Invanz (ertapenem) / Merck (MSD) - LARVOL DELTA

Genomic insights and molecular epidemiology through whole genome sequencing in clinical Serratia marcescens ST-367 isolated from the Kingdom of Bahrain. (PubMed, J Infect Public Health) - "To our knowledge, this is the first report of S. marcescens ST-367 in the Gulf Cooperation Council. The genetic diversity and mechanisms of virulence and antibiotic resistance in this isolate shed light on the evolution of high-risk isolates. Additionally, this will serve as a foundation for future extensively drug-resistant isolates."

Journal • Gene Therapies • Infectious Disease

A Rare Case of Emphysematous Pyelonephritis Following Retrograde Intrarenal Surgery in an Elderly Man. (PubMed, Am J Case Rep) - "Preoperative urine culture identified Klebsiella aerogenes and Citrobacter koseri, prompting 9 days of perioperative levofloxacin (500 mg/day), which cleared the infection...Urgent percutaneous nephrostomy, catheter replacement, and 11-day ertapenem therapy (1g/day) controlled the infection, and a second RIRS on June 12 cleared the stones, with no complications in 3-month follow-up. CONCLUSIONS Post-RIRS fever/abdominal pain requires urgent imaging to rule out steinstrasse-induced EPN. Early drainage, targeted antibiotics, and staged RIRS are critical for elderly patients with high stone burden, filling the literature gap on this complication."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pain • Renal Calculi • Respiratory Diseases

Combinatory in vitro effect of plant extracts with antibiotics on multi-resistant bacteria. (PubMed, J Infect Dev Ctries) - "These results are of great importance; regarding the valorization of natural resources for the creation of solutions to urgent health problems while taking advantage of existing pharmaceutical resources."

Journal • Preclinical • Infectious Disease • Pneumonia

A Case Report: Ertapenem-Induced Encephalopathy. (PubMed, Cureus) - "Among these, carbapenems have been occasionally associated with encephalopathy through GABAergic inhibition. This case highlights the importance of recognizing ertapenem-induced neuropsychiatric complications even in patients without conventional risk factors, underscoring the need for vigilance when evaluating acute behavioural changes during antibiotic therapy."

Journal • CNS Disorders • Musculoskeletal Diseases • Orthopedics • Psychiatry

Temporal Changes in Microbial Etiology and Antibiotic Resistance Profiles of Osteoarticular Infections: An 11-Year Retrospective Analysis. (PubMed, Cureus) - "This retrospective longitudinal study identified Enterobacteriaceae as the predominant pathogens in OAIs, coupled with a significant rise in antimicrobial resistance. These findings highlight the critical need to adapt prophylactic and empirical treatment guidelines to contemporary resistance trends to ensure optimal patient outcomes."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease

Post-operative Infections After Emergent Laparotomy for Traumatic Perforated Viscera: An Assessment of Risk Factors and Antimicrobial Prophylaxis. (PubMed, Cureus) - "Patients whose abdominal fascia was left open at the end of the index operation had 21 SSIs (16.4%) versus five SSIs (4.9%) for those whose fascia was closed immediately (p=0.01).  Conclusion Lack of antibiotic prophylaxis, MTP, post-operative vasopressors, and open abdomen predict SSI. Ertapenem was associated with a lower traumatic wound infection rate, but not SSI. Other specific antibiotic agents and timing intervals were not significant. Variables that are surrogates for trauma severity are more accurate predictors of SSI than specific antibiotic agents and timing."

Journal • Critical care • Infectious Disease

An observational study on multidrug resistance in pediatric patients with urinary tract infections. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Escherichia coli demonstrated high resistance to nalidixic acid (84.4%), ampicillin (78.1%), and ciprofloxacin (78.1%), while maintaining high susceptibility to fosfomycin (90.6%), ertapenem (81.3%), gentamicin (71.9%), and nitrofurantoin (71.9%)...exhibited high resistance to tetracycline (64.3%), and levofloxacin (63%). but remained sensitive to linezolid (93.27%), vancomycin (85.71%), teicoplanin (78.57%), and tigecycline (71.4%)...Fosfomycin, nitrofurantoin, and carbapenems retain efficacy, though over-reliance may accelerate resistance. Regular, pediatric-specific AMR surveillance and antimicrobial stewardship programs are essential to preserve treatment efficacy and improve outcomes in this vulnerable population."

Journal • Observational data • Infectious Disease • Nephrology • Pediatrics • Pneumonia

In Vitro Evaluation of the Co-Administration of Canine Blood Products and Drugs Used in Critical Illness. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "Platelet function will likely be adversely affected by the co-administration of any of the selected drugs. Co-administration of ketamine, fentanyl, and midazolam with WB resulted in significant hemolysis and is not recommended. It is reasonable to consider co-administering ampicillin, TXA, and ketamine with FDP and FFP."

Journal • Preclinical • Hematological Disorders

Regulatory relationships among aldB, ampH, and acoR and their impact on β-lactam susceptibility in Phytobacter diazotrophicus. (PubMed, Front Microbiol) - "Compared with the wild-type strain, the ampH-knockout strain exhibited significantly increased MICs for carbenicillin, piperacillin, cefalotin, cefoxitin, cefuroxime, cefotaxime, ceftazidime, cefepime, aztreonam, and ertapenem by at least 2-, 4-, 8-, 4-, 4-, 4-, 4-, 4-, 4-, and 2-fold, respectively. Under ceftazidime stress, P. diazotrophicus reduced aldB expression to increase its tolerance to the antibiotic. The discovery of the mechanism by which AcoR regulates aldB expression provides preliminary evidence for subsequent research on drug resistance mechanisms."

IO biomarker • Journal • Infectious Disease • ACACA • PD-1

Ertapenem as an Antibiotic Prophylaxis for Colectomies and Laparotomies: A Systematic Review. (PubMed, Surg Infect (Larchmt)) - "Ertapenem was compared with single-agent second-generation cephalosporins such as cefotetan, cefuroxime, and cefoxitin and to a single-agent penicillin with or without a combined β-lactamase inhibitor (i.e., ampicillin-sulbactam). However, most studies were observational. Therefore, RCTs, especially in trauma, are needed."

Journal • Review • Infectious Disease

Clinical epidemiological characteristics and antibiotic sensitivity of Escherichia coli urinary tract infection. (PubMed, PLoS One) - "Urinary tract infections caused by E. coli are predominantly community acquired, accounting for 84.5%(339/401), and most cases involved ESBL-negative strains. Therefore, third-generation cephalosporins remain the preferred choice for empirical treatment, while quinolones and second-generation cephalosporins are not recommended. Subsequently, the treatment regimen can be de-escalated based on confirmed infection type and patient condition, an approach that has been associated with reduced hospitalization."

Journal • Infectious Disease • Nephrology

Epidemiological Characteristics and Drug-Resistance Genotype of CRE in Patients with Hematological Diseases in a Single Center of China (ASH 2023) - "88% (111/301) of non-CP-CRE strains were resistant to Ertapenem alone but still susceptible to Meropenem and Imipenem. We discovered that some patients with hematological diseases carried or were infected with ETP-CRE, which was sensitive to Meropenem and Imipenem. In terms of therapy, ETP-CRE strains may differ from other CRE in patients with hematological diseases,it may not be a typical CRE."

Clinical • Hematological Disorders • Infectious Disease • Pneumonia

In vivo evolution of resistance to novel β-lactam/β-lactamase inhibitor combinations through overproduction of the horizontally acquired extended-spectrum AmpC β-lactamase FOX-14 and porin disruption in Serratia marcescens. (PubMed, Eur J Clin Microbiol Infect Dis) - "We tested the susceptibility of the isolates to ceftazidime/avibactam, aztreonam/avibactam, imipenem/relebactam and meropenem/vaborbactam. Purified FOX-14 displayed marked cephalosporinase activity against ceftazidime and cefepime, with low Km values, while negligible turnover for aztreonam and ertapenem and a low avibactam IC50. In S. marcescens, in vivo resistance in clinical isolates emerged from FOX-14 overproduction combined with reduced outer-membrane permeability, predominantly due to OmpF disruption. These findings elucidate resistance to newer β-lactam/β-lactamase inhibitor combinations and warrant close monitoring of antimicrobial activity during carbapenem-based therapy for S. marcescens infections."

Journal • Preclinical • Infectious Disease

Combined disk-based tests for phenotypic identification of KPC variants in Enterobacterales. (PubMed, Int J Antimicrob Agents) - "For the APB/EDTA inhibition test, all strains were non-susceptible to meropenem (17 resistant and 1 intermediate) but showed no ≥5 mm increase in inhibition zone diameter with APB, EDTA, or both, thus yielding negative results according to criteria for wild-type carbapenemases. Both patterns shared resistance to ceftazidime-avibactam and ertapenem, along with a negative APB/EDTA inhibition result, but differed in imipenem susceptibility and ESBL test one showed imipenem susceptibility with a positive ESBL test, whereas the other showed imipenem resistance with a negative ESBL test. In conclusion, this study proposes a simple disk-based approach for the phenotypic identification of KPC variants in Enterobacterales, which may aid preliminary screening in clinical laboratories and warrants further validation."

Journal • Infectious Disease • Pneumonia

Effect of a Dedicated Medical Care Unit on Management of Kidney Transplant Patients with Extended-Spectrum Beta-Lactamase Urinary Tract Infection Requiring Parenteral Ertapenem: A Single-Centre Study (KIDNEY WEEK 2025) - "Importantly, no treatment-associated complications were reported in the DMCU. Conclusion The utilization of the DMCU for managing kidney transplant patients with ESBL UTI requiring parenteral ertapenem significantly reduced hospital bed occupancy and readmission rates, without any treatment-associated complications."

Clinical • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease • Transplantation

From Resistance to Resilience: Autologous Bacterial Lysate as a Novel Adjunct in a Pediatric Kidney Transplant Recipient (KIDNEY WEEK 2025) - "Despite treatment (anticholinergics, clean intermittent catheterization, and antimicrobials), the infections persisted even with IV ertapenem and amikacin. However, our preliminary experience suggests that personalized immunotherapy could reduce the infectious burden, preserve graft function, and improve quality of life. Further studies are needed to define its role in pediatric post-transplant care."

Clinical • Infectious Disease • Nephrology • Pediatrics • Pneumonia • Transplantation

Infection-Associated Allograft Inflammation Mimicking Acute Cellular Rejection: A Case of Spontaneous Resolution with Targeted Antimicrobial Therapy (KIDNEY WEEK 2025) - "She had low level DSA to DQ1 necessitating additional dose of Rituximab to standard Induction therapy...She ended up with a prolonged course of targeted ertapenem therapy...This case also emphasizes recognizing infection as a significant mimicker of acute rejection and supports initiating antimicrobial therapy before escalating immunosuppression in actively infected recipients. In individualized cases, modified rejection management strategies with less aggressive immunosuppression may be warranted while actively treating ongoing infection."

Clinical • Infectious Disease • Inflammation • Nephrology • Transplant Rejection

Rising Antimicrobial Resistance and Epidemiology of Haemophilus spp. in Urethritis: A Four-Year Analysis. (PubMed, Int J Infect Dis) - "Haemophilus spp., particularly H. parainfluenzae, accounted for nearly 10% of urethritis cases, supporting its likely pathogenic role. High MDR/XDR rates raise concerns for treatment and underscore the need for updated antimicrobial stewardship and surveillance."

Journal • Infectious Disease • Influenza • Respiratory Diseases

At-Home Allogeneic Stem Cell Transplantation: A Single Centre Experience (ASH 2024) - "Patients were planned to be admitted to the SCT unit to receive as inpatient the conditioning regimen, stem cells infusion and post-transplant cyclophosphamide on days +3 and +4...Antimicrobial prophylaxis was performed with oral levofloxacin 500 mg qd, posaconazole 300 mg qd and acyclovir 800 mg bid and intravenous ertapenem 1g qd...The rate of readmission was low which was associated to a significant avoidance of days of admission in the SCT unit. In this sense, this study highlights the relevance of expanding at-home programs to avoid unnecessary admissions among other potential benefits."

Clinical • Acute Graft versus Host Disease • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Chronic Myeloid Leukemia • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Hodgkin Lymphoma • Immunology • Infectious Disease • Leukemia • Lymphoma • Mucositis • Myelodysplastic Syndrome • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Stomatitis • Transplantation

Retrospective Analysis of Carbapenem Antibiotic Use Expenditures and Market Patterns in Medicaid (1991-2023) (ISPOR-EU 2025) - "This study evaluated longitudinal patterns in carbapenem use, market dynamics, and economic impact within the U.S. Medicaid program from 1991 to 2023.We conducted a retrospective analysis using publicly available Medicaid State Drug Utilization data, focusing on four carbapenems: Imipenem/Cilastatin, Meropenem, Ertapenem, and Doripenem. This study highlights evolving patterns in carbapenem prescribing, influenced by clinical practices, stewardship, and policy interventions. Continued surveillance is essential to balance appropriate antibiotic use with resistance prevention and cost control. Further research should assess the long-term impact of stewardship and the role of new therapies in guiding future trends."

Medicaid • Reimbursement • Retrospective data • US reimbursement • Infectious Disease

A Complex Interdisciplinary Case of Prolonged Oral and Neck Angioedema (ACAAI 2025) - "Case Description A 59-year-old male with HIV, dental caries, and hypertension on lisinopril was admitted to ICU after 5 days of progressive facial, lip, and tongue swelling requiring intubation...Initial treatment with diphenhydramine, methylprednisolone, and epinephrine yielded no improvement...Tracheal aspirate grew Enterobacter cloacae , prompting a switch to ertapenem which led to resolution of fever and leukocytosis...The clinical course and lack of response to standard therapies suggest an infectious etiology. Evaluation was limited by the absence of an oromaxillofacial surgery service."

Clinical • Cardiovascular • Dental Disorders • Hereditary Angioedema • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Pneumonia • Respiratory Diseases

Pediatric Urinary Tract Infections: Pathogen Prevalence, Antibiotic Susceptibility, and Cost-Effectiveness Analysis in a Tertiary Medical Center in Israel. (PubMed, Isr Med Assoc J) - "E. coli was the predominant pathogen in pediatric UTIs among hospitalized children. Carbapenems and amikacin showed high susceptibility but were costly. Fosfomycin demonstrated high susceptibility, favorable cost-effectiveness, and the advantage of oral administration, making it a promising option for empiric treatment. Empiric antibiotic selection should integrate susceptibility patterns, clinical context, and economic considerations."

HEOR • Journal • Retrospective data • Infectious Disease • Nephrology • Pediatrics

The role of fractional-order dynamics in understanding Escherichia coli resistance to carbapenem antibiotics. (PubMed, J Biol Phys) - "This study introduces a fractional-order differential equation model incorporating memory effects to analyze resistance and susceptibility dynamics in E. coli populations exposed to Ertapenem, Imipenem, and Meropenem, using real-world data from 2018 to 2023 from a hospital in Northern Cyprus. Basic reproduction number analysis identifies thresholds for resistance persistence or decline, suggesting that reducing mutation rates and enhancing decay factors can control resistance. Projections forecast an 800% rise in resistance cases by 2030 compared to 2018, underscoring the need for optimized antibiotic stewardship."

Journal • Gene Therapies

Liver Abscess and ARDS in a Healthy Young Male Following Routine Dental Cleaning: An Uncommon Sequelae of Group G Streptococcal bacteremia (ACG 2025) - "He was started on IV piperacillin-tazobactam and underwent IR-guided abscess drainage...Post-extubation, antibiotics were narrowed to ampicillin-sulbactam...He improved with ertapenem and was discharged with outpatient follow-up. PLA in healthy individuals is rare...Early recognition and multidisciplinary care are critical to favorable outcomes as complications of PLA, such as ARDS, can occur due to systemic inflammatory response. This case adds to the limited literature on GGS-induced liver abscess in healthy individuals, highlighting the systemic implications of what may appear to be a routine outpatient procedure.Figure: CT abdomen with contrast shows a 6.1 cm * 6.2 cm * 6.4 cm right hepatic lobe fluid collection"

Clinical • Acute Respiratory Distress Syndrome • Hepatology • Immunology • Infectious Disease • Inflammation • Mood Disorders • Respiratory Diseases • Systemic Inflammatory Response Syndrome

A Double Hit: COVID-19-Associated Hepatic Artery Thrombosis Post-Transplant in PSC-ESLD (ACG 2025) - "He was initially treated with IV Meropenem, then transitioned to Ertapenem. Shortly after, he developed hepatic artery thrombosis, leading to acute liver failure and sepsis. This case underscores a rare but severe complication of COVID-19 in a post-transplant patient, necessitating a second liver transplant."

Post-transplantation • Cardiovascular • Celiac Disease • Fatigue • Gastroenterology • Gastroesophageal Reflux Disease • Hematological Disorders • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Liver Failure • Novel Coronavirus Disease • Septic Shock • Solid Tumor • Thrombosis • Transplantation