Invanz (ertapenem) / Merck (MSD) - LARVOL DELTA

This is a Phase 2 Study to Evaluate the Efficacy, Safety, and Tolerability of Intravenous Ertapenem-zidebactam Versus Ceftazidime-Avibactam in the Treatment of Hospitalized Adult Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis (clinicaltrials.gov) - P2 | N=279 | Not yet recruiting | Sponsor: Wockhardt

New P2 trial • Infectious Disease • Nephrology

Recurrent Pyogenic Liver Abscess Unmasking an Occult Duodeno-Hepatic Fistula: A Rare and Delayed Complication of Necrotizing Pancreatitis (ACG 2026) - "Over three years, he had multiple admissions for recurrent hepatic abscess requiring repeated drainage and prolonged antibiotics (ertapenem, amoxicillin-clavulanate). Chapter 6. Figure: Endoscopy showing duodenal fistula with pus Figure: CT abdomen with IV contrast showing liver abscess with air bubble"

Cardiovascular • Crohn's disease • Dyslipidemia • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypertriglyceridemia • Immunology • Infectious Disease • Inflammatory Bowel Disease • Pancreatitis • Peptic Ulcer • Thrombosis

Carbapenem-Associated Hepatitis and Hepatic Failure: A FDA Adverse Event Reporting System (FAERS) Pharmacovigilance Analysis (ACG 2026) - "Future investigations should aim to confirm causality and elucidate the underlying pathophysiology, while also evaluating combination drugs like meropenem-vaborbactam. ADRs for both hepatitis and hepatic failure were analyzed. Doripenem had no relevant ADRs and was excluded from the data analysis. Meropenem, imipenem, and ertapenem all showed statistically significant RORs with hepatitis and hepatic failure."

Adverse events • Hepatology • Infectious Disease • Inflammation • Liver Failure

Endoscopic Closure of a Recto-Ejaculatory Duct Fistula With an Over-the-Scope Clip Following Low Anterior Resection for Rectal Cancer (ACG 2026) - "Pneumaturia and fecaluria resolved postprocedure, though recurrent urinary tract infections required intravenous ertapenem...While OTSC can provide symptomatic improvement, long-term recurrence rates remain high, and concurrent ureteral obstruction complicates reconstruction options. This case highlights the importance of multidisciplinary management in complex radiation-associated pelvic fistulas."

Colorectal Adenocarcinoma • Colorectal Cancer • Infectious Disease • Nephrology • Oncology • Rectal Adenocarcinoma • Rectal Cancer • Solid Tumor

From Bacteremia to Dual-Organ Transplant: Streptococcus Intermedius Liver Abscesses Complicated by Portal Vein Thrombosis, Non-Cirrhotic Portal Hypertension, and Hepatorenal Syndrome (ACG 2026) - "He received ertapenem followed by prolonged oral amoxicillin-clavulanate and linezolid, and started on apixaban on discharge for PVT...A) Coronal T2-weighted fat-suppressed MRI sequence with a few dilated venous collaterals along the main portal vein (red circle) and two liver parenchyma T2 hyperintensities, consistent with pyogenic liver abscesses (light blue circles). B) 12-week coronal T2-weighted fat-suppressed MRI sequence, with interval resolution of the liver abscesses, but increased size and number of venous collaterals, consistent with cavernous transformation of portal vein (circle in red), and worsening ascites."

Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Diabetic Nephropathy • Fibrosis • Heart Failure • Hepatology • Hypertension • Immunology • Infectious Disease • Liver Failure • Metabolic Disorders • Nephrology • Portal Hypertension • Renal Disease • Septic Shock • Solid Organ Transplantation • Thrombosis • Transplantation • Type 2 Diabetes Mellitus

Recurrent Pancreatic Abscess Due to Streptococcus gallolyticus Without Bacteremia: Expanding Its Clinical Spectrum (ACG 2026) - "Empiric ertapenem was initiated, and percutaneous drainage yielded 150 mL of necrotic fluid...Figure: Contrast-enhanced abdominal CT demonstrating walled-off necrotizing pancreatitis with a large encapsulated peripancreatic collection measuring 11.4 Ã 8.0 Ã 13.1 cm (estimated volume 633 cm³), consistent with a pancreatic abscess. Figure: Follow-up contrast-enhanced abdominal CT obtained two weeks after initial drainage showing recurrence of a smaller walled-off necrotic collection measuring 6.9 Ã 3.7 Ã 3.5 cm (estimated volume 48.1 cm³)."

Clinical • Cardiovascular • Colorectal Cancer • Diabetes • Diabetic Nephropathy • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Pancreatitis • Renal Disease • Solid Tumor • Type 2 Diabetes Mellitus

The Unexpected Cause of a Biliary Filling Defect: A Parasitic Surprise (ACG 2026) - "She was treated with ertapenem and underwent ultrasound-guided aspiration of both collections, with cultures confirming the same organism...Early recognition, targeted therapy and further research into this correlation among human subjects, are essential to prevent long-term hepatobiliary adverse events. Figure: Figure 1: (a) Magnetic resonance cholangiopancreatography showing filling defect in the mid CBD with intrahepatic ductal dilatation (b) Endoscopic ultrasound showing an amorphous hypodensity in the distal CBD Figure: Figure 2: Gross specimen of Fasciola hepatica parasite"

Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Nephrology • Urticaria

Persistent Recurrent ESBL Escherichia coli Bacteremia Following Transjugular Intrahepatic Portosystemic Shunt (TIPS) Placement: Presumed EndoTIPSitis (ACG 2026) - "Within days of TIPS placement, he developed polymicrobial bacteremia with vancomycin-resistant Enterococcus (VRE) and extended-spectrum beta-lactamase (ESBL) Escherichia coli , treated with IV daptomycin and meropenem (11/27-12/10)...The patient was treated with six weeks of IV ertapenem followed by indefinite suppressive trimethoprim-sulfamethoxazole therapy, resulting in resolution of fevers and clearance of bacteremia...Recurrent bacteremia with enteric pathogens following TIPS placement â particularly with repeated relapse despite appropriate antimicrobial therapy â should prompt consideration of endoTIPSitis after alternative sources are excluded. Because TIPS removal is generally not feasible, management may require prolonged antimicrobial therapy, chronic suppressive treatment, and consideration of liver transplantation for definitive source control."

Fibrosis • Gastroenterology • Hepatology • Immunology • Infectious Disease • Thrombosis

Delayed Anorectal Wound Healing Following Transanal Excision of Anal Melanoma: An Underrecognized Complication of Immune Checkpoint InhibitorâAssociated Colitis (ACG 2026) - "After receiving and responding to neoadjuvant nivolumab and ipilimumab, her course was complicated by severe ICI colitis requiring prolonged high-dose corticosteroids and multiple infliximab infusions...She improved after a 2-week course of ertapenem...Figure: Figure 2. Endoscopic ultrasound demonstrating a 30mm x 17mm, localized, posterolateral anal canal melanoma without invasion of the internal or external anal sphincters."

Checkpoint inhibition • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Melanoma • Mucosal Melanoma • Oncology • Primary Immunodeficiency • Rectal Cancer • Solid Tumor

From Prevention to Peril: Potassium Iodide Overdose Causing Gastric Necrosis (ACG 2026) - "The patient was managed conservatively with bowel rest, total parenteral nutrition (TPN), proton pump inhibitor therapy, and intravenous ertapenem... Massive KI ingestion may act as a potent corrosive agent causing severe mucosal injury and the rare endoscopic finding of âblack stomach.â This case highlights that extensive gastric necrosis can resolve with prolonged conservative management when perforation/full-thickness ischemia is absent and underscores the risks of KI use for unvalidated indications without clear dosing instructions. Figure: "Black Stomach" due to superficial gastric necrosis in the pre-pyloric region Figure: Repeat EGD at 16 weeks showing well-healed mucosa in the pre-pylorus region"

Cardiovascular • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Inflammation • Nephrology

Fulminant Clostridioides difficile Infection Masquerading as Progression of Ischemic Colitis: A Diagnostic Pitfall (ACG 2026) - "She was treated with intravenous ertapenem with improvement...She was treated for fulminant CDI with oral vancomycin and intravenous metronidazole with symptom improvement, but due to persistent WBC >40 K/μL and repeat CT scan showing progressive pancolitis, she was transitioned to fidaxomicin (Figure 2B)...Figure: Figure 2. CT Abdomen/Pelvis showing A) worsening diffuse proctocolitis and B) progressive pancolitis."

Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Metabolic Disorders

A Rare Recurrent Pyogenic Liver Abscess Due to Gut Commensals ( Pediococcus acidilactici and Gemella morbillorum ) in an Immunocompetent Individual (ACG 2026) - "Intravenous (IV) ceftriaxone and metronidazole were started; the serology for Entamoeba histolytica & Echinococcus was negative. The pus culture showed Pediococcus acidilactici, and the patient was discharged on oral amoxicillin-clavulanate for 3 weeks...IV vancomycin and piperacillin-tazobactam were initiated, and the drainage of the abscesses was not feasible. The blood culture grew Gemella morbillorum ; antibiotics were switched to IV daptomycin and meropenem...On follow-up, the repeat CT showed interval resolution of the abscess (Figure 4), and the patient was discharged on IV daptomycin and ertapenem for a total of 6 weeks...Figure 4. Follow-up CECT abdomen (axial view) demonstrating interval improvement in the previously identified right hepatic lobe abscesses, with decreased size and surrounding inflammatory changes."

Clinical • Addiction (Opioid and Alcohol) • CNS Disorders • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammatory Bowel Disease • Metabolic Disorders • Pneumonia • CA 19-9 • CEACAM5 • MUC16

Pseudomembranous Colitis Beyond Clostridioides difficile : A Diagnostic Pattern Rather Than a Diagnosis (ACG 2026) - "Case Description/ A 55-year-old man with alcohol-associated cirrhosis status post liver and deceased-donor kidney transplant, type 2 diabetes mellitus, hypertension, and chronic pancreatitis was admitted with ESBL E. coli bacteremia and treated with ertapenem. Prednisone and cyclosporine were continued while MMF was held...The patient was empirically treated with oral vancomycin with complete resolution of diarrhea...This case highlights the importance of maintaining a broad differential diagnosis while recognizing that pseudomembranous colitis can strongly suggest C. difficile despite absent stool confirmation when clinical, endoscopic, and therapeutic responses align. Figure: Flexible sigmoidoscopy demonstrating pseudomembranes Figure: Flexible sigmoidoscopy demonstrating pseudomembranes"

Cardiovascular • Cytomegalovirus Infection • Diabetes • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hepatology • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Pancreatitis • Type 2 Diabetes Mellitus

When Diverticulitis Extends Beyond the Colon: Colo-Salpingeal Fistula Presenting Without Gynecologic Symptoms (ACG 2026) - "She was discharged on ciprofloxacin and metronidazole...The patient was discharged on a two-week course of ertapenem with plans for interval colonoscopy and coordinated elective sigmoid resection with General Surgery and Gynecology...Figure: Figure 1A and 1B. CT showing tubular air-filled structure between the sigmoid colon and left adnexa."

Constipation • Gastroenterology • Gastrointestinal Disorder • Gynecology • Infectious Disease • Infertility • Nephrology • Sexual Disorders • Urology • Women's Health

Clostridioides septicum Prosthetic Joint Infection Revealing Cecal Adenocarcinoma (ACG 2026) - "Empiric cefepime and vancomycin were initiated for presumed septic arthritis. Blood cultures grew C. septicum after 16 hours, prompting change to ertapenem...Figure: Image 2. Biopsy of ulcerated mass confirming invasive moderately differentiated adenocarcinoma."

Colon Cancer • Colorectal Cancer • Immunology • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Oncology

Staged Treatment of Cutaneous Calcinosis with Polylactic Acid Matrix, Negative Pressure Wound Therapy and Skin Grafting: A Case Report. (PubMed, Reports (MDPI)) - "Deep-tissue culture grew Escherichia coli, treated with intravenous ertapenem...This case supports the feasibility of this sequence for wound reconstruction in selected complex ulcerated lesions. Further studies are needed to define its comparative role."

Journal • Dermatomyositis • Immunology • Inflammatory Arthritis • Metabolic Disorders • Myositis • Pain • Rheumatoid Arthritis • Rheumatology • Scleroderma • Systemic Sclerosis

Localized Multidrug-Resistant Morganella morganii Urinary Tract Infection in a Dapagliflozin-Treated Man with Bladder Outlet Obstruction and Incomplete Ureteral Duplication: A Case Report. (PubMed, Reports (MDPI)) - "Antimicrobial susceptibility (VITEK® 2 Compact, EUCAST v14.0, 2024) demonstrated resistance to ampicillin, amoxicillin-clavulanate, ampicillin-sulbactam, ceftriaxone, ceftazidime, gentamicin and trimethoprim-sulfamethoxazole, with susceptibility (S) retained only to piperacillin-tazobactam, levofloxacin/norfloxacin, cefepime and carbapenems (ertapenem, meropenem)...Transurethral resection of the prostate (TUR-P) was performed 18 days after completing antibiotics (28 days after presentation) for bladder outlet obstruction refractory to tamsulosin 0.4 mg daily, with complete resolution of symptoms, normalization of inflammatory markers and PVR 0 mL...The narrative is hypothesis-generating; urinary stasis was the dominant modifiable factor. Culture-guided therapy, individualized decisions on SGLT2 continuation, and definitive correction of outlet obstruction are the practical takeaways."

Journal • Benign Prostatic Hyperplasia • Cardiovascular • Infectious Disease • Nephrology • Pain • Urology

Comparison of Antibiotic Prophylaxis Regimens for Preventing Prostatitis After Transrectal Ultrasound-Guided Prostate Biopsy. (PubMed, Cureus) - "A single dose of IM ertapenem or amikacin appears to be associated with a lower risk of infections after a TRUS-guided prostate biopsy. They may represent a potential prophylactic alternative to fluoroquinolone-based regimens, especially in places where routine rectal culture-guided prophylaxis is not done."

Journal • Genito-urinary Cancer • Infectious Disease • Oncology • Prostate Cancer • Septic Shock • Solid Tumor

In Vitro antibacterial, anti-biofilm, and virulence-modulating activity of Cinnamomum verum-mediated iron oxide nanoparticles against carbapenem-resistant uropathogenic Escherichia coli. (PubMed, Int Microbiol) - "These proof-of-concept findings indicate that C. verum-mediated Fe₂O₃-NPs show potent in vitro multi-mechanism antibacterial activity against two clinically confirmed CRE UPEC isolates, combining promising antibacterial potency with transcriptional suppression of key virulence determinants; validation in a larger isolate panel is required to confirm generalisability. These findings identify the nanoparticle preparation as a promising in vitro candidate for further antibacterial and anti-virulence investigation. However, cytotoxicity, biocompatibility, validation using a larger collection of clinical isolates, and in vivo studies are required before any therapeutic application can be considered."

Journal • Preclinical • Infectious Disease • Nephrology

Characterization of the novel transposon Tn7722 harboring blaNDM-1: Insights into the evolutionary dynamics of resistance in Klebsiella pneumoniae. (PubMed, J Glob Antimicrob Resist) - "NDM-producing K. pneumoniae in French Polynesia remain sporadic but genetically diverse, without evidence of local outbreak. This suggests a contribution of plasmid and Tn7722-associated elements to the diversity and evolution of carbapenem resistance. Ongoing genomic surveillance is vital to track the evolution of high-risk clones and MGEs guiding effective containment."

Journal • Gene Therapies • Infectious Disease • Pneumonia

Hidradenitis Suppurativa: Part of a Tetrad of Follicular Occlusion Disorders. (PubMed, Adv Skin Wound Care) - "This article outlines evidence-informed wound care strategies for both nonsurgical and postsurgical presentations, including dressing selection, exudate and odor management, pain and itch control, infection management, and the emerging role of intravenous ertapenem as rescue therapy...This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and registered nurses with an interest in skin and wound care. After participating in this educational activity, the participant will: Assess clinical characteristics of each follicular occlusion disorderEvaluate the basic disease mechanisms for follicular occlusion disordersDescribe principal disease burdens that require wound care attentionIdentify the unique wound care strategies and follicular occlusion disorder challenges JOURNAL/aswca/04.03/00129334-202610000-00004/figure1/v/2026-09-18T181327Z/r/image-jpeg."

Journal • Review • Acne Vulgaris • Dermatology • Genetic Disorders • Hidradenitis Suppurativa • Immunology • Infectious Disease • Obesity • Pain • IL17A • IL1B • TNFA

Meropenem-Colistin Combination Mitigates Porin-Associated Carbapenem Resistance Development in Ertapenem-Mono-Resistant Enterobacterales. (PubMed, J Infect Dis) - "In ETP-mono-R Enterobacterales, subinhibitory carbapenem exposure promotes carbapenem resistance, with porin-associated mechanisms predominating in E. coli and K. pneumoniae. Co-exposure to COL attenuates this process, suggesting a potential strategy to delay the emergence of carbapenem resistance."

Journal • Infectious Disease • Pneumonia

Ceftazidime-avibactam in elastomeric pump for vascular graft infection: a case report. (PubMed, Infez Med) - "A subsequent isolate of K. pneumoniae demonstrated resistance to both ertapenem and ceftolozane-tazobactam.Treatment was transitioned to daptomycin (500 mg daily) and ceftazidime-avibactam (2.5 g three times a day), with oral rifampin added for anti-biofilm activity.To facilitate early discharge per the patient's request, ceftazidime-avibactam was administered off-label via an elastomeric pump. This case demonstrates that continuous 12-hour infusion of ceftazidime-avibactam via elastomeric pumps is a feasible and safe strategy for managing complex CRE infections in the OPAT setting. Such tailored approaches can enhance patient quality of life and reduce hospital stays, though further prospective studies are needed."

Journal • Cardiomyopathy • Cardiovascular • Diabetes • Infectious Disease • Metabolic Disorders • Peripheral Arterial Disease • Pneumonia

Disseminated adenovirus and rejection in a kidney transplant recipient: Walking the fine line between infection and rejection (TTS 2026) - "Primary renal pathology was anti glomerular basement membrane disease diagnosed in 2022, managed with therapeutic plasma exchange (TPE), corticosteroids and cyclophosphamide...Transplant induction regimen included tacrolimus, mycophenolate mofetil (MMF), basiliximab and corticosteroids...One month post kidney transplantation macroscopic haematuria developed and persisted despite therapy of Enterobacter cloacae and Streptococcus mitis bacteriuria with ciprofloxacin followed by ertapenem...Cidofovir was then commenced at 2.5mg/kg weekly for two weeks then fortnightly with probenecid and intravenous (IV) fluid therapy...This was treated with pulse IV methylprednisolone and MMF recommenced at 250mg twice daily. Follow up biopsy showed features of antibody mediated rejection which was managed with an increase in MMF and candesartan for a detected angiotensin receptor 1 antibody... We present a case of disseminated adenovirus infection post kidney transplantation. This case..."

Clinical • Antibody-mediated Rejection • Autoimmune Hemolytic Anemia • Cardiovascular • Complement-mediated Rare Disorders • Hematological Disorders • Infectious Disease • Pulmonary Embolism • Respiratory Diseases • Solid Organ Transplantation • Transplantation

Assessment of a Relaxed Acute Care Ertapenem Restriction Criteria on Carbapenem Utilization (IDWeek 2026) - No abstract available

Infectious Disease