemoglobin burden and scavenging capacity, highlighting a persistent deficit in endogenous clearance. These findings provide a strong rationale for therapeutic strategies targeting hemoglobin clearance in preterm IVH and support the use of the rabbit pup IVH model for translational studies."

Journal • Preclinical • Hematological Disorders • Inflammation • HP

Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease. (PubMed, Biomed Pharmacother) - "Finally, a multi-omic analysis of whole lung and heart tissue demonstrates a rebalancing of proteins related to PH, iron, inflammation, and oxidative stress. This data provides strong pre-clinical evidence for the clinical study of combined Hb and heme scavenger proteins in the treatment of PH-associated SCD."

Journal • Cardiovascular • Genetic Disorders • Hematological Disorders • Hypertension • Inflammation • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Sickle Cell Disease • HP • HPX

Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization. (PubMed, PLoS One) - "Using human genetic data, we provide evidence to support a causal role of higher CSF haptoglobin in improving outcomes after aSAH. However, there was no evidence for an effect on the risk of aSAH or related cerebrovascular events. These findings support haptoglobin as a potential treatment in aSAH to mitigate the neurotoxic effects of free haemoglobin and improve outcomes."

Journal • Cardiovascular • Subarachnoid Hemorrhage • HP

Plasma Free Hemoglobin, Haptoglobin, and Risk of CSA-AKI. A Translational Systematic Review and Meta-Analysis. (ERA 2025) - "This meta-analysis of seven studies, encompassing 547 patients, revealed that one-third of the patients developed CSA-AKI. The findings underscore hemolysis and Hp depletion as significant mechanisms contributing to the incidence of AKI post-CS. Given the stronger association of Hp with CSA-AKI, future clinical trials should focus on monitoring Hp levels and evaluating the preventive use of Hp to reduce the incidence of CSA-AKI.Figure"

Retrospective data • Review • Acute Kidney Injury • Cardiovascular • Hematological Disorders • Nephrology • Preventive care • HP

Supplementing sialyllactose to colostrum replacer improved intestinal health and blood immunity by affecting the abundance of intestinal bacteria in dairy calves. (PubMed, J Dairy Sci) - "The SL administration affected the inflammatory cytokines in serum by increasing interleukin-6 and haptoglobin protein (HPT) on d 1 and interleukin-1β, tumor necrosis factor-α (TNF-α) and HPT on d 7, then decreasing interleukin-1β and TNF-α on d 28 and interleukin-6, TNF-α, c-reaction protein, serum amyloid A and HPT on d 56...Lactobacillus prophage enriched in the intestine of CSL group calves on d 28 had a negative correlation with IL-1β, IL-6, TNF-α, serum amyloid A, HPT, diamine oxidase and D-lactic acid in serum. In conclusion, supplementing SL in colostrum replacer may promote the growth and health by increasing starter intake, improving the barrier of intestine, and changing the abundance of intestinal bacteria in calves."

Journal • Inflammation • Oncology • HP • IL1B • IL6 • TJP1 • TNFA

HEMMA - AN OBSERVATIONAL STUDY REVEALING DISTINCT NOVEL BIOMARKER PROFILES FOR SICKLE CELL DISEASE PATIENTS COMPARED TO ETHNICITY-MATCHED CONTROL SUBJECTS (EHA 2024) - "1b) while haptoglobin (Hp), the natural scavenger of Hb, was markedlydecreased (13-fold, Fig... Biomarker profiles showed a distinctive signature for SCD compared to controls. Hp-Hb complex arises as apromising biomarker to better illustrate free Hb elimination downstream of RBC lysis. However, furtherinvestigations are needed to establish reference values."

Biomarker • Clinical • Observational data • Beta-Thalassemia • Genetic Disorders • Hematological Disorders • Inflammation • Renal Disease • Sickle Cell Disease • CXCL8 • HP • HPX • TNFA • TNFRSF1A • VCAM1

Haptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in Sheep. (PubMed, Transl Stroke Res) - "We identified a neurological phenotype of CSF-Hb toxicity in conscious sheep, which is rather due to neurovascular dysfunction than structural brain injury. Haptoglobin was effective at attenuating CSF-Hb-induced neurological deterioration, supporting its therapeutic potential."

Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Inflammation • Subarachnoid Hemorrhage • Vascular Neurology • HP

Haptoglobin treatment contributes to regulating nitric oxide signal and reduces oxidative stress in the penis: A preventive treatment for priapism in sickle cell disease. (PubMed, Front Physiol) - "Cumulative concentration-response curves to the acetylcholine, sodium nitroprusside, phenylephrine and KCL, as well as to electrical field stimulation (EFS), were obtained in CC. Treatment with haptoglobin also increased contractile activity due to up-regulation of ROCK2. Therefore, haptoglobin treatment may be an additional strategy to prevent priapism in SCD."

Journal • Erectile Dysfunction • Genetic Disorders • Hematological Disorders • Sickle Cell Disease • HP • NOS3

The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury. (PubMed, BMC Neurol) - P=N/A | "We hypothesize that this study will validate the value of CSF-Hb as a biomarker to monitor for SAH-SBI. In addition, the results of this study will provide the potential base to define an intervention threshold for future studies targeting CSF-Hb toxicity after aSAH."

Biomarker • Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology

Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics. (PubMed, Mol Pharm) - "Haptoglobin (Hp) captures Hb in an irreversible protein complex and prevents its pathophysiological contributions to vascular nitric oxide depletion and tissue oxidation...The functions of these proteins were then characterized for Hb and heme-binding, binding of the Hp-Hb complexes with the clearance receptor CD163, antioxidant properties, and vascular nitric oxide sparing capacity. Our platform is designed to support the generation of innovative Hb scavenger biotherapeutics with novel modes of action and potentially improved formulation characteristics, function, and pharmacokinetics."

Journal • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage • CD163 • HP • HPX

Haptoglobin treatment prevents cell-free hemoglobin exacerbated mortality in experimental rat sepsis. (PubMed, Intensive Care Med Exp) - No abstract available

Journal • Preclinical • Infectious Disease • Septic Shock • HP