Invanz (ertapenem) / Merck (MSD) - LARVOL DELTA

Gram-negative bacterial sepsis, antimicrobial susceptibility pattern and treatment outcomes at two neonatal intensive care units in Addis Ababa, Ethiopia: A retrospective observational study. (PubMed, PLoS One) - "Klebsiella spp. was the most common GNB isolated from the NICUs. More than half neonatal sepsis was caused by MDR organisms and associated with significant poor treatment outcomes. high prevalence of MDR-gram-negative bacteremia is alarming and highlights the need for the implementation of routine surveillance and infection control measures to decrease morbidity and mortality and to combat the development of antimicrobial resistance."

Journal • Observational data • Retrospective data • Critical care • Infectious Disease • Septic Shock

Subacute Bifocal Salmonella Osteomyelitis of the Mid Shaft of Femur and Ipsilateral Proximal Tibia in a Healthy Female: A Case Report. (PubMed, J Orthop Case Rep) - "The patient was treated with 6 weeks on intravenous ertapenem and 2 weeks of oral cotrimoxazole. Adult-onset acute bifocal Salmonella osteomyelitis is extremely rare. Early diagnosis and prompt debridement with tailored antibiotics help in preventing the spread of the disease and is curative."

Journal • Infectious Disease • Inflammation • Musculoskeletal Diseases • Orthopedics • Pain

Aztreonam Acts as a Synergist for Ceftazidime/Avibactam Against Carbapenem-Resistant Enterobacteriaceae (CRE) of Various Carbapenemase Phenotypes in Southwestern China. (PubMed, Infect Drug Resist) - "All 87 CRE strains showed high resistance to most antibiotics, especially cefazolin, ceftriaxone, piperacillin/tazobactam, ertapenem, and meropenem, with a rate of 100.00%. Notably, The combination of CZA and ATM showed synergy in 95.40% (83/87) of the CRE strains overall, with specific rates of 100.00% (4/4) in strains lacking detectable carbapenemase genes, 94.29% (33/35) in those with blaNDM, and 100.00% (3/3) in those with blaNDM plus blaKPC-2 or blaKPC-2 plus blaIMP-4. In conclusion, ATM significantly enhances CZA's activity against CRE strains in Guangxi, achieving a high synergy rate across diverse isolates, regardless of the carbapenemase genes present."

Journal • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

The NitroSpeed Taniborbactam NP test as a rapid test for detection of β-lactamase-mediated susceptibility to taniborbactam. (PubMed, FEMS Microbiol Lett) - "Taniborbactam (TAN) is an investigational β-lactamase inhibitor in clinical development combined with cefepime for the treatment of bacterial infections caused by broad-spectrum β-lactamase-expressing bacteria...The test is based on the hydrolysis of (i) nitrocefin (to determine the presence or absence of β-lactamase), (ii) ertapenem (to confirm the presence or the absence of carbapenemase), and (iii) TAN (to assess whether the carbapenemase is inhibited by TAN)...The NitroSpeed Taniborbactam NP test is simple, easy to perform, and provides results within ≤ 15 minutes. When evaluated against a broad set of β-lactamases, the test demonstrated 100% sensitivity, specificity, and accuracy."

Journal • Infectious Disease

A Cross-Sectional Study of Catheter-Related Bloodstream Infections in a Tertiary Care Hospital in India. (PubMed, Cureus) - "CRBSI among our study participants was mainly caused by Klebsiella pneumoniae, Acinetobacter baumannii, Burkholderia cepacia, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida tropicalis. The Gram-negative bacteria were highly susceptible to tigecycline. Staphylococcus aureus specimens demonstrated their sensitivity to vancomycin, linezolid, and daptomycin. The Candida tropicalis specimens were sensitive to echinocandins. We suggest further studies with more participants to investigate the pathogens causing CRBSI and their AST patterns."

Journal • Observational data • Infectious Disease • Pneumonia

DIAGNOSTIC CHALLENGES IN COMPLICATED DIVERTICULITIS: A CASE REPORT (SSAT 2025) - "She was treated with a 3-week course of meropenem, after which her condition stabilized. A midline catheter was placed to facilitate outpatient ertapenem therapy under infectious disease follow-up...Physicians should maintain a high index of suspicion for malignancy in patients with atypical presentations, poor treatment response, or concerning imaging findings such as a fixed mass or bowel obstruction. Prompt biopsy and multidisciplinary care are essential to prevent diagnostic delays.Abrupt decompression of the proximal sigmoid colon which is encased by a soft tissue mass measuring approximately 5.5 x 4.1 x 4.5 cm containing trace internal fluid/necrosis."

Case report • Clinical • Anemia • Colorectal Cancer • Constipation • Embryonal Tumor • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Oncology • Pain • Pediatrics • Solid Tumor • CEACAM5

EFFICACY OF PROPHYLACTIC ANTIBIOTICS IN ELECTIVE GASTRIC VARICEAL OBTURATION FOR PATIENTS WITH CIRRHOSIS: A RANDOMIZED CONTROLLED TRIAL (DDW 2025) - "Patients were randomized 1:1 to receive prophylactic antibiotics (ertapenem 1 g IV 30 minutes before GVO) or no antibiotics... Prophylactic antibiotic administration does not confer additional benefits for cirrhotic patients undergoing elective GVO without acute GVB. Concurrent HCC is the primary independent risk factor for post-GVO infection and GVB."

Clinical • Fibrosis • Gastrointestinal Disorder • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis • Oncology • Solid Tumor

INCREASED RISK OF PYOGENIC LIVER ABSCESS AFTER ENDOSCOPIC SPHINCTEROTOMY: A RETROSPECTIVE STUDY (DDW 2025) - "The secondary outcomes included the need for surgical PLA drainage, developing sepsis, risk of receiving broad-spectrum antibiotics (meropenem, ertapenem, imipenem, cefepime, and piperacillin/tazobactam), and post procedure mortality; all within one year of the index ERCP. We didn't find a mortality difference between the two groups. Our study highlights the significance of acknowledging PLA as a potential adverse event of ERCP in patients undergoing ES and calls for a careful selection of patients for ES."

Retrospective data • Hepatology • Infectious Disease • Pancreatitis • Septic Shock

DIAGNOSTIC CHALLENGES IN COMPLICATED DIVERTICULITIS: A CASE REPORT (DDW 2025) - "She was treated with a 3-week course of meropenem, after which her condition stabilized. A midline catheter was placed to facilitate outpatient ertapenem therapy under infectious disease follow-up...Physicians should maintain a high index of suspicion for malignancy in patients with atypical presentations, poor treatment response, or concerning imaging findings such as a fixed mass or bowel obstruction. Prompt biopsy and multidisciplinary care are essential to prevent diagnostic delays."

Case report • Clinical • Anemia • Colorectal Cancer • Constipation • Embryonal Tumor • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Oncology • Pain • Pediatrics • Solid Tumor • CEACAM5

Public Health Risk of Campylobacter spp. Isolated from Slaughterhouse and Retail Poultry Meat: Prevalence and Antimicrobial Resistance Profiles. (PubMed, Pathogens) - "Following antimicrobial resistance profile determinations using the Kirby-Bauer disc diffusion assay, the isolated strains showed resistance to the following antimicrobials in descending order: ciprofloxacin (41.6%), tetracycline (25.0%), chloramphenicol (16.6%), gentamicin (11.1%), ertapenem (5.6%), and erythromycin (2.8%). The study results confirm that chicken meat may pose a threat to public health and, moreover, that due to the widespread use of antimicrobials, a large number of strains have developed antimicrobial resistance, leading to difficulties in the treatment of various foodborne diseases."

Journal • Gastroenterology • Gastrointestinal Disorder

Developing multifunctional zwitterionic-xanthan gum-anchored network copolymers for biomedical applications. (PubMed, Soft Matter) - "The slow and gradual release of ertapenem was observed through supra-molecular interactions and occurred more frequently under neutral to slightly basic conditions...The developed hydrogel-based drug delivery (DD) carriers were found to be bioadhesive with 100.0 ± 5.0 mN force of adhesion, biocompatible with 1.078 ± 0.073% haemolytic index and antioxidant in nature by displaying 28.384 ± 0.963% inhibition during DPPH assay. The physicochemical and biomedical properties of XG-based hydrogels are indicative features for their utilization in gastrointestinal DD applications."

Journal • Gastrointestinal Disorder

Molecular Mechanisms of Resistance in Morganella morganii with Exclusive Resistance to Imipenem: Whole Genome Sequencing Analysis of 12 Clinical Isolates. (PubMed, Microb Pathog) - "These findings suggest that selective imipenem resistance in M. morganii may be associated with carbapenemase genes and the potential for plasmid-mediated horizontal transmission of resistant clones. The results highlight the need for continuous monitoring of resistance gene dissemination across hosts, targeted interventions to curb resistant clone spread, and sustained vigilance regarding global epidemiological trends."

Journal • Infectious Disease

The Abscess Doesn't Fall Too Far From Biliary Tree - A Unique Case Presentation (ATS 2025) - "Initial broad-spectrum antibiotics were switched to ertapenem and Daptomycin considering this finding. This case demonstrates a rare but important association between PLA and acalculous cholecystitis, both of which may present with nonspecific symptoms and require a high index of suspicion for accurate diagnosis. Clinicians should consider the possibility of these co-existing conditions, especially in patients with risk factors for infections and compromised immunity. Early diagnosis, appropriate antibiotic therapy, and drainage of the liver abscess, along with management of the gallbladder inflammation, are critical for optimal patient outcomes."

Clinical • Cardiovascular • Coronary Artery Disease • Diabetes • Gastroenterology • Hepatology • Hypotension • Infectious Disease • Metabolic Disorders • Oncology • Type 2 Diabetes Mellitus

What Is the Culprit? The Quest to Determine the Cause of Daptomycin Associated Acute Eosinophilic Pneumonia (ATS 2025) - "He was placed on ertapenem and daptomycin (650 milligrams daily) for complete coverage of all potential organisms causing his osteomyelitis...He was switched from daptomycin to linezolid to complete his osteomyelitis treatment and was started on a prednisone taper for AEP treatment...We suggest that his multiple comorbidities may have played a role, though the specific mechanisms remain unclear at this time. We hope to highlight this case to prompt further investigation into the association between daptomycin and AEP."

Cough • Eosinophilia • Genito-urinary Cancer • Immunology • Infectious Disease • Oncology • Pain • Pneumonia • Renal Cell Carcinoma • Rheumatology • Solid Tumor • Testicular Cancer

A Rare Pair: Mucormycosis and Pneumocystis Coinfection in a Mantle Cell Lymphoma Patient on Pirtobrutinib (ATS 2025) - "She was started on systemic and retrobulbar liposomal amphotericin-B, vancomycin, and cefepime. Cultures grew Rhizopusand ESBL Klebsiella pneumoniae, prompting a switch of bacterial coverage to ertapenem...Remdesivir, TMP/SMX, and posaconazole were added. Given increasing ventilatory settings, the decision to start prednisone 40mg BID was made...Concurrent IFIs, as observed in this case, are rare. Patients on BTKis who have additional IFI risk factors—such as uncontrolled diabetes, corticosteroid use, and recent COVID-19 infection—may benefit from prophylactic TMP/SMX and require close monitoring."

Clinical • Acute Kidney Injury • Acute Respiratory Distress Syndrome • Anemia • Cardiovascular • Cough • Diabetes • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Mantle Cell Lymphoma • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Oncology • Otorhinolaryngology • Pneumonia • Pulmonary Disease • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Septic Shock • Thrombocytopenia • Type 2 Diabetes Mellitus

GLP1s: Hidden Menace! Novel Chronic Medication Regimen Leads to Pancreatopleural Fistula and Tube Feed Effusion (ATS 2025) - "Here we present a patient with a severe complication of pancreatitis caused by a GLP-1 We have a 69 year old male with history of recent acute necrotizing pancreatitis s/p cyst gastrostomy stent placement, T2DM on mounjaro, and HTN on hydrochlorothiazide who was recently treated with doxycycline for a left side abscess, who presented with epigastric pain radiating to his back and found to have recurrent pancreatitis...He was treated with a long course of Ertapenem, Linezolid and fluconazole...Some studies suggest increased risk with regimens that include exenatide, sitagliptin, and liraglutide while others show no association with increased risk or only a slight risk. One such consideration would be to better understand the cumulative risks for development of pancreatitis in the setting of therapeutic regimens that include multiple drugs known to increase risks. Additionally, investigating the incidence of fistulaization to better understand severity of side effects..."

Diabetes • Metabolic Disorders • Pain • Pancreatitis • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

A Case of Purulent Pericarditis Due to Actinomyces From an Odontogenic Focus (ATS 2025) - "Two weeks prior, he was diagnosed with a dental infection and completed a course of amoxicillin-clavulanate...The patient's purulent pericarditis was treated with ampicillin-sulbactam 3g and he was transitioned to ertapenem 1g daily on discharge...This case highlights the potential for actinomyces odontogenic infections to cross fascial planes and result in unexpected purulent infections in the thoracic region. It also underscores the importance of promptly treating oral infections and emphasizes the need to expand antibiotic coverage to include anaerobic organisms."

Clinical • Cardiovascular • Immunology • Infectious Disease • Inflammation • Mood Disorders • Pain • Pulmonary Disease

A Case of Fatal Ureaplasma-Induced Hyperammonemia in a Patient With Activated PI3Kdelta (APDS) Syndrome (ATS 2025) - "Urine cultures identified ESBL Klebsiella pneumoniae and Escherichia coli, for which she was treated with Ertapenem...Antimicrobial susceptibility testing is not widely available, but most Ureaplasma isolates are susceptible to tetracyclines...This is the first reported case of Ureaplasma-Induced hyperammonemia in a patient with APDS. Prompt suspicion and considering empiric treatment in immunocompromised patients with unexplained hyperammonemia and neurological deterioration may result in better outcomes."

Clinical • Cardiovascular • CNS Disorders • Epilepsy • Extranodal Marginal Zone Lymphoma • Hematological Disorders • Hematological Malignancies • Hepatology • Immunology • Infectious Disease • Inflammatory Arthritis • Lymphoma • Marginal Zone Lymphoma • Oncology • Pneumonia • Primary Immunodeficiency • PIK3CD • PIK3R1

Confronting a Clinical Dead End: Insights From a Pan-resistant Pseudomonas Case (ATS 2025) - "They often lead to therapeutic dead ends, where the only remaining treatment options, such as colistin, are associated with significant toxicity...Empiric therapy with meropenem and oral Bactrim was started based on prior culture results, along with oral vancomycin for C. difficile suppression...The antibiotic regimen was adjusted to cefiderocol and polymyxin for a total of 7 days, with a plan to initiate 3 months of ertapenem therapy post-regimen for the management of ESBL Klebsiella pneumoniae.He was placed on contact precautions and repeat blood cultures did not show any bacterial growth but sputum cultures continued to grow pan-resistant Pseudomonas aeruginosa...Strict hygiene practices, proper use of personal protective equipment, and thorough cleaning, especially of high-risk areas like sinks and drains, are essential. This case is a terrifying but very possible future for all infections and emphasizes the importance of optimizing antibiotic use through stewardship..."

Clinical • CNS Disorders • Hypotension • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock • Vascular Neurology

Prostatic Abscess Presenting as Penile Discharge: A Case Report. (PubMed, WMJ) - "We report a unique presentation of prostate abscess to educate and improve clinical suspicion of a rare, yet potentially fatal urological complication."

Journal • Infectious Disease • Pain • Septic Shock • Urology

Minimum Inhibitory Concentration and Antibiotic Sensitivity Patterns in Pediatric Patients With Urinary Tract Infections. (PubMed, Cureus) - "Escherichia coli was more sensitive to ertapenem (135 (93.1%)) and meropenem (130 (89.6%)), followed by amikacin (118 (81.3%)), nitrofurantoin (115 (79.3%)), and imipenem (111 (76.5%)). Conclusion Different antibiotics have shown different levels of sensitivity toward various strains of bacterial pathogens causing UTIs. It is recommended that antibiotics as a medication be suggested on the basis of antibiotic sensitivity patterns in different cases of UTIs. Also, regional data may be effective in the selection of suitable drugs."

Journal • Infectious Disease • Nephrology • Pediatrics

The Impact of Emergency Department Antibiotic Discordance on the Outcomes of Hospitalized Patients with Urinary Tract Infections: A Multi-Center Retrospective Cohort Study. (PubMed, Life (Basel)) - "Within our results, Escherichia coli emerged as the predominant pathogen (64.8%), but concordance varied widely among antibiotics, with Ertapenem showing the highest (91.3%) and Cefazolin showing the lowest rates (21.5%). Our findings suggest that, while choosing concordant antibiotics might not significantly affect mortality, it might be associated with a shorter recovery period during hospitalization. Choosing concordant antibiotics based on patient severity and punctually updated local sensitivity reports might minimize healthcare costs, and prevent ED overcrowding."

Journal • Retrospective data • Infectious Disease • Nephrology

Current Antimicrobial Susceptibility Trends and Clinical Outcomes of Typhoidal Salmonella in a Large Health Authority in British Columbia, Canada. (PubMed, Trop Med Infect Dis) - "Currently, in British Columbia, MDR typhoidal Salmonella remains rare. Empiric ciprofloxacin should be avoided due to persistently high resistance rates. With ongoing travel patterns, it is beneficial for institutions to continue typhoidal Salmonella antimicrobial susceptibility surveillance, and travelers should seek pre-travel health assessments."

Clinical data • Journal • Infectious Disease

Evolution of carbapenemase activity in the class C β-lactamase ADC-1. (PubMed, mBio) - "In this study, we selected a triple mutant of the intrinsic class C Acinetobacter-derived cephalosporinase ADC-1 (ADC-1TM) that confers high-level resistance to the carbapenems meropenem, ertapenem, and doripenem. Here, we demonstrate that the intrinsic ADC-1 β-lactamase of the clinically important pathogen Acinetobacter baumannii can evolve high-level resistance to carbapenems by just three amino acid substitutions and disclose the molecular mechanisms of its carbapenemase activity. This study demonstrates the potential for the evolution of carbapenemase activity in class C β-lactamases."

Journal • Infectious Disease

Bacteriological Profile of Diabetic Foot Ulcer With Special Reference to Biofilm Formation. (PubMed, Cureus) - "On antibiotic sensitivity of organisms tested against each antibiotic, more than 75% of tested samples were resistant to ampicillin, cefuroxime, and erythromycin, and around 70% and more of tested samples were sensitive to ertapenem, meropenem, amikacin, gentamicin, benzylpenicillin, vancomycin, and clindamycin. Conclusion The ability to form biofilms adds immensely to the virulence and antibiotic resistance. Detection of biofilm formers is non-invasive and convenient to measure and would help provide insight into antibiotics to be administered to the patient, thereby reducing development of MDROs and reducing healing time."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Pneumonia