metronidazole vaginal gel / Generic mfg. - LARVOL DELTA

Vaginitis: Diagnosis and Treatment. (PubMed, Am Fam Physician) - "Bacterial vaginosis is treated with oral or intravaginal metronidazole or intravaginal clindamycin...Trichomoniasis is treated with oral metronidazole or tinidazole. When treating trichomoniasis, testing for reinfection, as well as other sexually transmitted infections, is recommended. Treatments for noninfectious vaginitis include vaginal lubricants and moisturizers, topical hormones, and topical steroids, depending on the cause."

Journal • Review • Candidiasis • Dermatology • Gynecology • Infectious Disease • Inflammation • Pruritus • Vaginitis

Metronidazole Induced Fixed Drug Eruption (ACAAI 2025) - "This occurred one day after starting metronidazole for vulvovaginal trichomoniasis. Metronidazole is the most common and readily available drug to treat trichomoniasis in the United States. Cross reactivity with other nitroimidazoles such as tinidazole and secnidazole is variable, and patients can reasonably receive a trial of another drug in the class or undergo provocation testing to find the most suitable alternative."

Immunology • Infectious Disease • Inflammation

Understanding Patient Perceptions of Bacterial Vaginosis Treatments: Mixed Methods Sentiment Analysis Study of Online Drug Review Forums. (PubMed, Online J Public Health Inform) - "Overall, people want a BV treatment that is easy to use, quickly alleviates symptoms, and has minimal side effects. Patients use product reviews to inform their decision-making about BV treatment, ask and seek answers to health-related questions, and share their experiences, presenting a unique opportunity for comprehensive patient education through clinical encounters or public health outreach efforts."

Journal • Infectious Disease • Vaginitis

Real-Time PCR Test (Flora Select™) for Assessing the Effectiveness of Bacterial Vaginosis Treatment During Pregnancy. (PubMed, Microorganisms) - "Treatments with metronidazole vaginal tablets resulted in the improvement of 88.0% (22/25) of classical BV, 65.2% (15/23) of BV-FS A, and 50.0% (1/2) of BV-FS B cases, whereas positive rates of Ureaplasma species in women with classical BV increased by 42.9%...It could identify pregnant women who require additional treatments for residual molecular BV and Ureaplasma species. Therefore, the FS test may be clinically useful for assessing the vaginal microbiome and evaluating the effectiveness of BV treatments."

Journal • Vaginitis

CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease (clinicaltrials.gov) - P1 | N=100 | Active, not recruiting | Sponsor: The Cleveland Clinic | Enrolling by invitation ➔ Active, not recruiting

Enrollment closed • Cardiovascular

Cervicovaginal Secretions in Young Women with Bacterial Vaginosis Enhance HIV Infection. (PubMed, J Infect Dis) - "These findings provide a potential mechanistic link that may contribute to the increased risk of HIV in association with BV and highlight the importance of early diagnosis and improved treatments."

Journal • Human Immunodeficiency Virus • Infectious Disease • Vaginitis • TNFA

Temporal dynamics of the vaginal microbiome and host immune markers before, during, and after metronidazole treatment for bacterial vaginosis. (PubMed, mSystems) - "There is limited data regarding the effects of oral metronidazole on the vaginal microbiome starting at the initiation of treatment, as most studies have compared measurements taken before and after treatment completion. This study utilized metagenomic sequencing, pan-bacterial qPCR, and immune marker measurements to analyze the longitudinal dynamics of the vaginal microbiome and host immune response before, during, and after metronidazole treatment."

Journal • Infectious Disease • Vaginitis

A Prospective, Randomized Controlled Study of the Probiotics as Adjuvant Treatment for Bacterial Vaginosis (clinicaltrials.gov) - P4 | N=140 | Recruiting | Sponsor: Peking University Shenzhen Hospital | Trial completion date: Dec 2024 ➔ Dec 2026 | Trial primary completion date: Dec 2024 ➔ Dec 2026

Trial completion date • Trial primary completion date • Gynecology • Obstetrics • Vaginitis

Evaluation of the Medical Device Vagitab - T as Adjuvant Therapy in Patients With Bacterial Vaginosis. (clinicaltrials.gov) - P=N/A | N=30 | Recruiting | Sponsor: S.I.I.T. Srl | Not yet recruiting ➔ Recruiting | Initiation date: Dec 2024 ➔ Mar 2025 | Trial primary completion date: May 2025 ➔ Sep 2025

Enrollment open • Trial initiation date • Trial primary completion date • Vaginitis

Development and Characterization of Mucoadhesive Films Containing Metronidazole for Vaginal Drug Delivery. (PubMed, Turk J Pharm Sci) - "The release of MET was found to be 92.7%, 65.5%, and 87.6% for F4, F5, and F6, respectively. Mucoadhesive films can be used as an alternative dosage form for vaginal delivery of MET in the treatment of BV."

Journal • Vaginitis

Revolutionizing bacterial vaginosis treatment through an immunomodulatory natural approach in Baku Azerbaijan (IMMUNOLOGY 2025) - "The control group (n=40) received the standard Metronidazole Vaginal Gel (MVG) 0.75% combined with all three of the above ingredients over seven days...By nine months, 17.5% of the intervention group and nearly 50% of the control group had recurrences. Observed trends suggest that the intervention may enhance local immune defense, reduce inflammation, and support microbial stability.Keywords: Animals Human; Cells Natural Killer Cells; Infections Bacterial; Tissues Mucosa"

Immunomodulating • Infectious Disease • Inflammation • Vaginitis

Diagnostics of Chronic Endometritis in Infertility (clinicaltrials.gov) - P=N/A | N=102 | Completed | Sponsor: Jagiellonian University | Trial completion date: Oct 2023 ➔ Oct 2024

Trial completion date • Endometriosis • Infertility • Obstetrics • Sexual Disorders • Women's Health

Efficacy and safety of probiotics in the treatment of bacterial vaginitis (ChiCTR) - P=N/A | N=200 | Completed | Sponsor: The Ninth Hospital of Nanchang; The Ninth Hospital of Nanchang

New trial • Gynecology • Vaginitis

Temporal Dynamics of the Vaginal Microbiome and Host Immune Markers Before, During, and After Metronidazole Treatment for Bacterial Vaginosis. (PubMed, bioRxiv) - "There is limited data regarding the effects of oral metronidazole on the vaginal microbiome starting at initiation of treatment as most studies have compared measurements taken before and after treatment completion. This study utilized metagenomic sequencing, pan-bacterial qPCR, and immune marker measurements to analyze the longitudinal dynamics of the vaginal microbiome and host immune response before, during and after metronidazole treatment."

Journal • Infectious Disease • Vaginitis

Probiotics reduce the recurrence of asymptomatic bacterial vaginosis in Chinese women. (PubMed, Sci Rep) - P4 | "Participants received either a 10-day intravaginal probiotic capsules or a 7-day oral metronidazole...Probiotics emerge as a superior therapeutic option for aBV due to their comparable cure rates, lower recurrence rates, and minimal side effects. Chinese Clinical Trial Registry (ChiCTR1800019436, 11/11/2018 )."

Clinical • Journal • Vaginitis

Clinical Characteristics of Vaginal Trichomoniasis Infection and Metronidazole Resistance in Vaginitis Patients. (PubMed, Infect Drug Resist) - "Infected vaginal trichomonas samples were cultured in vitro, and metronidazole gradient concentration plates were prepared to determine the minimum lethal concentration (MLC) of metronidazole against vaginal trichomonas, allowing for an assessment of resistance...Additionally, resistance to metronidazole was identified in some cases. Clinical efforts should prioritize prevention and treatment strategies for high-risk populations."

Journal • Gynecology • Infectious Disease • Vaginitis

Evaluation of the Medical Device Vagitab - T As Adjuvant Therapy in Patients with Bacterial Vaginosis. (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: S.I.I.T. Srl

New trial • Vaginitis

Mucoadhesive polyelectrolyte complexes of fucoidan and chitin nanowhiskers to prolong the antiprotozoal activity of metronidazole. (PubMed, Carbohydr Polym) - "At concentrations of 1-3 mg/mL, the CWN-FUC-MET particles showed no cytotoxicity (HeLa cell line). The sustained drug release rate, combined with pronounced mucoadhesive properties, improved pharmacological activity, and non-cytotoxicity makes the developed biopolymer delivery systems promising candidates for further clinical trials."

Journal • Infectious Disease

Probiotic Efficacy in Postmenopausal Women with Bacterial Vaginosis (clinicaltrials.gov) - P=N/A | N=12 | Recruiting | Sponsor: Hasanuddin University

Immunomodulating • New trial • Vaginitis

A Prospective, Randomized Controlled Study of the Probiotics as Adjuvant Treatment for Bacterial Vaginosis (clinicaltrials.gov) - P4 | N=140 | Recruiting | Sponsor: Peking University Shenzhen Hospital | Trial completion date: Dec 2023 ➔ Dec 2024 | Trial primary completion date: Dec 2023 ➔ Dec 2024

Trial completion date • Trial primary completion date • Gynecology • Obstetrics • Vaginitis

Safety and Efficacy of Two Oral Tinidazole Regimens for Refractory Trichomonas Vaginitis (clinicaltrials.gov) - P=N/A | N=20 | Not yet recruiting | Sponsor: Shangrong Fan | Trial completion date: Dec 2023 ➔ Dec 2025 | Trial primary completion date: Dec 2023 ➔ Dec 2025

Trial completion date • Trial primary completion date • Gynecology • Vaginitis

Treating male partners of women being treated for bacterial vaginosis (BV): randomised controlled trial (ANZCTR) - P3 | N=684 | Completed | Sponsor: Monash University | Active, not recruiting ➔ Completed

Trial completion • Vaginitis

Lactic Acid Enhances the Antibacterial Effect of Metronidazole by Preventing Gardnerella vaginalis Biofilm Formation via Quorum Sensing Inhibition (ASM Microbe 2024) - "We have demonstrated that lactic acid could inhibit AI-2, leading to the suppression of biofilm formation as well as the enhancement of antimicrobial effect of metronidazole against G. vaginalis. This suggests a new role for lactic acid in vaginal health."

Infectious Disease • Vaginitis

Prophylaxis Effect of Metronidazole Vaginal Gel in Decreasing the Risk of Surgical Site Infections after Elective Hysterectomy. (PubMed, J Res Pharm Pract) - "Patients with higher hospitalization duration had higher infection rates (P = 0.009). Administration of a single dosage of metronidazole vaginal gel before abdominal hysterectomy may reduce surgical site infection and have clinical values."

Clinical • Journal • Cardiovascular • Diabetes • Gynecology • Hematological Disorders • Hypertension • Infectious Disease • Metabolic Disorders

Diagnostics of Chronic Endometritis in Infertility (clinicaltrials.gov) - P=N/A | N=100 | Completed | Sponsor: Jagiellonian University | Active, not recruiting ➔ Completed

Trial completion • Endometriosis • Infertility • Obstetrics • Sexual Disorders