Invanz (ertapenem) / Merck (MSD) - LARVOL DELTA

Epidemiological factors associated with the prevalence of mobile genetic elements, and antimicrobial resistance patterns in Klebsiella pneumoniae of farm environments in Bangladesh. (PubMed, BMC Med Genomics) - "Regarding resistance patterns, the highest resistance was observed to ertapenem (90.6%) and ampicillin (84%), while complete sensitivity was noted to several antibiotics, including amikacin and tigecycline. Importantly, these also carry serious implications for human health, as resistance genes may transfer to clinical settings, exacerbating the burden of AMR. Strengthening environmental and agricultural policies through a One Health approach is essential to mitigate the public health threat posed by antimicrobial resistance."

Journal • Infectious Disease • Pneumonia

Carbapenem-resistant Enterobacterales among patients with bloodstream infections in South Africa: Consolidated surveillance data, 2015-2021. (PubMed, PLoS One) - "Periodic surveillance for CRE should be performed on regular basis to support infection prevention and stewardship program at each facility."

Journal • Infectious Disease • Pneumonia

Dosage Regimen Optimization of Ertapenem Against ESBL-Producing Enterobacterales Infection in Critically Ill Patients Using Monte Carlo Simulation. (PubMed, Clin Transl Sci) - "Moreover, the study highlights the need for an individualized ertapenem dosage regimen based on renal function in critically ill patients, as ertapenem in divided doses might be more optimal for both efficacy and safety compared to once daily dosing in patients with creatinine clearance ≥ 60 mL/min. Further randomized controlled trials are needed to confirm these dose recommendations."

Journal • Infectious Disease

Pathogen distribution and antibiotic sensitivity analysis in urosepsis associated with urinary stones: A retrospective observational study. (PubMed, Medicine (Baltimore)) - "The antibiotic sensitivity test indicated that E coli was most susceptible to tigecycline (100%), nitrofurantoin (100%), ertapenem (92%), imipenem (92%), meropenem (92%), and amikacin (92%). Antibiotics to which E faecium was highly susceptible included vancomycin (100%) and daptomycin (100%). Among patients with urinary-stone-associated urosepsis, women and those with diabetes are likelier to exhibit urine culture-positive pathogens, with the principal pathogens being gram-negative bacteria, mainly E coli. Carbapenems have the highest overall susceptibility to gram-negative bacteria."

Journal • Observational data • Retrospective data • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Urolithiasis

Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast India. (PubMed, Monaldi Arch Chest Dis) - "Alarmingly, high resistance rates were observed for widely used antibiotics such as ceftriaxone and cefuroxime, while meropenem, amikacin, and ertapenem retained high sensitivity. These findings emphasize the critical need for tailored, region-specific empirical treatment strategies in light of emerging antibiotic resistance trends in CAP."

Journal • Observational data • Cardiovascular • Chronic Obstructive Pulmonary Disease • Cough • Hypertension • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Unravelling Pasteurella multocida Toxin (PMT): Structural insights, antibiotic assessment, and identification of potential inhibitors. (PubMed, Comput Biol Chem) - "Amikacin, Ertapenem, Tigecycline, and Vancomycin are identified as promising antibiotics by utilizing a computational virtual screening and molecular docking approach. Validation through disc diffusion tests confirmed their sensitivity and is superior to the standard drug, suggesting potential therapeutic agents against PMT. Our findings not only highlight promising antibiotic candidates but also pave the way for identification of potential inhibitors against Pasteurella multocida infection, thereby addressing critical needs in both veterinary and microbiological domains."

Journal • Infectious Disease • Inflammation

Key Data Elements for Hidradenitis Suppurativa: Consensus Recommendations for Clinical and Research Practices (CDA 2025) - "Twenty-two items were unanimously deemed “Mandatory,” including: gender; year of disease onset; current treatment(s) for HS; treatment outcomes; specific medications: IV ertapenem, metformin, adalimumab, secukinumab; procedures: wide local excision; medical history: diabetes, dyslipidemia, obesity, depression, Crohn's disease, ulcerative colitis, or inflammatory bowel disease, psoriasis, and pilonidal sinus; social history: cigarette smoking, marijuana use; physical exam: affected sites, Hurley stage, lesion count; and patient-reported pain score. Conclusions This study establishes expert consensus on core data items for routine collection in HS clinical care and real-world research settings. It is an important step toward harmonizing HS data infrastructure and promoting collaborative, comprehensive data collection to address gaps in clinical care and evidence-based research."

Clinical • CNS Disorders • Crohn's disease • Depression • Dermatology • Diabetes • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hidradenitis Suppurativa • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Obesity • Pain • Psoriasis • Psychiatry • Ulcerative Colitis

Rising Threats and Evolving Trends: Five Years of Urinary Tract Infection Prevalence in a Portuguese Hospital. (PubMed, Clin Pract) - "For E. coli, resistance ranged from 2% (amikacin) to 41% (ampicillin), with increasing resistance to ertapenem and fosfomycin and decreasing resistance to several key antibiotics...pneumoniae showed 4-36% resistance across antimicrobials, with notable increases for fosfomycin, meropenem, and cefuroxime axetil...Identified risk factors may inform targeted prevention strategies. Ongoing surveillance and antimicrobial stewardship are crucial to mitigate the rising burden of UTIs and resistance."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia

Genomic Characterization of Carbapenem-Resistant Acinetobacter baumannii (OXA-23) and Klebsiella pneumoniae (KPC-2) Causing Hospital-Acquired Infections in Dogs. (PubMed, Antibiotics (Basel)) - "All three strains exhibited resistance to multiple antimicrobial classes, including β-lactams (amoxicillin-clavulanic acid, ampicillin, cephalotin, piperacillin-tazobactam, cefoxitin, ceftiofur, cefotaxime, ertapenem, imipenem and meropenem), aminoglycosides (gentamicin, neomycin), tetracyclines (doxycycline, tetracycline and oxytetracycline), fluoroquinolones (ciprofloxacin, enrofloxacin), and folate pathway antagonists (trimethoprim-sulfamethoxazole). These findings provide the first evidence of fatal, healthcare-associated infections caused by these multidrug-resistant pathogens in dogs and underscore the need to strengthen surveillance and infection control practices in veterinary hospitals. Furthermore, the results raise concerns about the potential of companion animals to act as reservoirs for multidrug-resistant organisms of public health relevance."

Journal • Infectious Disease • Pneumonia

Stability of four carbapenem antibiotics in discs used for antimicrobial susceptibility testing. (PubMed, J Appl Microbiol) - "Imipenem in discs for AST showed to be the most stable carbapenem under unfavourable conditions."

Journal

Development of a UHPLC-UV/Vis Method for Simultaneously Determining Six Beta-Lactam Antibiotics in Plasma: A Tool for the Clinical Implementation of Therapeutic Monitoring of Beta-Lactams. (PubMed, Antibiotics (Basel)) - " To address this, we developed and validated an ultra-high-performance liquid chromatography (UHPLC-UV/Vis) method for the simultaneous quantification of six beta-lactams (cefepime, ceftolozane, ceftazidime, meropenem, ampicillin, and ertapenem) in plasma. These findings underline the importance of beta-lactam monitoring in optimizing treatment outcomes and combating antibiotic resistance in vulnerable populations. Further studies to assess free drug concentrations are warranted to enhance clinical applicability."

Journal

Antibiotic resistance profiles of gram-negative bacteria in southern Tunisia: Focus on ESBL, carbapenem and colistin resistance. (PubMed, Infect Genet Evol) - "For these strains, the minimum inhibitory concentrations (MICs) of imipenem and ertapenem ranged from >32 to 6 μg/mL and > 32 to 2 μg/mL, respectively, with blaOXA-48 and blaNDM detected in 21.7 % and 19.6 % of isolates, respectively. Seven A. baumannii isolates resistant to imipenem and meropenem (MICs >32 μg/mL and 8 μg/mL, respectively) carried blaOXA-23 (n = 5) and blaOXA-24 (n = 2)...Two K. pneumoniae were colistin-resistant and carried the blaOXA-48 gene. These results highlight the urgency of developing new strategies for the identification and surveillance of pathogenic strains in humans to effectively combat this growing public health threat in Tunisia."

Journal • Infectious Disease • Pneumonia

Identification and Antimicrobial Susceptibility of Gram-Negative Bacteria Causing Infections Among Intensive Care Unit Patients at Two Hospitals in Addis Ababa, Ethiopia (ASM Microbe 2025) - "Isolate identification was conducted by standard microbiology techniques and antimicrobial susceptibility testing by Kirby-Bauer Disk diffusion to trimethoprim-sulfamethoxazole, ciprofloxacin, gentamicin, amikacin, meropenem, ertapenem, ceftriaxone, ceftazidime and cefepime. The findings show high prevalence of MDR and CP-CREs in gram-negative isolates causing infections in ICU patients. Continued laboratory support for rapid detection of MDR-gram negative infections is important to inform patient management and infection prevention and control actions."

Clinical • Gram negative • Critical care • Infectious Disease • Pneumonia

Controlled Inoculum Functionality of an Automated Rapid AST System Leads to Consistent MIC Determination (ASM Microbe 2025) - " MIC determination for Meropenem and Ertapenem by the ASTar System was consistent despite large variations of PBC bacterial concentrations. Results from this study confirm that ASTar can handle large concentration variations in PBCs and still deliver reliable MIC data. This is crucial for overcoming the inoculum effect and for supporting clinical decision-making."

Infectious Disease

Comparison of the Lifescale Gram Negative Kit to the Microscan Gram Negative Minimum Inhibitor Concentrations Panel Type 56 for Antimicrobial Susceptibility Testing (ASM Microbe 2025) - "14 antibiotics were evaluated: amikacin, ampicillin, aztreonam, cefazolin, cefepime, ceftazidime, ceftazidime/avibactam, ertapenem, gentamicin, levofloxacin, meropenem, meropenem/vaborbactam, piperacillin/tazobactam, and trimethoprim/sulfamethoxazole. In this study, the AST results provided by the LifeScale system were in high agreement with the SOC AST results for the most common Gram-negative bacteria recovered in our patient population. The simplicity and rapid time to results of this novel platform should have a positive impact on implementation of targeted therapy for bacteremic patients."

Gram negative • Infectious Disease • Pneumonia

Impact of Antibiotic Post-Prescription Authorization in Resource-Limited Emergency Rooms and Acute Care Units (ASM Microbe 2025) - "In August 2020, a PPA was implemented for piperacillin/tazobactam, meropenem, imipenem/cilastatin and ertapenem. This study demonstrates the positive impact of PPA on antibiotic consumption and clinical outcomes in emergency settings. Future studies should evaluate PPA early in the course of treatment to identify the most effective interventions for improving the quality of care."

Infectious Disease

Kinetic and Molecular Dynamics Reveal the Role of the V120L Substitution in OXA-788 β-Lactamase (ASM Microbe 2025) - "Inrelation to the kinetic behavior, the catalytic efficiency (kcat/Km) for nitrocefin,cephalothin, imipenem, meropenem and ertapenem were 7.16, 5.2 , 0.41, 0.2and 0.36 µM-1 s-1, respectively. Ceftriaxone and ceftazidime didn't exhibitdetectable catalytic efficiency, with Km app greater than 1,000 µM. On the otherhand, a greater fluctuation of the Cα was observed compared to OXA-163,although in both cases with a RMSD less than 1 Å.In OXA-788, The V120L mutation affects the hydrolytic capacity of different β-lactams, compared to OXA-163, possibly due to the role of V120 in thedeacylation process. This study reinforces the structural plasticity of OXA-163 β-lactamase and its relevance in the emergence of novel variants upon intensiveuse of carbapenems."

Multicenter Evaluation of VITEK® REVEAL™ AST System vs. Standard BD Phoenix™ for Antimicrobial Susceptibility Testing of Gram-Negative Bacteria from Positive Blood Cultures (ASM Microbe 2025) - "We observed 100% CA for amikacin, amoxicillin/clavulanate, ertapenem, meropenem, meropenem/vaborbactam, and trimethoprim/sulfamethoxazole, and the remaining drugs demonstrated CA>90% except for ampicillin/sulbactam (89%). Depending on the drug/bug combination, the median TTR for VITEK® REVEAL™ results was 6.5 h (ranging between 3-8 h), while BD Phoenix™ displayed average TTR results of 32-42 h (including subculturing of 18-24 h).Our study shows that the VITEK® REVEAL™ AST system had acceptable CA against the BD Phoenix™ system for all tested antimicrobials except ampicillin/sulbactam. The VITEK® REVEAL™ average TTR was more than 20 h shorter than BD Phoenix™'s average TTR, allowing for faster assessment of optimal antimicrobial therapy."

Gram negative • Infectious Disease • Pneumonia

Evaluation of a Fast vs. Conventional System for Antimicrobial Susceptibility Testing of Gram-Negative Bacteria from Positive Blood Cultures (ASM Microbe 2025) - "We observed 100% CA for amikacin, ceftazidime/avibactam, ertapenem, meropenem, meropenem/vaborbactam, and trimethoprim/sulfamethoxazole. The VITEK® REVEAL™ AST system displayed acceptable CA for all antimicrobials tested except for ampicillin/sulbactam. The VITEK® REVEAL™ average TTR was 20-28 h shorter than MicroScan™'s, allowing for faster assessment of optimal antimicrobial therapy."

Gram negative • Infectious Disease • Pneumonia • Septic Shock

Phylogroup Diversity and Antimicrobial Resistance Profiles of Thermotolerant E. coli Isolated from an Urban and a Rural Tributary River of Laguna Lake, Philippines (ASM Microbe 2025) - "In both environments, most isolates exhibited resistance to ampicillin (64.86%) and sulfonamides (20.27%). One urban river isolate was reported ESβL-positive, showing resistance to cefuroxime, cefuroxime (oral), cefepime, and ertapenem...These findings suggest that the identified E. coli phylogroups can infer possible transmission routes of contamination. Moreover, urban and rural river environments, though varying in surrounding land-use activities and other ecological stresses, are still both potential reservoirs of ARGs."

Hospital Surveillance of Carbapenemase-Harboring Gram-Negative Bacteria (ASM Microbe 2025) - "Swabs were then plated on TSA with 5% Sheep Blood, MacConkey agar with meropenem and ertapenem disks, and CHROMagar™ mSuperCARBA™. Sink drains are known environmental reservoirs for multidrug resistant bacteria. CHROMagar™ mSuperCARBA™ best helps select and differentiate carbapenem resistant bacteria."

Clinical • Gram negative • Infectious Disease

Genome Analysis of Escherichia coli Isolated from Environmental Wastewater in Manila, Philippines (ASM Microbe 2025) - "Antibiotics include Imipenem, Meropenem, Ertapenem, Cefotaxime, and Levofloxacin. In the Philippines, there have been reports of cefotaxime resistance in poultry farms and agricultural settings. However, the study's findings show the first documented cefotaxime-resistant E. coli in urban institutional wastewater settings."

Infectious Disease

What is the Best Synergistic Combination Against Enterococcus faecalis? In-Vitro Synergy Activity of Ampicillin in Combination with Cephalosporins and Carbapenems for Determining Synergy, Addition, and Antagonism (ASM Microbe 2025) - "In this study we compared the activity and potential synergy between ampicillin (AMP) with cephalosporins (ceftaroline-CPT or ceftriaxone-CRO) and carbapenems (ertapenem-ERTP or imipenem-IMI) in vancomycin susceptible E. faecalis. The combination AMP with cephalosporins demonstrated the most synergy/additive effect with AMP + CPT at 67% (n=16), followed by the combination of AMP and CRO at 37.5% (n=9). AMP and carbapenem combination yielded the least effects with AMP and IMI being the lowest with no synergy observed."

Combination therapy • Preclinical • Cardiovascular • Gastrointestinal Disorder • Infectious Disease • Nephrology

Differential Antibiotic Impact on Bacterial Extracellular Vesicle Release and Endothelial Cell Activation (ASM Microbe 2025) - "Clinically relevant antibiotics, including five β-lactams (ceftriaxone, imipenem, ertapenem, meropenem, cefepime), two aminoglycosides (tobramycin, amikacin), and one quinolone (ciprofloxacin) were tested. Quinolones showed a relatively less inflammatory profile. These findings highlight the importance of antibiotic choice in shaping host-pathogen interactions and inflammation."

Infectious Disease • Inflammation • Septic Shock • ICAM1

Impact of Antimicrobial Stewardship Program Suspension on Antibiotic Use during a Healthcare System Crisis: A Single-Center Experience in South Korea (ASM Microbe 2025) - "Preauthorization antibiotics included carbapenems (meropenem, imipenem/cilastatin, and ertapenem), ceftazidime/avibactam, and ceftolozane/tazobactam. PAF antibiotics included colistin, daptomycin, glycopeptides (vancomycin and teicoplanin), linezolid, and tigecycline... The suspension of antimicrobial stewardship interventions resulted in a significant increase in the use of restricted antibiotics, particularly those requiring preauthorization, highlighting the essential role of ASP in controlling antibiotic overuse and misuse."

Clinical